당뇨병에서의 혈장 Renin 활성에 관한 연구

이정상,이문호,김성권,최강원,표희정,박정식 대한핵의학회 1979 핵의학 분자영상 Vol.13 No.1

당뇨병에서의 고혈압 및 신합병증에 따른 Renin Angiotensin-Aldosterone계의 동태를 밝히기 위하여 40예의 당뇨병 환자에서 기저 및 furosemide 정주 2시간 후의 PRA를 측정하였다. 1) 40예의 당뇨병 환자는 신합병증과 고혈압의 유무에 따라 4군으로 분류하였으며, 임상적인 합병증이 없는 Ⅰ군에는 15명, 신합병증이 있는 Ⅱ군에는 7명, 신합병증과 고혈압이 같이 있는 Ⅲ군에는 8명, 고혈압만 있는 Ⅳ군에는 10명의 환자가 속하였다. 2) 각 군의 24시간 요중 Na배설량의 평균치 사이에는 유의한 차이가 없었다. 3) 기저 PRA치는 Ⅰ군이 1.53±1.09ng/ml/hr(Mean±S.D), Ⅱ군이 0.63±0.59ng/ml/hr, Ⅲ군이 0.79±0.62ng/ml/hr, Ⅳ군이 1.11±0.80ng/ml/hr로서 Ⅱ군과 Ⅲ군은 Ⅰ군에 비하여 유의하게 저하되어 있으나(P$lt;0.05), 다른 군들 간에는 유의한 차를 볼 수 없었다. 4) furosemide 정주 2시간 후의 PRA치는 Ⅰ군이 2.72±1.96ng/ml/hr, Ⅱ군이 0.92±0.78ng/ml/hr, Ⅲ군은 1.03±0.76ng/ml/hr, Ⅳ군은 1.73±1.39ng/ml/hr로써 Ⅰ군과 Ⅱ군사이에서만 유의한 차이를 보이고(P$lt;0.05), 다른 당뇨병 환자군 사이에서는 유의한 차를 볼 수 없었다. 5) furosemide 정주에 의한 Renin 분필 자극시험에 대한 반응도 Ⅱ군과 Ⅲ군에서는 둔화되어 있는 양상을 보이나, 시험대상도 적고하여 통계적 유의성에는 미치지 못하였다. 이상의 성적에서 신합병증이 있는 당뇨병에서는 혈장 Renin활성이 저하되며 furosemide 정주에 의한 Renin 분필자극시험에 대한 반응도 둔화됨을 알 수 있었다. 또한 당뇨병성 신합병증에 의한 고혈압에서도 혈장 Renin활성은 저하되는 경향을 보여서 이 경우의 고혈압은 Renin이외의 다른 요인이 작용할 것으로 보인다. To evaluate the renin-angiotensin-aldosterone system in diabetes mellitus, basal plasma renin activity(PRA) and its response to intravenous furosemide were determined in 40 diabetic subjects. The diabetics were divided into 4 groups according to the pressence of nephropathy and/or hypertension. Uncomplicated diabetics(Group I) were taken as control group and the results of the other groups were compared to this group. In diabetics viith nephropathy alone(Group Ⅱ), and with nephropathy and hypertension (Group Ⅲ), basal PRA values were 0.63±0.59ng/ml/hr., and 0.79±0.62ng/ml/hr., respectively, both significantly lower than control group. (1.53±1.09ng/ml/hr.). (P$lt;0.05) In both of the above groups, the responses to intravenous furosemide tended to be blunted. On the other hand, in diabetics, with hypertension only (Group Ⅳ), the basal and stimulated PRA were not significantly different from control. Above results suggests that nephropathy may be one of the factors which suppress renin activity in diabetes me.

The dynamics of long-term transgene expression in engrafted neural stem cells

Lee, Jean-Pyo,Tsai, David J.,In Park, Kook,Harvey, Alan R.,Snyder, Evan Y. Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of comparative neurology Vol.515 No.1

<P>To assess the dynamics and confounding variables that influence transgene expression in neural stem cells (NSCs), we generated distinct NSC clones from the same pool of cells, carrying the same reporter gene transcribed from the same promoter, transduced by the same retroviral vector, and transplanted similarly at the same differentiation state, at the same time and location, into the brains of newborn mouse littermates, and monitored in parallel for over a year in vivo (without immunosuppression). Therefore, the sole variables were transgene chromosomal insertion site and copy number. We then adapted and optimized a technique that tests, at the single cell level, persistence of stem cell-mediated transgene expression in vivo based on correlating the presence of the transgene in a given NSC's nucleus (by fluorescence in situ hybridization [FISH]) with the frequency of that transgene's product within the same cell (by combined immunohistochemistry [IHC]). Under the above-stated conditions, insertion site is likely the most contributory variable dictating transgene downregulation in an NSC after 3 months in vivo. We also observed that this obstacle could be effectively and safely counteracted by simple serial infections (as few as three) inserting redundant copies of the transgene into the prospective donor NSC. (The preservation of normal growth control mechanisms and an absence of tumorigenic potential can be readily screened and ensured ex vivo prior to transplantation.) The combined FISH/IHC strategy employed here for monitoring the dynamics of transgene expression at the single cell level in vivo may be used for other types of therapeutic and housekeeping genes in endogenous and exogenous stem cells of many organs and lineages. J. Comp. Neurol. 515:83–92, 2009. © 2009 Wiley-Liss, Inc.</P>

한국어 마찰음과 파찰음의 음향학적 및 공기역학적 특성에 관한 연구

표화영,이주환,최성희,심현섭,최홍식 한국음성과학회 1999 음성과학 Vol.6 No.1

21 normal Korean native speakers participated as subjects to investigate the acoustic and aerodynamic study of Korean fricatives and affricated and to make good use of the results for the patients with articulation problems. Their productions of [sa], [s'a], [ca], [c^ha],[c'a] [asa], [as'a], [aca], [ac^ha] , and [ac'a] were analyzed with CSL and AP II instruments. The results are as followings : (1) Fricative showed higher frequency in minimum and maximum frequency and longer duration than affricates. (2) Fricatives showed higher peak flow rate and longer rise time than affricates. (3) When we compared the different phonemes with each other, their differences were usually statistically significant, but when we compared CV and VCV syllables, they did not show significant difference, even VCV's showed higher and longer values than CV syllables. (4) Normaly, lax fricatives and affricates showed lower frequency and higher peak flow rate, shorter frication duration, and longer rise time. Keywords: Fricatives, affricates, acoustics, aerodynamics.

糖尿病을 合倂한 上腹部臟器의 部分傳位症

朴俊明,李公錫,表潤浩,李鍾星 中央醫學社 1940 中央醫學 Vol.9 No.1

만성신부전증에서 혈청 CEA치에 관한 연구

이정상,신영태,정순일,고창순,김성권,표희정,권인순 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자들은 1979년 3월부터 1980년 10월까지 서울대학교병원내과에 입원하여 만성신부전증으로 진단받고 혈액투석요법을 받지 않은 환자 15예, 혈액투석요법을 시행중인 환자 39예 및 신장이식술을 받고 신장능이 호전된 환자 23예에서 혈청 CEA치를 방사면역측정법으로 측정하여 정상대조군과 비교하여 다음과 같은 결과를 얻었다. 1) 정상 성인 65명의 혈청 CEA치의 범위는 1.0∼4.3 ng/ml이었으며 평균은 1.6±0.66 ng이었다. 2) 혈액투석요법을 시행치 않은 만성신부전증 환자 15예의 혈청 CEA치는 0.3∼8.3 ng/ml이었고 평균은 3.6±2.10 ng/ml로써 정상대조군에 비하여 유의하게 증가되어 있었다(p$lt;0.001). 3) 혈액투석요법으로 치료중인 만성신부전증 환자 39예의 혈청 CEA치는 0.7∼6.7 ng/ml로 평균이 3.0±1.52 ng/ml이며, 정상대조군에 비하여 유의하게 상승되어 있으나(p$lt;0.001), 혈액투석을 받지 않은 환자군과는 유의한 차이가 없었다. 4) 신이식 환자 23예의 혈청 CEA치의 분포는 1.8∼10.8 ng/ml이고 평균은 3.8±1.96 ng/ml로 역시 정상대조군에 비하여 유의하게 증가되어 있으나(p$lt;0.001), 만성신부전증 환자군과는 유의한 차이가 없었다. 5) 이상의 혈청 CEA치가 정상범위 이상으로 상승된 49명��환자중 이학적 소견이나 검사소견상 악성종양은 발견되지 않았다. The serum CEA levels were measured by radioimmunoassay technique in 15 patients with chronic renal failure, who were not treated with hemodialysis, in 39 patients under hemodialysis and in 23 patients who received renal transplantation. The results were compared with those in 65 normal adults and the following results were obtained. 1) Serum CEA concentrations in 65 normal adults were in the range of 1.0 to 4.3 ng/ml with a mean value of 1.6±0.66 ng/ml. 2) Serum CEA concentrations in 15 chronic renal failure patients who were not treated with hemodialysis, were in the range of 0.3 to 8.3 ng/ml with a mean value of 3.6±2.10 ng/m1 which was significantly higher than those of normal controls(P$lt;0.001). 3) Serum CEA concentrations in 39 chronic renal failure patients under hemodialysis were also much higher than normal controls(p$lt;0.001), but not significantly different from those of the patients who were not under hemodialysis(P$gt;0.05). 4) In 23 patients who received renal transplantation, serum CEA levels were snificantly higher than normal controls(P$lt;0.001), but not significantly different from those of chronic renal failure patients.

열간압연으로 제조된 Ti Aluminide 다층판재의 미세조직 : Ⅱ. 금속간화합물의 성장거동 Part Ⅱ: Growth Behavior of Intermetallic Phases

吳振根,表成奎,李聖鶴,金洛俊 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.4

The present study is to investigate the growth behavior of intermetallic phases in multilayered Ti/TiAl_3 sheets fabricated by hot rolling. When these sheets were heat-treated at 1000℃, interfacial phases such as Ti_3Al, TiAl, and TiAl_2 were grown consuming Ti and TiAl_3. As the heat treatment proceeded, TiAl was grown consuming TiAl_2, thereby finally fabricating multilayered sheets composed of Ti_3Al and TiAl. Conventional lamellar structure composed of Ti_3Al and TiAl could also be fabricated by heat treatment of multilayered Ti/TiAl_3 sheets at 1400℃. The growth rate and activation energy of interfacial phases were obtained from their growth behavior. The results indicated that the growth of intermetallic phases was mainly controlled by volume diffusion than by grain boundary diffusion. The formation process of the multilayered sheets and the formation mechanism of interfacial phases were elucidated, and an idea to fabricate multilayered or bulk Ti aluminide sheets by hot rolling and heat treatment was eventually suggested in this study.

Leak behavior of SCC degraded steam generator tubings of nuclear power plant

Hwang, Seong Sik,Kim, Hong Pyo,Kim, Joung Soo,Kasza, Kenneth E.,Park, Jangyul,Shack, William J. Elsevier 2005 Nuclear engineering and design Vol.235 No.23

<P><B>Abstract</B></P><P>A forced outage due to a steam generator tube leak in a Korean nuclear power plant has been reported <ce:cross-ref refid='bib3'>[Kim, J.S., Hwang, S.S., et al., 1999. KAERI Internal Report (Korean). Destructive analysis on pulled tubes from Ulchin unit 1. Korea Atomic Energy Research Institute]</ce:cross-ref>. Primary water stress corrosion cracking has occurred in many tubes in the plant, and they were repaired using sleeves or plugs. In order to develop proper repair criteria, it is necessary to understand the leak behavior of the tubes containing stress corrosion cracks. Cracked specimens were prepared using a room temperature cracking technique, and the leak rates and burst pressures of the degraded tubes were determined both at room temperature and at a high temperature. Some tubes with 100% through wall cracks did not show a leakage at 10.8MPa, which is the typical pressure difference of the pressurized water reactors (PWRs) during a normal operation. In some tests, the leak rates of the tubes increased with time at a constant pressure. In a high temperature pressure test at 282°C one specimen showed a very small leakage at 18.6MPa, which stopped after a small increase in the test pressure. Because stress corrosion cracks can develop at relatively low stresses, even 100% through wall cracks can be so tight that they will not leak at a normal operating pressure.</P>

Metal bonding strength in low-temperature processed titanium using atomic force microscopy with single-wall carbon nanotube tip

Choi, E. M.,Cui, Y. H.,Kwon, S. H.,Kim, A. R.,Choi, H. S.,Lee, S. J.,Pyo, S. G. John Wiley Sons, Ltd 2014 Physica Status Solidi. Rapid Research Letters Vol.8 No.2

We report the development of a Ti-Ti bonding process at a low bonding temperature below 200 degrees C using chemically surface-activated Ti thin films and a reliable evaluation method for measuring the Ti-Ti bond strength by means of atomic force microscopy (AFM). Using Ti as an interlayer enables void-free bonding because Ti exhibits fast diffusion and oxide solubility. On the other hand, wafer bonding is an important processing step for 3D circuit integration that requires a high reliability of the process. However, the reliability of bonding-strength values obtained by employing conventional measurement devices is limited by comparably large measurement errors and restricted the availability of suitable sample material. In this study, the use of AFM to measure the bonding strength is proposed. The interfacial bonding properties depend on the Ti deposition parameters. A bonding temperature of 200 degrees C was found to be appropriate for the development of a low bonding temperature wafer-bonding process. The pretreatment methods like plasma activation and chemical activation at 200 degrees C result in a Ti bonding strength of approximately 8.22 J/m(2), sufficient for applications in 3D circuit integration. ((c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

국내 분리 일본뇌염 바이러스 유전자에 대한 항체생성 연구(Ⅰ) : cloning of JEV viral genes

박찬,최우영,이호동,채수림,신은진,김인범,표재환,박근용,조해월 국립보건연구원 1999 국립보건원보 Vol.36 No.-

UKIRT Widefield Infrared Survey for Fe+

Lee, J.-J.,Koo, B.-C.,Lee, Y.-H.,Lee, H.-G.,Shinn, J.-H.,Kim, H.-J.,Kim, Y.,Pyo, T.-S.,Moon, D.-S.,Yoon, S.-C.,Chun, M.-Y.,Froebrich, D.,Davis, C. J.,Varricatt, W. P.,Kyeong, J.,Hwang, N.,Park, B.-G. Oxford University Press 2014 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.443 No.3