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Cho, S.,Im, H.,Lee, K.Y.,Chen, J.,Kang, H.J.,Yoon, H.J.,Min, K.H.,Lee, K.R.,Park, H.J.,Lee, B.J. S.E.C.T. [etc.] ; Elsevier Science Ltd 2016 European journal of medicinal chemistry Vol.108 No.-
The crystal structure of 3-deoxy-d-manno-octulosonate-8-phosphate synthase (KDO8PS) from Helicobacter pylori (HpKDO8PS) was determined alone and within various complexes, revealing an extra helix (HE) that is absent in the structures of KDO8PS from other organisms. In contrast to the metal coordination of the KDO8PS enzyme from Aquifex aeolicus, HpKDO8PS is specifically coordinated with Cd<SUP>2+</SUP> or Zn<SUP>2+</SUP> ions, and isothermal titration calorimetry (ITC) and differential scanning fluorimetry (DSF) revealed that Cd<SUP>2+</SUP> thermally stabilizes the protein structure more efficiently than Zn<SUP>2+</SUP>. In the substrate-bound structure, water molecules play a key role in fixing residues in the proper configuration to achieve a compact structure. Using the structures of HpKDO8PS and API [arabinose 5-phosphate (A5P) and phosphoenolpyruvate (PEP) bisubstrate inhibitor], we generated 21 compounds showing potential HpKDO8PS-binding properties via in silico virtual screening. The capacity of three, avicularin, hyperin, and MC181, to bind to HpKDO8PS was confirmed through saturation transfer difference (STD) experiments, and we identified their specific ligand binding modes by combining competition experiments and docking simulation analysis. Hyperin was confirmed to bind to the A5P binding site, primarily via hydrophilic interaction, whereas MC181 bound to both the PEP and A5P binding sites through hydrophilic and hydrophobic interactions. These results were consistent with the epitope mapping by STD. Our results are expected to provide clues for the development of HpKDO8PS inhibitors.
Y.N. Zhang,J. Wang,B. Qi,S.G. Wu,H.R. Chen,H.Y. Luo,D.J. Yin,F.J. Lu,H.J. Zhang,G.H. Qi 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.8
Objective: The objective of the present study was to determine whether mango saponin (MS) could be used as a feed additive in broiler chicks by evaluating growth performance, carcass characteristics, meat quality, and plasma biochemical indices. Methods: A total of 216 1-d-old Arbor Acres male broiler chicks were randomly assigned into three dietary treatments supplemented with 0 (control), 0.14% (MS 0.14%), or 0.28% (MS 0.28%) MS. Each treatment had six replicates (cages) with 12 chicks each. The feeding trial lasted for six weeks. Results: Compared with the control, dietary supplemented with 0.14% or 0.28% MS increased average daily weight gain of chicks in the grower (22 to 42 d) and the whole (1 to 42 d) phases, and the final body weight of chicks on d 42 was higher in MS supplemented groups (p<0.05). Lower L45 min* (lightness) and L24 h* values, lower b24 h* (yellowness) value, and higher a45 min* (redness) and a24 h* values of the breast muscle were observed in chicks fed with 0.28% MS on d 42 (p<0.05). The total antioxidant capacity in plasma increased in MS 0.14% group on d 21 (p<0.001). Lower contents of plasma total cholesterol and triglyceride were observed in chicks fed with 0.28% MS on d 21 and d 42, whereas the group supplemented with 0.14% MS only decreased plasma triglyceride content on d 21 (p<0.05). The glucose content in plasma decreased in MS 0.28% group on d 42 (p<0.001). Conclusion: Overall, MS could be used as a feed additive in broiler chicks, and the supplemental level of 0.28% MS in diet could improve growth performance, meat quality, and plasma lipid metabolism in broiler chicks.
간호대생과 비보건계열 여대생의 미세먼지 위험에 대한 인식과 지식, 건강 관리행위 비교 연구
김선미,김슬기,김진선,박주형,배다희,유수빈,유영주,임지향,최유진,Chen Mengyao,양숙자,손지희 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53
Purpose: This study aimed to know whether there is a comparison of perception, knowledge and health promoting behaviors about particular matter between nursing students and non-health departments college students. Methods: A quantitative research is used. Data were collected from August 1 to 19. The study sample was nursing students and non-health departments students. For the similar condition of samples, this study excluded whose first language is not Korean. Independent T-test and pearson’s correlation was used for this study. Results: A significant positive correlation did not existed between difference of major and perception(t=0.017, p=0.986), knwledge(t=0.652, p=.516) and health promoting behaviors(t=-0.114, p=.910) about particular matters. Conclusion: Based on the study results, there is no significant correlation of perception and actions about particular matters between nursing students and non-health department college students.
Chen, L.,Wu, D.,Lim, C.,Kim, D.,Nam, S. J.,Lee, W.,Kim, G.,Kim, H.,Yoon, J. unknown 2017 Chemical communications Vol. No.
<P>Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a 'turn-on'' fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy.</P>
Pseudonocardia endophytica sp. nov., isolated from the pharmaceutical plant Lobelia clavata
Chen, H.-H.,Qin, S.,Li, J.,Zhang, Y.-Q.,Xu, L.-H.,Jiang, C.-L.,Kim, C.-J.,Li, W.-J. Microbiology Society 2009 International journal of systematic and evolutiona Vol.59 No.3
<P>An endophytic actinomycete strain, designated YIM 56035(T), was isolated from the inner tissue of the traditional Chinese medicinal plant Lobelia clavata. The strain stained Gram-positive, was aerobic and exhibited branching, white aerial mycelium and yellowish-brown substrate mycelium. The strain formed spore chains on aerial hyphae. The G+C content of the genomic DNA was 70.3 mol%. On the basis of morphological, physiological, chemotaxonomic and phylogenetic characteristics, strain YIM 56035(T) was assigned to the genus Pseudonocardia. Analysis of 16S rRNA gene sequences showed 98.5, 97.3, 97.3 and 97.1 % similarity to the closely related type strains Pseudonocardia kongjuensis LM 157(T), Pseudonocardia autotrophica IMSNU 20050(T), Pseudonocardia ammonioxydans H9(T) and Pseudonocardia compacta IMSNU 20111(T), respectively. The results of DNA-DNA hybridizations and comparison of some phenotypic characteristics revealed that the strain represents a novel species of the genus Pseudonocardia. The name Pseudonocardia endophytica sp. nov. is proposed, with the type strain YIM 56035(T) (=DSM 44969(T) =CCTCC AA 206026(T) =KCTC 19150(T)).</P>
Wang, J.,Chen, M.,Shen, H.,Park, J.H.,Wu, Z.G. Elsevier Science B. V., Amsterdam 2017 NONLINEAR ANALYSIS HYBRID SYSTEMS Vol.26 No.-
In this paper, the problem of reliable event-triggered H<SUB>~</SUB> control is addressed for networked control systems by using retarded dynamic output feedback. The randomness of actuators failures is modeled by a stochastic variable in a Markov jump model framework. To guarantee the considered closed-loop system is stochastically stable with a prescribed H<SUB>~</SUB> performance level, a Markov jump event-triggered retarded dynamic output feedback H<SUB>~</SUB> controller is designed in this paper, which is the main purpose of our study. By using the stochastic analysis techniques and novel integral inequalities, some sufficient conditions for the solvability of the addressed problem are derived. Finally, an example using a satellite control system model is provided to explain the validity of the proposed method.
Experimental Study of the Runaway Current in the J-TEXT Tokamak
Y. H. Luo,Z. Y. Chen,X. Q. Zhang,D. W. Huang,W. Jin,Y. H. Huang,Y. Tang,J. C. Li,R. H. Tong,W. Yan,G. Zhuang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.3
Major plasma disruptions in tokamaks often generate runaway currents, which contain electronswith energies of several tens of megaelectron-volts (MeV). These currents can cause substantialdamage when control is lost and the current hits the limiters or the vessel wall. The interactionbetween the runaway electrons and the impurities inside the plasma results in soft X-ray emission,which can provide detailed information about the runaway generation process and the confinementof runaway electrons. A vertical soft X-ray array at the top of Joint Texas Experimental Tokamak(J-TEXT) was used to study the runaway beams resulting from major disruptions. Runawayelectron production and confinement of runaway current were observed by using soft X-ray images.
Du, J.,Chen, H.,Yang, H.,Sang, R.,Qian, Y.,Li, Y.,Zhu, G.,Mao, Y.,He, W.,Kang, D.J. Elsevier 2013 Microporous and mesoporous materials Vol.182 No.-
A porous Nd-doped TiO<SUB>2</SUB> monolith was successfully synthesized with polystyrene spheres as a template using a sol-gel method followed by calcination at high temperature. The porous Nd-doped TiO<SUB>2</SUB> monolith was characterized by X-ray diffractometry, scanning electron microscopy and Brunauer-Emmett-Teller measurements. Nd doping can increase the TiO<SUB>2</SUB> surface area by hindering the growth of large TiO<SUB>2</SUB> particles, and suppressing the recombination of photo-produced hole/electron (h<SUP>+</SUP>/e<SUP>-</SUP>) pairs. Moreover, its porous structure can provide a large surface area, facilitating enhanced adsorption and fast transfer of pollutants. To evaluate the photocatalytic activity of the porous Nd-doped TiO<SUB>2</SUB> monolith, the photo-degradation for methyl orange was investigated under UV-Vis irradiation. The porous 0.5% Nd-doped TiO<SUB>2</SUB> monolith showed better behavior than the other as-prepared samples and Degussa P25 due to its narrow band gap, high efficiency for h<SUP>+</SUP>/e<SUP>-</SUP> pair separation, and large surface area. The synergistic combination of Nd doping and the porous structure is a promising material design strategy for use in the degradation of organic pollutants.