Large-Eddy Simulations of Wind and Thermal Environments around Tall Buildings

G. Oh,M. Yang,J.-I. Choi 한국전산유체공학회 2022 한국전산유체공학회 학술대회논문집 Vol.2022 No.10

A genetic system for RNase E variant-controlled overproduction of ColE1-type plasmid DNA

Go, H.,Lee, K. Elsevier Science Publishers 2011 Journal of biotechnology Vol.152 No.4

Escherichia coli endoribonuclease RNase E (Rne) regulates replication of ColE1-type plasmids by cleaving RNA I transcripts, which are synthesized from the plasmid and regulate the plasmid replication as antisense RNA. Here, we report the development of a genetic system that efficiently overproduces ColE1-type plasmid DNA when an RNase E variant that confers a hyperactive phenotype in RNA I cleavage is conditionally expressed from chromosome. This genetic system offers a method for isolation of large quantities of pure ColE1-type plasmid DNA, which have been most commonly used as molecular biology and biotechnology tools for research and industrial purposes.

Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients

Go, H.,Koh, J.,Kim, H.S.,Jeon, Y.K.,Chung, D.H. Baillière Tindall, in association with the 2014 Respiratory medicine Vol.108 No.5

Background: Idiopathic interstitial pneumonia (IIP) is characterized by chronic interstitial inflammation and fibrosis. Although mounting evidence has suggested that toll-like receptor (TLR) 2 and TLR4 are involved in the pathogenesis of non-infectious lung injury in vitro and in mouse models, their roles in human IIP remain unknown. Methods: To address this issue, we investigated the expression patterns of TLR2 and TLR4 by immunohistochemistry in resected lung tissues from patients with usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP). Results: Type II pneumocytes, bronchial epithelial cells (BECs), and alveolar macrophages accounted for the majority of TLR2- and TLR4-expressing cells in both UIP and NSIP. The numbers of TLR2 and TLR4-positive respiratory epithelial (RE) cells, including type II pneumocytes and BECs, were significantly greater in UIP and NSIP than in the control. In particular, the numbers of TLR2-positive RE cells were much greater in UIP than in NSIP. The intensities of TLR2 and TLR4 expression in type II pneumocytes were also significantly stronger in UIP and NSIP than in the control. A comparison of the TLR expression patterns between the fibroblastic and fibrotic areas in UIP indicated that the numbers TLR2 and TLR4-positive RE cells were similar in fibroblastic areas, whereas the TLR2-positive RE cells outnumbered the TLR4-positive RE cells in the fibrotic areas. Conclusions: This study demonstrates that RE cells over-express TLR2 and TLR4 in the lungs of IIP patients. These findings suggest that high expression of TLRs may contribute to the pathogenesis of human IIP.

Scytalidium parasiticum sp. nov., a New Species Parasitizing on Ganoderma boninense Isolated from Oil Palm in Peninsular Malaysia

Goh, Yit Kheng,Goh, Teik Khiang,Marzuki, Nurul Fadhilah,Tung, Hun Jiat,Goh, You Keng,Goh, Kah Joo The Korean Society of Mycology 2015 Mycobiology Vol.43 No.2

A mycoparasite, Scytalidium parasiticum sp. nov., isolated from the basidiomata of Ganoderma boninense causing basal stem rot of oil palm in Johor, Malaysia, is described and illustrated. It is distinct from other Scytalidium species in having smaller asci and ascospores (teleomorphic stage), longer arthroconidia (anamorphic stage), hyaline to yellowish chlamydospores, and producing a fluorescent pigment. The phylogenetic position of S. parasiticum was determined by sequence analyses of the internal transcribed spacers and the small-subunit ribosomal RNA gene regions. A key to identify Scytalidium species with teleomorphic stage is provided.

Fish Purchasing Behavior and Implications for Promoting Sustainable Consumption: A Malaysian Case

Ee Von GOH(Ee Von GOH ),Susan AZAM-ALI(Susan AZAM-ALI ),Fiona MCCULLOUGH(Fiona MCCULLOUGH ) 한국유통과학회 2023 Asian Journal of Business Environment (AJBE) Vol.13 No.2

Purpose: Motivated by the fact that Malaysians fish consumption patterns and preferences have raised sustainability concerns, this study aims to understand the key entry points to promote sustainable consumption and increased uptake of sustainably sourced fish among Malaysian consumers. This is achieved by exploring the individual determinants of Malaysian consumers’ fish purchasing behaviors and their subjective and objective knowledge of fish. Research design, data, and methodology: A survey was conducted using interviewled questionnaire on 250 consumers in selected Malaysian populations recruited via street-intercept random sampling. Results: Findings confirmed the homogeneous societal culture of fish consumption amongst Malaysians. Females and consumers with advanced degree are found to be potentially effective primary targets of sustainable consumption interventions. Future interventions should consider the solutions to the low health and sustainability literacies among Malaysian consumers, and limited availability, accessibility, and affordability of sustainable options in Malaysia. Conclusion: The study findings provide new insights for the multisectoral stakeholders in the region working on promoting sustainable fish consumption and sustainable fisheries in general.

Tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis B patients compared to nucleos(t)ide-naive patients

( Goh Eun Chung ),( Eun Ju Cho ),( Jeong-hoon Lee ),( Jeong-ju Yoo ),( Minjong Lee ),( Yuri Cho ),( Dong Hyeon Lee ),( Hwi Young Kim ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-hwan Yoon ),( Fabien Zouli 대한간학회 2017 Clinical and Molecular Hepatology(대한간학회지) Vol.23 No.1

Background/Aims: A recent study reported that entecavir had inferior efficacy in nucleos(t)ide analogue (NA)-experienced chronic hepatitis B (CHB) patients compared to NA-naive patients. We sought to compare the efficacy of tenofovir disoproxil fumarate (TDF) in NA-experienced and NA-naive CHB patients. Methods: We retrospectively enrolled 252 consecutive patients who had a serum hepatitis B virus (HBV) DNA level greater than 2,000 IU/mL at the initiation of TDF treatment and who received TDF for at least 6 months. Complete virologic suppression (CVS) was defined as undetectable serum HBV DNA. We generated a multivariate Cox proportional-hazard model to examine predictive factors that were independently associated with time to CVS. Results: The mean age of patients was 48.2 years, and the cohort included 181 NA-naive patients and 71 NA-experienced patients. The median duration of TDF treatment was 14.4 (interquartile range, 9.5-17.8) months. A total of 167 (92.3%) of 181 NA-naive patients achieved CVS, and 60 (84.5%) of 71 NA-exposed patients achieved CVS. Forty-nine (89.1%) of 55 patients who previously took an NA aside from adefovir and 11 (68.8%) of 16 adefovir-experienced patients achieved CVS. In multivariable analysis, previous adefovir exposure significantly influenced time to CVS (hazard ratio, 0.37; 95% confidence interval, 0.19-0.72; P=0.003), after adjusting for HBeAg positivity, baseline HBV DNA level and cirrhosis. Conclusions: Tenofovir had inferior efficacy in adefovir-experienced CHB patients compared to NA-naive patients. The response of patients with previous adefovir exposure to TDF monotherapy should be monitored closely. (Clin Mol Hepatol 2017;23:66-73)

A Lexicalist Analysis of the Prepositional Passive in English

Goh, Gwang-Yoon 한국현대언어학회 2003 언어연구 Vol.19 No.2

The goal of this paper is to provide a lexical analysis of the English prepositional passive. We first consider briefly what really happens when the object of a preposition is passivized and what really determines the passivization possibilities of the prepositional object, and make two main proposals about the prepositional passive, following Goh (2001, 2003) and other relevant studies. On the basis of these conclusions, we provide formulations of the prepositional passive within the framework of Head-Driven Phrase Structure Grammar in the version of Pollard & Sag (1987, 1994), thereby showing that the new analysis of the P-Passive, despite certain functional aspects in it which usually defy formulation in formal syntax, can be given a coherent treatment within formal syntactic theory.

Nonalcoholic Fatty Liver Disease Is Associated with Benign Prostate Hyperplasia

Goh Eun Chung,Jeong Yoon Yim,Kim Donghee,Kwak Min-Sun,Yang Jong In,Park Boram,An Seong Joon,김주성 대한의학회 2020 Journal of Korean medical science Vol.35 No.22

Background: Nonalcoholic fatty liver disease (NAFLD) is associated with a wide spectrum of metabolic abnormalities. This study aimed to evaluate whether NAFLD is associated with benign prostatic hyperplasia (BPH) independent of other risk factors. Methods: A total of 3,508 subjects who underwent prostate and hepatic ultrasonography were enrolled. NAFLD was diagnosed and graded by ultrasonographic findings. BPH was defined by total prostate volume. Results: The prevalence of BPH was significantly increased according to NAFLD severity (P < 0.001). The multivariate analysis showed that NAFLD was associated with a 22% increase in the risk of BPH (odds ratio [OR], 1.22; 95% confidence interval [CI], 1.02–1.45). In non- obese subjects, NAFLD was associated with a 41% increase in the risk of BPH (OR, 1.41; 95% CI, 1.14–1.73), and an incremental increase in the risk of BPH according to NAFLD severity was pronounced (adjusted OR [95% CI], 1.32 [1.05–1.68] for mild NAFLD, 1.55 [1.15–2.10] for moderate to severe NAFLD vs. no NAFLD, P for trend = 0.004). However, in the obese population, the association of NAFLD in the risk of BPH was insignificant (P = 0.208). Conclusion: NAFLD is associated with an increased risk of BPH regardless of metabolic syndrome, especially in non-obese subjects. An incrementally increased risk of BPH according to NAFLD severity is prominent in non-obese subjects with NAFLD. Thus, physicians caring for non-obese patients with NAFLD may consider assessing the risk of BPH and associated urologic conditions.

An Alternative Approach for Determination of Rock Material Cohesion and Internal Friction Angle: Case Study of Marble from Peninsular Malaysia

( Goh Thian Lai ),( Abdul Ghani Rafek ),( Ailie Sofyaiana Serasa ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

The determination of rock material cohesion, c and the internal friction angle, Φ requires triaxial testing where expensive triaxial testing equipment as well as complicated testing procedures are needed. As an alternative approach, uniaxial compression with tensile strength testing can determine these two parameters. As part of an overall research programme characterising Malaysian rock mass parameters, sites composed of marble were also investigated. For Gunung Lang site; the average values of cohesion of triaxial testing, uniaxial compression & tensile strength testing at low stress regime and high stress regime are 14.5 MPa, 8.8 MPa and 14.3 MPa. The average friction angles are 49.7°, 50.3° and 35.3°. For Gunung Keriang site; the average values of cohesion for triaxial testing, uniaxial compression & tensile strength testing at low stress regime and high stress regime are 12.0 MPa, 9.6 MPa and 15.2 MPa. The average friction angles are 55.0°, 57.6° and 39.0°. For Gunung Rapat site; the average values of cohesion for triaxial testing, uniaxial compression & tensile strength testing at low stress regime and high stress regime are 20.0 MPa, 12.0 MPa and 18.0 MPa. The average friction angles are 50.0°, 48.0° and 35.5°. From this comparison, it can be seen that the use of uniaxial compression and tensile strength offers a viable option to determine cohesion, c and internal friction angle, Φ of rock.

Improved Temperature Stability in Dielectric Properties of 0.8BaTiO₃-(0.2-x)NaNbO₃-xBi(Mg_1/2Ti_1/2)O₃ Relaxors

Goh, Yumin,Kim, Baek-Hyun,Bae, Hyunjeong,Kwon, Do-Kyun The Korean Ceramic Society 2016 한국세라믹학회지 Vol.53 No.2

Ferroelectric relaxor ceramics with $BaTiO_3-NaNbO_3-Bi(Mg_{1/2}Ti_{1/2})O_3$ ternary compositions (BT-NN-BMT) have been prepared by sol-gel powder synthesis and consequent bulk ceramic processing. Through the modified chemical approach, fine and single-phase complex perovskite compositions were successfully obtained. Temperature and frequency dependent dielectric properties indicated typical relaxor characteristics of the BT-NN-BMT compositions. The ferroelectric-paraelectric phase transition became diffusive when NN and BMT were added to form BT based solid solutions. BMT additions to the BT-NN solid solutions affected the high temperature dielectric properties, which might be attributable to the compositional inhomogeneity of the complex perovskite and resulting weak dielectric coupling of the Bi-containing polar nanoregions (PNRs). The temperature stability of the dielectric properties was good enough to satisfy the X9R specification. The quasi-linear P-E response and the temperature- stable dielectric properties imply the high potential of this ceramic compound for use in high temperature capacitors.