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Deep Brain Stimulation for the Treatment of Movement Disorders
Jürgen Voges 대한신경외과학회 2003 Journal of Korean neurosurgical society Vol.34 No.4
Recently, deep brain stimulation(DBS) has been applied in many patients to treat movement disorder. Though this new methodology is in the stage of settlement, many aspects on DBS has not been well known yet. I reviewed related articles and my experience to summarize facts on DBS. Key words:Deep brain stimulation;Movement disorder.
Biofabrication: reappraising the definition of an evolving field
Groll, Jü,rgen,Boland, Thomas,Blunk, Torsten,Burdick, Jason A,Cho, Dong-Woo,Dalton, Paul D,Derby, Brian,Forgacs, Gabor,Li, Qing,Mironov, Vladimir A,Moroni, Lorenzo,Nakamura, Makoto,Shu, Wenmiao,Ta IOP Publishing 2016 Biofabrication Vol.8 No.1
Bulitta, Jü,rgen B.,Paik, Soo Heui,Chi, Yong Ha,Kim, Tae Hwan,Shin, Soyoung,Landersdorfer, Cornelia B.,Jiao, Yuanyuan,Yadav, Rajbharan,Shin, Beom Soo Elsevier 2017 European journal of pharmaceutical sciences Vol.107 No.-
<P><B>Abstract</B></P> <P>Fimasartan is a novel angiotensin II receptor blocker. Our aims were to characterize the time-course of the antihypertensive activity of fimasartan <I>via</I> a new population pharmacokinetic/pharmacodynamic model and to define its optimal dose range. We simultaneously modelled all fimasartan plasma concentrations and 24-h ambulatory blood pressure monitoring (ABPM) data from 39 patients with essential hypertension and 56 healthy volunteers. Patients received placebo, 20, 60, or 180mg fimasartan every 24h for 28days and healthy volunteers received placebo or 20 to 480mg as a single oral dose or as seven doses every 24h. External validation was performed using data on 560 patients from four phase II or III studies. One turnover model each was used to describe diastolic and systolic blood pressure. The input rates into these compartments followed a circadian rhythm and were inhibited by fimasartan. The average predicted (observed) diastolic blood pressure over 24-h in patients decreased by 10.1±7.5 (12.6±9.2; mean±SD)mmHg for 20mg, 14.2±7.0 (15.1±9.3) mmHg for 60mg, and 15.9±6.8 (11.5±9.9)mmHg for 180mg daily relative to placebo. The model explained the saturation of antihypertensive activity by counter-regulation at high fimasartan concentrations. Drug effect was maximal at approximately 23ng/mL fimasartan for diastolic and 12ng/mL for systolic blood pressure. The proposed mechanism-based population model characterized the circadian rhythm of ABPM data and the antihypertensive effect of fimasartan. After internal and external model validation, 30 to 60mg oral fimasartan given once daily was predicted as optimal dose range.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Primary Information Sector Services and Foreign Trade: Evidence from Korea and Japan
Hans-Jü,rgen Engelbrecht 서울대학교 경제연구소 1989 Seoul journal of economics Vol.2 No.3
Industrialized economies and Newly Industrializing Countries are increasingly information intensive. To some, this heralds 'deindustrialization', to others it indicates a new stage in economic development, i.e. the advent of the global information economy. The paper contributes to this debate by exploring the trade involvement of primary information sector services in Japan and Korea. Empirical evidence of direct and total exports of such services and their future prospects, is discussed. We then explore the hypothesis that purchased information services are a statistically significant determinant of comparative advantage and export involvement of manufacturing sectors. This test is only partly successful. Although useful for some other analytical purposes, our information services variable is likely to be too heterogeneous for fruitful trade analysis.
위르겐 몰트만(Jü,rgen Moltmann),이인기 혜암신학연구소 2016 신학과교회 Vol.6 No.-
Why is Christianity such a unique religion of joy, even though at its center stands the suffering of God and the cross of Christ? Because we remember the death of Christ in the light of his resurrection, and we remember his resurrection in the splendor of the divine, eternal life that is embracing our human and mortal life already here and now. This is the logic of ‘how much more’ (Paul Ricoeur): Where sin is powerful, God’s grace is much more powerful (Rom. 5:20), for Christ has died but how much more is Christ risen and has he overcome death (Rom. 8:34). So pain too will be caught up and gathered into joy, despair into hope, and temporal death into the joy of divine life. Pains are passing, and I hear praise everlasting. This is why Christianity is a religion of joy. 기독교의 핵심에는 하나님의 고통과 그리스도의 십자가가 놓여 있는데, 어째서 기독교가 그처럼 독특한 기쁨의 종교라고 할 수 있는가? 우리는 그리스도의 죽음을 그분의 부활의 관점에서 기억하고, 그분의 부활을 바로 지금 이곳에서 우리 인간의 생명을 포용하는 거룩하고 영원한 생명의 영광으로 기억하기 때문이다. 이것이 바로 “얼마나 더 많이”의 논리이다: 죄가 강력한 곳에 하나님의 은혜가 훨씬 더 강력하다(롬5:20), 왜냐하면 그리스도께서 죽으셨지만 얼마나 더 많이 그리스도께서 부활하셔서 죽음을 극복해 오셨던가(롬8:38-39)! 그러므로 고통 역시 붙들려서 기쁨에로 거둬들여지게 될 것이고, 절망은 희망으로, 일시적인 죽음은 거룩한 삶의 기쁨으로 회복될 것이다. 고통이 지나가고 있다. 그리고 나는 찬양 소리가 끝없이 이어지는 것을 듣는다. 이것이 기독교가 기쁨의 종교인 이유이다.