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      • Empathic Modelling for Product Design Engineering Students

        ( Ibrahim,N. I. ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-

        This paper explains the use of empathic modelling as a pedagogical tool for Product Design Engineering students. The objective is to expose students to the challenges of being physically impaired when using products. The method that had been used include using low technology props and focusing on simulating people with multiple disabilities. Based on students` responses, it can be concluded that empathic modelling has helped students to gain better understanding the difficulties that older and disabled people usually encounter when carrying out daily tasks. Finally, several issues and challenges related to the use of empathic modelling method are discussed. It is hope that this paper will be valuable for those interested in using empathic modelling in teaching Product Design Engineering.

      • KCI등재

        Ameliorative effect of hesperidin against high dose sildenafil-induced liver and testicular oxidative stress and altered gene expression in male rats

        Ibrahim M. Ibrahim Laila,Samar HassabAllah Kassem,Marwa Salah ElDin Mohamed Diab 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.3

        Background: The clinical use of sildenafil citrate (Viagra), a drug used to treat erectile dysfunction, is limited because of its many side effects on tissues. In this context, we aimed to investigate the protective effects of hesperidin, a citrus flavonoid, on hepatic and testicular damage induced by a high dose of sildenafil citrate in male rats. Rats were randomly divided into four groups. The first group was used as the control group. The second group was orally administered sildenafil citrate at a high dose of 75 mg/kg thrice a week. In the third group, hesperidin was administered orally at a dose of 50 mg/kg/day. The fourth group was administered 75 mg/kg sildenafil citrate three times a week with 50 mg/kg hesperidin daily. The experiment lasted for 28 days. Results: In the sildenafil-treated groups, blood indices were altered, liver function tests were deranged, and serum testosterone levels were reduced. In the liver and testicular tissue, sildenafil citrate treatment resulted in significant reductions in catalase and total antioxidant capacity; as well as increased malondialdehyde, reactive oxygen species, and nitrous oxide levels. In addition, sildenafil citrate treatment caused abnormal histopathological patterns in both the liver and the testes. Liver vascular endothelial growth factor and testicular steroidogenic acute regulatory protein gene expression were upregulated. Conclusions: Hesperidin attenuated the harmful effects of intensive sildenafil citrate treatment on liver and testicular functions, alleviated oxidative stress and normalized blood indices. Therefore, hesperidin could be protective against sildenafil citrate-induced oxidative damage that may develop over the long term.

      • KCI등재

        Numerical characterization of downburst wind field at WindEEE dome

        Ibrahim Ibrahim,Haitham Aboshosha,Haitham Aboshosha 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.3

        Downbursts are acknowledged for being a major loading hazard for horizontally-extending structures like transmission line systems. With these structures being inherently flexible, it is important to characterize the turbulence associated with the wind flow of downburst events being essential to quantify dynamic excitations on structures. Accordingly, the current study numerically characterizes the downburst wind field of open terrain simulated at the Wind Engineering, Energy and Environment (WindEEE) dome testing facility at The University of Western Ontario in Canada through a high-resolution large eddy simulation (LES). The study validates the numerical simulation considering both the mean and the turbulent components of the flow. It then provides a detailed visual description of the flow at WindEEE through the capabilities enabled by LES to identify the key factors affecting the flow. The study also presents the spatial distribution of turbulence intensities and length scales computed from the numerical model and compares them with previous values reported in the literature. The comparison shows the ability of the downburst simulated at WindEEE to reproduce turbulence characteristics similar to those reported from field measurements. The study also indicates that downburst turbulence is well-correlated circumferentially which imposes high correlated loads on horizontally-distributed structures such as transmission lines.

      • Challenges and Opportunities for Niger's Economic Development: A Focus on Agriculture and Mining

        Ibrahim Aïchatou(Ibrahim Aïchatou ),Ousmane Mariama(Ousmane Mariama ) 아시아사회과학학회 2023 Jornal of Asia Social Science Vol.10 No.1

        This paper examines the challenges and opportunities for sustainable economic development in Niger, focusing on the agriculture and mining sectors. While agriculture is the mainstay of Niger's economy, it faces challenges such as climate change, low productivity, and lack of infrastructure. The mining sector has great potential, but also faces challenges related to regulation, environmental protection, and social impacts. The government has implemented policies and initiatives to support these sectors and promote sustainable development. The paper identifies key policy options, including revising regulations, improving infrastructure, promoting local content, and implementing social and environmental safeguards. To achieve sustainable and inclusive development, Niger needs to prioritize investments in human capital, social protection, and environmental sustainability, while also promoting private sector engagement and regional integration.

      • Effect of horizontal joints on structural behavior of sustainable self-compacting reinforced concrete beams

        Ibrahim, Omar Mohamed Omar,Heniegal, Ashraf Mohamed,Ibrahim, Khamis Gamal,Agwa, Ibrahim Saad Techno-Press 2020 Advances in concrete construction Vol.10 No.5

        This study investigated the effect of horizontal casting joints on the mechanical properties and structural behavior of sustainable self-compacting reinforced concrete beams (SCRCB). The experimental research consisted of two stages. The first stage used four types of concrete mixtures which were produced to indicate the effects of cement replaced with cement waste at 0%, 5%, 10%, and 15% by weight of cement content on fresh concrete properties of self-compacting concrete (SCC) such as, passing ability, filling ability, and segregation resistance. In addition, mechanical properties such as compressive, tensile, and flexural strength were also studied. The second stage selected the best mixture from the first stage and studied the effect of horizontal casting joints on the structural behavior of sustainable SCRCBs. The effect of horizontal casting joints on the mechanical properties and structural behavior were at the 25%, 50%, 75%, and 100% of sample height. Load deflection, failure mode, and theoretical analysis were studied. Results indicated that the incorporation of replacement with cement waste by 5% to 10% led to economic and environmental advantages, and the results were acceptable for fresh and mechanical properties. The results indicated that delaying the time for casting the second layer and increasing the cement waste in concrete mixtures had a great effect on the mechanical properties of SCC. The ultimate load capacity of horizontal casting joints reinforced concrete beams slightly decreased compared with the control beam. The maximum deflection of casting joint beams with 75% of samples height is similar with the control beam. The experimental results of reinforced concrete beams were substantially acceptable with the theoretical results. The failure modes obtained the best forced casting joint on the structural behavior at 50% height of casting in the beam.

      • KCI등재
      • KCI등재

        Rheological and Mucoadhesive Characterization of Poly(vinylpyrrolidone) Hydrogels Designed for Nasal Mucosal Drug Delivery Ibrahim

        Ibrahim A. Alsarra,Amel Y. Hamed,Steven H. Neau,Fars K. Alanazi 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4

        Poly(vinylpyrrolidone) (PVP) hydrogels were crosslinked by gamma irradiation to add structure and rigidity, and then rheological and mucoadhesive properties were evaluated. The effects of PVP concentration, radiation dose, and additives, such as poly(ethylene glycol) (PEG) and glycerol, on rheological properties were investigated. In an oscillatory analysis, an increase in polymer concentrations increased the storage modulus (G') and the loss modulus (G'') but decreased the loss tangent (tan δ < 1). The relationships between G' or G'' and the frequency levelled off at higher frequencies, which is indicative of polymer chain entanglement and network formation. Each of the 6% PVP hydrogels exhibited plastic flow with rheopectic behavior. PVP concentration, radiation dose, and the presence of PEG or glycerol influenced the rheological and mucoadhesive properties of the hydrogels. However, adding acyclovir to the formulation did not have a profound effect on the rheological behavior of the hydrogels. The results suggest that a 3% PVP hydrogel with 1% PEG crosslinked with 20 kGy is the most appropriate hydrogel. The results demonstrated the successful complementary application of oscillatory and flow rheometry to characterize and develop a hydrogel for mucosal drug administration.

      • KCI등재

        Association of Syntax Score II with Contrast-induced Nephropathy and Hemodialysis Requirement in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

        Ibrahim Rencuzogullari,Metin Çağdaş,Süleyman Karakoyun,Yavuz Karabağ,Mahmut Yesin,Mustafa Ozan Gürsoy,İnanç Artaç,Doğan İliş,Süleyman Çağan Efe,Kevser Tural,Ibrahim Halil Tanboğa 대한심장학회 2018 Korean Circulation Journal Vol.48 No.1

        Background and Objectives Contrast-induced nephropathy (CIN) is a common complication of primary percutaneous coronary intervention (pPCI) and is associated with high mortality and morbidity and long hospital stay in patients with ST elevation myocardial infarction (STEMI). The Syntax Score (SS) has previously been studied in STEMI patients, and it was associated with increased CIN development and long-term mortality. This study investigates a possible relationship between CIN development and Syntax Score II (SSII) and compares SS and SSII by assessing CIN risk in STEMI patients treated with pPCI. Methods A total of 1,234 patients who underwent pPCI were divided into 2 groups according to CIN development. Patients with CIN were further divided into 2 groups according to whether or not they required hemodialysis. Reclassification tables, net reclassification improvement, and integrated discriminative improvement methods were used to assess the additive predictive value of SSII for predicting CIN. Results In the present study, 166 patients (13.5%) had CIN. Although both SS and SSII were significantly higher in CIN patients, only SSII was an independent predictor of CIN (odds ratio [OR], 1.031; 95% confidence interval [CI], 1.012–1.051; p<0.001) and hemodialysis requirement (OR, 1.078; 95% CI, 1.046–1.078; p<0.001). When comparing SSII and SS in their ability to determine CIN risk, we found SSII to have a reclassification improvement of 27.59% (p<0.001) and an integrated discrimination improvement of 9.1% (p<0.001). Conclusions The combination of clinical and anatomic variables can more accurately identify patients who are at high risk for CIN after pPCI. While SSII is harder to calculate than SS, it provides better prediction for CIN and hemodialysis requirement than SS.

      • SCIESCOPUSKCI등재

        Precepitation and purification of amylase enzyme produced by streptomyces aureofaciens 77

        Ibrahim, A.N.,Ahmed, F.H.,Ibrahim, M.M.K.,Arafa, M.A.I. The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.1

        Precipitation and purification of amylase secreted by Streptomyces aureofaciens 77 in liquid inorganic salts-starch medium under the optimum conditions were carried out. Ammonium sulphate fractionation was used to precipitate amylase in cell free culture filtrate. (NH/sub 4/)/sub 2/ SO/sub 4/ at a concentration of 50-70% saturation gave the highest enzyme yield. The obtained precipitates were redissolved in phosphate buffer (pH 7.0) and subjected to dialysis. The dialyzed enzyme preparation was applied to DEAE-cellulose column chromatography which resulted in an increase of purification up to 59.48 fold. A further step of purification was done by applying the obtained purified sample to Sephadex-G200 column chromatography which resulted in ann increase of purification up to 73. 92 fold. The results clearly indicated that the isolated amylase from S. aureofaciens 77 was only on type.

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