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RISS 인기검색어
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- 저자 : Ibrahim M. Ibrahim Laila (검색결과 3 건)
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Ibrahim M. Ibrahim Laila,Samar HassabAllah Kassem,Marwa Salah ElDin Mohamed Diab 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.3
Background: The clinical use of sildenafil citrate (Viagra), a drug used to treat erectile dysfunction, is limited because of its many side effects on tissues. In this context, we aimed to investigate the protective effects of hesperidin, a citrus flavonoid, on hepatic and testicular damage induced by a high dose of sildenafil citrate in male rats. Rats were randomly divided into four groups. The first group was used as the control group. The second group was orally administered sildenafil citrate at a high dose of 75 mg/kg thrice a week. In the third group, hesperidin was administered orally at a dose of 50 mg/kg/day. The fourth group was administered 75 mg/kg sildenafil citrate three times a week with 50 mg/kg hesperidin daily. The experiment lasted for 28 days. Results: In the sildenafil-treated groups, blood indices were altered, liver function tests were deranged, and serum testosterone levels were reduced. In the liver and testicular tissue, sildenafil citrate treatment resulted in significant reductions in catalase and total antioxidant capacity; as well as increased malondialdehyde, reactive oxygen species, and nitrous oxide levels. In addition, sildenafil citrate treatment caused abnormal histopathological patterns in both the liver and the testes. Liver vascular endothelial growth factor and testicular steroidogenic acute regulatory protein gene expression were upregulated. Conclusions: Hesperidin attenuated the harmful effects of intensive sildenafil citrate treatment on liver and testicular functions, alleviated oxidative stress and normalized blood indices. Therefore, hesperidin could be protective against sildenafil citrate-induced oxidative damage that may develop over the long term.
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Electric, Thermoelectric and Magnetic Properties of Nickel(II) Imine Nanocomplexes
A. Elshafaie,Laila H. Abdel-Rahman,Ahmed M. Abu-Dief,Samar Kamel Hamdan,A. M. Ahmed,E. M. M. Ibrahim 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.7
Production of novel organic semiconductor nanomaterials is essential for enabling the development of personal, portable and flexible electronic modules. This work presents Ni(II)-Schiff base complexes with enhanced Seebeck coefficient and weak ferromagnetic ordering for thermoelectric and magnetic devices. Four Ni(II)-Schiff base complexes (namely [Ni(C12H10N3O4Br)] · 2H2O, [Ni(C16H11N3O4] · 2H2O, [Ni(C21H14N5O8Br)] and [Ni(C25H17N5O8)] · 1/2H2O) have been synthesized in nanosized dimensions. The electrical and thermoelectric properties have been studied, and comprehensive discussions have been presented to understand the electrical conduction mechanisms. The electrical conductivity measurements reveal that the conduction is due to the charge carriers hoping between the atomic sites of the same energy levels in the molecule as well as the transfer of the charge carriers between the neighboring complex molecules due to overlapping of their orbitals. The thermoelectric measurement confirms that the nanocomplexes (NCs) are non-degenerate P-type semiconductors with enhanced Seebeck coefficient values compared with those reported for other organic materials. The NCs exhibit antiferromagnetic to paramagnetic transitions with the increase of temperature and weak ferromagnetic ordering at 300 K.
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Rania Ibrahim Shebl,Mohamed E. Amer,Tamer M. M. Abuamara,Emadeldin R. Matar,Hassan Fathy Ahmed,Tamer Albasyoni Gomah,Laila E. El Moselhy,Mohammed Abu-Elghait,Aly Fahmy Mohamed 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.3
Purpose: One of the essential goals regarding the successful control of rabies infection is the development of a safe, effective, and inexpensive vaccine. the current study aimed to evaluate the inactivation potential of β-propiolactone (βPL), binary ethyleneimine (BEI), and hydrogen peroxide (H2O2). Materials and Methods: Estimating the inactivation kinetics of βPL, BEI, and H2O2 revealed that the tested inactivants could completely and irreversibly inactivate rabies virus within 2, 12, and 4 hours, respectively while maintaining its viral immunogenicity. The potency of βPL, BEI, and H2O2 inactivated vaccines was higher than the World Health Organization acceptance limit and were in the order of 3.75, 4.21, and 3.64 IU/mL, respectively. Monitoring the humoral and cellular immunity elicited post-immunization using Staphylococcus aureus derived hyaluronic acid (HA) and bacillus Calmette-Guérin purified protein derivative (PPD) adjuvanted rabies vaccine candidates were carried out using enzyme-linked immunosorbent assay. Results: Results demonstrated that both adjuvants could progressively enhance the release of anti-rabies total immunoglobulin G as well as the pro-inflammatory mediators (interferon-gamma and interleukin-5) relative to time. However, a higher immune response was developed in the case of HA adjuvanted rabies vaccine compared to PPD adjuvanted one. The harmful consequences of the tested adjuvants were considered via investigating the histopathological changes in the tissues of the immunized rats using hematoxylin and eosin stain. Lower adverse effects were observed post-vaccination with HA and PPD adjuvanted vaccines compared to that detected following administration of the currently used alum as standard adjuvant. Conclusion: Our findings suggested that HA and PPD could serve as a promising platform for the development of newly adjuvanted rabies vaccines with elevated immune enhancing potentials and lower risk of health hazards.
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