http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The Changes in Respiratory and Enteric Adenovirus Epidemiology in Korea From 2017 to June 2022
Kim Kyung-Ran,Won Jisu,Kim Hyungjun,Kim Bryan Inho,Kim Mi Jin,Kim Jae Young,Gwack Jin,Kim Yae-Jean 대한의학회 2023 Journal of Korean medical science Vol.38 No.9
Since October 2021, severe acute hepatitis of unknown etiology in pediatric patients has been observed in many countries around the world. Adenovirus (mainly enteric adenovirus) was detected in more than 50% of the cases. Nationwide surveillance on acute hepatitis of unknown etiology in pediatric patients was started in May 2022 in Korea. Taking into account the severity of the illness and the urgency of the epidemiological situation worldwide, we report a summary of changes in adenovirus epidemiology during the past five years and six months in Korea.
Kim, Choong-Ki,Jeong, Eun Gyo,Kim, Eungtaek,Song, Jeong-Gyu,Kim, Youngjun,Woo, Whang Je,Lee, Myung Keun,Bae, Hagyoul,Jeon, Seong-Bae,Kim, Hyungjun,Choi, Kyung Cheol,Choi, Yang-Kyu IOP 2017 Nanotechnology Vol.28 No.5
<P>Field-effect transistors (FETs) composed of 2D materials (2DMs) such as transition-metal dichalcogenide (TMD) materials show unstable electrical characteristics in ambient air due to the high sensitivity of 2DMs to water adsorbates. In this work, in order to demonstrate the long-term retention of electrical characteristics of a TMD FET, a multidyad encapsulation method was applied to a MoS<SUB>2</SUB> FET and thereby its durability was warranted for one month. It was well known that the multidyad encapsulation method was effective to mitigate high sensitivity to ambient air in light-emitting diodes (LEDs) composed of organic materials. However, there was no attempt to check the feasibility of such a multidyad encapsulation method for 2DM FETs. It is timely to investigate the water vapor transmission ratio (WVTR) required for long-term stability of 2DM FETs. The 2DM FETs were fabricated with MoS<SUB>2</SUB> flakes by both an exfoliation method, that is desirable to attain high quality film, and a chemical vapor deposition (CVD) method, that is applicable to fabrication for a large-sized substrate. In order to eliminate other unwanted variables, the MoS<SUB>2</SUB> FETs composed of exfoliated flakes were primarily investigated to assure the effectiveness of the encapsulation method. The encapsulation method uses multiple dyads comprised of a polymer layer by spin coating and an Al<SUB>2</SUB>O<SUB>3</SUB> layer deposited by atomic layer deposition (ALD). The proposed method shows wafer-scale uniformity, high transparency, and protective barrier properties against adsorbates (WVTR of 8?×?10<SUP>−6</SUP> g m<SUP>−2</SUP> day<SUP>−1</SUP>) over one month.</P>
Self-assembled nanoparticles comprising aptide–SN38 conjugates for use in targeted cancer therapy
Kim, Hyungjun,Lee, Yonghyun,Kang, Sukmo,Choi, Minsuk,Lee, Soyoung,Kim, Sunghyun,Gujrati, Vipul,Kim, Jinjoo,Jon, Sangyong IOP 2016 Nanotechnology Vol.27 No.48
<P>Self-assembled nanoparticles (NPs) have been intensively utilized as cancer drug delivery carriers because hydrophobic anticancer drugs may be efficiently loaded into the particle cores. In this study, we synthesized and evaluated the therapeutic index of self-assembled NPs chemically conjugated to a fibronectin extra domain B-specific peptide (APT<SUB>EDB</SUB>) and an anticancer agent SN38. The APT<SUB>EDB</SUB>–SN38 formed self-assembled structures with a diameter of 58?±?3 nm in an aqueous solution and displayed excellent drug loading, solubility, and stability properties. A pharmacokinetic study revealed that the blood circulation half-life of SN38 following injection of the APT<SUB>EDB</SUB>–SN38 NPs was markedly higher than that of the small molecule CPT-11. The APT<SUB>EDB</SUB>–SN38 NPs delivered SN38 to tumor sites by both passive and active targeting. Finally, the APT<SUB>EDB</SUB>–SN38 NPs exhibited potent antitumor activities and low toxicities against EDB-expressing tumors (LLC, U87MG) in mice. This system merits further preclinical and clinical investigations for SN38 delivery.</P>
Kim, Young-Jin,Park, Junbeom,Jeong, Hyeon Su,Park, Min,Baik, Seulki,Lee, Dong Su,Rho, Heesuk,Kim, Hyungjun,Lee, Joong Hee,Kim, Seung-Min,Kim, Young-Kwan The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.12
<P>The seed-mediated growth strategy of Au nanoparticles (Au NPs) inside carbon nanotube (CNT) fibers is demonstrated to greatly improve their mechanical and electrical properties and provide a function for catalytic applications. The resulting Au NP@CNT nanocomposite fibers exhibit 100% knot efficiency, catalytic activity and considerably enhanced modulus, tensile strength, and electrical conductivity from 7 GPa, 109 MPa and 1300 S cm<SUP>−1</SUP> to 24 GPa, 351 MPa and 3600 S cm<SUP>−1</SUP>, respectively. The enhancement mechanism is also revealed by systematic characterization and theoretical simulations.</P>
Kim, Hyungjun,Kim, Min Ku,Jang, Hanmin,Kim, Bongjoong,Kim, Dong Rip,Lee, Chi Hwan American Chemical Society 2019 ACS NANO Vol.13 No.7
<P>Real-time monitoring of cellular behaviors and functions with sensor-instrumented scaffolds can provide a profound impact on fundamental studies of the underlying biophysics and disease modeling. Although quantitative measurement of predictive data for <I>in vivo</I> tests and physiologically relevant information in these contexts is important, the long-term reliable monitoring of cellular functions in three-dimensional (3D) environments is limited by the required set under wet cell culture conditions that are unfavorable to electronic instrument settings. Here, we introduce an ultrabuoyant 3D instrumented scaffold that can remain afloat on the surface of culture medium and thereby provides favorable environments for the entire electronic components in the air while the cells reside and grow underneath. This setting enables high-fidelity recording of electrical cell-substrate impedance and electrophysiological signals for a long period of time (weeks). Comprehensive <I>in vitro</I> studies reveal the utility of this platform as an effective tool for drug screening and tissue development.</P> [FIG OMISSION]</BR>
Input Voltage Mapping Optimized for Resistive Memory-Based Deep Neural Network Hardware
Taesu Kim,Hyungjun Kim,Jinseok Kim,Jae-Joon Kim IEEE 2017 IEEE electron device letters Vol.38 No.9
<P>Artificial neural network (ANN) computations based on graphics processing units (GPUs) consume high power. Resistive random-access memory (RRAM) has been gaining attention as a promising technology for implementing power-efficient ANNs, replacing GPU. However, nonlinear I-V characteristics of RRAM devices have been limiting its use for ANN implementation. In this letter, we propose a method and a circuit to address issues due to the nonlinear I-V characteristics. We demonstrate the feasibility of the method by simulating its application to multiple neural networks, from multi-layer perceptron to deep convolutional neural network based on a typical RRAM model. Results from classifying datasets including ImageNet show that the proposed method produces much higher accuracy than the naive linear mapping for a wide range of nonlinearity.</P>
Son, Suji,Lee, Jang Mee,Kim, Se-Jun,Kim, Hyejin,Jin, Xiaoyan,Wang, Kang Kyun,Kim, Minho,Hwang, Jeong Wook,Choi, Wonyong,Kim, Yong-Rok,Kim, Hyungjun,Hwang, Seong-Ju Elsevier BV 2019 Applied Catalysis B Vol.257 No.-
<P><B>Abstract</B></P> <P>Hybridization with conductive 2D nanosheets (NSs) attracts plenty of research activities because of its effectiveness for improving the photocatalyst performance of diverse semiconductors. Here, versatile roles of conductive NSs in hybrid-type photocatalysts are systematically investigated with three representative conductive 2D NSs to synthesize highly efficient visible light-active photocatalysts. Among several conductive NS-based nanohybrids, the RuO<SUB>2</SUB> NS-based nanohybrid exhibits the highest photocatalytic activities. Based on systematic spectroscopic analyses, polar RuO<SUB>2</SUB> NS appears to be more effective as electron reservoir, photosensitizer, cocatalyst and charge carrier pathway in hybrid-type photocatalyst than MoS<SUB>2</SUB> and graphene NSs. The high efficiency of RuO<SUB>2</SUB> NS as hybridization matrix is attributable to the high surface hydrophilicity, high surface bond polarity, and enhanced interfacial electronic coupling of this hydrophilic NS with semiconductor. The present study underscores that hydrophilic conductive metal oxide NS can act as the most efficient hybridization matrix for exploring high-performance photocatalysts with strong interfacial electronic coupling.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 2D conductive nanosheets play versatile roles in hybrid-type photocatalysts. </LI> <LI> Hybridization with conductive nanosheet remarkably enhances photocatalyst activity. </LI> <LI> Interfacial electronic coupling is the most crucial factor for hybrid-type photocatalyst. </LI> <LI> Hydrophilic metal oxide nanosheet is the most efficient hybridization matrix. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>