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- 검색키워드
- 저자 : Hyung Sun Sohn ) (검색결과 190 건)
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수종 치과재료의 제I급 와동에서의 변연 누출에 관한 실험적 연구
이선희,손흥규,최형준 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.1
Microleakage is a problem of all filling materials of losted teeth structure and is clinically undetectable. Because marginal leakage may be responsible for pulp irritation, pulp inflammation, necrosis and recurrent caries, it is essential to prevent and control it. For the evaluations of microleakage of various class I filling materials, 175 extracted teeth were filled with amalgam, light curing composite resin, glass inomer cement, IRM and Fermit-N. After thermocycling, speciemens were placed in 1% methylene blue dye solution for 24 hours in an incubator set 37℃. The teeth were sectioned at filling body center and margin and degree of dye penetration was observed with a stereomicroscope. The following results were obtained. 1. Light cured composite resin has the excellent results and microleakage is increased in the order of amalgam, IRM, Fermit-N, glass ionomer cement.(SAS-6.0 system) and there was a statistically significancy in marginal leakage for each filling materials.(Kruskal-Wallis analysis, P<0.05) 2. Microleakage of the center and margin was statistically insignificant (Mann-Whitney analysis P<0.05) 3. There was less microleakage for amalgam than light cured composite resin but was statistically insignificant (Mann-Whitney analysis, P<0.05) and also showed less marginal leakage for Fermit-N compared to glass ionomer cement but also was statistically insignificant. (Mann-Whitney analysis, P<0.05).
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양동원,김범생,김의녕,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1
Background: Subcortical vascular dementia(SVaD) is relatively homogeneous subtype of VaD, but the mechanisms of cognitive dysfunction of subcortical VaD are not completely understood yet This study investigated the changes of cerebral blood flow(CBF) in patients with SVaD and the contribution of the white matter hyperintensity(WMHI) and clinical severity to CBF changes. Methods: 99mTc-ethyl cysteinate dimer single photon emission computed tomography(SPECT) was performed to measure the regional CBF and statistical parametric mapping(SPM)99 software was applicated to automated and objective analysis of the SPECT image data Twenty three patients (male 12, female 11) of mild to moderate dementia who met both the criteria of the DSM-IV and probable or possible NINDS-AIREN for VaD and have subcortical white matter changes and lacunar infarction on brain MRI and seventeen normal control subjects (male 7, female 10) were evaluated The severity of the WMHI was measured by semi-quantitative scale method proposed by Mantyla. The seventy of dementia was measured by clinical dementia rating (CDR) scale Results: SPM analysis of SPECT image revealed significantly reduced regional CBF in the right thalamus, left caudatd nucleus, cingulate, bilateral superior temporal, and left ventral subcallosal gyri in SVaD patients when it compared to normal controls (corrected p<0 001). Among four WMHIs, only the WMHI was associated with the small CBF reduction in the left superior temporal gyrus (uncorrected p<0 01) The reduction of CBF according to the severity of dementia was noted in the anterior and posterior association areas (uncorrected p<0 01). Conclusions: our study suggests that cognitive dysfunction of SVaD may be related with CBF reduction in the above mentioned brain areas, which probable are not associated with the severity of periventncular WMHI and dementia.
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양동원,김범생,손영민,박정욱,정용안,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2
Background and Objectives . Alzheimer's disease (AD) is the most common cause of the dementia Pathologic and functional changes of AD are known to be unevenly distributed in the brain. This study investigates changes of cerebral blood flow (CBF) in patients with AD to determine brain regions with hypoperfusion that reflects progression of disease. Methods. Tc-99m-ECD single photon emission computed tomography (SPECT) was performed to measure regional CBF and statistical parametric mapping (SPM) 99 soft ware was used for the automated and objective approach to analyze SPECT image data. Twenty-five patients with mild to moderate dementia who met NINCDS-ADRDA critena for AD (male 11 female 14) and 17 age-matched normal control subjects were studied. The severity of AD was measured by clinical dementia rating (CDR) scale Results. SPM analysis of SPECT images revealed that CBF in the anterior cingulate gyrus left superior panetal cortex left medial frontal cortex left infenor temporal cortex. right thalamus and left hippocampus was significantly decreased in AD patients compared with normal controls (corrected p<0.05). The reduction of CBF according to CDR was localized in the left hippocampus and infenor temporal cortex right antenor and postenor ciagulate cortex and right superior panetal cortex (uncorrected p<0.01). Conclusions : Our data suggest that the cognitive dysfunction of AD is strongly related with functional abnormality in discrete brain areas 99m-Tc ECD SPECT with SPM analysis could be used as a useful functional imaging tool in AD study.
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이승재,양동원,손영민,김범생,정용안,손형선,주라형 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1
Background & Objectives:Transient global amnesia (TGA) is a clinical syndrome characterized by sudden memory loss of recent events, transient inability to retain new information, and retrograde amnesia in the absence of other neurological signs and symptoms, resolving within 24 hours. This study investigated alterations in regional cerebral blood flow (rCBF) in patients with TGA by using statistical parametric mapping 99 (SPM99). Methods:5 patients with TGA and 9 age-matched normal control subjects were evaluated. Tc-99m-ethyl cysteinate dimer (ECD) SPECT were performed within 1 to 4 days of the event to measure the regional CBF, and SPM99 were applied to the objective analysis of SPECT data between two groups. Follow-up ECD SPECT was done at 49 to 107 days (mean 76.8) after the previous SPECT to evaluate the long term changes of the regional CBF. Results:The SPM analysis of SPECT images revealed significantly decreased rCBF in the left superior temporal gyrus, the left parietal supramarginal gyrus and the left thalamus (corrected p=0.01) and increased CBF in the contralateral mirror regions in patients with TGA. Follow-up SPECT showed persistent rCBF changes in the same regions. Conclusions:We demonstrate decreased perfusion in the left cerebral hemisphere and increased perfusion in the right cerebral hemisphere in patients with TGA. This reciprocal change of rCBF might suggest that imbalanced neuronal activity between two hemispheres may be important in the pathogenesis of the TGA. Also, the abnormal rCBF changes appeared to last long after the complete recovery of clinical manifestation of TGA.
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Radioimmunoscintigraphy Using IMACIS-1 in Gastrointestinal Cancer
Sohn, Hyung Sun,Kim, Sung Hoon,Lee, Jae Mun,Kim, Choon-Yul,Bahk, Yong Whee CATHOLIC MEDICAL CENTER 1990 Bulletin of the Clinical Research Institute Vol.18 No.1
Most of the diagnostic methods currently used for the detection of neoplastic masses provide indirect evidence. To obtain greater specificity in the interpretation of neoplasias by in vivo methods, the immunological approach appears to be most promising. Two problems that interfered with progress in this field were the lack of turner specific antigen and the lack of well-defined and reproducible antibodies. To improve the sensitivity and specificity of radioimmunoscintigraphy as a technique for tumor localization, the use of monoclonal antibodies, fragments of antibodies and single photon emission computerized tomography (SPECT) are reasonable. The obvious advantages of monoclonal antibodies are their homogeneity, their specificity for the immunizing antigen and the reaction with a single determinant-thus no large immunecomplexes with antigen are formed. Monoclonal antibody technique has recently provided an opportunity to reevaluate the role of nuclear medicine for the diagnosis of malignant diseases by using the immunological approach. Our first results by means of radioimmunoscintigraphy of CEA and CA 19-9 producing tumors using a cocktail of F (ab’)2 fragments of monoclonal antibodies to CA 19-9 and CEA labeled with I-131 (IMACIS-1) are reported. The aims of this investigation was to evaluate the role of immunoscintigraphy in patients with colorectal and other cancers for diagnosis of local recurrences and metastasis. This report contains results of the first 8 colorectal and pancreas cancer patients with the elevation of the level of serum CEA and/or CA 19-9. IMACIS-1 was injected intravenously during 30 minutes in 100 ml saline solution after skin test. Planar scintigrams were recorded 3, 5 and 7 days after the injection of the IMACIS-1. Anterior, lateral and posterior views of the liver as well as anterior and posterior view of the pelvis were obtained at each patients as an I-131 antibody image. We were able to localize exactly the malignant process with the double-nuclide double-compound Tc-99m I-131 (Tc-I) scintigrams. In Tc & I double-nuclide scintigraphy, computer subtraction display provided more clear localization of the tumor. We compared the results of radioimmunoscintigraphy with CT, ultrasonograms, conventional scintigrams. The results were as follows: 1. The sensitivity and specificity of radioimmunoscintigraphy using the fragments F (ab’) 2 of the cocktails of CEA and CA 19-9 monoclonal antibodies were 82% and 100% respectively. 2. Tumor detection rate was not proportionated to the level of serum tumor markers. 3. Double nuclide scintigraphy technique was essential for tumor localization as an anatomic landmark using double-nuclide scintigraphy. 4. A slow in fusion of the antibodies was necessary to prevent the formation of large immune complexes. 5. Tumor/non-tumor radioactivity was most elevated at 7 days delayed imaging. 6. Using planar scintigraphic technique of I-131 labeled monoclonal antibodies are possible for imaging most of the tumors.
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( Hyung Rae Sohn ),( Soo Hyung Ryu ),( Seung Hye Heo ),( Sun Young Kim ),( Jin Nam Kim ),( You Sun Kim ),( Jeong Seop Moon ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Introduction: Dictamnus dasycarpus is one of the most common causes of drug-induced hepatitis in South Korea. Generally, most patients with drug-induced toxic hepatitis can fully recover after cessation of causative agents and supportive care. However, there has been some cases of Dictamnus dasycarpus-induced toxic hepatitis with progression to fulminant hepatitis and even death. We introduce a case of dramatic complete recovery from Dictamnus dasycarpus-induced severe toxic hepatitis after oral predinisolone treatment. Case: A 78-year-old woman was admitted with jaundice. She had consumed a decoction made by boiling down the root of Dictamnus dasycarpus, 1L per day for recent 3 months. Besides that, she did not have any medical and drug history. In-hospital laboratory test results are as follows: AST/ALT 1607/996 IU/L, total bilirubin 21.6 mg/dl, direct bilirubin 16.9 mg/dl, protein/albumin 5.8/3.5 g/dl, ALP 164 IU/L, r-GTP 47 IU/L, PT INR 1.03, and aPTT 39.6 seconds. All hepatic viral markers were negative. We diagnosed Dictamnus dasycarpus-induced toxic hepatitis as RUCAM scored 6. Even though interruption of taking Dictamnus dasycarpus for 10 days, total bilirubin increased up to 34 mg/dl. We decided to try oral prednisolone before consideration of liver transplantation. After start of oral prednisolone 40 mg per day, she showed a dramatic improvement in the clinical course and laboratory tests. Continued step-down prednisolone therapy for two months made her liver function test almost normal; total bilirubin was 2.2 mg/dl and AST/ALT was 27/28 IU/L. Discussion: Oral prednisolone treatment may be helpful and recommendable in clinically serious cases of Dictamnus dasycarpus-induced toxic hepatitis which are not respond to cessation of Dictamnus dasycarpus and best supportive care.
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임선형(Sun-Hyung Lim),김재광(Jae Kwang Kim),김동헌(Dong Hern Kim),손성한(Seong-Han Sohn),이종렬(Jong-Yeol Lee),김영미(Young-Mi Kim),하선화(Sun-Hwa Ha) 한국원예학회 2011 원예과학기술지 Vol.29 No.6
화색은 화훼 육종의 주요한 목표형질이다. 최근 유전공학 기술의 발달로 기존의 전통육종에서는 볼 수 없었던 파란장미와 파란카네이션과 같은 새로운 화색 개발이 성공적으로 보고되었다. 플라보노이드 생합성에 관해 축적된 지식기반 연구 결과를 바탕으로 새롭고 독특한 형질의 화색을 도입하는 것이 가능하게 된 것이다. 이러한 화색변경은 플라보노이드 대사경로의 조절, 즉 내재유전자의 발현조절 및 새로운 플라보노이드 합성 또는 특정 플라보노이드 합성을 위한 외래유전자의 추가도입과 플라보노이드 대사 전체를 조절하는 전사인자의 도입을 통해서 이루어져 왔다. 그러나 보다 실증적으로 이러한 플라보노이드 대사를 조절하기 위해서는 작물별 내재 플라보노이드의 조절 기작에 대한 이해를 바탕으로 목표로 하는 플라보노이드 합성을 위해 보다 정교한 대사흐름의 조절이 요구된다. 본 총설에서는 화훼작물의 화색변경 성공 예들을 자세히 소개하고 그 요인 분석을 통해 향후 더 성공적인 화색변경의 전략을 수립하는데 도움이 되고자 한다. Flower color is one of the main target traits in the flower breeding. Recently, technological advances in genetic engineering have been successfully reported the flower colors, such as blue roses and blue carnations that are impossible to develop by traditional breeding. Accumulated knowledge-based approaches for flavonoid biosynthesis enabled to introduce novel and unique colors into flowers. These flower color modifications have been made through the regulation of flavonoid metabolic pathway - control of endogenous gene expression and introduction of foreign genes to produce novel and specific flavonoids - and the introduction of transcription factors that are known to regulate sets of genes being involving in the flavonoid biosynthetic pathway. More empirical regulation of the flavonoids metabolism requires the understanding for regulatory mechanism of intrinsic flavonoids depending on the flower crops and the very sophisticated control of flavonoid metabolic flow. In this review, we summarized successf ul examples of flower color modification. It might be useful to deduce the strategy for the creation of exquisite colors in flower plants.
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