젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

생물변환 천연식용색소 생산공정기술 개발 : Ⅰ. 홍화 황색소의 안정성에 미치는 pH 및 온도의 영향 Ⅰ. Effect of pH and Temperature on the Stability of the Yellow Pigment from Carthamus tinctorious L.

홍성현,박성길,이종민,한태룡,백영숙,정인식 경희대학교 생명자원과학연구원 1999 硏究論文集 Vol.20 No.-

홍화로부터 열에 의한 안정성을 검토하였다. 황색소의 분해반응은 산성, 중성, 염기성 조건에서 UV/Vis spectral measurement에 의해 조사되었다. 시간변화에 다른 흡광도를 측정해 본 결과 온도가 상승함에 따라 황색소의 분해되는 정도가 점차적으로 증가하는 것을 확인 할 수 있었다. 40℃에서 황색소의 분해 반감기는 pH3.0, pH7.0, 그리고 pH12.0에서 각각 112.1, 39.3 과 25.3 시간이었다. 이것은 황색소가 pH3.0에서 비교적 더 안정함을 말한다. pH3.0, 7.0 그리고 12.0에서 황색소의 activation energy는 각각 519, 15.0 그리고 12.3 kJ/mol이었다 We investigated thermal stability of yellow pigment from Carthamus tinctorious L. Decomposition reactions of yellow pigment were monitored at acidic, neutral and alkaline conditions by UV/Vis spectral measurement. Decomposition of yellow pigment increased as temperature increased Decomposition half lives of yellow pigment at 40℃ were 112.1 39.3, and 25.3 hrs at pH 3.0 , pH 7.0, and pH 12.0, respectively, indicating that yellow pigment is more stable at pH 3.0. The activation energies of yellow pigment at pH 3.0, pH 7.0, and pH 12.0 were 51.9, 15.0, and 12. 3 kJ/mol, respectively.

다형성교아세포종을 동반한 Von Recklinghausen氏 병 1예

이현개,이종수,백민우,이승재,박효일,지제근 인제대학교 1981 仁濟醫學 Vol.2 No.4

가족성으로 신경섬유종증에 동반되는 중추신경계의 종양으로 수막종, 신경교종, 신경초종 등이 있으며 이들은 드물지 않게 보고되었다. 그러나 신경교세포에 생기는 종양 중 신경섬유종증에 동반되어 대뇌에 생긴 다형성교아세포종은 매우 드물다. 본 교실에서 가족성으로 발생한 신경섬유종증의 환자에 동반된 다형성교아세포종을 경험하였으며 가족중 부친은 von Recklinghausen씨 병을, 또 두 자녀는 다발성 cafe´ au lait spots를 가지고 있었다. The tumors of the central nervous system associated with familial neurofibromatosis are meningioma, glioma, and neurilemmoma, which are not uncommon. Of the glial tumors of the central nervous system, the association of cerebral glioblastoma multiforme with neurofibro matosis is very rare. We have experienced the unusual coincidence of neurofibromatosis and glioblastoma multiforme in a 33 year old man, whose father was afflicted with von Recklinghausen's disease and whose son and daughter had also multiple cafe´ au lait spots on their bodies.

[논문]리빙 라디칼 중합의 응용: 단백질과 고분자의 결합을 통한 새로운 하이브리드 재료 개발

이효경,백현종 釜山大學校生産技術硏究所 2006 生産技術硏究所論文集 Vol.65 No.-

리빙라디칼 중합은 원하는 구조의 잘 규정된 고분자를 손쉽게 만들 수 있는 새로운 합성 방법이다. 리빙라디칼 중합은 다양한 재료의 합성에 응용되고 있으며 특히 바이오 분야에서 활발한 연구가 진행되고 있다. 본고에서는 단백질과 고분자의 결합을 통한 소재개발 연구를 중심으로 리벙 라디칼 중합의 바이오응용에 대하여 소개하고자 한다.

거제지역 당뇨병 및 고혈압 환자의 복합질병 위험요인

박필숙,정기만,김종현,백지현,박미연 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.2

The purpose of this study is to compare the correlation of clinical characteristics and patterns of disease. Subjects of the study were the adults(207) living in Geoje City, the diabetes mellitus and the hypertension patients(166) and the normal people(41). In the diabetes mellitus group and the hypertension group, blood pressure, blood glucose, total cholestero LDL-cholesterol and atherogenic index(AI) were significantly high. As the obesity index was getting higher, the blood pressure of the diabetes mellitus group was high, and the HDL-cholesterol of the hypertension group was low, but AI of it was significantly high. The AI was significantly high as serum lipid index were getting higher in both groups. The rate of the prevalence was very high in the diabetes mellitus group(74.3%) and the hypertension group(73.7%). The pattern in the diabetes mellitus group was in order of the hypertension, the hyperlipidemia, and the obesity but, in the hypertension group was the hyperlipidemia, and the obesity. The obesity index and serum lipid index of complex patient group were higher than single patient group.

보신 관광에서 감염된 수입성 Sparganosis 1예 : Intake of Thailand Snake during Trip

서환조,박명재,고경식,백영한,조유정,양현종,류경남,정형근,전정열 대한감염학회 1992 감염 Vol.24 No.1

Human sparganosois was reported more than 100 cases in Korean population. However no case reported yet in Korea as a patient was infected by sparganum from other geographical area, such as Thailand. The case we are reported here is a 38 year-old Korean male who had been suffered from mass being a small, round and soft consistance in upper portion of his right thigh. The patients stated that he had an opportunity to eat living snake in Bangkok, Thailand during trip. As therapy praziquantel (75㎎/㎏/day) was given p.o. for 14 days, but in vain to cure. Following medical treatment, surgical exicision was performed to remove a alive, soft, whitish-milky, mobile and elongated sparganum. Serlogical test by micro-ELISA for sparganum-specific antibody revealed a high serum antibody level of absorbance 0.67 (positive criterion: absorbance 0.22).

Covalent Functionalization of Carbon Nanotubes using Atom Transfer Radical Polymerization

Hyun-Jong Paik 한국고분자학회 2006 한국고분자학회 학술대회 연구논문 초록집 Vol.2006 No.10

Comparison of the Thermal-Hydraulic Characteristics of Optimised Fuel Assembly with That of Standard Fuel Assembly

Paik, Hyun-Jong,Rim, Chang-Saeng,Park, Goon-Cherl Korean Nuclear Society 1990 Nuclear Engineering and Technology Vol.22 No.1

The thermal-hydraulic characteristics of the 17$\times$17 OFA (Optimized Fuel Assembly) used in the KNU 7&8 are analyzed and compared with that of the 17$\times$17 SFA (Standard Fuel Assembly) loaded in the KNU 5&6. The thermal-hydraulic characteristics analyzed are minimum DNBR, fuel centerline temperature and exit void fraction at normal operation and design over power transient. Additionally, local linear rod power, which will cause fuel centerline melting, is calculated. The DNBR sensitivity calculations are performed with respect to the reactor operating parameters. COBRA-IV-I code is used for these calculations. The modified W-3 correltion and the drift-flux model are applied for the critical heat flux calculation and the void fraction calculation, respectively. From the calculated results, it has been found that the possibility of DNB occurrence is higher in the OFA than in the SFA. The other hand, the local linear power resulting in fuel centerline moiling of the OFA is nearly equal to that of the SFA.

A New Design Procedure for the Evaluation of Rod Bow DNBR Penalty

Paik, Hyun-Jong,Yang, Seung-Geun Korean Nuclear Society 1996 Nuclear Engineering and Technology Vol.28 No.3

In the thermal-hydraulic design, the effect of fuel rod bow is quantified tv the rod bow DNBR penalty which is a key design parameter to assure the coolability of fuel assembly in the pressurized water reactor. In this work, a computer program for the evaluation of the rod bow DNBR penalty based on Westinghouse methodology is developed and its application procedure is proposed. The computer simulation is based on the Monte-Carlo method. The qualification of developed computer program is performed by a comparison of calculational result with that given by Westinghouse's document. A new application procedure is built using batch mean and batch standard deviation. The normality of sample population generated by the batch calculation is confirmed by means of a chi-square test for goodness of fit. On the view point of statistics it is effected that the more reliable design value may be produced by the new application procedure.

Association between Hepatitis B Virus Appearance and Overall Survival in Hepatitis B Virus-related Hepatocellular Carcinoma in Patients with Undetectable Serum HBV DNA Levels

( Jong-in Chang ),( Dong Hyun Sinn ),( Hyun Cho ),( Seonwoo Kim ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung-woon Paik ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: At the time of hepatocellular carcinoma (HCC) diagnosis, some of hepatitis B surface antigen (HBsAg) positive HCC patients show undetectable serum hepatitis B virus (HBV) DNA levels. The evidence whether antiviral treatment (AVT) for HCC patients without active HBV replication is needed is limited. Methods: A total of 985 HBV-related HCC patients with undetectable serum HBV DNA levels (<12 IU/mL) at the time of HCC diagnosis between 2008 and 2016 (112 AVT-naïve patients; 873 patients under AVT) were analyzed. Incidence and risk factors for HBV appearance (detection of HBV DNA in serum) during follow-up were assessed. In addition, the association between HBV appearance and overall survival was analyzed using the multivariable Cox regression model with time-dependent covariates. Results: During a median of 33.4 months of follow-up (range: 0.2 - 124.2 months), HBV appearance was observed in 279 patients. AVT and tumor stage were independent factors associated with HBV appearance. HBV appearance rate was significantly higher for AVT-naïve patients than patients on AVT (5- year cumulative incidence rate: 65.7% vs. 31.8%, P<0.001), and for patients with advanced tumor stage than early stage (5-year cumulative incidence rate: 31.9% vs. 48.9% for mUICC stage I - II vs. III - IV P<0.001). HBV appearance was associated with a higher risk of overall mortality (adjusted hazard ratio: 5.15, 95% confidence interval: 3.60 - 7.38, adjusted for age, ALBI grade, mUICC stage, and initial treatment modality). Conclusions: HBV appearance was associated with the increased risk of overall mortality in HBV-related HCC patients with undetectable serum HBV DNA levels at diagnosis. AVT was an independent factor for HBV appearance. These findings suggest prompt AVT should be considered for AVT-naïve, HBV-related HCC patients with undetectable serum HBV DNA levels in order to decrease HBV appearance and improve survival.