이소 맹출한 하악 측절치의 교정적 치험례

임현화,김용수,장기택,김종철 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.3

이소 맹출(ectopic eruption)은 치배가 그 발생지에서부터 정상 맹출 경로가 변화된 것을 의미한다. 즉, 치아가 치조골 혹은 기저골의 어느 위치에서 정상 맹출 과정에서 벗어나 비정상적인 위치나 방향으로 맹출하게 됨을 말한다. 이에 대한 다른 예로써 보다 드물고 특별한 치아 이상으로 전위(transposition)가 있는 데, 이는 같은 치열궁상에서 치아의 위치가 서로 바뀐 것을 말한다. 본 증례는 하악 측절치가 혼합치열기 초기에 제 1 유구치 하방으로 이소 맹출중인 치아 이상을 보여주는 데, 이 하악 측절치의 치관은 원심으로 심하게 경사졌고, 인접 유견치와 제 1 유구치의 치근 흡수를 야기하고 있다. 이와 같은 맹출 이상의 원인은 아직 확실히 규명되지 않았으나 현재 다음의 몇가지 원인을 생각할 수 있다.; (1)과거의 외상 병력, (2)유치의 만기 잔존, (3)유치의 조기 탈락, (4)유전적 요인. 치료법으로는 조기의 interceptive treatment와 보다 나중의 definitive treatment로 구분된다. 이소 맹출하는 하악 측절치는 인접 견치와 완전 전위되는 경향이 있으므로 조기의 교정적 간섭이 요구된다. 이는 이후의 영구치 발거나 완전 전위를 예방할 수 있을 것이다. 이러한 측절치의 이소 맹출을 바로잡는 데 있어서 고려해야할 중요한 요인은 치료 시기로써 일반적으로 혼합 치열기의 inter-transitional period 초기에 발육 중인 견치에서부터 멀리 떨어져 있을 때, 해당 측절치의 levelling과 근심화가 시행되어야 할 것이다. 본 증례는 아직 영구 견치가 맹출하기 이전인 혼합 치열기 초기에 적극적인 교정적 처치를 시행하여 이소 맹출중인 측절치를 본래 위치로 유도하였다. 주요어 : 이소 맹출, 전위, 교정적 간섭 Ectopic eruption should be understood as a change in the course of the normal eruption path of a dental bud at any moment its origin. An example of this alteration is the dental transposition, a rare and more specific dental anomaly that may be defined as a change of position between two teeth. This case shows ectopic eruption of transposed mandibular lateral incisor beneath primary first molar at the first transitional period of the mixed dentition. The crown of the lateral incisor has tipped distally, compelling root resorption and exfo1iation of the adjacent primary cuspid and primary first molar. The reason for such eruption is not elearIy understood, but it may involve ; (1)trauma history. (2)prolonged retention of the deciduous teeth. (3) premature exfoliation of the deciduous teeth. and (4)genetic factor. Treatment is divided into interceptive and definitive treatment. Ectopically erupting mandibular incisor tends to become transposed with the adjacent cuspid and thus seems to warrant early orthodontic intervention Early treatment may obviate later extraction of transposition of the incisor and canine in the permanent dentition. Timing is an important factor to be considered regarding in the correction of the lateral incisor transposition. This case advocates treatment with an active orthodontic therany at the early stage of the mixed dentition. before the eruption of the permanent cuspid.

효율적인 영상 이진화를 위한 적응적 Water Flow Model에 관한 연구

임길택,오현화 경주대학교 정보전자기술연구소 2004 情報電子技術論叢 Vol.3 No.-

In this paper, we propose an improved method to overcome the drawbacks of the existing water flow model based method for document image binarization. The proposed method defines the region of interest (ROI) around character areas to restrict rainfall onto the terrain surface. The amount of water required to fill a local valley is automatically determined according to the properties of the valley, thereby eliminating an iterative rainfall procedure which is very time consuming process in the existing method. Finally, to threshold the amount of water filled, a local adaptive method is applied to each pond. In the experiments on three document images, the proposed method showed better performances than the existing water flow model based method in terms of both quality and speed.

에탄 분자의 적외선 스펙트럼의 이론적 합성

鄭玹采,윤대현,임화준,김기선 慶熙大學校 1987 論文集 Vol.16 No.-

The ν_6 band of the ethane gas molecule was theoretically synthesized. The intensity and the frequency of each rotational line were computed with VAX-11 computer. The theoretically synthesized spectrum was compared with the experimentally obtained spectrum, which was taken through FT-IR spectrophotometer MX-3600. The R and P branches of the ν_6 band contour of the ethane gas molecule were different from the regular symmetrie top molecule and rather similar to the linear molecules as if there were no K dependence. The absorbance of the P-branch spectrum was overlapped by the unknown branches of the neighbour bands The intensities and frequencies of the unknown lines were not indentified. The overall band contour of the observed spectrum was quite well coincided with the theoretical spectrum except the P-branch.

홍삼류의 섭취가 비만과 혈중 지질의 상호관계에 미치는 영향

박화진,이정희,이소진,함혜선,조현정,임창률,유영빈,박기현 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

비만은 동맥경화의 위험인자로서 혈중에 triglyceride의 농도를 종가시키고, 상대적으로 HDL-Cholesterol의 농도를 감소시킴과 동시에 수축기 혈압을 상승시킨다. 본 연구에서 홍삼제품류를 4년 또는 5년 동안 복용해 온 건강한 사람 (ginseng군)과 홍삼제품을 복용하지 않은 건강한 사람 (control군)을 대상으로 하여 신체 계측치로부터 비만지수를 구하고 이것과 혈중의 triglyceride (TG)농도, TG/HDL-Cholesterol ratio 및 수축기 혈압과의 상호관계를 연구한 바, ginseng군에서는 대조군에 비해 혈중의 TG 농도가 일정하게 유지되었고, TG/HDL-Cholesterol ratio 및 수축기 혈압도 일정하게 유지되었다. 이러한 현상은 ginseng군에서 기호품으로 alcohol을 섭취하거나, 흡연을 한 경우에도 상관없이 일정하게 유지 되었다. 이 결과는 홍삼제품류를 장기 복용하면 비만의 저하 및 고혈압 또는 동맥경화의 위험인자가 억제될 수 있고, 결론적으로 비만, 고혈압 및 동맥경화를 예방할 수 있을 것으로 추정한다. Obesity is the risk fcactor of atherosclerosis and not only increases triglyceride concentration in blood but also decreases relatively the ratio of TG to HDL-Cholesterol in blood. In case of obesity, systolic blood pressure is also increased in responding the increase of TG in blood. Index of obesity in red ginseng-taking group (ginseng group) was lower as compared with non-red ginseng-taking group (control group). The TG concentration, the ratio of triglyceride to HDL-cholesterol in blood and systolic blood pressure were decreased in the subjects of ginseng group compared with that in control group. It is inferred that long-term intake of ginseng products may help to prevent the risk of atherosclerosis and obesity.

토란의 황화경으로부터 캘러스 형성 및 식물체 재생

윤애화,이지영,임순희,김현정,안장순 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

토란의 기지 shoot를 암배양하여 절간이 신장한 황하경을 얻고 이황하경의 절편을 계대배양하여 기내증식을 시도하였다. 황하경은 NAA 0.2mg/ℓ가 첨가된 배지에서 가장 길게 신장하였다. 황하경은 자구형성형이 모구배대형보다 길게 신장하였다. 호르몬이 첨가된 거의 모든 배지에서 protocorm이 형성되었으나 0.2mg/ℓ NAA + 0.2mg/ℓ BA를 첨가한 배지에서 특히 많이 형성되었고 이 protocorm을 MS기본 배지에 옮겼을 때 8.5%의 재분화율을 보였다. Etiolated stems with elongated internodes were obtained from the in vitro culture of shoots of Colocasia esculenta schout under dark condition and plant differntiation was achived by subculturing the ethiolated stem segments. The etiolated stems elongates better on the media containing 0.2mg/ℓNAA than of those lacking it. Subculture of the etiolated stem segments produced protocorm-like structures in all the media examined. The medium containing 0.2mg/ℓNAA and 0.2mg/ℓBA produced the higest number of protocorm-like structure, which regenerated into plantets at 85% when transferred to phytohormone-free MS medium.

Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [^(3)H]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20 ㎍/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.

결핵군 55 kDa 항원의 면역학적 분석

김화중,김홍성,임재현,조은경,송창화,박정규 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Identification and characterization of mycobacterial antigens are critical for evaluation of their role in diagnosis, vaccination, and pathogenesis of mycobacterial diseases. An attempt has been made to immunologic characterize the 55 kDa protein antigen of Mycobacterium tuberculosis H37Rv which attracted our interest because it is present in high concentration in 50-80% ammonium sulfate fraction of the culture filtrate. Two monoclonal antibodies (MAbs) directed to 55 kDa antigen were produced. MAbs MT55-1 and MT55-2 reacted with a single 55 kDa protein band. On examination of degree for cross-reactivity with other mycobacterial species by enzymelinked immunosorbent assay (ELISA) and immunoblotting, these antibodies reacted strongly with M. tuberculosis and M. bovis BCG, and reacted weakly with M. marinum and M. smegmatis. To investigated the subcellular distribution of MAbs defined epitopes in the 55 kDa antigen within the mycobacterium, we isolated three major subcellular factions of M. tuberculosis, namely, cell wall, cytoplasmic membrane, and cytosol, by a simple fractionation procedure. MAb MT55-1 reactive cpitope was found in the cytosol when tested by immunoblotting. A sandwich ELISA was initially developed for detecting 55 kDa antigen using MT55-1 MAb in mycobacterial culture filtrate before detecting it in clincal specimens. The minimal detectable concentration was 1.0 ㎍/m1 for M. tuberculosis culture filtrate and 100 ㎍/ml for sonic extracts of M. bovis BCG and M. marinum, respectively. But the 55 kDa antigen was not detected in sonic extracts of other mycobacterial species examined. Although further evaluations are required, this study suggests that the 55 kDa antigen may be of interest as potential diagnostic reagent.

WDHA(Watery diarrhea, Hypokalemia, Achlorhydria) syndrome 1예

박기룡,김현영,김지혜,임영찬,최영식,박요한,최경현,이재화,장희경 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1

저자들은 부갑상선절제술 이후에도 교정되지 않는 고칼슘혈증과 계속된 수양성 설사로 인한 하지마비 및 전신쇠약을 주소로 내원한 70세 남자환자에서 일반 화학검사, 호르몬 건사, 방사선 검사 등으로 VIPoma와 동반된 MEN Ⅰ으로 진단하여 외과적 절제술 후 수양성설사, 저칼슘혈증 및 고칼슘혈증이 호전된 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Multiple endocrine neoplasia I (MEN Ⅰ) is a genetic disorder that consists of neoplasia of neuroendocrine type in the parathyroid glands, in the islets of Langerhans in the pancreas, and in the anterior pituitary gland. Primary hyperparathyroidism is most common feature of the MEN I and occurs is approximately 95% of patients. Pancreatic islet cell tumors occur in 40% of MEN I patients. Most of these tumors produce excessive amounts of hormone, such as gastrin, insulin, glucagon and vasoactive intestinal polypeptide (VIP). VIP-producing pancreatic tumors (VIPoma) associated with MEN I are rare and there was only one case report in Korea so far. Recently we experienced a case of MEN I, especially VIPoma presented in a 70 year old man. He got subtotal parathyroidectomy for hyperparathyroidism 5 months ago, but his symptoms of watery diarrhea, severe general weakness and paralysis of lower limbs were not improved and hypercalcemia, hypokalemia were persisted. On computerized tomography scan of abdomen, demonstrated a mass of 3㎝ in diameter at the tail of pancreas. Serum level of VIP hormone was 250pg/㎖ (normal range : 0∼23pg/㎖). After partial pancreatectomy, his symptoms were improved dramatically and biochemical parameters such as, serum potassium, calcium, and VIP returned to the normal ranges.

Epidermal Growth Factor(EGF)가 개의 손상된 슬관절 전방십자인대의 치유에 미치는 영향

김용식,정도현,정진화,우영균,임영욱,이화성,권순용 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

결핵균 30 kDa 항원과 Triton X-100 Solubilized Protein 항원에 의한 대장암 주변 림프절 단핵구의 활성화

박정규,김광호,조은경,임재현,민들레,송영자,김화중,백태현 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Tumor-draining lymph node mononuclear (TDLMN) cells are specifically sensitized to the growing tumor but such cells are deficient for mediating an antitumor response. In this study, we examined the feasibility of using mycobacterial 30 kDa or Triton X-100 solubilized protein (TSP) antigen to stimulate mononuclear cells of colon cancer-draining lymph node for the generation of cell mediated immune effector cells. The proliferative response of TDLMN cells stimulated with mycobacterial 30 kDa or TSP antigen was determined by ^(3)H-thymidine incorporation assay. The proliferation of TDLMN cells to mycobacterial 30 kDa or TSP antigen was significantly increased in PPD (+) patients, but a poor response to the 30 kDa or TSP antigen was observed in PPD (-). The expression on γδ T cells to mycobacterial 30 kDa or TSP antigen was assessed by flow cytometry. The γδ T cells from PPD ( + ) patient responded only to 30 kDa antigen but to TSP antigen. An investigation of cytokine mRNA expression was undertaken using reverse transcription-polymerase chain reaction (RT-PCR) to follow TDLMN cells stimulated with the 30 kDa or TSP antigens for 5 days. The IFN-γ and TNF-α mRNA expression was only induced in TDLMN cells of PPD ( + ) patient in response to the 30 kDa or TSP antigen. The IL-2 mRNA expression was induced in both PPD (+) and PPD (-) in response to the 30 kDa or TSP antigen. But the IL-4 mRNA expression was not induced in response to the 30 kDa or TSP antigen. These results suggest that the 30 kDa and TSP antigens may serve as biologic response modifier for the generation of cell mediated immune effector cells.