하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

한국인 혀동맥의 형태

김희진(KIM Hee Jin),강민규(KANG Mill Kyu),김진학(KIM Jm Hak),박재한(PARK Jae Han),이상섭(LEE Sang Heon),이상헌(LEE Sang Sup),정인혁(CHUNG In Hyuk2) 대한체질인류학회 1997 대한체질인류학회지 Vol.10 No.2

연구자들은 한국인 어른 남녀 시신의 머리와 목 61 을 대상으로 깊은 층 육안해부를 시행하여 혀동맥의 형태를 조사하였다 혀동맥이 일어나는 유형은 위갑상동맥, 혀동맥, 그리고 얼굴동맥이 바깥목동액에서 따로 가지를 내어 나뉘는 경우가 563% 호 가장 않았으며, 얼굴동맥과 혀동맥이 강은 가지에서 얼어나 나뉘는 경우 (312%), 그리고 위 강상동액과 혀동맥이 같은 가지에서 나뉘는 경우 (12 5%) 등이 있었다. 혀동맥과 혀동맥의 둘째 부분은 덮는 목뿔혀근 과의 영대학적 관계는 각각 혀동맥의 첫째 부분이 목뿔혀근 뒤에서 심하게 휘어져 깊은 층으로 들어가는 유형 (41 2 %), 그리고 혀동맥의 첫째 부분이 목뿔혀근의 뒤쪽 근육모셔리 바로 뒤흘 지나 깊은 층으로 들어가는 경우가 661% 로 가장 많았다 목뿔혀근 깊은층에서 혀동맥의 둘째 부분이 달리는 양상은 급하게 위쪽으로 꺾역 달리다가 다시 앞쪽으로 꺾여 혀의 깊은 곳으로 들어가는 경우와 목뿔빼에서 혀쪽으로 완만한 굽이플 이루며 올라가는 경우가 비슷한 반도로 관찰되었다. 입안바닥에 분포하는 혀밑동맥이 혀동맥 셋째 부분에서 나오는 경우슨 전체의 590% 에서만 관창되었으며 그 외는 대부분 얼굴동맥의 턱끝 및동맥 가지가 턱옥뽕근응 옳고 입안바닥에 분포하였다. 따라서 연구자들은 한국인 업안바 닥에는 혀동액이 전체의 59%에서만 분포하며 그외는 영굴동액의 턱끝밑동맥 가지 , 그리고 기타 다른 동맥의 가지들이 분포한다는 사실을 확인하였다

아파트형 공장의 기준층규모별 CORE 공간구성비에 관한 연구

김진태,정지석,최무혁 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)

The purpose of this study is to analyze the decision factors of core size and their area ratio by the typical floor size of apartment-type factories in Seoul. The process of this study 1) investigated the decision factors of core size through documents, 2)analyzed and researched the decision factors of core size with a case of apartment-type factories. The results of this stud were as follows; 1)The core area ratio of apartment-type factories was on an average investigated into 21.73%, 2)The core type of One side A was used in small typical floor size, and the core type of Center was used in large typical floor size, 3)The area ratio of core constitution elements was investigated into elevators 13.81%, corridors 52.62%, stairs 13.85%, toilets 12.93%, and the others 5.19%.

CA1 신경세포의 수상돌기에 국소 적용된 glutamate에 의한 AMPA 수용체 활성화

해마, 수상돌기, 시납스 漢陽大學校 精神健康硏究 1999 精神健康硏究 Vol.18 No.-

광섬유를 이용한 고감도 압력센서의 개발

김창원,권대혁,김진섭,이정희,손병기 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

KOH 수용액을 이용하여 실리콘 식각공정기술을 확립하였으며, 이를 이용하여 실리콘 기판 위에 스트레스 균형이 이루어진 150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4 두께를 가지는 구조의 평탄한 3층 유전체 멤브레인을 제작하였다. 본 실험에서 사용되는 파장인 1.3 ㎛ 근방에서 다이아프레임의 광투과도는 약 50 %로 광반사막으로 사용이 불가능하였다. 따라서, 다이아프레임 뒷면에 약 1000 Å의 금을 증착하여 N/O/N/Au박막의 광투과도를 수 %정도로 감소시킴으로써, 센서의 광반사막으로 사용할 수 있었다. source fiber를 단일모드로 했을 때 다이아프레임의 크기에 따라 감도는 각각 0.52㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟)였다. 광손실을 최소화하기 위해 광전송용 다모드 광섬유를 사용하였을 때는, 2×2 ㎟의 다이아프레임의 크기에 대해 0∼800 torr의 넓은 측정범위에서 거의 선형적인 압력특성을 나타내었다. Using KOH solution, silicon etching technology has been established and stress-balanced flat 600 ㎚ thick triple dielectric membrane(150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4) on silicon substrate has been fabricated. At the wavelength of the sensor light source near 1.3 ㎛, the optical transmittance of the diaphragm was about 50 %, it was impossible to be used as a reflecting film. To decrease to a few percents, the back-side of the diaphragm was deposited 1,000 Å thick gold layer, which is sufficient enough to be used as a light reflection layer of the sensor. When was used 8/126 ㎛ single-mode fiber, the respective sensitivities for diaphragm size were 0.52 ㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟). When was used 62/126 ㎛ multi-mode fiber for the light transmission to minimize optical loss, the pressure characteristics was showed almost linearly curve in a wide pressure range, 0 torr∼800 torr, for the 2×2 ㎟ diaphragm in dimensions.

Retinoic acid에 의해 유발된 흰쥐의 구개열에서 Transforming Growth Factor-beta 1, 2, 3의 발현의 변화

김종환,박진혁,신선호,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Craniofacial malformations are among the most frequent congenital birth defects in humans : cleft palate, that is inadequate fusion of the palatal shelves. Retinoic acid is teratogenic in many species, producing multiple malformations, including cleft palate. Also it plays an important role in embryogenesis, by regulating morphogenesis, cell proliferation, differentiation, and deposition of the extracellular matrix. The effects of retinoic acid which leads to cleft palate vary depending on the stage of development exposed. After exposure of embryonic mice to retinoic acid on gestational day(GD) 10, abnormally small palatal shelves form. And the elevation of palatal shelves is delayed. The growth and differentiation factor, transforming growth factor-beta(TGFβ) family is thought to play important roles in multiple developmental processes, especially, the development of the embryonic palate. The expression of the TGFβ family in embryonic palate suggests a functional role for these molecules. In this study, author has determined the tissue distributions of TGFβ family in murine embryonic palate, and compared them in terms of developmental stage and locations in normal and retinoic acid-induced cleft palate. Methods and Material : Retinoic acid was administered orally at gestational day(GD) 10 to ICR mice. The pregnant mice were sacrifeced on GD 12, 13. 14, 15 to obtain the fetuses and immunohistochemistry was performed. And using the scanning electron microscope, morphology of normal palate and cleft palate was studied. Results : In the retinoic acid-treated fetuses, palatal shelves did not elevate and cleft palate was induced. On GD 13 in the palates of the retinoic acid-treated fetuses, expression of the TGFβ1, 3 decreased dramatically, but that of TGFβ2, did not change. The expression of the TGFβ1, 3 in the palates of the retinoic acid-treated fetuses, increased on GD 14, 15, Significant differences in TGFβ family expression were observed with areas of the palate. Conclusion : These results suggest that retinoic acid inhibits the expression of TGFβ 1, 3, which is critical in the developing palate, and elevation of palatal shelves is delayed and impaired, therefore cleft palate is induced. These data demonstrate a role for retinoic acid and retinoic aicd-induced TGFβ family in the regulation of palatal development and suggest a role for TGFβ in retinoic acid-induced cleft palate.

척추 수술시 자가혈액 수혈기를 이용한 자가수혈의 효과

김명호,유문집,유석주,박진영,정홍근,박희곤,문기혁 단국대학교 2000 論文集 Vol.35 No.-

Study Design : Spine fusion with fixation procedure is associated with substantial operative blood loss, which frequently necessitates transfusion. The authors evaluated the safety and efficacy of intraoperative autotransfusion using Cell Saver during spinal surgery. Summary of Literature Review : It has been reported that the contraindications to the use of intraoperative autologous transfusion are malignancy, infection, and gross wound contamination. Objectives : The purpose of this study was to evaluate the safety and efficacy of intraoperative autotransfusion using Cell Saver during spine surgery. Material and Methods : We retrospectively reviewed 62 patients who had operation for lumbosacral spinal stenosis and hypotensive anesthesia. Among them, Group Ⅰwhich received autotrans fusion using Cell Savers included 26 patients with fusion of 2 segments, and Group Ⅱ as control group included 13 patients. Group Ⅲ which received autotransfusion using Cell Savers included 17 patients with function of 3 segments, and Group Ⅳ as control group included 6 patients. We analyzed the amount of intraoperative blood salvage using a Cell Saver, the amount of total homologous transfusion amount, intraoperative blood loss, the amount of postoperative drainage amount and perioperative changes of hemoglobin, hematocrit and platelet count. Results : There was no statistical significance between Cell-Saver group and control group in amount of total homologous transfusion and intraoperative(except in 2 segment of fusion using cell saver: 86.5% increased) & postoperative blood loss(p>0.05). The circulatory balance(amount of intraoperative blood salvage using a Cell Saver plus amount of total homologous transfusion minus amount of total blood loss) was statistical significance between Cell-Saver group and Control group. The Cell-Saver group had positive balance and Control group had negative balance. There were no statistical differance in the evolusion of hemoglobin, hematoocrit and platelet count between Cell-Saver group and Control group(p>0.05). There was no transfusion reaction and thromboembolic disease in all group. Conclusion : In retrospective study, Cell Savers was safe and immediate availability in orthopedic surgery such as spinal surgery. It was effective methods for storing a sufficient volume of blood for spine surgery without affecting the patient's postoperative hemodynamic ststes, too. It was possible to operation without intraoperative homologous blood transfusion in 2 or 3 segment fusion. We may need further study.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

The effect of neuropeptides on secretion of Interleukin-8(IL-8)

Kim, Kyung-Jun,Park, Sang-Hyuk,Choi, Kyoung-Kyu,Park, Sang-Jin 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.3

본 연구는 치수조직, 치은, 치주인대로부터 배양된 조직을 SP (Substance P)로 4시간, SP, CGRP (Calcitonin Gene-related Peptide), Tumor necrosis factor-α (TNF-α)로 8시간 자극 후 RNase Protection Assay를 시행하고, IL-8의 분비량을 측정해 다음 결과를 얻었다. 1. IL-8 mRNA는 모든세포에서 발현됐다. 2. IL-8 mRNA 발현은 SP (10^(-5)M)와 SP (10^(-8)M)로 4시간 자극 시 증가되지 않았다. 3. IL-8 mRNA 발현은 SP (10^(-4)M)와 CGRP (10^(-6)M)로 8시간 자극 시 증가되지 않았다. 4. TNF-α (2 ng/㎖) 자극 시, IL-8 mRNA 발현이 증가됐다. 5. 치은 세포를 CGRP (10^(-6)M)로 8시간 자극 시, IL-8 분비량이 증가했다 (p < 0.05). 6. 치주인대 세포를 SP (10^(-4)M)로 8시간 자극 시 IL-8 분비량이 증가했다 (p < 0.05). We investigated the secretion of Interleukin-8 (IL-8) from ginviva and periodontal ligament stimulated with Substance P (SP) and Calcitonin Gene-related Peptide (CGRP). Gingiva (GF), periodontal ligament (PDLF) and pulp (PF) tissues were collected from extracted instact 3rd molars. Cultured cells were stimulated with different concentrations of SP for 4 hrs, and stimulated with SP, CGRP and Tumor Necrosis Factor-α (TNF-α) for 8 hrs. Then RNase Protection Assay was carried out. ELISA was performed using supernatants of stimulated cells for quantitative analysis of IL-8. Results were assessed using supernatants of stimulated cells for quantitative analysis of IL-8. Results were assessed using student t-test with significance of P < 0.05. According to this study, the results were as follows: 1. IL-8 mRNA was detected in all type of cells studied (PF, GF and PDLF). 2. IL-8 mRNA expression was not increased after stimulating 4 hrs with SP (10^(-5)M) and SP (10^(-8)M) compared with Mock stimulation in all type of cells studied. 3. IL-8 mRNA expression was not increased after stimulating 8 hrs with SP (10^(-4)M) and CGRP (10^(-6)M) compared with Mock stimulation in all type of cells studied. 4. TNF-α (2 ng/㎖) increased the expression of IL-8 mRNA in all kind of cells studied. 5. The secretion of IL-8 from GF was increased 8 hrs after the stimulation with CGRP (10^(-6)M) (p < 0.05). 6. The secretion of IL-8 from PDLF was increased 8 hrs after the stimulation with SP (10^(-4)M) (p < 0.05). Calcitonin Gene-related Peptide (CGRP) increased Interleukin-8 (IL-8) which plays an important role in chemotaxis of neutrophil in Calcitonin Gene-related Peptide (CGRP) gingival tissue, whereas Substance P increased the secretion of IL-8 from periodontal ligament.