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A Parametric Study of Ridge-cut Explosive Bolts using Hydrocodes
Lee, Juho,Han, Jae-Hung,Lee, YeungJo,Lee, Hyoungjin The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.1
Explosive bolts are one of pyrotechnic release devices, which are highly reliable and efficient for a built-in release. Among them, ridge-cut explosive bolts which utilize shock wave generated by detonation to separate bolt body produce minimal fragments, little swelling and clean breaks. In this study, separation phenomena of ridge-cut explosive bolts or ridge-cut mechanism are computationally analyzed using Hydrocodes. To analyze separation mechanism of ridge-cut explosive bolts, fluid-structure interactions with complex material modeling are essential. For modeling of high explosives (RDX and PETN), Euler elements with Jones-Wilkins-Lee E.O.S. are utilized. For Lagrange elements of bolt body structures, shock E.O.S., Johnson-Cook strength model, and principal stress failure criteria are used. From the computational analysis of the author's explosive bolt model, computational analysis framework is verified and perfected with tuned failure criteria. Practical design improvements are also suggested based on a parametric study. Some design parameters, such as explosive weights, ridge angle, and ridge position, are chosen that might affect the separation reliability; and analysis is carried out for several designs. The results of this study provide useful information to avoid unnecessary separation experiments related with design parameters.
A Parametric Study of Ridge-cut Explosive Bolts using Hydrocodes
Juho Lee,Jae-Hung Han,YeungJo Lee,Hyoungjin Lee 한국항공우주학회 2015 International Journal of Aeronautical and Space Sc Vol.16 No.1
Explosive bolts are one of pyrotechnic release devices, which are highly reliable and efficient for a built-in release. Among them, ridge-cut explosive bolts which utilize shock wave generated by detonation to separate bolt body produce minimal fragments, little swelling and clean breaks. In this study, separation phenomena of ridge-cut explosive bolts or ridge-cut mechanism are computationally analyzed using Hydrocodes. To analyze separation mechanism of ridge-cut explosive bolts, fluid-structure interactions with complex material modeling are essential. For modeling of high explosives (RDX and PETN), Euler elements with Jones-Wilkins-Lee E.O.S. are utilized. For Lagrange elements of bolt body structures, shock E.O.S., Johnson-Cook strength model, and principal stress failure criteria are used. From the computational analysis of the author’s explosive bolt model, computational analysis framework is verified and perfected with tuned failure criteria. Practical design improvements are also suggested based on a parametric study. Some design parameters, such as explosive weights, ridge angle, and ridge position, are chosen that might affect the separation reliability; and analysis is carried out for several designs. The results of this study provide useful information to avoid unnecessary separation experiments related with design parameters.
Kim, Andrew HyoungJin,Yoon, Sumin,Lee, Yujin,Lee, Jieon,Bae, Eunjin,Lee, Hajeong,Kim, Dong Ki,Lee, SeungHwan,Yu, Kyung-sang,Jang, In-Jin,Cho, Joo-Youn The Korean Academy of Medical Sciences 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.53
<P><B>Background</B></P><P>The renal function of individuals is one of the reasons for the variations in therapeutic response to various drugs. Patients with renal impairment are often exposed to drug toxicity, even with drugs that are usually eliminated by hepatic metabolism. Previous study has reported an increased plasma concentration of indoxyl sulfate and decreased plasma concentration of 4β-hydroxy (OH)-cholesterol in stable kidney transplant recipients, implicating indoxyl sulfate as a cytochrome P450 (CYP) inhibiting factor. In this study, we aimed to evaluate the impact of renal impairment severity-dependent accumulation of indoxyl sulfate on hepatic CYP3A activity using metabolic markers.</P><P><B>Methods</B></P><P>Sixty-six subjects were enrolled in this study; based on estimated glomerular filtration rate (eGFR), they were classified as having mild, moderate, or severe renal impairment. The plasma concentration of indoxyl sulfate was quantified using liquid chromatography-mass spectrometry (LC-MS). Urinary and plasma markers (6β-OH-cortisol/cortisol, 6β-OH-cortisone/cortisone, 4β-OH-cholesterol) for hepatic CYP3A activity were quantified using gas chromatography-mass spectrometry (GC-MS). The total plasma concentration of cholesterol was measured using the enzymatic colorimetric assay to calculate the 4β-OH-cholesterol/cholesterol ratio. The correlation between variables was assessed using Pearson's correlation test.</P><P><B>Results</B></P><P>There was a significant negative correlation between MDRD eGFR and indoxyl sulfate levels. The levels of urinary 6β-OH-cortisol/cortisol and 6β-OH-cortisone/cortisone as well as plasma 4β-OH-cholesterol and 4β-OH-cholesterol/cholesterol were not correlated with MDRD eGFR and the plasma concentration of indoxyl sulfate.</P><P><B>Conclusion</B></P><P>Hepatic CYP3A activity may not be affected by renal impairment-induced accumulation of plasma indoxyl sulfate.</P>
Lee, Junsung,Kim, Jiyoung,Jeong, Moonkyoung,Lee, Hyoungjin,Goh, Unbyeol,Kim, Hyaeyeong,Kim, Byungji,Park, Ji-Ho American Chemical Society 2015 NANO LETTERS Vol.15 No.5
<P>Natural membrane vesicles (MVs) derived from various types of cells play an essential role in transporting biological materials between cells. Here, we show that exogenous compounds are packaged in the MVs by engineering the parental cells via liposomes, and the MVs mediate autonomous intercellular migration of the compounds through multiple cancer cell layers. Hydrophobic compounds delivered selectively to the plasma membrane of cancer cells using synthetic membrane fusogenic liposomes were efficiently incorporated into the membrane of MVs secreted from the cells and then transferred to neighboring cells via the MVs. This liposome-mediated MV engineering strategy allowed hydrophobic photosensitizers to significantly penetrate both spheroids and in vivo tumors, thereby enhancing the therapeutic efficacy. These results suggest that innate biological transport systems can be in situ engineered via synthetic liposomes to guide the penetration of chemotherapeutics across challenging tissue barriers in solid tumors.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-5/nl5047494/production/images/medium/nl-2014-047494_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl5047494'>ACS Electronic Supporting Info</A></P>
Lee, Junsung,Lee, Hyoungjin,Goh, Unbyeol,Kim, Jiyoung,Jeong, Moonkyoung,Lee, Jean,Park, Ji-Ho American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.11
<P>Engineering of extracellular vesicles (EVs) without affecting biological functions remains a challenge, limiting the broad applications of EVs in biomedicine. Here, we report a method to equip EVs with various functional agents, including fluorophores, drugs, lipids, and bio-orthogonal chemicals, in an efficient and controlled manner by engineering parental cells with membrane fusogenic liposomes, while keeping the EVs intact. As a demonstration of how this method can be applied, we prepared EVs containing azide-lipids, and conjugated them with targeting peptides using copper-free click chemistry to enhance targeting efficacy to cancer cells. We believe that this liposome-based cellular engineering method will find utility in studying the biological roles of EVs and delivering therapeutic agents through their innate pathway.</P>
전형진(Hyoungjin Jeon),이기동(Kidong Lee),이원구(Wongu Lee),한주권(Jukwon Han) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
Currently, the major material for headliner in automobile is produced by hot compression molding process with Polyurethane substrate. One of the main raw materials of polyurethane substrate is polyol On This study, main properties of headliner such as foaming reactions while manufacturing large block foam for mass production of polyurethane substrate using the lately developed biomass-based polyol, the performance of Headliner applied sliced foam of biomass-based polyurethane foam have been evaluated.
이형진(Hyoungjin Lee),곽노윤(Noyoon Kwak?) 한국정보과학회 2005 한국정보과학회 학술발표논문집 Vol.32 No.1
본 논문은 2D 실사 기반 가상 헤어스타일의 자연스런 착용감을 제공하기 위한 것으로, 가상 헤어스타일러의 모발 블렌딩 방법에 관한 것이다. 제안된 방법은 2D 실사 영상에서 추출한 헤어스타일을 임의의 인물 영상의 두상에 정렬시킨 상태에서 원래의 헤어스타일에서 추출한 헤어스타일로 변해가는 반자동 필드 모핑을 수행할 시에 머리모양의 변형을 따라 단계적으로 변하는 가변 모핑 마스크를 사용하여 가상헤어스타일을 생성하고 이렇게 생성된 헤어스타일을 가변 모핑 마스크의 경계 영역에서 시그모이드 함수에 기반한 모발 블렌딩을 수행함으로써 이중 노출 현상이 제거됨과 동시에 자연스러운 착용감을 제공하는 여러 유형의 헤어스타일을 자동으로 생성할 수 있다. 통상 이러한 작업은 사용자의 수작업에 전적으로 의존하는 반면에 제안된 방법은 반자동 필드 모핑에 기반한 편리한 사용자 인터페이스를 제공할 수 있기 때문에 반자동화를 통해 작업 피로도와 작업 시간을 경감시킬 수 있고 비숙련자도 간단한 사용자 입력을 통해 이중 노출 현상이 제거됨과 동시에 자연스런 착용감을 제공하는 가상 헤어스타일을 생성할 수 있는 이점이 있다.