<P>Engineering of extracellular vesicles (EVs) without affecting biological functions remains a challenge, limiting the broad applications of EVs in biomedicine. Here, we report a method to equip EVs with various functional agents, including flu...
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https://www.riss.kr/link?id=A107656527
2016
-
SCOPUS,SCIE
학술저널
6790-6795(6쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Engineering of extracellular vesicles (EVs) without affecting biological functions remains a challenge, limiting the broad applications of EVs in biomedicine. Here, we report a method to equip EVs with various functional agents, including flu...
<P>Engineering of extracellular vesicles (EVs) without affecting biological functions remains a challenge, limiting the broad applications of EVs in biomedicine. Here, we report a method to equip EVs with various functional agents, including fluorophores, drugs, lipids, and bio-orthogonal chemicals, in an efficient and controlled manner by engineering parental cells with membrane fusogenic liposomes, while keeping the EVs intact. As a demonstration of how this method can be applied, we prepared EVs containing azide-lipids, and conjugated them with targeting peptides using copper-free click chemistry to enhance targeting efficacy to cancer cells. We believe that this liposome-based cellular engineering method will find utility in studying the biological roles of EVs and delivering therapeutic agents through their innate pathway.</P>
Controlling the Resistive Switching Behavior in Starch-Based Flexible Biomemristors
Flexible Organic Phototransistor Array with Enhanced Responsivity via Metal–Ligand Charge Transfer