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Hyojin Lee,Kihwan Kim,Inseok Park,Hyunjin Cho,Geumhee Gwak,Keunho Yang,Byung-Noe Bae,Hong-Ju Kim,Young Duk Kim 한국간담췌외과학회 2016 Annals of hepato-biliary-pancreatic surgery Vol.20 No.4
Backgrounds/Aims: We investigated patients’ clinical and radiological data to determine preoperative factors that predict cholesterol gallbladder (GB) polyps of large size, which can be helpful for decision on further diagnostic tools. Methods: In this study, we retrospectively analyzed 126 patients who underwent laparoscopic cholecystectomy for GB polyps >10 mm diagnosed preoperatively by abdominal ultrasonography between February 2002 and February 2016 in Department of Surgery, Sanggye Paik Hospital. Patients were divided into non-cholesterol polyps group and cholesterol polyps group, based on the postoperative pathologic diagnosis. Clinical and radiological data, such as gender, age, body weight, height, body mass index (BMI), laboratory findings, size, number and shape of the polypoid lesions, and presence of the concurrent GB stone were compared between the two groups. Results: Of the 126 cases, 73 had cholesterol polyps (57.9%) and 53 cases were non-cholesterol polyps (42.1%). The younger age (<48.5 years), size of polyp <13.25 mm and multiple polyps were independent predictive variables for cholesterol polyps, with odd ratios(OR) of 2.352 (p=0.045), 5.429 (p<0.001) and 0.472 (p<0.001), respectively. Conclusions: Age, size and polyp number were used to predict cholesterol GB polyp among polypoid lesions of the gallbladder >10 mm. For cases in which these factors are not applicable, it is strongly recommended to evaluate further diagnostic tools, such as computed tomography, endoscopic ultrasonography and tumor markers.
( Hyojin Lee ),( Seung Il Ahn ),( Byung Wook Yang ),( Jong Dae Park ),( Wang Soo Shin ),( Sung Kwon Ko ),( Young Tae Hahm ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 한국미생물·생명공학회지 Vol.47 No.2
Biotransformation of ginsenosides by microorganisms alters the absorption and bioavailability of ginseng as a medicinal herb. In this study, we isolated two kinds of fermenting microorganisms from Eoyukjang, which is a traditional Korean fermented food made from soybean. Next, we identified and detected their ability to convert major ginsenosides to compound K. The two microorganisms, referred to as R2-6 and R2- 15, had 100% similarity with Lactobacillus plantarum subsp. plantarum ATCC 14917<sup>T</sup> and Lactobacillus rhamnosus JCM 1136<sup>T</sup>, respectively. The optimal pH and growth temperature of the isolates were determined to be pH 6-7 and 30℃. After fermentation for 30 days, the major ginsenosides in the mountain-cultivated ginseng were transformed to the highly bioactive ginsenoside, compound K, in the final product.
Yang, Ui-Jeong,Maeng, Hyojin,Park, Tae-Sik,Shim, Soon-Mi Mary Ann Liebert, Inc 2015 Journal of medicinal food Vol.18 No.9
<P>Vascular function is mediated by various regulatory molecules, including endothelial nitric oxide (NO), which regulates the vasodilation of smooth muscle cells. We investigated whether standardized Houttuynia cordata extract (SHCE) could improve physical endurance performance by regulating the endothelial production of NO. For the standardization of Houttuynia cordata (HC) extract, its bioactive components were identified and quantified using ultraperformance liquid chromatography-mass spectrometry. Bioaccessibility and biological activity were measured by the in vitro digestion model system and free radical scavenging capacity, respectively. The vascular function in the endothelium was assessed by the phosphorylation of endothelial nitric oxide synthase (eNOS). A preliminary clinical trial was carried out to assess the physical endurance performance. HC extract was standardized to bioactive components, including chlorogenic acid, rutin, and quercitrin, with the concentration of 5.53, 6.09, and 16.15?mg from 1?g of dry weight, respectively. Bioaccessibility was 33.17%, 31.67%, and 11.18% for chlorogenic acid, rutin, and quercitrin, respectively. Antioxidant activities of SHCE were expressed as vitamin C equivalent antioxidant capacity in 55.81 and 17.23?mg/g of HC extract using ABTS and DPPH scavenging assay, respectively. In human aortic endothelial cells, insulin-mediated phosphorylation of eNOS was increased by SHCE in the presence of palmitate. However, the expression of blood pressure-regulating genes was not altered. The level of blood lactate concentration and the heart rate of subjects who drank SHCE were lower than those of subjects who drank plain water. Oxygen uptake from subjects drinking SHCE was slightly higher than that from those who drank plain water. This study demonstrated that SHCE decreased heart rate and blood lactate, increased oxygen uptake, and improved physical performance, presumably due to the increased NO production.</P>
Yang, Sunmo,Kim, Chan Yeong,Hwang, Sohyun,Kim, Eiru,Kim, Hyojin,Shim, Hongseok,Lee, Insuk Oxford University Press 2017 Nucleic acids research Vol.45 No.d1
<P>The use of high-throughput array and sequencing technologies has produced unprecedented amounts of gene expression data in central public depositories, including the Gene Expression Omnibus (GEO). The immense amount of expression data in GEO provides both vast research opportunities and data analysis challenges. Co-expression analysis of high-dimensional expression data has proven effective for the study of gene functions, and several co-expression databases have been developed. Here, we present a new co-expression database, COEXPEDIA (www.coexpedia.org), which is distinctive from other co-expression databases in three aspects: (i) it contains only co-functional co-expressions that passed a rigorous statistical assessment for functional association, (ii) the co-expressions were inferred from individual studies, each of which was designed to investigate gene functions with respect to a particular biomedical context such as a disease and (iii) the co-expressions are associated with medical subject headings (MeSH) that provide biomedical information for anatomical, disease, and chemical relevance. COEXPEDIA currently contains approximately eight million co-expressions inferred from 384 and 248 GEO series for humans and mice, respectively. We describe how these MeSH-associated co-expressions enable the identification of diseases and drugs previously unknown to be related to a gene or a gene group of interest.</P>
방효진(Hyojin Bang),이재호(Jaeho Lee),장석채(Seokchae Chang),양천석(Chunsuk Yang) 전력전자학회 2010 전력전자학술대회 논문집 Vol.2010 No.7
본 논문에서는 전기 자동차 탑재형 충전기 모듈에 대하여 설명한다. 기존의 충전기와는 달리 저압 충전부를 겸비하고 있어 저압 배터리도 동시에 충전시킬 수 있는 절연형 3.3kW 충전기 모듈이다. 전기 자동차 탑재형으로 온도와 진동에 강한 전장용 부품을 사용하여 주요 하드웨어를 구성하였으며, 유로해석 및 PCB진동해석을 통해 외부 온도변화와 진동에 강인하도록 설계하였다.
Kim Hyojin,Yoon Yune-Jung,Kim Hyunmi,Cha Eun-Young,Lee Hye Suk,Kim Jeong-Han,Yi Kyu Yang,Lee Sunkyung,Cheon Hyae Gyeong,Yoo Sung-Eun,Lee Sang-Seop,Shin Jae-Gook,Liu Kwang-Hyeon The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.11
KR-33028 (N-[4-cyano-benzo[b]thiophene-2-carbonyl]guanidine) is a new cardioprotective agent for preventing ischemia-reperfusion injury. This study was performed to identify the metabolic pathway of KR-33028 in human liver microsomes and to compare its metabolism with that of cryopreserved human hepatocytes. Human liver microsomal incubation of KR-33028 in the presence of NADPH and UDPGA resulted in the formation of four metabolites, M1, M2, M3, and M4. M1 and M2 were identified as 5-hydroxy-KR-33028 and 7-hydroxy-KR-33028, respectively, on the basis of LC/MS/MS analysis with the synthesized authentic standard. M3 and M4 were suggested to be dihydroxy-KR-33028 and hydroxy-KR-33028-glucuronide, respectively. Metabolism of KR-33028 in cryopreserved human hepatocytes resulted in the formation of M1, M2, and M4. These data show a good correlation between major metabolites formed in human liver microsomes and cryopreserved human hepatocytes. In addition, KR33028 was found to inhibit moderately the metabolism of CYP1A2 substrates. Based on the results obtained metabolic pathway of KR-33028 is proposed.
Kang, Hyojin,An, Su Yeon,Walker, Bright,Song, Seyeong,Kim, Taehyo,Kim, Jin Young,Yang, Changduk The Royal Society of Chemistry 2015 Journal of Materials Chemistry A Vol.3 No.18
<▼1><P>A series of small molecule semiconductors based on the recently conceived thienoisoindigo (TIIG) moiety and three end-capping moieties with varied electron-donating strength and conformations has been synthesized and utilized for organic photovoltaics (OPVs).</P></▼1><▼2><P>In this contribution, a series of small molecule semiconductors based on the recently conceived thienoisoindigo (TIIG) and three different end-capping moieties (benzene (Bz), naphthalene (Np), and benzofuran (Bf)) with varied electron-donating strength and conformations has been synthesized by Suzuki coupling and utilized for organic photovoltaics (OPVs). Incorporation of different end-capping blocks onto the TIIG core facilitated the tuning of optical properties and the electronic structure (HOMO/LUMO energy levels), solid-state morphology and performance in OPVs. It is apparent that the bandgaps within this series (TIIG-Bz, TIIG-Np, and TIIG-Bf) were progressively red-shifted and the absorption coefficients were enhanced by increasing the conjugation length and/or the donor ability of the end-capping units. In addition, HOMO and LUMO levels were shown to simultaneously follow changes made to the end-capping moieties. The best performing OPVs using TIIG-Np : PC71BM exhibited a power conversion efficiency (PCE) of 1.81% with <I>J</I>sc = 7.15 mA cm<SUP>−2</SUP>, FF = 0.39, and <I>V</I>oc = 0.66 V. With the aim of exploring underlying structure–property relationships for this new class of molecular systems, we have quantitatively investigated various morphological structures in both the pristine small molecule films and small molecule/PC71BM blend films using a combination of grazing incidence wide angle X-ray scattering (GIWAXS) and atomic force microscopy (AFM). In this study, a correlation between the molecular structure, thin film morphology, and photovoltaic properties of these conjugated small molecules was established that provides guidance for the molecular design of new photovoltaic semiconductors based on TIIG units.</P></▼2>