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Durability Evaluation Method of Handling Structure using Hand Calculation and Simulation
Sung-Min Cho(조성민),Hyo-Jung Bang(방효중),Byung-Ik Kang(강병익) 한국기계가공학회 2019 한국기계가공학회지 Vol.18 No.4
Most product structural components are assembled by various members and castings except casting products. In such cases, a particular structure is required to move and fix each component. In particular, the safety uncertainty of heavy product assemblies can be linked to large accidents. Thus, the safety design and evaluation of additional structures have become more important. In the field and factories, these additional structures are called handling structures, which are designed and manufactured. As the types of products produced become more diverse, the design and manufacture of a handling structure are also diversified. The results of each evaluation should be derived. We develop a logical design and evaluation method, which was previously designed based on empirical data, for the handling structure.
Enhanced Development Properties of IPA (Isopropyl Alcohol) on the PMMA Electron Beam Resist
( Jung Sub Wi ),( Hyo Sung Lee ),( Ki Bum Kim ) 대한금속재료학회 ( 구 대한금속학회 ) 2007 ELECTRONIC MATERIALS LETTERS Vol.3 No.1
Development characteristics of PMMA electron-beam resist were quantitatively investigated by employing IPA (isopropyl alcohol) as a single component developer. Compared with a conventionally used MIBK:IPA (1:3) developer, the contrast value is improved by about 80% and the surface roughness of the resist by nearly 30%, although the critical dose was sacrificed. These improvements were confirmed by the patterning of semi-dense line arrays and explained in terms of the development rate and phase separation behavior of PMMA.
( Hyo Joon Yang ),( Chang Hyun Lee ),( Seon Hee Lim ),( Jong In Yang ),( Seung Joo Kang ),( Min Jung Park ),( Su Jin Chung ),( Jong Pil Im ),( Sang Gyun Kim ),( Joo Sung Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: This study aimed to identify the clinical characteristics and prognosis of primary gastric lymphoma detected by screening upper endoscopy in high prevalence area of Helicobacter pylori ( H. pylori) infection. Methods: Between October 2003 and May 2013, consecutive subjects who were diagnosed with primary gastric lymphoma by screening upper endoscopy were retrospectively enrolled at Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea. Results: During the study period, a total of 101,103 subjects received 207,114 screening upper endoscopy. Among them, primary gastric lymphoma was detected in 49subjects. They were 53.0 ± 10.5 years of age, and 72.9% (35/49) were female. Histologic type of primary gastric lymphoma was predominantly (98.0%, 48/49) extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), and one remaining case (2.0%) was diffuse large B-cell lymphoma. Initial stage was IEa in 95.9% (47/49), and H. pylori was positive in 91.8% (43/49). Among 41 H. pylori-positive patients with gastric MALT lymphoma stage IEa, H. pylori eradication achieved complete remission in 95.1% (39/41). There were three cases of recurrence with (n = 2) or without (n = 1) reinfection of H. pylori. Conclusions: Upper endoscopy as a screening for upper gastrointestinal malignancymay detect gastric MALT lymphoma in early stage, which can be successfully treated with H. pylori eradication, especially in H. pylori endemic area. For those who achieved complete remission, it is needed to undertake surveillance for recurrence.
Jung, Deok-Beom,Lee, Hyo-Jeong,Jeong, Soo-Jin,Lee, Hyo-Jung,Lee, Eun-Ok,Kim, Young Chul,Ahn, Kyoo Seok,Chen, Chang-Yan,Kim, Sung-Hoon Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.6
<P>Hypoxia inducible factor 1 alpha (HIF-1α) is frequently over-expressed in the numerous types of cancer and plays an important role in angiogenesis. In the present study, the inhibitory mechanism of rhapontigenin isolated from <I>Vitis coignetiae</I> was investigated on HIF-1α stability and angiogenesis in human prostate cancer PC-3 cells. Rhapontigenin significantly suppressed HIF-1α accumulation at protein level but not at mRNA level in PC-3 cells under hypoxia. Also, rhapontigenin suppressed hypoxia-induced HIF-1α activation in various cancer cells, such as colorectal adenocarcinoma (SW620), breast adenocarcinoma (MCF-7), fibrosarcoma (HT-1080) and prostate carcinoma (LNCaP). Interestingly, rhapontigenin had more potency in inhibition of hypoxia-induced HIF-1α expression than that of resveratrol, a known HIF-1α inhibitor. In addition, rhapontigenin promoted hypoxia-induced HIF-1α degradation and cycloheximide (CHX) blocked protein synthesis. A prolyl hydroxylase (PHD) inhibitor dimethyloxalylglycine (DMOG) is usually utilized to examine whether prolyl hydroxylation is involved in inhibition of HIF-1α accumulation. Here, DMOG recovered HIF-1α accumulation inhibited by rhapontigenin. Immunoprecipitation assay also revealed that rhapotigenin enhanced the binding of hydroxylated HIF-1α to von Hippel-Lindau (VHL) tumor suppressor protein. Furthermore, rhapontigenin reduced vascular endothelial growth factor (VEGF) secretion in hypoxic PC-3 cells as well as suppressed tube formation in human umbilical vein endothelial cells (HUVECs) treated by the conditioned media of hypoxic PC-3 cells. However, anti-angiogenic effect of rhapontigenin in hypoxic PC-3 cells was reversed by DMOG. Taken together, these findings suggest that rhapontigenin inhibits HIF-1α accumulation and angiogenesis in PC-3 prostate cancer cells.</P>
Essential Mixed Cryoglobulinemia with Hepatitis C Virus Infection : A Case Report
Jung, Mi Kyung,Lee, Jae Sung,Jin, So Young,Kim, Won Bae,Lee, Dong Wha,Park, Hyo Sook,Kim, Yang Soo,Woo, Jun-Hee,Ryu, Jiso 대한감염학회 1996 감염 Vol.28 No.6
본태성 혼합 한랭글로불린혈증의 정확한 원인은 아직 밝혀지지 않았으나 한랭글로불린이 혈청에서 비교적 높게 관찰되면서 관절통, 쇠약, 자반증과 사구체신염, 말초성 신경병증, 혈관염, 만성간염 등의 다장기침범이 발현되는 질환이며, C형 간염바이러스 감염과 합병되는 경우가 드물지 않다. 외국에서는 C형 간염 바이러스 감염을 동반한 본태성 혼합 한랭글로불린혈증이 자주 보고되고 있으나 우리나라에서는 몇 예 보고되지 않았다. 이에 저자들은 C형 간염 바이러스 감염이 합병된 본태성 혼합 한랭글로불인혈증 1례를 경험하였기에 부검소견 및 문헌고찰과 함께 보고하는 바이다.
Comparison of Various Antiadhesives for Preventing Postoperative Severe Adhesion Formation
Hyo Jun Hwang,Jung Min Kim,Jae Ho Shin,Min Sung An,Tae Geun Ha,Kwang Hee Kim,Ki Beom Bae,Tae Hyeon Kim,Chang Soo Choi,Kwan Hee Hong,Soo Jin Jung,Sun-Hee Kim,Kuk Hwan Rho 대한외과학회 2011 대한외과학회 학술대회 초록집 Vol.2011 No.11