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간경변증 환자에서 Escherichia coli 균혈증 합병 시 간기능 장애에 따른 C-reactive protein 생성 능력에의 영향
박완범,강철인,김동민,이기덕,장희창,김홍빈,오명돈,이효석,최강원 대한감염학회 2003 감염과 화학요법 Vol.35 No.5
목적 : C-reactive protein(CRP)은 간에서 생성되는 급성 반응물질이다. 하지만 간부전증 환자에서 CRP의 반응이 간기능에 따라 어느 정도 영향을 받는지는 별로 알려진 바가 없다. 본 연구에서는 간기능에 따른 CRP 생성 능력을 평가하고자 하였다. 방법 : E. coli 균혈증이 있는 간경변증 환자 30명을 대상으로 하였고 간기능은 균혈증이 발생하기 전 2개월 이내에 측정된 혈청 빌리루빈, 혈청 알부민, 프로트롬빈시간, Child-Pugh 점수로 평가하였다. 대조군 A는 간질환이 없으면서 E. coli 균혈증이 발생한 환자 30명으로 하였고 대조군 B는 간경변증이 있으면서 급성 감염의 증거가 없는 환자 30명으로 하였다. 환자군과 대조군 간에 CRP의 최대값을 비교하였다. 결과 : CRP의 최대값은 환자군에서 7.3±5.0㎎/dL, 대조군 A에서 17.9±8.3㎎/dL로 환자군에서 유의하게 낮았다.(P<0.001). 간경변증 환자에서 CRP의 생성은 Child-Pugh 점수에 비례하여 감소하였으나(P=0.004) Child=Pugh class C의 간기능을 가진 환자군에서도 대조군 B와 비교하여 의미있는 CRP의 생성을 보였다(5.3±3.2 vs. 0.5±0.4㎎/dL, P<0.001). 결론 : 간기능부전 환자에서 CRP 반응은 간기능 저하 정도에 따라 둔화되지만 심한 간기능 장애를 가진 환자에서도 CRP의 생성은 유지된다. Background : C-reactive protein (CRP) is an acute phase reactant produced in the liver. To assess the influence of liver dysfunction on the production of CRP, we evaluated CRP response to E. coli bacteremia in patients with or without liver cirrhosis (LC). Methods : 30 LC patients who developed spontaneous peritonitis with E. coli bacteremia were enrolled in the study. Baseline values of total bilirubin, serum albumin, and prothrombin time were obtained within 2 months prior to infection. Liver dysfunction was categorized according to the Child-Pugh score. 30 patients with E. coli bacteremia who had no underlying liver dysfunction were included as a control group. Matched-control of 30 LC patients without evidence of acute infection was also included. The peak CRP values were compared among the groups. Results : In the patients with E. coli bacteremia, the mean value of peak CRP was 7.3 (+/- 5.0) ㎎/dL in LC patients, 17.9 (+/- 8.3) mg/dL in patients without liver dysfunction (p<0.001). In the advanced LC patients with Child-Pugh class C, the level of CRP was 5.2 (+/- 3.3) ㎎/dL in patients with E. coli bacteremia, 0.5 (+/- 0.4) ㎎/dL in patients without acute infection (P<0.001). Child-Pugh score had correlation with decrease of CRP (linear regression test, P=0.004). Conclusion : CRP response during E. coli bacteremia was attenuated but maintained even in patients with advanced liver dysfunction.
Serum osteocalcin levels in overweight children
Seok Bin Oh,Won Young Lee,Hyo-Kyoung Nam,Young-Jun Rhie,Kee-Hyoung Lee 대한소아내분비학회 2019 Annals of Pediatirc Endocrinology & Metabolism Vol.24 No.2
Purpose: Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass, and mitochondrial proliferation and functional enhancement. This study aimed to determine serum osteocalcin levels in overweight children and to investigate the relationships of osteocalcin with glucose metabolism and insulin sensitivity. Methods: After overnight fasting, serum osteocalcin levels were measured in overweight (n=50) children between 6.0 and 12.9 years of age and nonoverweight controls (n=60). Height, weight, fasting serum glucose, insulin, alkaline phosphatase, total cholesterol, and 25 hydroxy vitamin D3 (25(OH)VitD3) were also measured in all subjects. Results: There were significant differences in serum osteocalcin levels between the overweight and control groups (64.00±20.44 vs. 89.56±28.63, P<0.001). Serum osteocalcin levels were inversely correlated with body mass index (BMI) (r=-0.283, P=0.003), weight standard deviation score (SDS) (r=-0.222, P=0.020), BMI SDS (r=0.297, P=0.002), insulin (r=-0.313, P=0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) index (r=-0.268, P=0.005). In the subsequent multiple regression analyses, BMI, HOMA-IR, and age were determined to be independent predicting factors for serum osteocalcin. Conclusion: Our findings showed associations of serum osteocalcin with glucose metabolism and insulin sensitivity in overweight children, but we could not establish a causal relationship.
Glasswort Powder Diet Activates Lipid Metabolism in Rat
Hyo Bin Seo,Yunyoung Kwak,Ju-Ock Nam,Young Ju Song,Byung-Oh Kim,Sungpil Ryu 한국생명과학회 2012 생명과학회지 Vol.22 No.4
본 연구에서는 함초분 섭취가 지질대사에 미치는 영향을 알아보고자 하였다. 흰쥐를 일반식이 대조군(CON), 고지방식이 대조군(HFC), 고지방식이에 함초분 첨가군(HFG)로 각각 구분하여 4주간 섭취시켰다. 체중은 HFG가 HFC에 비하여 9% 정도 낮았다. 분변칼로리 분석을 한 결과, HFG의 지방량(CON에 비하여 120%, HFC에 비하여 138)과 분변 칼로리(약 110%)가 높은 것으로 나타났다. 혈중 중성지방과 LDL-C는 HFG가 HFC에 비하여 낮았으며(각각 71.8% 및 58%), HDL-C는 HFG가 HFC에 비하여 152% 높았다. 간의 FABP 발현은 HFG가 HFC보다 197% 높았으며, CPT-1 역시 동일한 경향을 보였다. 이러한 결과는 함초분 섭취가 체중의 증가를 억제하였고, 간세포 수준에서의 지방대사를 개선하였다는 점을 시사한다. 이러한 결과를 함초분이 소화관에서의 지방흡수를 억제함으로써 항비만 효과를 가지는 것으로 제안하고자 한다. The purpose of this study was to investigate the effects of glasswort powder intake on lipid metabolism. Rats were divided into three groups: a group fed a normal diet (CON), one fed a high fat diet (HFC), and one fed a high fat diet with glasswort powder (HFG). They were fed their respective diet for four weeks. Body weight was significantly lower (9%) in the HFG group than in the HFC group at the fourth week. According to the feces analysis, the HFG group showed the highest fat level (120% vs. CON; 138% vs. HFC) and fecal calories (110%). The concentration level of TG and LDL-C was 71.8% lower in the HFG group compared to the HFC group, while the concentration level of HDL-C was 152% higher in the HFG group. Expression of FABP in the liver was 197% greater in the HFG compared to the HFC group, with the expression of CPT-1 showing a similar tendency. These results suggest that glasswort powder intake suppresses weight gain and improves fat metabolism at the level of liver cells. From these results, we suggest that glasswort powder is effective against obesity by inhibiting the absorption of fat in the digestive tract.
Hyo-Ju Lee,Ki-Yeop Cho,Semi Oh,So-Yeon Park,Ye-Bin Im,Suyeon Son,Yong-Jin Yoon,Seong-Ju Park,Kyoung-Kook Kim 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.2
We report on the optical and electrical properties of MgZnO/Ag/MgZnO (MAM) grid electrodes grown at room temperature; these are proposed as an alternative to metal-based grid electrodes to meet the requirement for high stability in a harsh environment. The optical transmittance of Ag grid electrodes improved when the Ag grid layer was embedded in an MgZnO grid layer regardless of the fi ll factor. This improvement depends critically on the Ag grid layer thickness in the MAM grid electrodes. The Haack figure of merit for a MAM grid electrode with a 20 nm-thick Ag grid layer was approximately threefold higher than that of an Ag grid electrode. The electrode has an average transmittance of 85.8% at wavelengths range from 400 to 1100 nm and a sheet resistance of 26.9 Ω/sq. These results indicate that MAM grid electrodes can be an alternative to metal-based grid electrodes in optoelectronic devices that require stable wideband operation in a harsh environment and over a wide wavelength region.