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갑상선 유두암의 일차 수술 후 경부 림프절 재발의 원인
김형규(Hyeung Kyoo Kim),하은주(Eun Ju Ha),이인화(Inhwa Lee),이정훈(Jeonghun Lee),소의영(Euy Young Soh) 대한두경부종양학회 2019 대한두경부 종양학회지 Vol.35 No.2
Background/Objectives: Papillary thyroid carcinoma (PTC) has generally an indolent character with a good prognosis. However, recurrence remains a major concern for the patients during their lifetime. Despite the slowly progressing character of PTC, recurrence can occur within a short period after initial surgery. This study aimed to determine the clinical findings and cause of recurrence in patients who underwent re-oper-ative surgery due to neck node recurrence by reviewing the CT (computed tomographic) scan imaging of the recurrence of PTC retrospectively. Materials & Methods: We reviewed the medical records of patients referred to Ajou University Hospital from January 2002 to January 2018. All patients had re-operative surgery due to neck node recurrence and CT scan results of preoperative evaluation and postoperative follow up. Over this period, 110 patients who underwent re-op-eration due to neck node recurrence with a CT scan were included in our cohort, resulting in a total of 220 re-operations. Results: The time from initial operation to first re-operation was examined in 110 patients. The median time to re-operation was 28 months, with a range of 4 months to 186 months. Most re-operations (82.7%) occurred within the first five years, 43.6% were in the first two years from the initial surgery. The result of the retrospective CT review showed newly developed cases (21,19.1%), missed diagnosis cases (42,38.2%), real recur cases after surgery (33,30.0%), and remnant lymph nodes (LNs) cases (14,12.7%). We further sub-analyzed 14 cases with remnant LNs. Reasons for remnant LNs included insufficient operation (N=5) and beyond general surgical extent. (N=9). Conclusion: Re-operation due to cervical lymph node recurrence is mostly a persistent disease. They included a missed diagnosis and incomplete operation. These finding may reduce the reoperation of cervical lymph node recurrence by accurate preoperative evaluation and complete surgical resection at the initial surgery.
( Yul Hee Kim ),( Hyeung Kyoo Kim ),( Jee Woong Choi ),( You Chan Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1
Background: Hypertrophic scars after thyroidectomy are a critical dermatologic concern. Despite various approaches, the prevention of such scars remains challenging. Objectives: To evaluate the efficacy and safety of home-based low-level light therapy (LLLT) using an 830-nm light-emitting diode (LED)-based device for the prevention of and pain relief from thyroidectomy scars. Methods: Participants were randomized to receive LLLT using an LED device or a sham device without an LED from 1 week postoperatively for 4 weeks. Scars were assessed using satisfaction scores, the numeric rating scale (NRS) score for pain, Global Assessment Scale (GAS), and Vancouver Scar Scale (VSS) scores. The scars were also assessed using an Antera 3D camera to detect color, height, pigmentation, and vascularity. Assessments were performed at the 1-, 3- and 6-month follow-ups. Results: Forty-three patients completed this trial. The treatment group showed significantly higher patient satisfaction and GAS scores and lower NRS and VSS scores than the control group at 6 months. Improvements in color variation, height, pigmentation, and vascularity at 6 months were greater in the treatment group than in the control group, although the differences were not significant. Conclusion: Early application of 830-nm LED-based LLLT treatment significantly prevents hypertrophic scar formation and reduces postoperative pain without noticeable adverse effects.
( Yul Hee Kim ),( Hyeung Kyoo Kim ),( Jee Woong Choi ),( You Chan Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-
Background: Hypertrophic scars after thyroidectomy are a critical dermatologic concern. Despite various approaches, the prevention of such scars remains challenging. Objectives: To evaluate the efficacy and safety of home-based low-level light therapy (LLLT) using an 830-nm light-emitting diode (LED)-based device for the prevention of and pain relief from thyroidectomy scars. Methods: Participants were randomized to receive LLLT using an LED device or a sham device without an LED from 1 week postoperatively for 4 weeks. Scars were assessed using satisfaction scores, the numeric rating scale (NRS) score for pain, Global Assessment Scale (GAS), and Vancouver Scar Scale (VSS) scores. The scars were also assessed using an Antera 3D camera to detect color, height, pigmentation, and vascularity. Assessments were performed at the 1-, 3- and 6-month follow-ups. Results: Forty-three patients completed this trial. The treatment group showed significantly higher patient satisfaction and GAS scores and lower NRS and VSS scores than the control group at 6 months. Improvements in color variation, height, pigmentation, and vascularity at 6 months were greater in the treatment group than in the control group, although the differences were not significant. Conclusion: Early application of 830-nm LED-based LLLT treatment significantly prevents hypertrophic scar formation and reduces postoperative pain without noticeable adverse effects.
Lee, Eun-Jung,Kim, Chulwon,Kim, Jin-Young,Kim, Sung-Moo,Nam, Dongwoo,Jang, Hyeung-Jin,Kim, Sung-Hoon,Shim, Bum Sang,Ahn, Kyoo Seok,Choi, Seung-Hoon,Jung, Sang Hoon,Ahn, Kwang Seok Informa Healthcare 2012 Immunopharmacology and immunotoxicology Vol.34 No.2
<P><I>Patrinia scabiosaefolia</I> (PS) has been used for curing various types of inflammatory-related disorders. However, the precise mechanism of the anti-inflammatory activity of PS remains unclear. Here, we investigated the anti-inflammatory effects of several fractions isolated from the PS in RAW 264.7 macrophages. The results indicated that the ethyl acetate fraction of PS (EAPS) concentration highly suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) and IL-6 productions without a cytotoxic effect on RAW 264.7 cells. EAPS inhibited the expressions of LPS-induced iNOS and COX-2 protein and their mRNA in a dose-dependent manner. Particularly, EAPS suppressed the level of nuclear factor-κB (NF-κB) activity, which was linked with the suppression of LPS-induced phosphorylation of p65 at serine 276 and p65 translocation into nuclei, but not MAPK signaling. In addition, treatment with <B>EAPS</B> inhibited the production of TNF-α in LPS-injected mice and suppressed the production of IL-6 and TNF-α in LPS-stimulated splenocytes from BALB/c mice. Therefore, we demonstrate here that <I>Patrinia scabiosaefolia</I> potentially inhibits the biomarkers related to inflammation through the blocking of NF-κB p65 activation, and it may be a potential therapeutic candidate for the treatment of inflammatory diseases.</P>
A Case of Mammary Tumor Consisted of Fibroadenoma and Fibroma in Sprague-Dawley Rat
Seung-Kyoo Seong,Hyeung-Sik Lee,Kwang-Ho Cho,Hyeong-Dong Kim,Dae-Yong Kim,Saekwang Ku 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.3
An 8-month-old female Sprague-Dawley (SD) rat showed a nodular subcutaneous mass (2.5×5㎝) that arises in the proximity of the mammary glands. The mass was surgically removed, and grossly and histologically observed. Grossly, it divided distinct two regions - one was squishy and grayish region, and the other was firm and white region. Histologically, the squishy and grayish region is consisted of dense collagenous stroma separating nests of secretory and non-secretory acini, and firm and white region is consisted of dense collagenous stroma only. The epithelium of acini is one to two cuboidal cell layers thick and slightly dilated. Base on the histological and gross examination, this case was diagnosed as mammary tumor consisted of fibroadenoma and fibroma. This report is very rare case of mammary tumor consisted of fibroadenoma and fibroma in a SD rat.
Im, Inhwan,Park, Kyung-Ran,Kim, Sung-Moo,Kim, Chulwon,Park, Jeong Ha,Nam, Dongwoo,Jang, Hyeung-Jin,Shim, Bum Sang,Ahn, Kyoo Seok,Mosaddik, Ashik,Sethi, Gautam,Cho, Somi K,Ahn, Kwang Seok Lawrence Erlbaum Associates, Publishers [etc.] 2012 Nutrition and cancer Vol.64 No.2
<P>The leaf extract of guava (Psidium cattleianum Sabine) has traditionally been used for the treatment of diarrhea and diabetes in East Asia and other countries. Recently, the leaf extract has been employed in the therapy of cancer, bacterial infections, and inflammation in experimental models. However, the exact mechanisms of how guava leaf extract inhibits tumor metastasis and invasion are still unknown. In the present study, we investigated in detail the molecular mechanism(s) responsible for the potential antimetastatic and antiinvasive effects of the butanol fraction of guava leaf extract (GBF). Interestingly, we observed for the first time that GBF suppressed both matrix metalloproteinases (MMP)-9 and MMP-2 expression and activity in part through the downregulation of the ERK1/2 activation in lung cancer cells. Also, importantly, the major components of the GBF were identified as d-glucuronic acid, quercetin 3-glucuronide, loganin, and xanthyletin by LC-ESI-MS/MS. Collectively, our data indicate that the guava leaf could reduce the metastasis of lung cancer cells and therefore suggest that it could be advantageously used to control the metastatic process.</P>