http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeonghun Lee,Kuk Young Na,Jandee Lee,Su Jin Lee,Young Sil An,Joon Kee Yoon,Euy Young Soh 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.4
Purpose: Regional lymph node (LN) metastases are detected in 57?85% of patients with papillary thyroid carcinoma (PTC) and are associated with increased tumor recurrence. However, the management of lymphatic disease in patients with PTC has been ongoing source of debate. We have prospectively assessed the usefulness and accuracy of sentinel LN (SLN) biopsy for the detection of LN metastases in patients with PTC on preoperative imaging using single photon emission computed tomography/computed tomography (SPECT/CT) and 99mTc phytate. Methods: We prospectively assessed 39 patients with PTC who had risk factors for recurrence or with the necessity of intraoperative LN sampling for suspicious LN metastases on preoperative imaging from August 2010 to March 2011. The patients underwent preoperative lymphoscintigraphy and SPETC/CT and intraoperative SLN biopsy (SLNB). Results: 99mTc lymphoscintigraphy and SPECT/CT localized SLN in 38 patients (97.4%), with the gamma probe identifying 2.15 mean SLNs in the lateral neck of the 39 patients. Skip metastasis was found in one patient, and lateral compartment LN metastasis in 17 (43.5%). The sensitivity, specificity, and accuracy of SLNB for lateral compartment LN metastasis were 88.2%, 100%, and 94.8%, respectively. SLNB was more accurate and useful for lateral than for central compartment LN metastasis. Conclusion: SPECT/CT improved SLN detection and anatomical localization compared with lymphoscintigraphy. SLNB in patients with risk factors for recurrence or the necessity of intraoperative LN sampling for suspected LN metastases on preoperative imaging was accurate in detecting LN metastases and may help in deciding whether to perform lateral compartment dissection in patients with PTC.
Lee, Jeonghun,Kim, Hyunjung,Kim, Seahee,Lee, Hyemi,Kim, Jin,Kim, Namkug,Park, Heon Joo,Choi, Eun Kyoung,Lee, Jin Seong,Kim, Chulhee The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.28
<P>We report on the dual function of a silica–iron oxide hybrid nanoparticle combined with a stimulus responsive gatekeeper on the surface. Multifunctional hybrid nanoparticles (Fe@Si–DOX–CD–PEG) composed of an Fe<SUB>3</SUB>O<SUB>4</SUB> core, a mesoporous silica shell, and GSH-responsive CD gatekeepers are an excellent platform for anticancer drug delivery and MR imaging. In particular, the CD gatekeepers on the surface of the hybrid nanoparticle play a key role in accommodating anticancer drug molecules in the pore of the silica shell without premature release until CD gatekeepers are cleaved by GSH. We confirmed, from an <I>in vitro</I> study with the A549 cell line, that DOX was released from the internalized carriers due to GSH-mediated cleavage of the CD gatekeeper. Consequently, apoptotic and clonogenic death occurred in the cells treated with Fe@Si–DOX–CD–PEG. The accumulation of Fe@Si–DOX–CD–PEG in the tumors was detected by <I>in vivo</I> MR imaging. The growth of the tumor <I>in vivo</I> was effectively suppressed by the intravenously injected Fe@Si–DOX–CD–PEG. In addition, the results of the <I>in vivo</I> MR imaging reflected the <I>in vivo</I> inhibition of the cancer growth by Fe@Si–DOX–CD–PEG.</P> <P>Graphic Abstract</P><P>Multimodal hybrid nanoparticles composed of a Fe<SUB>3</SUB>O<SUB>4</SUB> core, a mesoporous silica shell, and GSH-responsive CD gatekeepers are an excellent theranostic platform for MR imaging and anticancer drug delivery not only <I>in vitro</I> but also <I>in vivo</I>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm32137h'> </P>
KIM, SANGMIN,KIL, WON HO,LEE, JEONGMIN,OH, SOO-JIN,HAN, JEONGHUN,JEON, MYEONGJIN,JUNG, TAEWOO,LEE, SE KYUNG,BAE, SOO YOUN,LEE, HYUN CHUL,LEE, JUN HO,YI, HA WOO,KIM, SEOK WON,NAM, SEOK JIN,LEE, JEONG E Spandidos Publications 2014 ONCOLOGY REPORTS Vol.32 No.6
<P>Expression of the CD44 gene is upregulated in breast cancer cells and is correlated with patient survival. Aberrant CD44 expression promotes tumor progression and metastasis. In the present study, we investigated the role of zerumbone (ZER) on regulatory mechanisms of CD44 expression in breast cancer cells. Our results showed that CD44 expression was significantly increased by epidermal growth factor receptor (EGFR) ligands in SKBR3 breast cancer cells. In contrast, EGF-induced CD44 expression was decreased by a MEK1/2 inhibitor, UO126, or STAT3 inhibitor, STAT3 VI, respectively. Notably, ZER downregulated the basal level of CD44 expression in CD44+ breast cancer cells. In addition, the induction of CD44 expression by EGFR ligands, EGF or TGF-α, was markedly decreased by ZER treatment. Finally, we investigated the inhibitory mechanism of ZER on EGF-induced CD44 expression. Our results showed that EGF-induced phosphorylation of STAT3 was completely suppressed by ZER. Collectively, ZER suppressed EGF-induced CD44 expression through inhibition of the STAT3 pathway. Therefore, we suggested that ZER may act as a promising therapeutic drug for the treatment of breast cancer.</P>
Lee, Jiae,Kim, Jaeyun,Nguyen, Thanh Luan,Kim, Miso,Park, Juhyung,Lee, Yeran,Hwang, Sungu,Kwon, Young-Wan,Kwak, Jeonghun,Woo, Han Young American Chemical Society 2018 Macromolecules Vol.51 No.9
<P>A semicrystalline p-type thermoelectric conjugated polymer based on a polymer backbone of cyclopentadithiophene and benzothiadiazole, poly[(4,4′-(bis(hexyldecylsulfanyl)methylene)cyclopenta[2,1-<I>b</I>:3,4-<I>b</I>′]dithiophene)-<I>alt</I>-(benzo[<I>c</I>][1,2,5]thiadiazole)] (PCPDTSBT), is designed and synthesized by replacing normal alkyl side-chains with bis(alkylsulfanyl)methylene substituents. The sp<SUP>2</SUP>-hybridized olefinic bis(alkylsulfanyl)methylene side-chains and the sulfur-sulfur (S-S) chalcogen interactions extend a chain planarity with strong interchain packing, which is confirmed by density functional calculations and morphological studies, i.e., grazing incidence X-ray scattering measurement. The doping, electrical, morphological, and thermoelectric characteristics of PCPDTSBT are investigated by comparison with those of poly[(4,4′-bis(2-ethylhexyl)cyclopenta[2,1-<I>b</I>:3,4-<I>b</I>′]dithiophene)-<I>alt</I>-(benzo[<I>c</I>][1,2,5]thiadiazole)] (PCPDTBT) with ethylhexyl side-chains. Upon doping with a Lewis acid, B(C<SUB>6</SUB>F<SUB>5</SUB>)<SUB>3</SUB>, the maximum electrical conductivity (7.47 S cm<SUP>-1</SUP>) of PCPDTSBT is ∼1 order higher than that (0.65 S cm<SUP>-1</SUP>) of PCPDTBT, and the best power factor is measured to be 7.73 μW m<SUP>-1</SUP> K<SUP>-2</SUP> for PCPDTSBT with doping 9 mol % of B(C<SUB>6</SUB>F<SUB>5</SUB>)<SUB>3</SUB>. The Seebeck coefficient-electrical conductivity relation is analyzed by using a charge transport model for polymers, suggesting that the doped PCPDTSBT film has superb charge transport property based on a high crystallinity with olefinic side-chains. This study emphasizes the importance of side-chain engineering by using the sp<SUP>2</SUP>-hybridized olefinic substituents to modulate interchain packing, crystalline morphology, and the resulting electrical properties.</P> [FIG OMISSION]</BR>
Lee Jeonghun 대한내분비외과학회 2024 The Koreran journal of Endocrine Surgery Vol.24 No.1
Purpose: For recent decades, there have been many studies on the relationship with thyroid dysfunction and mood disorder, anxiety, or stress, but the results have been inconsistent. Also, few studies have examined the effects of psychological disorder on thyroid function in patients who underwent thyroidectomy. In this study, we investigated the relationship between stress and thyroid dysfunction in such patients. Methods: Twenty-eight patients were enrolled who underwent thyroidectomy from July 2007 to January 2016 and who experienced life events after thyroid surgery. Five patients underwent lobectomy. The mean follow-up period was 49 months. In this retrospective cohort study, thyroid stimulating hormone (TSH) and thyroid hormones (T4, T3) tested periodically were compared with PROC MIXED with SAS v9.4. The stressors were found by open questionnaire during outpatient’s visits. Results: The patients enrolled in this study took 3–8 thyroid function tests during the follow-up period (mean 49 months). Eight patients (28.5%) had mild to moderate hypothyroidism with TSH less than 10 μIU/mL and 14 patients (50.0%) had overt hypothyroidism with TSH >10 μIU/ mL. When the patients were under stress, free T4 decreased and TSH increased after adjusting the effect of decreased T4 (P<0.001), despite identical levothyroxine dose and good compliance. Conclusion: In the patients who underwent thyroidectomy, TSH increased under stress, because of the loss or lack of the compensatory response of thyroid. Therefore, for patients with thyroid cancer under stress, levothyroxine dose and frequency of outpatient visit will be needed to be adjusted during follow-up.
Lee, Jeonghun,Oh, Eun-Taex,Lee, Jinyoung,Kang, Taehyeong,Kim, Ha Gyeong,Kang, Hansol,Park, Heon Joo,Kim, Chulhee The Royal Society of Chemistry 2019 NEW JOURNAL OF CHEMISTRY Vol.43 No.3
<P>Adopting conformational conversion of a peptide as a trigger to control on-off gatekeeping on the surface of mesoporous silica nanoparticles has several advantages. Here, we designed a dual-functional cyclic peptide with an iRGD sequence as a stimulus-responsive on-off gatekeeper on the surface of mesoporous silica nanocontainers. The cyclic peptide gatekeeper with an intramolecular disulfide bond between the two cysteine units at both terminals of the peptide sequence exhibited selective drug release triggered by stimulus-induced conformational conversion. Furthermore, the iRGD sequence of the cyclic peptide gatekeeper enhanced the intracellular uptake and therapeutic efficacy of the nanoparticles by specifically binding with NRP-1 receptor on the surface of target cancer cells.</P>