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- 검색키워드
- 저자 : Hyeon-Son Choi (검색결과 265 건)
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Choi, Ihn-Geun,Son, Hyun-Gyun,Yang, Byung-Hwan,Kim, Seok Hyeon,Lee, Jun-Suk,Chai, Young-Gyu,Son, Bong Ki,Kee, Baik Seok,Park, Byung Lae,Kim, Lyoung Hyo,Choi, Yoo Hyun,Shin, Hyoung Doo Wiley Subscription Services, Inc., A Wiley Company 2005 Human mutation Vol.26 No.3
<P>Alcoholism is a multifactorial and polygenic disorder involving complex gene-to-gene and gene-to-environment interactions. Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. These genetic polymorphisms are believed to influence drinking behavior and development of alcoholism. Direct DNA sequencing of whole ADH1B and ADH1C genes revealed 36 sequence variants, including six nonsynonymous and 14 novel polymorphisms. Seventeen polymorphisms among them were selected for genotyping in a larger study (n=352) based on linkage disequilibria (LDs) among SNPs, locations, and frequencies. Hardy-Weinberg equilibrium (HWE) analyses of polymorphisms revealed severe deviations only in alcoholics, which strongly suggest that a selection bias (or pressure) may be involved. The analyses of genotype distribution in alcoholics (n=106) and normal controls (n=246) showed dramatic associations with the risk of alcoholism. Fourteen polymorphisms in ADH1C and ADH1B showed a series of different strengths of association and magnitudes of risk. Based on referent and subgroup analysis, it was strongly suggested that the genetic effects come from the ADH1B*47Arg/*47Arg genotype, and that the positive signals from other sites are just tracking the genetic effect of ADH1B His47Arg. In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism. The information derived from this study could be valuable for understanding the genetic factors involved in the risk of alcoholism and facilitate further investigation in other ethnic groups. Hum Mutat 26(3), 224–234, 2005. © 2005 Wiley-Liss, Inc.</P>
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Choi, Hyeon-gyu,Son, Moon,Choi, Heechul Elsevier 2017 CHEMOSPHERE - Vol.185 No.-
<P><B>Abstract</B></P> <P>Thin-film composite mixed matrix membrane (TFC MMM) with functionalized carbon nanotube (fCNT) blended in polyethersulfone (PES) support layer was synthesized via interfacial polymerization and phase inversion. This membrane was firstly tested in lab-scale integrating seawater desalination and wastewater reclamation forward osmosis (FO) process. Water flux of TFC MMM was increased by 72% compared to that of TFC membrane due to enhanced hydrophilicity. Although TFC MMM showed lower water flux than TFC commercial membrane, enhanced reverse salt flux selectivity (RSFS) of TFC MMM was observed compared to TFC membrane (15% higher) and TFC commercial membrane (4% higher), representing membrane permselectivity. Under effluent organic matter (EfOM) fouling test, 16% less normalized flux decline of TFC MMM was observed compared to TFC membrane. There was 8% less decline of TFC MMM compared to TFC commercial membrane due to fCNT effect on repulsive foulant–membrane interaction enhancement, caused by negatively charged membrane surface. After 10 min physical cleaning, TFC MMM displayed higher recovered normalized flux than TFC membrane (6%) and TFC commercial membrane (4%); this was also supported by visualized characterization of fouling layer. This study presents application of TFC MMM to integrated seawater desalination and wastewater reclamation FO process for the first time. It can be concluded that EfOM fouling of TFC MMM was suppressed due to repulsive foulant–membrane interaction.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TFC MMM was synthesized with fCNT-blended PES layer. </LI> <LI> TFC MMM was firstly applied to integrating seawater desalination & wastewater reclamation FO process. </LI> <LI> Performances of TFC MMM were enhanced in FO test. </LI> <LI> EfOM fouling resistance was enhanced for TFC MMM due to electrostatic repulsion. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Choi, Hyeon-Son,Kim, Sun Young,Park, Yooheon,Jung, Eun Young,Suh, Hyung Joo The Korean Society of Ginseng 2014 Journal of Ginseng Research Vol.38 No.4
Background: In this study, we examined the effects of various enzymes on chemical conversions of ginsenosides in ginseng extract prepared by amylases. Methods: Rapidase, Econase CE, Viscozyme, Ultraflo L, and Cytolase PCL5 were used for secondary enzymatic hydrolysis after amylase treatment of ginseng extract, and ginsenoside contents, skin permeability, and chemical compositions including total sugar, acidic polysaccharide, and polyphenols were determined on the hydrolyzed ginseng extract. Results: Rapidase treatment significantly elevated total ginsenoside contents compared with the control (p < 0.05). In particular, deglycosylated ginsenosides including Rg3, which are known as bioactive compounds, were significantly increased after Rapidase treatment (p < 0.05). The Rapidase-treated group also increased the skin permeability of polyphenols compared with the control, showing the highest level of total sugar content among the enzyme treatment groups. Conclusion: This result showed that Rapidase induced the conversion of ginsenoside glycosides to aglycones. Meanwhile, Cytolase PCL5 and Econase treatments led to a significant increase of uronic acid (acidic polysaccharide) level. Taken together, our data showed that the treatments of enzymes including Rapidase are useful for the conversion and increase of ginsenosides in ginseng extracts or products.
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Valerian/Cascade mixture promotes sleep by increasing non-rapid eye movement (NREM) in rodent model
Choi, Hyeon-Son,Hong, Ki-Bae,Han, Sung Hee,Suh, Hyung Joo Elsevier 2018 Biomedicine & pharmacotherapy Vol.99 No.-
<P><B>Abstract</B></P> <P>The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarbital-induced sleep model, Valerian, Cascade, and Valerian/Cascade mixture significantly reduced the latency time for sleeping, and total sleeping time effectively increased in these sample groups compared with the control. Valerian/Cascade mixture increased sleep duration by 37%. The mixture significantly increased the non-rapid eye movement (NREM) sleep time by 53% compared with the control, while REM sleeping time was decreased by 33% with Valerian/Cascade mixture, in Electroencephalography (EEG) analysis, resulting in the increase of total sleep time and the decrease of awakening. This sleep-promoting effect was obvious in caffeine-induced awakening model; Valerian, Cascade, and the mixture significantly enhanced NREM and total sleep time, which were reduced by caffeine. Caffeine-induced increase of awakening was effectively deceased to the normal level by these three samples. In particular, delta wave responsible for deep sleep in NREM was greatly increased by the mixture in both normal and caffeine-induced awake models. This sleep-promoting effect of Valerian/Cascade mixture was shown to be due to the upregulation of gamma-aminobutyric acid A receptor (GABA<SUB>A</SUB>R). Valerian/Cascade mixture showed 91% binding capacity to GABA<SUB>A</SUB>-BZD receptor. Two compounds, Valerenic acid and Xanthohumol, were shown to significantly contribute to the binding activity of Valerian/Cascade mixture on the GABA receptor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Valerian/Cascade mixture significantly reduced latency time of sleep in mice. </LI> <LI> Valerian/Cascade mixture increased NREM and total sleep time in rat. </LI> <LI> Valerian/Cascade mixture effectively reversed caffeine-induced sleep disturbance. </LI> <LI> Valerian/Cascade mixture played a GABAergic action. </LI> <LI> Valerenic acid and Xanthohumol contributed to sleep-promoting effect of the mixture. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Choi, Hyeon-gyu,Yoon, Sang Hyeon,Son, Moon,Celik, Evrim,Park, Hosik,Choi, Heechul Informa UK (Taylor Francis) 2016 Desalination and Water Treatment Vol.57 No.16
<P>Cellulose acetate membrane has been applied to reverse osmosis for desalination due to chlorine tolerance and biofouling resistance. Since it requires optimized synthesis condition for application, we investigated the effect of different conditions on membrane performances. It was found that polymer concentration, solvent ratio, and evaporation time were critical to determine membrane selectivity and permeability. Based on the study, optimized conditions were obtained, which were 14 wt% of polymer concentration, 1:2.(of ratio of 1,4-dioxane to acetone, and 30 s of evaporation time. Further, functionalized multi-walled carbon nanotubes (MWCNTs) were applied to the optimized bare membrane in order to enhance the performances. The composite membranes were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, and contact angle measurement. It was found that the MWCNTs influenced the morphology and surface chemistry of the membrane. This study could contribute to develop a commercial composite RO membrane with nanomaterial for desalination application.</P>
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Nano-Calcium Ameliorates Ovariectomy-Induced Bone Loss in Female Rats
Hyeon-Son Choi,JeungHi Han,Seungsik Chung1,Yang Hee Hong,and Hyung Joo Suh 한국축산식품학회 2013 한국축산식품학회지 Vol.33 No.4
In this study, we examined the effects of organic types of calcium derived from oyster shell (OS-Ca) and nano-calcium (Nano-Ca) on the bio-availability and physiological responses associated with bone health in ovariectomised rats. Increased body weight, which is one of the physiological effects of ovary removal, was significantly recovered by Nano-Ca treatment (p<0.05). The reduced calcium level in the liver in ovariectomised rat was increased significantly with OS-Ca and Nano-Ca treatment (p<0.05), suggesting improved calcium bio-availability. Alkaline phosphatase (ALP), osteocalcin, and deoxypyridinoline (DPD) were analysed as biochemical markers of bone metabolism and health in the presence or absence of OSCa and Nano-Ca. ALP, osteocalcin, and DPD levels increased following ovary removal and tended to decrease after treatment with Nano-Ca, indicating that Nano-Ca induces favourable bone metabolism. This result was reflected in the recovery of bone mineral density (BMD) and bone mineral content (BMC) of the femur after Nano-Ca treatment following ovary removal. Taken together, our data show that the tested calcium treatments, especially using Nano-Ca, enhanced the bioavailability or absorption of calcium and positively affected bone metabolism in ovariectomised rats.
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Nano-Calcium Ameliorates Ovariectomy-Induced Bone Loss in Female Rats
Choi, Hyeon-Son,Han, JeungHi,Chung, Seungsik,Hong, Yang Hee,Suh, Hyung Joo Korean Society for Food Science of Animal Resource 2013 한국축산식품학회지 Vol.33 No.4
In this study, we examined the effects of organic types of calcium derived from oyster shell (OS-Ca) and nano-calcium (Nano-Ca) on the bio-availability and physiological responses associated with bone health in ovariectomised rats. Increased body weight, which is one of the physiological effects of ovary removal, was significantly recovered by Nano-Ca treatment (p<0.05). The reduced calcium level in the liver in ovariectomised rat was increased significantly with OS-Ca and Nano-Ca treatment (p<0.05), suggesting improved calcium bio-availability. Alkaline phosphatase (ALP), osteocalcin, and deoxypyridinoline (DPD) were analysed as biochemical markers of bone metabolism and health in the presence or absence of OSCa and Nano-Ca. ALP, osteocalcin, and DPD levels increased following ovary removal and tended to decrease after treatment with Nano-Ca, indicating that Nano-Ca induces favourable bone metabolism. This result was reflected in the recovery of bone mineral density (BMD) and bone mineral content (BMC) of the femur after Nano-Ca treatment following ovary removal. Taken together, our data show that the tested calcium treatments, especially using Nano-Ca, enhanced the bioavailability or absorption of calcium and positively affected bone metabolism in ovariectomised rats.
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손소연 ( So Yeon Son ),류대열 ( Hyeon Soo Son ),손현수 ( Dae Yeol Ryu ),강신석 ( Sin Seok Kang ),박재명 ( Jae Myoung Park ),변현섭 ( Hyeon Seop Byeon ),최해연 ( Hae Yeon Choi ) 한국가축위생학회 2006 韓國家畜衛生學會誌 Vol.29 No.3
This is a case report on the occurrence of caprine arthritis-encephalitis(CAE) disease among dairy goats in a local farm located in Yeongdong-gun, Chungbuk. Previously, it was reported that the farm experienced intermittent deaths numbering 15 of the 97 goats raised for 5 months. Most of the goats less than 6 months of age were suffering from ataxia and posterior paresis, body tremor and abnormal head posterior. Affected animals frequently had stunted growth and had a rough coat. Goats more than 6 months of age were affected with an insidious, chronic arthritis characterized by articular swelling("big knee") of the carpal, hock, and stifle joints. Necropsy revealed severely swollen mesenteric lymph nodes, under-flow of 2-3㎖ synovial fluid in the articular space and fibrous proliferation of synovial membrane. Histopathological examination showed perivascular accumulations of mononuclear inflammatory cells in the white matter of the brain, proliferative synovitis characterized by villous hypertrophy, synovial cell hyperplasia and infiltration by mononuclear inflammatory cells. Pulmonary lesions consists of patchy interstitial pneumonia with hyperplasia of lymphoid tissues and an extensive mononuclear inflammatory cell infiltration into the alveolar septa. Confirmation by nested PCR involves amplification of a 296bp(1st PCR) and 184bp(2nd PCR) fragments corresponding to the gag region of the CAE virus. This is the first time CAE has been reported in a local farm in Korea and emphasizes the importances of developing preventive measures against CAE.
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