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심화정,윤혜은,강수경,이재란,송미라,김기순,류소연 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : This study was conducted to investigate the actual conditions and the relevant factors of acnes, the most common skin troubles of the adolescent period. Materials and Method : This study was carried out through a survey on 382 female students in a high school from October 24, 2002 to October 31. The survey was formed with questions on the general characteristics of the subject; questions relevant to the actual conditions of acnes; questions of the bio-rhythm; questions on washing and hair shape, the condition of the skin, eating habits; and questions on stress and sicknesses Chi-square test, t-test and multiple logistic regression were used as the method of statistical analysis, to investigate the associated factors with acnes that occur on the face. Results : 1. There were 65.4% of the female students who had acnes, and the most common site were on the forehead and nose, then the cheeks and the whole of the face respectively. On the type of the acnes, 39.1% non-inflammatory acnes, 29.7% were inflammatory and 12.3% were the combination of both 2 As a result of bivariate analysis, there was statistically significant relevance of sleeping time, number of time of washing face, type of cleansing product, type of skin, condition of skin, sensitiveness of skin, preference of meat, menstrual irregularity and stress with acnes 3 Multiple logistic regression analysis showed that the odds ratio(OR) of acnes in case of use of soap instead of cleansing products was 3.00 (95% confidence interval(CI): 1.03 - 8.79), in case of the use of special pimple soap was 27.32 (95% CI 2.68 - 278.51), in case of oily face, 9.40 (95% CI 3.45 - 25.61); in case of combination face was 3.95 (95% CI. 1.64 - 9.50); in case of moist face without shine when compared to seriously lightened skin was 0.22 (95% CI. 0.07 - 0.72); in case of non-preference of meat when compared to preference of meat was 2.00 (95% CI : 1.11 - 3.61) Apart from this, there was no significant relevance with sleeping time, menstrual irregularity and stress Conclusion : It was concluded that there was relevance in the skin condition, skin type and face-wash with the acnes on the face of adolescent female students. There is a necessity of conducting studies about the occurrence of acnes and its relevant factors, in the future.
캡슐내시경과 단일풍선 소장내시경으로 진단된 공장의 간질종양 1예
송도경,심기남,태정현,김경진,송명은,송하응,윤혜원,정가영,정정화 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2
Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors that arise in the wall of the gastrointestinal tract. We report a case of obscure gastrointestinal bleeding due to a GIST of the jejunum successfully documented by videocapsule endoscopy (VCE) and single-balloon enteroscopy (SBE). A 36-year-old man with hematochezia was referred for further evaluation of no evidence of bleeding focus on esophagogastroduodenoscopy and colonoscopy. A VCE showed a suspicious ulcerative hyperemic mass that located in about 1 hour apart from duodenal second portion. SBE revealed a nonbleeding 4×2 cm mass with an ulcer at the proximal jejunum. The patient underwent laparoscopic resection without complication. Histological examination revealed a well circumscribed, dumbbell-shaped firm mass comprised of spindle cells. Immunohistochemical staining for CD 117 was diffusely positive, whereas staining for S-100, CD 34 and MIB-1 was all negative. It was confirmed to be a low-grade GIST at the proximal jejunum.
HCV : PE-098 ; Myasthenia gravis triggered by antiviral therapy for chronic hepatitis C
( Hye In Kim ),( Tae Hun Kim ),( Il Hwan Moon ),( Kwon Yoo,),( Sun Young Yi ),( Sung Ae Jung ),( Ki Nam Shim ),( Hye Kyung Jung ),( Seong Eun Kim ),( Won Yung Cho ),( So Yoon Yoon ),( Eun Mi Song ),( 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Myasthenia gravis (MG) is an uncommon disease characterized by muscular weakness and fatigability, caused in 85% of the cases by Acetylcholine receptor (AChR) antibodies. And it is reported as a rare side effect of interferon administration which can develop during chronic hepatitis C treatment. And about 15% of MG patients have thymoma while half of the patients with thymoma eventually develop MG. But it is hardly reported that MG was triggered by antiviral therapy in patient with thymoma. We experienced a rare case of myasthenia gravis induced by antiviral therapy for chronic hepatitis C in patient with mediastinal thymoma. A 47-year-old male complained of diplopia after 9 weeks of administration of peginterferon and ribavirin. A brain imaging study showed no abnormality but we diagnosed as MG by positive repetitive nerve stimulation test and positive anti AChR antibody. And we found thymoma after chest CT scan.
( Hye Kyung Song ),( Ki Nam Shim ),( Hye Won Yun ),( Chung Hyun Tae ),( Chang Mo Moon ),( Seong Eun Kim ),( Hye Kyung Jung ),( Tae Hun Kim ),( Sung Ae Jung ),( Kwon Yoo ),( Il Hwan Moon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Caustic ingestion can cause severe injury to upper gastrointestinal track. There were a few studies about clinical characteristics and treatments of caustic injury in Korea. We investigated the changes of caustic injury over 20 years in clinical characteristics including the pattern of endoscopic mucosal injury and the modality of treatments. Methods: This study was a retrospective review of medical records from patients with caustic injury from September 1993 through December 2012. Patients with caustic injury who visited hospital from 1993 to 2002 were classifi ed as early period group and patients with caustic injury who visited from 2003 to 2012 were classifi ed as late period group. Results: A total 140 patients (mean age 44±17 yrs, male 41.7%) were included [early period group (n= 50) vs. late period group (n= 90)]. Annual incidence of caustic ingestion did not decrease (range 2-20) over 20 years. Ingestion of alkali agents increased (10% vs. 57%, p<0.0001) and more than grade 2B of mucosal injury decreased (47.8% vs. 27.3%, p=0.0015) in late period group. There was no difference between two groups in sex, age, proportion of accidental ingestion, systemic and GI complication. Use of gastric lavage, NPO and broad spectrum antibiotics decreased in late period group (p<0.01). However, there was no difference in use of steroid between two groups (p=0.172). Conclusions: There was no decreasing trend in caustic ingestion and ingestion of alkali agents increased over the past 20 years. The tighter legislation on caustic agents is required and we need to be alert to the best management of caustic injury.
Hye Won Chae,Haehum Jung,Eun Jung Kim,Hyun Joo Shim,Joong In Lim,Hye Young Ji,Hye Suk Lee 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.9
(S)-2-ethoxy-3-(4-{3-methyl-5-[4-(3-methyl-isoxazol-5-yl)-phenyl]thiophen-2-ylmethoxy}-phenyl)-propionic acid (PAM-1616) is a novel peroxisome proliferators-activated receptor γ (PPARγ) partial agonist with excellent antihyperglycemic activity. It is a promising new drug candidate for the treatment of type-2 diabetes with reduced possibility of edema in vitro/in vivo. In order to evaluate the pharmacokinetics of PAM-1616, a reliable, selective and sensitive highperformance liquid chromatography/electrospray ionization tandem mass spectrometry was developed for the quantification of PAM-1616 in rat plasma. The analytes were extracted from rat plasma with ethyl acetate, separated on an Atlantis dC18 column with a mobile phase of 75% acetonitrile in 10 mM ammonium formate (pH 4.5), and detected by tandem mass spectrometry in the selective reaction monitoring mode. The calibration curve was linear (r2 = 0.999) over the concentration range of 0.05-20.0 μg/mL and the lower limit of quantification was 0.05 μg/mL. The coefficient of variation and relative error at four QC levels were 1.8% to 14.3% and −10.0% to 6.5%, respectively. The present method was successfully applied to the pharmacokinetic study of PAM-1616 after intravenous administration of PAM-1616 potassium at a dose of 1 mg/kg in rats.
Prevalence and Predictive Factors of Fecal Incontinence
( Hye Won Kang ),( Hye Kyung Jung ),( Kyoung Joo Kwon ),( Eun Mi Song ),( Ju Young Choi ),( Seong Eun Kim ),( Ki Nam Shim ),( Sung Ae Jung ) 대한소화기기능성질환·운동학회 (구 대한소화관운동학회) 2012 Journal of Neurogastroenterology and Motility (JNM Vol.18 No.1
Background/Aims Most previous epidemiologic studies about fecal incontinence were performed in specific populations in Korea. We aimed to estimate the prevalence and predictive factors of fecal incontinence in adult Korean population, both men and women aged 20 years and over. Methods Subjects who had undergone medical check-up for health screening were enrolled. They completed the structured questionnaires, including demographics, gastrointestinal symptoms, medical and social histories, and also about their bowel habits. Logistic regression models were constructed to identify the predictive factors for having fecal incontinence. Results Among the total of 1,149 subjects (mean age, 44.8 ± 10.2 years; 648 males), the overall prevalence of fecal incontinence was 6.4%, while the older group (> 50 years old) showed the higher prevalence than the younger group (≤ 50 years old) (10.4% vs 4.9%, P = 0.001) without gender difference. Most patients had mild fecal incontinence in 78.4%. By multivariate analysis, old ages (Odd ratio [OR], 3.1; 95% confidence interval [CI], 1.9-5.2; P < 0.001), watery stool (OR, 2.8; 95% CI, 1.5-4.9; P = 0.001) and functional diarrhea (OR, 2.7; 95% CI, 1.4-5.4; P = 0.004) were found to be independent predictors for fecal incontinence. Conclusions The prevalence of fecal incontinence in Korean adults was 6.4%, and it was significantly more prevalent in older people without any gender difference. Aging and diarrhea were independent predictive factors of fecal incontinence. Therefore, proper control of the bowel pattern would lead to the prevention of fecal incontinence. (J Neurogastroenterol Motil 2012;18:86-93)