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엔로플록사신 액제의 닭유래 병원세균에 대한 시험관내 항균효과 시험
윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-
In this study the antimicrobial spectrum and sensitivity of a liquid formulation of enrofloxacin against the major six pathogenic bacteria isolated from the diseased poultry in Korea were evaluated in comparison with ciprfloxacin (CFX), gentamicin (GM) and penicillin (PC). A liquid form of enrofloxacin, a test material and ciprofloxacin showed at least 83% antibacterial activity against all of six test pathogenic microorganisms at the fixed concentration of 10 ㎍/㎖. Gentamicin and penicillin revealed much lower antibacterial activity at the same condition. We evaluated the liquid form of enrofloxacin as having widespread antibacterial spectrum against poultry infections. The liquid form of enrofloxacin showed potent antibacterial activity, with the MIC range being 0.12∼2 ㎍/㎖ against Gram positives, 0.06∼2 ㎍/㎖ against Gram negatives and 0.5∼2 ㎍/㎖ against Mycoplasma spp. These values were equivalent to or somewhat higher than those of ciprofloxacin, but much lower than those of gentamicn and penicillin. This new liquid form of enrofloxacin would find its way in application of mixing with drinking water for the prevention and treatment of diverse infections in chickens.
엔로플록사신 액제의 닭 호흡기 및 소화기 감염증에 대한 예방 및 치료효과
윤효인,박병권,조준형,정상희,박경환,장범수,김종춘,황윤환,임종환,이내경,박승춘 충남대학교 수의과대학 동물의과학연구소 2000 動物醫科學硏究誌 Vol.8 No.-
We evaluated the efficacy of the liquid form of enrofloxacin against poultry respiratory and digestive infections, the major problems in the poultry industry, from diverse diagnosis viewpoints. Results obtained through this study were as follows: 1. The liquid form of enrofloxacin showed good acceptability to poultry owing to no abhorrence to the drug by chickens, which indicated its suitability for mixing in drinking water. 2. The application of the enrofloxacin formulation improved the productivity of the chicken farm to a great extent by lowering the death toll of chicken raised in the farm. 3. The use of the drug shortened the days to the market, and increased the body weight at the time of marketing. 4. Preventive and therapeutic effects of the liquid enrofloxacin were observed higher than ampicillin, a major antibiotic used in poultry farming. From above results, the liquid form of enrofloxacin would find its use for the prevention and treatment of digestive and respiratory infections, let alone the growth promotion and feed efficiency, especially in the chicken farming practice.
Mobile harbor: structural dynamic response of RORI crane to wave-induced rolling excitation
Cho, Jin-Rae,Han, Ki-Chul,Hwang, Soon-Wook,Cho, Choon-Soo,Lim, O-Kaung Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.43 No.5
A new concept sea-floating port called mobile harbor has been introduced, in order to resolve the limitation of current above-ground port facilities against the continuous growth of worldwide marine transportation. One of important subjects in the design of a mobile harbor is to secure the dynamic stability against wave-induced excitation, because a relatively large-scale heavy crane system installed at the top of mobile harbor should load/unload containers at sea under the sea state up to level 3. In this context, this paper addresses a two-step sequential analytical-numerical method for analyzing the structural dynamic response of the mobile harbor crane system to the wave-induced rolling excitation. The rigid ship motion of mobile harbor by wave is analytically solved, and the flexible dynamic response of the crane system by the rigid ship motion is analyzed by the finite element method. The hydrodynamic effect between sea water and mobile harbor is reflected by means of the added moment of inertia.
ALDC 12종의 경도와 내식성에 미치는 어닐링 열처리의 영향
조황래(Hwang-Rae Cho),이명훈(Myeong-Hoon Lee),이성열(Seung-Yeol Lee),문경만(Kyung-Man Moon) 한국마린엔지니어링학회 2006 한국마린엔지니어링학회 학술대회 논문집 Vol.2006 No.-
ALDC 12 Al alloy is often corroded with some forms such as pitting corrosion, intergranular corrosion, and galvanic corrosion etc., in case of severe corrosion environment like seawater. Annealing heat treatment was performed to improve the corrosion resistance of ALDC 12. Hardness was decreased with increasing of annealing temperature, however its corrosion resistance was clearly improved with increasing of annealing temperature.
조황래(Hwang-Rae Cho),방정석(Jeong-Suk Bang),이병호(Byung-Ho Rhee),이광진(Kwang-Jin Lee),임병직(Byoungjik Lim),한영민(Yeoung-Min Han),최환석(Hwan-Seok Choi) 한국추진공학회 2009 한국추진공학회 학술대회논문집 Vol.2009 No.11
액체로켓엔진 연소기의 내벽에 사용하기 위한 니켈/크롬 도금 공정 개발을 수행하였다. 열충격 시험을 통해 니켈 도금 조건을 선별하였고 니켈/크롬 도금이 수행된 축소형 연소기의 연소시험을 통해 도금 층의 내구성 검증을 수행하였다. 시험결과 도금 층의 균열 및 박리는 발견되지 않았고, 이 결과로부터 현재 사용중인 대기 플라즈마 용사된 세라믹 코팅의 대안으로 니켈/크롬 도금을 액체로켓엔진 연소기에 사용할 수 있으리라 사료된다. A Ni/Cr plating process has been developed for applying to inner wall of liquid rocket engine(LRE) thrust chamber. Ni plating conditions were selected through thermal shock test and endurance verification of the plating layers was performed through hot firing test of a subscale thrust chamber with Ni/Cr plating. Test results showed that a crack or separation of the plating layers was not found. Judging from the results, Ni/Cr plating could be applied to LRE thrust chamber as a substitute of air plasma sprayed ceramic coating which is presently being used.
Characterization of effector memory CD8+ T cells in the synovial fluid of rheumatoid arthritis.
Cho, Bon-A,Sim, Ji Hyun,Park, Ji Ah,Kim, Hye Won,Yoo, Wan-Hee,Lee, Seung-Hyun,Lee, Dong-Sup,Kang, Jae Seung,Hwang, Young-Il,Lee, Wang Jae,Kang, Insoo,Lee, Eun Bong,Kim, Hang-Rae Springer 2012 Journal of clinical immunology Vol.32 No.4
<P>Little is known about the cellular characteristics of CD8(+) T cells in rheumatoid arthritis (RA). We addressed this by investigating whether the frequency of the CD8(+) T cell subsets and their phenotypic characteristics are altered in the peripheral blood and synovial fluid (SF) from patients with RA. In this study, CD8(+) T cells, mainly CD45RA(-) effector memory (EM) CD8(+) T cells, were increased significantly in the SF, but not in the peripheral blood from RA patients, compared with healthy controls. The synovial EM CD8(+) T cells were activated phenotypes with high levels of CD80, CD86, and PD-1, and had a proliferating signature in vivo upon Ki-67 staining, whereas the Fas-positive cells were prone to apoptosis. In addition, EM CD8(+) T cells in the SF were less cytotoxic, as they expressed less perforin and granzyme B. In particular, the proportions of synovial fluid mononuclear cells that were CCR4(+)CD8(+) T cells and IL-4-producing CD8(+) T cells (i.e., Tc2 cells) were significantly higher than those in peripheral blood mononuclear cells of patients with RA and healthy controls. In addition, the number of IL-10-producing CD8(+) suppressor T (Ts) cells increased significantly in the SF of RA patients. Especially, CD8(+) T cells were inversely correlated with disease activity. These findings strongly suggest that EM CD8(+) T cells in the SF are increased, likely because of inflammation, and they may be involved in modulating inflammation, thereby affecting the development and progression of RA.</P>