다제내성 그람양성균에 대한 Linezolid(Zyvox^(�))의 시험관내 항균력 비교

박대원,정희진,엄중식,황병연,김성범,이재갑,이연주,정혜원,정성주,박재형,이진수,손장욱,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

배경 : MRSA, VRE, VRSA같은 다제 내성 그람 양성균의 등장에 따라 glycopeptide를 대체할 새로운 항생제의 개발이 필요하게 되었고 결과적으로 새로운 항생제인 linezolid라는 항생제가 개발되었다. Linezolid는 이전의 항생제와는 다른 새로운 계열의 oxazolidinone으로 경구 이용률이 우수하다. 원내 및 원외감염의 중요한 원인균이 되고 있는 MRSA, VRE에 대한 적절한 경구용 항균제가 없는 국내에서 폐렴 및 피부 연조직 감염에서 경구용으로 사용해 볼 수 있는 약제이다. 본 연구에서는 고대 구로 병원에서 분리된 MRSA, VRE 등을 대상으로 다른 여러 항균제와 비교한 linezolid의 시험관내 항균력을 조사하고자 하였다. 재료 및 방법 : 연구대상은 1998년 1월부터 2000년 12월까지 본원에서 입원 및 외래를 통하여 피부 연조직 감염증 및 호흡기 감염증, 요로감염증으로 진단된 환자들의 가검물로부터 분리된 MRSA 60균주, VRE 43균주, PRSP 25균주를 액체배지 또는 한천배지 희석법을 통하여 linezolid 및 기타 항균제에 대한 최소발육억제농도를 구하였다. 결과 : 실험에 사용한 S. aureus는 모두 MRSA였고 이들은 linezolid에 대해 MIC_(90) 2㎍/㎖(MIC 범위 1-2㎍/㎖), Enterococcus spp는 모두 VRE로 linezolid의 MIC_(90)은 2㎍/㎖로 MIC 범위는 1-4㎍/㎖였다. 한 개의 균주에서 MIC 4㎍/㎖로 중등도 감수성을 보였으나 MIC breakpoint가 (8㎍/㎖인 내성균주는 없고 모두 감수성을 보였다. S. pneumoniae의 경우 penicillin 내성이었고, linezolid MIC_(90) 1㎍/㎖ (MIC 범위 0.5-1㎍/㎖)로 전부 감수성을 보였다. 결론 : Linezolid는 MRSA를 위시한 VRE, PRSP 등의 다제 내성 그람 양성균에 대하여 우수한 시험관내 항균력을 보임을 알 수 있었다. Background : The emergence of multi-drug resistant Gram-positive cocci, such as MRSA, VRE, and VRSA, necessitated to develop new antibiotics, which could replace the glycopeptide. As a result, a new antibiotics named linezolid was developed. Linezolid is different line of oxazolidinones with a good oral bioavailability, compared to other antibiotics. Since appropriate oral antibiotics are not presently available for MRSA, which is a major cause of nosocomial and community acquired infections, the introduction of linezolid will have favorable effect on treatment of infections such as pneumonia or skin infections. In this study, we investigated the antibiotic effect of linezolid on MRSA and VRE isolated from patients who were treated in Korea University Guro Hospital. Material and Methods : By using broth microdilution and agar dilution method we measured minimum inhibitory concentration (MIC) with sixty S. aureus, forty three Enterococcus spp., and twenty five S. pneumoniae isolates from patients who were diagnosed as skin, soft tissue, respiratory, and urinary infections in Korea University Guro Hospital from January, 1998 to December, 2002. Results : All of S. aureus used in this study were MRSA, and MIG_(90) of linezolid was below 2 ㎍/㎖ (MIC ranged between 1-2 ㎍/㎖). All of Enterococcus spp. were VRE, and had MIG_(90) of 2 ㎍/㎖ (MIC ranged between 1 to 4 ㎍/㎖). One of the VRE showed intermediate susceptibility with MIC of 4 ㎍/㎖. However, none was resistant with MIC breakpoint above 8 ㎍/㎖. All of S. pneumoniae were resistant to penicillin, but they were susceptible to linezolid with MICao of 1 ㎍/㎖(MIC range 0.5-1㎍/㎖). Conclusion : In conclusions, linezolid has an excellent in vitro antibiotic effect on multi-drug resistant Gram-positive cocci, such as MRSA, PRSP, and VRE.

스마트 분리수거함

최재현(Jae-Hyeon Choi),김우진(Woo-Jin Kim),정선도(Seon-Do Jeong),구민송(Min-Song Gu),이재원(Jae-Won Lee),김동욱(Dong-Wok Kim),변황우(Hwang-Woo Byun) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.11

Rainbow Power 요법 시술이 퇴행성 슬관절염에 미치는 임상 효능연구

성현제 ( Hyun Jae Sung ),김이화 ( Ee Hwa Kim ),황재옥 ( Jae Wok Hwang ),류충열 ( Chungr Yeul Ryu ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.20 No.4

Objective: This study is designed to find out the effects of Rainbow Power therapy on knee joint with osteoarthritis. Methods: Patient with the osteoarthritis of knee joints are divided into Rainbow Power therapy group(20 people) and none-Rainbow Power therapy group(20 people). After treatment, we evaluated the effect per each group. Results: 1. Fifty and Sixty aged patients were the most in the Rainbow Power group(30% each) and sixty aged patients were the most in the None-Rainbow Power group(45%). 2. In the both groups, 1-3 years duration of disease was the most(40%, 45% each). 3. In the none-Rainbow Power group, patients improved (Lysholm score: 49.20±11.54→63.90±9.54, P<0.05), but, did not improved in the part of squatting and dystrophy. In the Rainbow Power group, patients improved(Lysholm score: 46.55±9.89→80.90±13.78, P<0.05), but, did not improved only in the part of dystrophy. 4. The effects of treatment by VNRS were follow: After treatment, 4.10±1.22 in Rainbow Power Group and 4.55±1.15 in none-Rainbow Power group. 5. The effects of treatment by nine points scale were follow: In the Rainbow Power group, the Excellent was 7 cases(35%), the Good was 9 cases(45%), the Fair was 4 cases(20%) and there was no Poor. The Excellent was 6 cases(30%), the Good was 8 cases(40%), the Fair was 6 cases(30%) and there was no Poor.

특발성 척추측만증 학생의 정적균형, 체간 근력 및 유연성에 관한 연구

전아영(Ah-Young Jun),고욱재(Wok-Jae Ko),황부근(Boo-Geun Hwang) 한국생활환경학회 2012 한국생활환경학회지 Vol.19 No.1

The purpose of this study was to find the difference on static balance(stability), muscular strength(flexion and extension) and flexibility of trunk in adolescent idiopathic scoliosis through comparing normal students. Fifty-one adolescent subject were participated in this study(scoliosis group; twenty-five, normal group; twenty-six). Data were analyzed with independent t-test using SPSS program. The results showed that there was no significant difference in static balance ability(stability) and also in flexor(60º/sec, 120º/sec), extensor(60º/sec) and flexibility(flexion, extension) of trunk between the two groups. But, there are statistically significant difference in trunk extensor power at 120º/sec. From this result, we have recognized the characteristics of adolescent idiopathic scoliosis patients, and we believe that these findings may lead us to treat the scoliosis patients in a way we have not tried before

Rainbow Power 요법 시술이 퇴행성 슬관절염에 미치는 임상 효능연구

성현제,김이화,황재옥,류충열,Sung, Hyun-Jae,Kim, Ee-Hwa,Hwang, Jae-Wok,Ryu, Chungr-Yeul 경락경혈학회 2003 Korean Journal of Acupuncture Vol.20 No.4

Objective : This study is designed to find out the effects of Rainbow Power therapy on knee joint with osteoarthritis. Methods : Patient with the osteoarthritis of knee joints are divided into Rainbow Power therapy group(20 people) and none-Rainbow Power therapy group(20 people). After treatment, we evaluated the effect per each group. Results : 1. Fifty and Sixty aged patients were the most in the Rainbow Power group(30% each) and sixty aged patients were the most in the None-Rainbow Power group(45%). 2. In the both groups, 1-3 years duration of disease was the most(40%, 45% each). 3. In the none-Rainbow Power group, patients improved (Lysholm score : $49.20{\pm}11.54{\rightarrow}63.90{\pm}9.54$, p<0.05), but, did not improved in the part of squatting and dystrophy. In the Rainbow Power group, patients improved(Lysholm score : $46.55{\pm}9.89{\rightarrow}80.90{\pm}13.78$, p<0.05), but, did not improved only in the part of dystrophy. 4. The effects of treatment by VNRS were follow : After treatment, $4.10{\pm}1.22$ in Rainbow Power Group and $4.55{\pm}1.15$ in none-Rainbow Power group. 5. The effects of treatment by nine points scale were follow : In the Rainbow Power group, the Excellent was 7 cases(35%), the Good was 9 cases(45%), the Fair was 4 cases(20%) and there was no Poor. The Excellent was 6 cases(30%), the Good was 8 cases(40%), the Fair was 6 cases(30%) and there was no Poor.

수소취화된 스테인레스 316L 강의 특성평가

이진경(Jin Kyung Lee),배동수(Dong Su Bae),이상필(Sang Pill Lee),정경욱(Kyong Wok Jeong),곽재환(Jae Hwan Kwak),이지혜(Ji Hye Lee),구현경(Hyeon Kyeong Koo),황성국(Seong Kook Hwang) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.열공학 No.-

The Effects of Spiral Taping Theraphy-A Randomisation Controlled Trial

Choi Sung-hun,Ko Kyoung-mo,Kim Kyung-woon,Lee Yoon-kyung,Lim Seong-chul,Jung Tae-young,Lee Kyung-min,Hwang Jae-wok,Seo Jung-chul 대한침구의학회 2006 대한침구의학회지 Vol.23 No.2

Objectives : This study was designed to estimate the effects of Spiral Taping theraphy on low back pain or neck pain patients by using pressure pain threshold, visual analogue scale(VAS), and range of motion(ROM).Methods : The patients were allocated into two groups by randomisation. Spiral Taping theraphy group consisted of 11 patients and acupuncture theraphy group consisted of 10 patients. The degree of improvement of neck pain was evaluated by pressure pain threshold, VAS, and ROM before treatment and after treatment. The patients were commonly treated with acupuncture theraphy. After acupuncture Spiral Taping theraphy was performed in Spiral Taping theraphy group.Results : Pressure pain threshold and VAS were significantly different between two groups. In Spiral Taping theraphy group the pressure pain threshold of the all points was significantly increased and VAS was significantly decreased than control group. But there was no significant difference between the two groups in ROM. Conclusion : The effectiveness of Spiral Taping theraphy on low back pain and neck pain patients was shown through pressure algometer and VAS. These imply that Spiral Taping theraphy may be useful for on low back pain or neck pain. Further study is needed about Spiral Taping theraphy.