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Oh, Hwa Sub,Ryu, Ho Soung,Park, Joon Mo,Lee, Hyung Joo,Kim, Young Jin,Jang, In Kyu,Park, Ji Hoon,Kwak, Joon Seop,Baek, Jong Hyeob American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.8
<P>We investigated 590 nm light-emitting diodes appropriate for full-color display applications in terms of their electrical and optical behaviors during operation according to their Mg doping profile in the p-cladding layer. As the hole concentration in the 'b' zone of the p-cladding layer is increased from 3 .4x10(17) to 6.7x10(17), the light output power increases by 41% due to the enhancement of the hole injection into the active region and also due to the minimization of the carrier overflow problem. However, at an oversaturation of Mg doping with excess [Cp2Mg]/[III] in the 'b' zone, the internal quantum efficiency degrades because of the decrease in hole concentration because of the oversaturated material problem.</P>
Oh, Hwa Sub,Song, A. Ri,Jung, Sung Hoon,Jung, Tae Hoon,Kim, Young Jin,Lee, Hyung Joo,Cho, Young Dae,Baek, Jong Hyeob American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.2
<P>We investigated high-brightness light emitting diodes appropriate for general lighting applications in terms of their optical behaviors and device performances according to the insertion of the sloped barrier between the well and the barrier and changing the sloped barrier thickness. As the sloped barrier thickness was increased from 0 to 5 nm, radiative recombination efficiency and device performances significantly improved, due to the suppression of carrier overflow by the stronger capture of carriers and the shortening of the carrier lifetime in the active region owing to the built-in quasi-electric field. At a further increase in the sloped barrier thickness to 10 nm, however, the optical and device performances started to degrade because of the loosening of the quantum confinement effect in the active region and due to the saturation of the improvement of the carrier capture by the sloped barrier region.</P>
Sim, Gwan-Sub,Lee, Bum-Chun,Chol, Ho-Seung,Lee, Jae-Woong,Kim, Jin-Hwa,Lee, Dong-Hwan,Kim, Jin-Hui,Pyo, Hyeong-Bae,Moon, Dong-Cheul,Oh, Ki-Wan,Hong, Jin-Tae 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Collagenase, a matrix metalloproteirases (MMPs), is a key regulator in the photoaging process of skin due to the reactive oxygen species generated after exposure to ultraviolet A(UVA). Flavonoid compounds have been demonstrated to possess antioxidant properties, and could be useful in the prevention of photoaging. In this study, to investigate the structure-activity relationship of flavonoid compounds on their antioxidant property and inhibitory effects against the MMP activity, the effects of several flavonoids; myricetin, quercetin, kaempferol, luteolin, apigenin and chrysin, on the reactive oxygen species scavengering activity and inhibit of effect against the MMP activity were examined in vitro and in human dermal fibroblasts induced by UVA. The relative order of antioxidative efficacy, as determined using the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) method and the xanthine/xranthine oxidase system, was as follows; flavones: luteolin > apigenin > chrysin, flavonols: myricetin > quercetin > kaempferol, and correlated with the respective number of OH group on their B-ring. In good correlation with the antioxidant properties, the flavonoids inhibited the collagenase activities, in a dose-dependent manner, and the MMP expression. These results suggested the UVA induced antioxidative activity and inhibitory effects of flavonoids on the collagenase in human dermal fibroblasts depends on the number of OH group in the flavonoid structure, and those with a higher number of OH group may be more useful in the prevention of UV stressed skin aging.
Variable TERRA abundance and stability in cervical cancer cells
Oh, Bong-Kyeong,Keo, Ponnarath,Bae, Jaeman,Ko, Jung Hwa,Choi, Joong Sub Spandidos Publications 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.6
<P>Telomeres are transcribed into long non-coding RNA, referred to as telomeric repeat-containing RNA (TERRA), which plays important roles in maintaining telomere integrity and heterochromatin formation. TERRA has been well characterized in HeLa cells, a type of cervical cancer cell. However, TERRA abundance and stability have not been examined in other cervical cancer cells, at least to the best of our knowledge. Thus, in this study, we measured TERRA levels and stability, as well as telomere length in 6 cervical cancer cell lines, HeLa, SiHa, CaSki, HeLa S3, C-33A and SNU-17. We also examined the association between the TERRA level and its stability and telomere length. We found that the TERRA level was several fold greater in the SiHa, CaSki, HeLa S3, C-33A and SNU-17 cells, than in the HeLa cells. An RNA stability assay of actinomycin D-treated cells revealed that TERRA had a short half-life of similar to 4 h in HeLa cells, which was consistent with previous studies, but was more stable with a longer half-life (>8 h) in the other 5 cell lines. Telomere length varied from 4 to 9 kb in the cells and did not correlate significantly with the TERRA level. On the whole, our data indicate that TERRA abundance and stability vary between different types of cervical cancer cells. TERRA degrades rapidly in HeLa cells, but is maintained stably in other cervical cancer cells that accumulate higher levels of TERRA. TERRA abundance is associated with the stability of RNA in cervical cancer cells, but is unlikely associated with telomere length.</P>