New Dioscin-Glycosidase Hydrolyzing Multi-Glycosides of Dioscin from Absidia Strain

( Yao Yao Fu ),( Hong Shan Yu ),( Si Hui Tang ),( Xiang Chun Hu ),( Yuan Hao Wang ),( Bing Liu ),( Chen Xu Yu ),( Feng Xie Jin ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.6

Numerical Investigation on the Design and Optimization of Stacking Pattern for High Flexural Performance Carbon Fiber Reinforced Resin Matrix Composites

Yao Cai,Xizhong An,Qingchuan Zou,Dengzhi Yao,Haitao Fu,Hao Zhang,Xiaohong Yang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9

The stacking sequences of fiber-reinforced composites for optimization of turbine blades with the bestperformance have become a focus of attention. However, the optimization and design principles of its flexural performanceare not yet mature. Referring to the problems in previous work, a 3D finite element flexural model of carbon fiber reinforcedcomposites was established based on the Abaqus/Explicit VUMAT subroutine through the Tsai-Wu failure criterion. Theinfluencing laws and optimization mechanisms of different stacking patterns (e.g., different orientations, number oforientation plies, combination of multiple orientation plies, and symmetry/asymmetry structures) on the flexural properties ofthe composites were systematically investigated, and corresponding design references for the optimization of stackingpatterns were given. The results show that the smaller the value of |θ-45 °| (θ represents the angle of the orientation ply), themore obvious the stress reduction of the orientation ply, and the orientation ply located in the outer layer is more conducive tothe improvement of flexural performance. As the number of orientation plies increases, the flexural strength anddisplacement increase, but the stability decreases, in which the laminate with 50 % 0 ° orientation plies has the best overallperformance. In addition, the stability ranking of the laminate stacking sequences for the same 0 ° orientation ply proportionis: multi-orientation asymmetric > multi-orientation symmetric > single-orientation symmetric. In particular, the [75/02/60/30/02/15] laminate has the best overall performance with the flexural strength of 974 MPa and the Y-axis offset of 0.057 mm,and its stability is 66 % higher than that of the [15/02/75]S laminate. Under the same tensile/compressive stresses, the actualstress of the warp/weft in the orientation ply is less than the maximum ideal stress and the stress of Y-axis direction SY ≠ 0,which delays the fracture of the orientation ply and causes displacement offset, and the increase of the number of orientationplies will aggravate this effect. The obtained highlighted results can provide valuable references for the design andoptimization of stacking patterns of plain fabric-reinforced laminates with high flexural properties.

Experimental investigation on dilute gas-solid multiphase jet in crossflow

Fu Yao,Wang Tong,Gu Chuangang 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.6

In the current study, an experimental setup was built to investigate the gas flow and particle distribution in a normal jet crossflow to a main flow in a confined test section. The experiments were conducted under two test conditions: with Re_c/Re_(jet) of 7.9×10⁴/3.1×10⁴and 7.0×10⁴/1.8×10⁴. Four classes of particles were used in both tests. The planar gas flow field and particle distribution on the symmetric cross-section were measured by a DPIV system. Mean fluid velocity results and transient flow visualization images were used to analyze the jet influence on the gas flow field. The analysis of the time-average particle concentration reveal that the jet control method may set a gas barrier in the flow field, which the tiny particles are able travel around, large particles are able travel through, and only 10-micronscale particles could be successfully blocked. The results show that the wall jet control method can be applied in inertia particle separator.

혼합 현실 기술을 활용한 무형 문화유산의 디지털 보호에 관한 연구

부 요(Fu, yao),안혜신(Ahn, Hye-shin) 한국조형디자인학회 2018 조형디자인연구 Vol.21 No.4

디지털 기술의 급속한 발전으로 인해 뉴미디어 시대의 디지털 기술 발전은 문화유산의 변화를 촉진했으며 무형 문화 유산(Intangible Cultural Heritage)의 합리적인 개발, 사용 및 보호에 많은 영향을 미치고 있다. 즉 무형 문화 유산의 효과적인 보호와 보급에 현대 과학적 및 기술적 수단을 효과적으로 사용하는 것이 특히 중요하다. 본 논문은 무형 문화유산의 디지털 보호 현황과 문제점을 분석하고 혼합 현실 기술을 이용한 무형 문화유산의 디지털 개발에 대해 논의를 목적으로 한다. 또한 디지털 보호와 무형 문화 유산의 확산을 위한 혼합 현실 기술의 장점에 대해 살펴보고 혼합 현실 기술을 활용한 무형 문화유산 보급 및 확산의 가능성에 대해 살펴보았다. 이를 위해 문헌연구를 통해 혼합 현실 기술에 대한 개념과 특징에 대해 살펴보았으며, 국내외 무형 문화유산의 혼합 현실 기술 적용 현황을 사례 연구를 중심으로 분석하였다. 연구 분석을 바탕으로 연구 결과에서는 혼합 현실 기술을 활용한 무형 문화유산 보급의 특징과 장점에 대해 논의하고, 혼합 현실 기술을 활용한 무형 문화유산 보급의 가능성에 대하여 제시하였다. 혼합 현실 기술에 기반한 무형 문화 유산의 디지털 보호는 다양한 가능성을 지니고 있다. 혼합 현실 기술과 무형 문화 유산의 적절한 조합은 효과적으로 문화 보급을 촉진하고 문화 경험의 의미를 고양하며 문화의 부가가치를 높이고 더 많은 사람들이 무형 문화 유산의 보호와 유산에 참여하도록 한다. The rapid development of digital technology has prompted changes in cultural heritage in the new media era. Also it has a significant impact on the rational development, use, and protection of Intangible Cultural Heritage. In other words, it is particularly important to use modern scientific and technical means effectively to effectively protect and distribute intangible cultural heritages. This paper analyzes the status and problems of digital protection of intangible cultural assets and discusses digital development of intangible cultural assets using mixed reality technologies. Also it purports to analyze the advantages of mixed reality technologies for digital protection and the spread of intangible cultural heritage and the possibility of dissemination and diffusion of intangible cultural assets using mixed reality technologies. Fot that, through literature concepts and characteristics of mixed reality technologies are reviewed and the status of application of mixed reality technologies of intangible cultural assets in Korea and other countries as case study are analyzed. As a result of the study, characteristics and advantages of the dissemination of intangible cultural assets using mixed real-world technologies, based on the result of analysis, are shown and the possibility of disseminating intangible cultural assets using mixed real-world technologies are suggested.

RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer

Tian-Hao Weng,Min-Ya Yao,Xiang-Ming Xu,Chen-Yu Hu,Shu-Hao Yao,Yi-Zhi Liu,Zhi-Gang Wu,Tao-Ming Tang,Pei-Fen Fu,Ming-Hai Wang,Hang-Ping Yao 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3

Purpose Triple-negative breast cancer (TNBC) is highly malignant and has poor prognosis and a high mortality rate. The lack of effective therapy has spurred our investigation of new targets for treating this malignant cancer. Here, we identified RON (macrophage-stimulating 1 receptor) and MET (MET proto-oncogene, receptor tyrosine kinase) as a prognostic biomarker and therapeutic targets for potential TNBC treatment. Materials and Methods We analyzed RON and MET expression in 187 primary TNBC clinical samples with immunohistochemistry. We validated the targeted therapeutic effects of RON and MET in TNBC using three tyrosine kinase inhibitors (TKIs): BMS-777607, INCB28060, and tivantinib. The preclinical therapeutic efficacy of the TKIs was mainly estimated using a TNBC xenograft model. Results Patients with TNBC had widespread, abnormal expression of RON and MET. There was RON overexpression, MET overexpression, and RON and MET co-overexpression in 63 (33.7%), 63 (33.7%), and 43 cases (23.0%), respectively, which had poor prognosis and short survival. In vivo, the TKI targeting RON ant MET inhibited the activation of the downstream signaling molecules, inhibited TNBC cell migration and proliferation, and increased TNBC cell apoptosis; in the xenograft model, they significantly inhibited tumor growth and shrank tumor volumes. The TKI targeting RON and Met, such as BMS-777607 and tivantinib, yielded stronger anti-tumor effects than INCB28060. Conclusion RON and MET co-overexpression can be significant pathological characteristics in TNBC for poor prognosis. TKIs targeting RON and MET have stronger drug development potential for treating TNBC.

Dual-Mode Liquid Crystal Devices with Switchable Memory and Dynamic Modes

Yao, I-An,Kou, Hsiao-Ti,Yang, Chiu-Lien,Liao, Shih-Fu,Li, Jia-Hsin,Wu, Jin-Jei The Korean Infomation Display Society 2009 Journal of information display Vol.10 No.4

A liquid crystal device with switchable dynamic and memory modes was investigated and developed. The proposed device reveals the splay, $\pi$-twist, and bend states via selective switching among them. In the dynamic mode, the device is operated in the bend state, which exhibits a wide viewing-angle and a fast-response-time due to its self-compensated bend structure and flow-accelerated fast response time, respectively. In the memory mode, the permanent memory characteristics in the splay and $\pi$-twist sates are obtained, respectively. The switching mechanisms of the tristate device are also proposed.

REVISITING CONSUMER CONTAMINATION: INFLUENCES OF PROXIMITY AND SCOPE OF CONTACT

Fu-Yung Kuan,En-Chi Chang,Sin-Yao Chen 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

According to theory of consumer contamination (Argo, Dahl & Morales, 2006), a product, after being touched by a customer, will be disgusted and devalued by the following customer. However, Argo, et al. (2006) considered only a high salience of contact product, i.e., T-shirts, and did not consider low salience of contact products. This study extended the study of Argo, et al. (2006) and examined whether perception of consumer contamination varies between products of different saliences of contact. The gender difference was also considered. The result from an experiment showed that consumers’ reactions to ‘contaminated’ products vary, depending on the salience of contact. The result also shows that female consumers tend to be more sensitive to consumer contamination.

Experimental investigation of a process cooling system retrofitted with HFC-404A refrigerant for precise manufacturing application

Fu-Jen Wang,Kuei-I Tsai,Yao-Jun Wang,Hao-Chuan Lee 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.2

Precise-manufacturing facilities, which emphasize accurate and stable machining of the working components to be used in semiconductor industry, cannot function properly without appropriate and precise cooling. HCFC (hydro-chloro-floro-carbon) has been commonly used as the coolant for precise manufacturing facilities; but it is facing the pressing schedule to be phased out. Additionally, the dramatic variation of heat load during high-accuracy and high-speed applications need a critical control of coolant (brine or water) temperature. Use of eco-friendly HFC 404A to replace HFC has been suggested as an effective alternative to alleviate the problems. In this study, the performance of a process cooling system retrofitted with HFC-404A refrigerant was evaluated; the energy efficiency ratio and accuracy of temperature control specific to -15℃ precise manufacturing application were examined. Effects of using thermostatic expansion valve associated with hot-gas by-pass control scheme under different loading conditions have been investigated extensively. The energy efficiency ratio and accuracy of temperature control for the cooling system were measured and analyzed for comparing and evaluating HCFC-22 and HFC-404A using different throttling devices under specific coolant temperatures. The comprehensive studies on improving the accuracy of temperature control and energy-saving efficiencies through different temperature control strategies are presented in this paper.

Study on the Kinetics and Mechanism of Grain Growth during the Thermal Decomposition of Magnesite

Fu, Da-Xue,Feng, Nai-Xiang,Wang, Yao-Wu Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8

The X-ray line broadening technique was used to calculate the grain size of MgO at 1023, 1123, 1223 K respectively either in $CO_2$ or during the thermal decomposition of magnesites in air as well as in vacuum. By referring to the conventional grain growth equation, $D^n=kt$, the activation energy and pre-exponential factor for the process in air are gained as 125.8 kJ/mol and $1.56{\times}10^8\;nm^4/s$, respectively. Ranman spectroscopy was employed to study the surface structure of MgO obtained during calcination of magnesite, by which the mechanism of grain growth was analyzed and discussed. It is suggested that a kind of highly reactive MgO is produced during the thermal decomposition of magnesites, which is exactly the reason why the activation energy of the grain growth during the thermal decomposition of magnesite is lower than that of bulk diffusion or surface diffusion.

Smad4 Expression in Hepatocellular Carcinoma Differs by Hepatitis Status

Yao, Lei,Li, Fu-Jun,Tang, Zhi-Qiang,Gao, Shuang,Wu, Qe-Quan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Aims: Primary hepatocellular carcinoma (HCC) is a common malignancy often related to hepatitis viral infection. Smad4 is known to mediate the TGF-${\beta}$ pathway to suppress tumorigenesis. However, the function of Smad4 in HCC is still controversial. In this study we compared levels of Smad4 in HCC tissues with or without hepatitis virus infection and adjacent normal-appearing liver. Methods: Samples from HCC patients were analyzed for Smad4 protein and mRNA expression by immunohistochemistry (IHC), RT-PCR and Western blotting. Results: We found that tumor tissues expressed less Smad4 mRNA and protein than the adjacent tissues. Most HCC tumor tissues were negative for Smad4 in IHC staining, while the majority of adjacent tissues were positively stained. Interestingly, protein levels were higher in HCC tissues with viral hepatitis than those without virus infection. Suppression of expression appeared closely related to HCC, so that Smad4 appears to function as a tumor suppressor gene (TSG). Conclusion: Patients with hepatitis viral infection, at higher risk for HCC, exhibited increased Smad4 protein expression suggesting hepatitis virus may modulate Smad4 expression, which is functionally distinct from its putative role as a TSG. Smad4 expression may thus be an applicable marker for diagnosis and/or a target to develop therapeutic agents for HCC.