Losartan과 Amlodipine의 병용투여에 의한 고혈압 및 혈관재협착 보호효과

한주희,정상혁,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

Abstract - To examine the protective effect of combination treatment of angiotensin II AT1-receptor blockers (ARBs) with Ca2+ channel blockers (CCBs) for high blood pressure and neointima hyperplasia, losartan and amlodipine were orally injected into telemetered-spontaneous hypertensive rats and vascular injury induced by cuff-inserted neointimal formation model in vivo. For the measurement of blood pressure, random orders of losartan 0, 4.79, 9.58 mg/kg/day, amlodipine 0, 0.48, 0.96 mg/kg/day, or higher/lower doses in combination were administered in spontaneous hypertensive rats (SHRs; n=10). For the measurement of neointimal hyperplasia, 9.58 mg/kg/day of losartan or 0.96 mg/kg/day of amlodipine in alone or combination were given for 2 weeks to cuffed C57BL/6 mice (n=6). Our results suggest that the combination therapy of high doses of losartan and amlodipine are effective in lowering systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of each drug, but not in combined therapy of low doses of two drugs. In protection for vascular remodeling, the combination therapy of losartan with amlodipine synergistically decreased BrdU-positive cells in neointima and DNA synthesis in [3H]-thymidine incorporation by reducing cell proliferation. Therefore, present study implies that combination of losartan with amlodipine may be effective for the treatment of hypertension and vascular remodeling such as restenosis.

혈압 및 혈관손상에 대한 Candesartan과 Cilnidipine의 병용투여 효능 평가

정상혁,한주희,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

This study was designed to evaluate the effect of candesartan combined with cilnidipine on high blood pressure in spontaneous hypertensive rats (SHRs) and vascular injury induced by cuff-placed neointimal hyperplasia model. To measure blood pressure, low and high doses of candesartan (0.765 and 1.53 mg/kg/day) and cilnidipine (0.96 and 1.92 mg/kg/day) alone or in combination were orally administered in telemetered-SHRs for 2 weeks. To examine the protective action of vascular injury, high doses of candesartan (1.53 mg/kg/day) and cilnidipine (1.92 mg/kg/day) alone or in combination was orally administered for 2 weeks in cuff-induced neointimal hyperplasia model of C56BL/6 mice. As a result, high doses of candesartan and cilnidipine in combination decreased in systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of high dose of each drug, but not statistically significant. In vascular injury model, candesartan and cilnidipine in combination decreased BrdU-positive cells in neointima and vascular smooth muscle cell proliferation as compared with monotheray of each drug. Thus, these results indicate that the combination of candesartan with cilnidipine is effective for the protection of vascular injury, suggesting this combination to be a valuable tool for the management of vascular remodelling such as restenosis.

위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예

김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.

冠岳樹木園 所藏標本을 中心으로 한 國內 木本 植物의 分布地와 識別에 대해서(Ⅱ) : Aceraceae 丹楓나무科에 대해서

장진성,김휘 서울大學校 農業生命科學大學 附屬樹木園 1996 서울大學校 樹木園 硏究報告 Vol.- No.16

Acer pictum complex is a Far-eastern Asian woody maple that exhibits a broad range of morphological variation and occurs in China, Korea and Japan. In this study morphological analyses of herbarium material were undertaken to determine whether the observed morphological variation was primarily attributable to morphological discontinuities among geographically distributed groups. A multivariate morphometric study of Acer pictum complex (A. pictum Thunb. ex Murray and A. okamotoanum Nakai) in Japan and Korea was undertaken to assess the numbers and ranks of taxa that usefully could be recognized. The results of cluster and principal components analysis on a matrix of 67 plants by 12 characters indicated that one taxon could be recognized. Although A. okamotoanum and A. pictum of Korea formed somewhat distinct clusters, neither of Acer pictum from Japan or from Korea could clearly be distinguished from populations of A. okamotoanum from Ullung island of Korea. Likewise, individuals of A. takesimense Nakai from Ullung island of Korea were indistinguishable from A. pseudosieboldianum (Pax) Komarov of interior populations of Korea. Variation at the summit of Sung-in on Ullung Island was expressed primarily within populations of A. pseudosieboldianum. Also, A. ginnala Maxim. of Japan and Korea should be recognized within A. tataricum L. due to the continuous leaf morphological variation(the number of leaf lobe). On the other hand, A. tschonoskii Maxim. of Korea and of Japan was morphologically distinct with respect to the number of flowers, middle lobe length, fruit size, petiole length and the number of serration in the middle lobe, although A. tschonoskii of Korea and A. tschonoskii var. autstrale of Japan represented intermediate forms between A. micranthum and A. tschonoskii of Japan. Therefore, A. tschonoskii of Korea and A. tschonoskii of Japan should be separated, such as A. tschonoskii var. rubripes Komarov and A. tschonoskii var. tschonoskii respectively. Finally using a key and a limited sample of Kwanak Arboretum herbarium specimens(SNUA) to the taxa produced from all results, the distribution of the other Korean maples were determined.

순환형 디지탈 필터의 설계와 구성

박상희,김종현 연세대학교 산업기술연구소 1982 논문집 Vol.14 No.1

The digital filter is the time invariant discrete system and has the advantages in accuracy, stability, flexibility and noise immunity. In this paper, digital low-pass filter, high-pass filter and digital differentiator are designed and its hardwares are implemented by using Intel 8085 microprocessor and digital LSI components. The digital butterworth low-pass filter and high-pass filter are designed by means of squared magnitude function and frequency transformation. The digital differentiator is designed by matched z-transformation.

디지탈 시스템의 故障診斷에 관한 硏究

李相孝,박상희,金在宇 연세대학교 산업기술연구소 1977 논문집 Vol.7 No.1

This paper deals with an efficient algorithm for generating the complete test set of every fault in combinational logic circuit, and fault detection and diagnosis technique based on Boolean Difference and Partial Boolean Difference. This study is mainly concerned with nonredundant combinational logic circuits. The type of fault is either stuck-at-o or stuck-at-1, i.e. at the input of a gate or at the output of a gate. The combinational logic circuits show a fault when the describing conditions correspond with the combinational logic circuits, for detecting S-A-O, or S-A-1, the method of generating test patterns is proposed, and the detection of fault at the circuit is attempted.

한국의 해양GIS 추진 방향과 현황 그리고 응용 사례

정희균,서상현 동아대학교 건설기술연구소 2003 硏究報告 Vol.27 No.1

At a turning point of new paradigm, each countries in the world are try to search solutions to a current problems of the times in maritime than land. To accomplish a powerful maritime power, it is necessary to construct MGII(Marine Geo-spatial Information Infrastructure) on the basis of Marine and Coastal GIS. In this paper, we establish concept, definition and framework about marine GIS in Korea through framework analysis of foreign GIS and so, in Korea, analyze the present status and application cases of marine GIS that have been developed and constructed until now.

상완골 근위부 골절 치료에서 잠김 압박 금속판의 유용성

김동휘,이준영,조승환,양훈,하상호 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1

Purpose: To prove the efficacy of locking compression plate (LCP) in proximal humerus fracture. Materials and Methods: Forty four out of 48 patients who had proximal humerus fracture operation with LCP from November, 2004 to June, 2008 and available for follow up for more than 6 months were evaluated. Eighteen cases were male and 26 cases were female with mean age of 56 years (range 29-85 years). Cause of injury was traffic accident in 17 cases, slip down in 20 cases and fall down in 7 cases. Mean interval from injury to operation was 6.8 days (range 2-30 days) and mean operation time was 80. 5 minutes(range 40-130 minutes). Open reduction and internal fixation with LCP using deltopectoral approach was used in all cases. Postoperative clinical evaluation was done using Constant-Murley assessment and bone union and neck-shaft angle was checked using radiographic exam. Results: Bone union was achieved in 41 out of 44 cases at mean interval of 11.2 weeks(range 6-16 weeks). Mean neck-shaft angle was 129.7 degree (range 101-146) with more than 20 degree of angular deformation in 2 cases. For the complication, 2 cases of temporary axillary nerve injury, 1 case of nonunion, 2 case of delayed unions with angulation, 2 case of ankylosis was observed. Conclusion: LCP can prevent reduction loss and minimize soft tissue injury which result in firm fixation and early immobilization. It seem to be very efficient in treating proximal humerus fracture in elderly.

담도폐쇄증 환아의 내인성 착색치아에 대한 증례보고

이창희,이상대,김영재,김정욱,한세현,이상훈 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.3

담도페쇄증은 간장외 담관의 부분적이거나 완전한 파괴 또는 부재로 인한 담즙흐름의 완전한 폐쇄로 정의된다. 이 질환은대략 10,000명당 1명 정도 비율로 발생하며 여성에서 약간 높은 빈도를 보인다. 원인인자는 명확히 밝혀지지 않았으며 증상은 과빌리루빈혈증과 함께 황달, 점토색변, 지방설사, 어두운 갈색뇨, 간비대 등을 보인다. 최근의 담도폐쇄증의 치료는 간문장문합술 단독 혹은 간이식술을 병행하는 경향이다. 본 증례의 환자에서는 다양한 정도의 치아변색을 보였으며 색상은 노란색에서부터 짙은 초록색까지 다양했다. 법랑질의 저형성증이 모든 치아에 나타났고 구강위생이 좋지 않았으며 다발성 우식증을 가지고 있었다. Biliary atresia is defined as a complete obstruction of bile flow owing to destruction or absence of all or part of the extrahepatic bile ducts. This disease is occurring in approximately 1:10,000 live births and moderate pre-dominance of female is noted. The etiology of biliary atresia remained unsolved. The signs and symptoms are hyperbilirubinemia, jaundice, clay-colored stools, steatorrhea, dark yellow urine and hepatomegaly. Currently biliary atresia is best managed by hepatic portoenterostomy with or without liver transplantation. Biliary atresia patients with these cases showed staining of the teeth. The stains ranged in color from yellowish-brown to deep green. Enamel hypoplasia was all erupted teeth present. Patients had poor oral hygiene and rampant caries.

9-11세 정상교합 어린이의 연조직 측모에 관한 두부방사선계측학적 연구

이창희,김정욱,김종철,이상훈 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

본 연구의 목적은 정상교합인 건치 어린이에서 여러 가지 연조직 측모 분석법을 이용한 평균치를 제시하고 연령별, 성별에 따른 차이를 비교함으로써 이 시기에 행해지는 교정진단과 치료에 유용하게 이용하고자 하는 것이다. 2000년에서 2004년까지 서울시 치과의사회가 주관하는 건치 어린이 선발대회에서 선발된 정상교합인 9-11세 어린이 169명(남자 82명, 여자 87명, 9세 26명, 10세 118명, 11세 25명)을 촬영한 측모 두부규격 방사선사진으로 여러 가지 연조직 측모분석법을 이용하여 연조직 평균치를 구한 후 다음과 같은 결론을 얻었다. 1. 성별에 따른 연조직 평균치는 두 가지 항목을 제외하고는 유의성있는 차이를 보이지 않았다(p>0.05). 2. 여자가 남자보다 H line에 대해 하순이 더 돌출된 위치에 존재했으며, 중안모 길이에 비해 하안모 길이가 짧았다(p<0.05). 3. 연령에 따른 연조직 평균치는 유의성있는 차이를 보이지 않았다(p>0.05). The purpose of this study is to develop soft tissue cephalometric standards in children with normal occlusion and to determine the differences between males and females and the differences according to age ranges of 9, 10 and 11 years. The lateral cephalometric radiographs of 169 children(82 boys, 87 girls) among the contestants in 2000-2004 Healthy Dentition Contest in Seoul were studied with several soft tissue profile analyses and cephalometric means and following results were obtained. 1. The sex differences were not statistically significant between males and females soft tissue parameters except for two soft tissue parameters(p>0.05). 2. Females had relatively more protrusive lower lip relative to the H line than males and middle third face height to lower third face height of females was larger than males(p<0.05). 3. The age differences in soft tissue parameters were not statistically significant according to age ranges of 9, 10 and 11 years(p>0.05).