Dehydroepiandrosterone sulfate(Mylis)^(�)의 자궁경부 숙화작용에 대한 영향

許準容,梁賢模,羅重烈,丘秉參,洪性鳳 최신의학사 1983 最新醫學 Vol.26 No.11

Flow characteristics around proximal and distal stenoses in a series of tandem stenosed vessels

Huh, H.K.,Choi, W.R.,Ha, H.,Lee, S.J. Pergamon Press ; Elsevier Science Ltd 2016 Journal of biomechanics Vol.49 No.13

The flow characteristics around the proximal and distal stenoses in tandem vessel models are experimentally investigated with varying flow rates (Q=0.25, 0.5, 1.0L/min), interspacing distances (L=3, 6, 10 of diameter D) and severities (S=50%, 75% reduction in diameter). When the interspacing L is larger than 10 D, no fluid-dynamic interaction is observed. The flow between the proximal and distal stenoses becomes stabilized (turbulence intensity of <3%) as the interspacing distance decreases. When the severity S is 75%, the transition from laminar to turbulent flow occurs at a flow rate higher than 0.5L/min, although the interspacing distance L is 3 D. Formation of recirculation flow is restricted by the presence of distal stenosis as the interspacing distance decreases. In this case, the flow between the stenoses is focused on the central region. The center-line velocity at the neck of the distal stenosis is approximately 10-15% higher than that of the proximal stenosis with equal severity of S=50%. When the inlet flow is center-focused, the lengths of the recirculation and the jet core behind the distal stenosis increase with decrease in interspacing distance L. When the inlet flow is turbulent, the transition from laminar to turbulent flow occurs early as the interspacing distance L is reduced. When the upstream proximal stenosis exhibits increased severity, the pressure drop is measured to be 20% compared with that when the severity of the downstream distal stenosis is increased at the flow rate of Q=1.0L/min.

Clinical Trial of Barnidipine HCI in Patients with Renal Parenchymal Hypertension

Cho, Y. S 大韓臨床藥理學會 1996 臨床藥理學會誌 Vol.4 No.1

뇌로 전이된 인세포암(Signet-Ring Cell Carcinoma) 1례 보고

허양옥,이동화,박응범,이유복,정헌화,김헌주,김상철,정상섭,이헌재 中央醫學社 1975 中央醫學 Vol.28 No.4

The metastatic carcinoma of the brain comprises about 15 to 25 per cent of total brain tumors and most of them originate from the lung. Additional primary sites such as the breast, kidney, large intestine, prostate are rare and the stomach as primary site is very rare. We experienced a case of metastatic signet-ring cell carcinoma to the brain originated from the stomach, which was thought as subdural hematoma at the time of admission.

Comparison of Catalase and Other Antioxidant Enzyme Activities in Various Plant Cell Lines

Jang, M. S 한국식물조직배양학회 1996 식물생명공학회지 Vol.23 No.3

객체 지향형 프로그램에 의한 유한 요소법 코드 개발에 관한 연구

사종엽,채은미,이철욱,성윤제,허준성,편상욱,강태영 嶺南大學校 工業技術硏究所 1994 工業技術硏究所論文集 Vol.22 No.1

A computer code of finite element method is developed by using the ?? programming language. The concept of class, inheritance, and polymorphism in ?? improves the modularity and the flexibility(such as potability, implantability, and expandability) of engineering software. The graphic user interface (GUI) is designed by using the MFC(Microsoft Foundation Class) based on ??, and combined successfully with the main code of FEM solver. This study shows the superior of OOP(Object-Oriented programming) such as ?? to other progamming languages when applied to complicated engineering problems.

새로 국내에서 밝혀진 균주(R19)와 전통적 균주를 이용하여 혈청학적으로 진단된 쯔쯔가무시병의 임상상 및 항체반응 양상

이수기,이은경,허충,임병욱,김용림,강재승,이진관,조준탁,박동철,박경현 대한감염학회 1991 감염 Vol.23 No.1

From September to December 1989, eighteen cases of tsutsugamushi disease were diagnosed by indirect immunofluorescent antibody test in Ulsan-Ulchu area. Their clinical features and patterns of antibody response to R. tsutsugamuschi were analyzed. It was most prevailing in female over 30 years old. Most of patients (16 patients) were rural inhabitants. Two patients in urban area had reaped the rice in the rice field at several days before onset of the disease. It occurred between September and November with a peak in October. Chief complaints of patients were febrile sensation with or without chills or headache. All patients had fever and chills. Headache and myalgia were common. In one patient, delirium with visual hallucination was seen. The major physical findings were skin rash (83%), eschr (78%), lymphadenopathy (11%). The skin rash appeared on whole body or on the trunk. The eschar appeared on the chest or abdomen or in the genial region. The antobody titer to R 19 that had been newly isolated strain in Korea was universally high. There often were anemia (31%), leukocytosis (23%). Microscopic hematuria and pyuria were also seen in routine urinalysis. Liver function tests showed eleveted aminotransferases and LDH. There were erythrophagocytic histiocytes in the bone marrows of six patients among the ten patients whose bone marrow had been aspirated. Chloramphenicol had been used in all patients. The mean time to alleviation of fever was 2.5 days. All patients were cured.

Wound healing potential of antibacterial microneedles loaded with green tea extracts

Park, S.Y.,Lee, H.U.,Lee, Y.C.,Kim, G.H.,Park, E.C.,Han, S.H.,Lee, J.G.,Choi, S.,Heo, N.S.,Kim, D.L.,Huh, Y.S.,Lee, J. Elsevier 2014 Materials Science and Engineering C Vol.42 No.-

This study evaluates the utility of an antibacterial microneedle composed of green tea (GT) extract and hyaluronic acid (HA), for the efficient delivery of GT. These microneedles have the potential to be a patient-friendly method for the conventional sustained release of drugs. In this study, a fabrication method using a mold-based technique to produce GT/HA microneedles with a maximum area of ~50mm<SUP>2</SUP> with antibacterial properties was used to manufacture transdermal drug delivery systems. Fourier transform infrared (FTIR) spectrometry was carried out to observe the potential modifications in the microneedles, when incorporated with GT. The degradation rate of GT in GT/HA microneedles was controlled simply by adjusting the HA composition. The effects of different ratios of GT in the HA microneedles were determined by measuring the release properties. In HA microneedles loaded with 70% GT (GT70), a continuous higher release rate was sustained for 72h. The in vitro cytotoxicity assays demonstrated that GT/HA microneedles were not generally cytotoxic to Chinese hamster ovary cells (CHO-K1), human embryonic kidney cells (293T), and mouse muscle cells (C2C12), which were treated for 12 and 24h. Antimicrobial activity of the GT/HA microneedles was demonstrated by ~95% growth reduction of gram negative [Escherichia coli (E. coli), Pseudomonas putida (P. putida), and Salmonella typhimurium (S. typhimurium)] and gram positive bacteria [Staphylococcus aureus (S. Aureus) and Bacillus subtilis (B. subtilis)], with GT70. Furthermore, GT/HA microneedles reduced bacterial growth of infected wound sites in the skin and improved wound healing process of skin in rat model.

Plastic η factor considering strength mismatch and crack location in narrow gap weldments

Koo, J.M.,Huh, Y.,Seok, C.S. North-Holland Pub. Co 2012 Nuclear engineering and design Vol.247 No.-

The fracture toughness for LBB analysis of piping is generally determined in terms of the J-integral according to ASTM E1820. The J-integral consists in the elastic component J<SUB>el</SUB> and the plastic part J<SUB>pl</SUB>. Experimental evaluation of J<SUB>pl</SUB> requires the plastic η factor. The J-integral evaluation by ASTM method was developed, however, essentially for homogeneous material. The fracture toughness of a strength mismatch weld evaluated as per ASTM method can, thus, differ from its actual value. In this study, the plastic η factors of similar as well as dissimilar metal narrow gap weld are suggested considering the influence of weld strength mismatch, weld width, and crack location. The proposed plastic η factors are compared with detailed finite element results. Few fracture tests were performed to quantify the influence of weld strength mismatch on fracture toughness of low alloy steels using C(T) specimens.

한국 성인에서 비알콜성 지방간의 중증도에 따른 대사이상의 특징

김형진,김대중,김수경,김세화,이유미,안철우,차봉수,송영득,임승길,김경래,이현철,허갑범 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.4

연구배경: 30세 이상의 성인 한국인에서 지방간의 중증도와 대사증후군의 여러 요소들 (특히 인슐린저항성 및 중심성비만)과의 관련성을 분석하고자 하였다. 방법: 대상자는 2001년 4월부터 6월까지 건강검진센터를 방문한 사람들 중 만성 바이러스성 간염이나 일주일에 2회 이상 음주력이 있는 사람들을 제외한 1074명 (남자 502, 여자 572)에서 문진, 신체검사, 채혈 그리고 복부초음파를 시행하였다. 결과: 1074명중 522명에서 지방간이 양성이어서 양성율은 49%였으며 남성은 여성에 비해 높은 유병률을 보였다. (57 vs 42%, p<0.05). 당뇨병, 비만 그리고 이상지질증을 가지지 않은 사람들에서 비알콜성 지방간의 유병률은 20%였다. 지방간이 양성인 522명중 218명은 경도, 273명은 중등도, 31명은 중증의 지방간 소견을 보였다. 체질량지수, 허리둘레, 체지방률, 수축기혈압, aspartate aminotransferase, alanine aminotransferase, 총콜레스테롤, 중성지방, 그리고 총콜레스테롤/고밀도지단백 비는 지방간의 중증도에 따라 의미있게 증가하는 양상을 보였다(p<0.05). 다중회귀분석을 시행하였을 때 지방간의 중증도를 잘 반영하는 인자로는 허리둘레, alanine aminotransferase, HONA_IR, 총콜레스테롤/고밀도지단백비, aspartate aminotransferase, 그리고 수축기혈압의 순서로 나타났다. 공복혈당장애, 고혈압 및 인슐린저항성은 지방간을 가진 군에서 대조군보다 의미있게 높은 빈도를 보였을 뿐만 아니라 지방간의 중증도에 따라 차이를 보였다(p<0.05). 인슐린저항성은 심한 지방간에 비교위험도가 14.7(CI; 6.8∼32.0), 중등도의 지방간에서 6.9(CI; 4.6∼10.3), 경도의 지방간에서 5.7(CI; 3.6∼8.8)이었으며 HOMA_IR의 상위 1/4을 인슐린저항성이 있는 군으로 정의하였을 때 각군에 인슐리저항성을 가진 비율은 7.6, 32.0, 36.0, 그리고 55%였다(p<0.05). 지방간의 중증도에 따른 비알콜성 지방간염의 고위험군 비율은 각각 5.0, 21.6, 27.8, 그리고 58.1%였다(p<0.05). 결론: 우리나라의 비알콜성 지방간의 빈도는 서구인에 비해 높은 것으로 나타났다. 또한 비알콜성 지방간이 있을 경우 대사증후군과 관련된 여러인자들(특히 인슐린저항성과 중심성비만)과 비알콜성 지방간염의 위험이 현저히 증가하며 초음파의 중증도 분류에 따라 비례하였다. Background: We evaluated the frequency of non-alcoholic fatty liver disease, and the associations between the metabolic abnormalities and severity of non-alcoholic fatty liver disease in Korean adults using ultrasonography. Methods: We examined 1074 Korean adults above the age of 30 years, comprising of 502 men and 572 women, participating in medical check-ups at the Health Promotion Center. Hepatitis B and C serologies were negative, and the average weekly alcohol intake was ≤ 2 standard drinks. A standard interview, physical exam and biochemical study, were conducted, and an experienced operator carried out ultrasound liver studies. Results: 522 of the subjects had non-alcoholic fatty liver disease, and the remaining 552 did not. The frequency in the men was higher than that in the women (57 vs 42%, p<0.05). The frequency of non-alcoholic fatty liver disease in the subjects without diabetes, obesity or dyslipidemia was 20%. We classified subjects into 4 groups: the controls (n=552) and those with mild (n=218), moderate (n=273) or severe fatty liver disease (n=31), according to their ultrasonographic findings. BMI, waist circumference, body fat, systolic blood pressure, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, the total-to HDL-cholesterol ratio, impaired fasting glucose, hypertension and insulin resistance, were all significantly increase with the increased severity of non-alcoholic fatty liver disease (p<0.05). Following the multiple regression analyses, waist, alanine, aminotransferase, HOMAIR, the total- to HDL-cholesterol ratio, aspartate aminotransferase and systolic blood pressure, were all associated with the severity of non-alcoholic fatty liver disease. Odd ratios of insulin resistance in the mild, moderate and severe non-alcoholic fatty liver disease were 14.7 (CI: 6.8∼32.0), 6.9 (CI: 4.6∼10.3) and 5.7 (CI 3.6∼8.8), respectively. The percentages of subjects with insulin resistance in each group were 7.6, 32.0, 36.0 and 55.0% (p<0.05), respectively. The percentages of subjects with risk of non-alcoholic steatohepatits in each groups were 5.0, 21.6, 27.8 and 581% (p<0.05) respectively. Conclusion: The frequency of non-alcoholic fatty liver disease was relatively high in Korean adults. Proportional differences in metabolic abnormalities, relation to the severity of non-alcoholic fatty liver disease, were found by ultrasonography (J Kor Soc Endocrinol 17:514∼525, 2002).