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      • KCI등재

        近代东亚的医生:古城梅溪的生涯与在朝鲜及清朝的活动

        ?永?(Huang, Yong-Yuan) 동북아시아문화학회 2020 동북아 문화연구 Vol.1 No.62

        As a doctor, Baikei Kojyo had a far-reaching impact in the modern history of East Asia. He started his career as a doctor in Korea where he established a private hospital. At the same time, he paid much attention to the health and epidemic prevention status in Korea and established the Training School for Vaccination Masters in order to cultivate doctors in the area of vaccination in Korea. Moreover, he was recruited by the Korean government as a teacher of Public Medical School, which made him an eyewitness and participant of the formation of Korean modern medicine. Baikei was once hired by Yuan Shi-kai as a health consultant of Chihli province as a reward for helping Yuan escape from Korea successfully during the Sino-Japanese War of 1894-1895, and he played a certain role in the development of the health system and medical education in Tianjin during his stay in Chihli. After Japan’s annexation of Korea, Baikei, with the support of his brothers, moved into the political and business circles, and finally became a celebrity of the Japanese society in Korea. Baikei Kojyo played an important part in the modern history of Korean medicine. His contribution to popularizing vaccination techniques and spreading western medical and health knowledge in Korea should be properly evaluated. But it was worth noting that much of his success was based on Japan’s expansion and colonization of Korea. He outlined poor medical and sanitation conditions in Korea. He shows a sense of superiority and an enlightener"s commanding attitude when faced with Korea, which is reminding us of modern western medicine"s construction system towards the society as well as the connotative power relationship and supremacy of medicine itself.

      • ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China

        Wen, Yuan-Yuan,Pan, Xiong-Fei,Loh, Marie,Tian, Zhi,Yang, Shu-Juan,Lv, Si-Han,Huang, Wen-Zhi,Huang, He,Xie, Yao,Soong, Richie,Yang, Chun-Xia Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

        Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: We designed a multicenter 1:1 matched case-control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P<0.05). Conclusions: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findings may offer insight into further similar large gene-environment and gene-gene studies in this region.

      • KCI등재

        A case study on safety integrity level analysis for shale gas station

        Yuan-Jian Yang,Chao Huang,Qiu-Yang Zhong,Hai-Jun Chen,Hong-Zhong Huang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.12

        Safety integrity level (SIL), as defined in IEC 61511, is a widely used safety performance measure for safety instrumented functions. Shale gas station is an important part of shale gas gathering and transportation system. To ensure the safety of its instrument system is of great significance to the safe and stable operation of the whole gathering and transportation system. This paper is motivated to conduct a case study on safety integrity analysis for shale gas station by using the layer of protection analysis method (LOPA). Firstly, the equipment under control (EUC) is identified. It is followed by the analysis of reaction reasons on safety instrumented function (SIF) from safety instrumented system (SIS). Finally, according to the identification of independent protection layer (IPL) and probability of failure on demand (PFD), the SIL analysis for every SIF is carried out. The result shows that the SIS of this shale gas station has reached the required of SIL and there is no need for further increase in SIS. Utilizing this method can accurately determine the reliability of the SIS in the station, and it can also be the reference of safe operation for this shale gas station.

      • KCI등재

        Identification and characterization of CONSTANS-like genes from Curcuma alismatifolia

        Yuan-Yuan Li,Xiao-Huang Chen,Hui-Wen Yu,Qi-Lin Tian,Luan-Mei Lu 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.2

        The CONSTANS ( CO ) and CONSTANS - like ( COL ) genes have an important role in the regulation of fl owering in photoperiod-sensitive plants. However, information on the molecular characterization of COL genes in Curcuma alismatifoliais very limited. The objective of this study was to identify and evaluate 8 COL homologs ( CaCOLs ) in the C. alismatifoliatranscriptome. Their structures, phylogenetic relationships and expressing patterns under short-day (SD) and long-day (LD)contexts were investigated. Our results showed that CaCOLs were classifi ed into three groups: CaCOL3 and CaCOL6 in groupI were the most CO - like genes; CaCOL7 and CaCOL8 in group II contains only one B-box; CaCOL1 to 2 and CaCOL4 to 5formed the group III. Phylogenetic analysis of the CaCOLs in Arabidopsis, Rice, Barley, Malaccensis and C. alismatifoliademonstrated that both the B-box and CCT domains were conserved in dicot and monocot plants, but diff erent groups ofCOL genes evolved independently. Diff erent patterns of mRNA accumulation in C. alismatifolia leaves in response to SDand LD treatments were observed. CaCOL1 , CaCOL2 , CaCOL4 and CaCOL7 showed signifi cantly higher expressions inLD treatment than that of SD, indicating that they were potential fl owering inducers, and are candidate genes for research infl owering regulation and circadian controlling in C. alismatifolia plants. Altogether, our study facilitates successful regulationof fl owering in Curcuma species and provides insights for future molecular breeding programs.

      • SCISCIESCOPUS

        Raman Spectral Band Oscillations in Large Graphene Bubbles

        Huang, Yuan,Wang, Xiao,Zhang, Xu,Chen, Xianjue,Li, Baowen,Wang, Bin,Huang, Ming,Zhu, Chongyang,Zhang, Xuewei,Bacsa, Wolfgang S.,Ding, Feng,Ruoff, Rodney S. American Physical Society 2018 Physical Review Letters Vol.120 No.18

        <P>Raman spectra of large graphene bubbles showed size-dependent oscillations in spectral intensity and frequency, which originate from optical standing waves formed in the vicinity of the graphene surface. At a high laser power, local heating can lead to oscillations in the Raman frequency and also create a temperature gradient in the bubble. Based on Raman data, the temperature distribution within the graphene bubble was calculated, and it is shown that the heating effect of the laser is reduced when moving from the center of a bubble to its edge. By studying graphene bubbles, both the thermal conductivity and chemical reactivity of graphene were assessed. When exposed to hydrogen plasma, areas with bubbles are found to be more reactive than flat graphene.</P>

      • KCI등재

        Adaptive Informed RRT*: Asymptotically Optimal Path Planning With Elliptical Sampling Pools in Narrow Passages

        Yuan Huang,Hee-Hyol Lee 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.1

        The rapidly exploring random tree star (RRT*) is a conventional algorithm for path planning that aims to establish a collision-free path for robots from a starting point to a goal by constructing an exploration tree using randomly generated samples. However, inefficient sampling strategies and inadequate scales of searching trees increase the burden of calculation. Moreover, the necessity of sufficient trees has a significant impact on computation time, which is rarely investigated in previous research. To address the challenges of optimal path planning in narrow passages, we propose the adaptive informed RRT* (AI-RRT*), which not only asymptotically converges to an optimal solution but also achieves this with reduced computational time and a shorter path length. An attempt to identify accessible narrow passages is executed in advance to satisfy the traversability of robots. Also, a hybrid sampler is constructed to generate samples efficiently using the prior knowledge of narrow passages. Significantly, an adaptive tree growth strategy is introduced to evaluate the necessity of a third tree. After finding an initial solution, a local optimization method based on elliptical sampling pools is devised to enhance existing solutions. The mathematical proof demonstrates the asymptotic optimization of the sampling pool method within a limited number of iterations. Finally, the simulation results confirm that the AI-RRT* algorithm outperforms other sampling-based path planners in obtaining both an initial solution and an optimal solution in narrow passages. This is evidenced by its faster computation time, shorter path length, higher travelability, and more stable performance of the algorithm.

      • KCI등재SCOPUS

        Framework for Digital Transformation of Intangible Cultural Heritage: Chinese Paper-Cutting Art

        Yuan Huang,Juyoung Chang,Gang Li 한국디자인학회 2024 디자인학연구 Vol.37 No.1

        Background : Intangible cultural heritage (ICH) serves as a tangible manifestation of the multiplicity of human culture. The fusion of ICH art with contemporary design amplifies the cultural and artistic value of products and instills cultural self-assurance. However, in escalating global cultural amalgamation, the protection and advancement of ICH assume greater significance. This is an important question that how can modern technology be used to promote the sustainable development of ICH? Consequently, this manuscript endeavors to explicate the plausibility of synergizing ICH, typified by paper cutting, with digital transformation (DX) as well as the development framework for promoting the formation of a paper-cutting digital ecosystem through digital transformation. Methods : This study adopts a qualitative exploratory research design to propose a framework for the DX development of paper-cutting art. The research methodology involves a literature review and expert interviews. First, the framework for the digital transformation of ICH was derived from the literature review. Subsequently, semi-structured expert interviews were conducted to collect data, which was then coded and integrated. Results : The research findings have proposed a framework for the digital transformation and development of paper-cutting art, which integrates the digitization of paper cutting, digitalization, and the digital ecosystem. This framework emphasizes the safeguarding of traditional art forms through digital technology and enhances their application and value in modern society. The digital transformation framework, represented by paper cutting, provides a roadmap for maintaining and enhancing the value of ICH, as well as promoting the development of the cultural and creative industries. Conclusions : After conducting a comprehensive qualitative investigation, we have reached the following conclusions: DX represents a new trend in safeguarding paper-cutting art. Building on this, a framework for the DX and development of paper-cutting art has been proposed, encompassing the entire spectrum from digital preservation to active application, ultimately resulting in the creation of a papercutting digital ecosystem. This approach satisfies the multifaceted needs of safeguarding paper-cutting art, enhancing its potential for sustainable development. By taking paper-cutting art as an example, this study provides a guide for researchers in the field of ICH safeguarding and developers in the culture and creative industries to help them devise new strategic plans for safeguarding ICH and promoting the strong development of the culture and creative industries.

      • SCIESCOPUSKCI등재

        Synthesis and Characterization of HPMC Derivatives as Novel Duodenum-Specific Coating Agents

        Huang Yuan,Zheng ling Ii,Liu Jun,Zhang Zhi rong The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.3

        HPMC (Hydroxypropyl methylcellulose) was chemically modified, using maleic anhydrides, to obtain pH-sensitive HPMCAM (Hydroxypropyl methylcellulose acetate maleate) polymers for use as novel duodenum-specific coating agents. The pharmaceutical properties of HPMCAM, such as film forming, acid values, pH-sensitive values, water vapor permeability, tensile strength and Tg, were investigated, and found to show good film forming properties. The pH­sensitive values were 3.0 to 3.7. In vitro results demonstrate that HPMCAM could completely suppress drug release within 2h in a simulated gastric fluid (pH 1.2) and rapidly release the drug in a simulated pathological duodenal fluid (pH 3.4). These results indicate that HPMCAM might be a useful material for a duodenum-specific drug delivery system.

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