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Ning Xue,Jian-Hua Lin,Shan Xing,Dan Liu,Shi-Bing Li,Yan-Zhen Lai,Xue-Ping Wang,Min-Jie Mao,Qian Zhong,Mu-Sheng Zeng,Wan-Li Liu 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1
Purpose The purpose of this study was to identify novel plasma biomarkers for distinguishing nasopharyngeal carcinoma (NPC) patients from healthy individuals who have positive Epstein-Barr virus (EBV) viral capsid antigen (VCA-IgA). Materials and Methods One hundred seventy-four plasma cytokines were analyzed by a Cytokine Array in eight healthy individuals with positive EBV VCA-IgA and eight patients with NPC. Real-time polymerase chain reaction, Western blotting, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry were employed to detect the expression levels of macrophage migration inhibitory factor (MIF) and CC chemokine ligand 3 (CCL3) in NPC cell lines and tumor tissues. Plasma MIF and CCL3 were measured by ELISA in 138 NPC patients, 127 EBV VCA-IgA negative (VN) and 100 EBV VCA-IgA positive healthy donors (VP). Plasma EBV VCA-IgA was determined by immunoenzymatic techniques. Results Thirty-four of the 174 cytokines varied significantly between the VP and NPC group. Plasma MIF and CCL3 were significantly elevated in NPC patients compared with VN and VP. Combination of MIF and CCL3 could be used for the differential diagnosis of NPC from VN cohort (area under the curve [AUC], 0.913; sensitivity, 90.00%; specificity, 80.30%), and combination of MIF, CCL3, and VCA-IgA could be used for the differential diagnosis of NPC from VP cohort (AUC, 0.920; sensitivity, 90.00%; specificity, 84.00%), from (VN+VP) cohort (AUC, 0.961; sensitivity, 90.00%; specificity, 92.00%). Overexpressions of MIF and CCL3 were observed in NPC plasma, NPC cell lines and NPC tissues. Conclusion Plasma MIF, CCL3, and VCA-IgA combination significantly improves the diagnostic specificity of NPC in high-risk individuals.
Jun-Ming Hong,Bing Lin,Jie-Shan Jiang,Bor-Yann Chen,Chang-Tang Chang 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
Mesoporous material Q-MCM and EX-Q-MCM were synthesized using waste quartz (99.9% SiO2) sand as a silicon source via the sol–gel method. The silicon source was extracted from the waste quartz sand using the hydrothermal method. This study selected methylene blue as a target dye to investigate the dye adsorption performance onto the EX-Q-MCM. The effects on adsorption performance under different initial dye concentrations and different pH values were also studied. The results show that the maximum adsorption capacity was 96.9 mg g 1 and a high pH is favorable for adsorption. Further, equilibrium isotherms of the adsorption of methylene blue on EX-Q-MCM are well described by the Freundlich model. It reveals that the adsorption of methylene blue onto the Q-MCM is a multilayer adsorption.
Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China
Xiang-Quan Xie,Kui-Cheng Zheng,Bing-Shan Wu,Tie-Hui Chen,Shan-Rong Lai,Zai-Sheng Lin,Kazuo Aoki 대한예방의학회 2014 Journal of Preventive Medicine and Public Health Vol.47 No.5
Objectives: In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increasedrisk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogenI:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthydietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developinggastric cancer than those in Nanjing do.
Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China
Xie, Xiang-Quan,Zheng, Kui-Cheng,Wu, Bing-Shan,Chen, Tie-Hui,Lai, Shan-Rong,Lin, Zai-Sheng,Aoki, Kazuo The Korean Society for Preventive Medicine 2014 Journal of Preventive Medicine and Public Health Vol.47 No.5
Objectives: In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increased risk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogen I:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthy dietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developing gastric cancer than those in Nanjing do.