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Hu, Jin-Ryul,Jang, Tae-Woo,Kang, Su-Jin,Ku, Sae-Kwang,Choi, Seong-Hun,Lee, Young-Joon The Society of Korean Medicine 2019 대한한의학회지 Vol.40 No.4
Objectives: Here, we investigated the effects of concentrated and lyophilized powders Blue honeysuckle (BH) on the PK of tamoxifen, to establish the pharmacokinetics (PK) profiles as one of essential process in new drug development. Methods: After single oral treatment of 0.4 mg/ml of tamoxifen or tamoxifen 0.4 with BH 40, 20 and 10 mg/ml, the plasma were collected at 0.5 hr before administration, 0.5, 1, 2, 3, 4, 6, 8 and 24 hr after end of single or mixed formula treatment. Plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. Tmax, Cmax, AUC, t1/2 and MRTinf were analyzed using noncompartmental PK data analyzer programs. Results: Tamoxifen and BH 40 mg/ml did not induce any significant change on the plasma tamoxifen concentrations, while significant decreases were observed in tamoxifen and BH 10 mg/ml from 2 to 8 hr as compared with tamoxifen only, respectively. Furthermore, significant increases of Tmax in tamoxifen and BH 40 mg/ml, significant decreases of Cmax in tamoxifen and BH 20 mg/ml, significant decreases of AUC0-t, AUC0-inf and MRTinf in tamoxifen and BH 10 mg/ml were demonstrated as compared with tamoxifen only. Conclusion: Taken together, tamoxifen and BH 10 mg/ml induced significant decrease of the oral bioavailability of tamoxifen, while tamoxifen and BH 40 or 20 mg/ml did not critically influenced, suggesting formulated BH concentration-independencies. It, therefore, seems to be needed that pharmacokinetic study after repeated administration should be tested to conclude the effects of BH on the pharmacokinetics of tamoxifen.
Hu, Jin-Ryul,Choi, Beom-Rak,Park, Hye-Rim,Sung, Mi-Sun,Yi, Hae-Yeon,Kang, Su-Jin,Ku, Sae-Kwang,Lee, Young-Joon The Society of Korean Medicine 2016 대한한의학회지 Vol.37 No.4
Objectives: The aim of this study was to solve skin moisturizing action mechanism issues of pomegranate concentrated solution (PCS) and dried pomegranate concentrate powder (PCP), at least partially. Materials and methods: In this study, ceramide and $TGF-{\beta}1$ contents with $TGF-{\beta}1$ mRNA expressions were analysis on the skin tissue homogenate samples after 56 days of continuous oral administration of PCS 1, 2, and 4 ml/kg, and PCP 100, 200 and 400 mg/kg. Results: Noticeable and dose-dependent increases of skin $TGF-{\beta}1$ contents and mRNA expressions were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, but no significant changes on the skin ceramide contents were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, in the current study. In addition, PCP 200 mg/kg showed similar increases of the skin $TGF-{\beta}1$ contents and mRNA expressions as compared to those of PCS 4 ml/kg. Conclusions: The presented results suggested that in vivo skin moisturizing effects of PCP and PCS after oral administration through up regulation of hyaluronan synthesis demonstrated in our previous results, may be possibly mediated by modulation of $TGF-{\beta}1$ expressions at least partially, without critical influences on the skin ceramide contents.
( Hu Li ),( Seung-woon Rha ),( Byoung Geol Choi ),( Min Suk Shim ),( Se Yeon Choi ),( Cheol Ung Choi ),( Eung Ju Kim ),( Dong Joo Oh ),( Byung Ryul Cho ),( Moo Hyun Kim ),( Doo-il Kim ),( Myung-ho Jeo 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.4
Background/Aims: Transradial intervention (TRI) is becoming the preferred method over transfemoral intervention (TFI) because TRI is associated with lower incidence of major bleeding and vascular complications. However, there has been limited published data regarding the clinical outcomes of TRI versus TFI in Korean patients with ST-elevation myocardial infarction (STEMI). Methods: A total of 689 consecutive STEMI patients who underwent primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) from January to December of 2009 at nine university hospitals were enrolled in this study. Mid-term angiographic and 12-month cumulative clinical outcomes of the TRI group (n = 220, 31.9%) were compared to those of the TFI group (n = 469, 28.1%). Results: After propensity score matching, in-hospital complications and the 12-month major clinical outcomes during follow-up in the two groups were similar to each other. However, the incidence rates of repeat revascularization (6.4% vs. 0.5%, p = 0.003), target vessel revascularization (6.4% vs. 0.5%, p = 0.003), and major adverse cardiac events (MACE; 11.6% vs. 4.6%, p = 0.018) in the TFI group were higher than those in the TRI group during the 12-month of follow-up. Conclusions: In our study, TRI in STEMI patients undergoing primary PCI with DESs was associated with lower incidence of access site hematoma, 12-month repeat revascularization, and MACE compared to TFI. Therefore, TRI might play an important role in reducing bleeding complications while improving major clinical outcomes in STEMI patients undergoing primary PCI with DESs.
前期加耶의 對外關係 : 釜山·金海勢力의 經濟的基盤과 對外關係를 中心으로
도동열,허재혁 동의공업대학 1999 論文集 Vol.25 No.1
There were many restrictions in the study about ancient Kaya located in southern area of Korea because of the political use of Japan and the shortage of historical materials. But new occasion came because of the archaelogical studies about the outcome of the excavations in downstream area of the NakDong-river(洛東江). Kaya can be divided into two periods -The first term and The preceding term) -and the changing point of time is analogized as 4∼5th century. The center of the first term of Kaya was located at Kimhae(金海). Kaya prospered through the production of iron and overseas trade. The evidence of prosperity can be searched on the cultural phenomenons of the ancient tombs at Daesung-dong(大成洞) that many remains bespeak mightly influence were excavated until the first half of the 5th century. But after that, preceding term kaya declined rapidity. This event can be connected with description of the southern expedition by Kokuryo(高句麗), recorded on the monument of the King Kwangeaeto(廣開土) The Great which is known as the most important material on the Korean ancient history. After that, A1a-kuk(阿羅國) at Haman(咸安) and Taekaya(大加耶) at Koryung(高靈) became new center of Kaya area located in southern Korea until the destruction.
Lee, Ga-Young,Lee, Hu-Ryul,Um, Myeong-Heon,Kang, Mi-Sook Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.9
To investigate the scattering layer effect of a $TiO_2$ multilayer in dye-sensitized solar cells (DSSCs), we designed a new DSSC system, assembled with a CdS-$TiO_2$ scattering layer electrode. A high-magnification SEM image exhibited hollyhock-like particles with a width of 1.5-2.0 ${\mu}m$ that were aggregated into 10-nm clumps in a hexagonal petal shape. The efficiency was higher in the DSSC assembled with a CdS-$TiO_2$ scattering layer than in the DSSC assembled with $TiO_2$-only layers, due to the decreased resistance in electrochemical impedance spectroscopy (EIS). The short-circuit current density ($J_{sc}$) was increased by approximately 7.26% and the open-circuit voltage ($V_{oc}$) by 2.44% over the 1.0 wt % CdS-$TiO_2$ composite scattering layer and the incident photon-to-current conversion efficiency (IPCE) in the maximum peak was also enhanced by about 5.0%, compared to the DSSC assembled without the CdS-$TiO_2$scattering layer.
PDP 격벽제작을 위한 롤-프레싱 공정에서의 유한요소해석을 통한 공정변수 분석에 관한 연구
류승민(Seung-Min Ryu),박상후(Sang Hu Park),이석렬(Seok-Ryul Lee),홍진태(Jin Tae Hong),양동열(Dong-Yol Yang) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
Plasma Display Panel (PDP) is considered as one of the most popular flat panel displays due to its characters such as wide screen area, thin thickness, and wide angle of view. However, there are still remained problems should be solved to improve the efficiency of consuming power, and many works have been conducted to change the structure of barrier-ribs in the PDP for improving its efficiency. Generally, enlarging the coating space of phosphors and the discharging space of the ribs is the way to improve the efficiency. In this work, a roll-pressing process has been proposed with various rolling paths to fabricate highly efficient rib as closed types such as rectangular shape for HDTV. Also, the finite element method was employed to analysis the process parameters and to optimize them. Through this work, some kinds of barrier-ribs were fabricated using the proposed process, and optimal conditions were estimated.