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Mechanical properties of coconut filter fiber
Suardana Ngakan Putu Gede,Ruihua Hu,Yoon Ho-Chel,Chul-In Kim,Yingjun Piao,Ri Xu,Jae Kyoo Lim 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
In this study, mechanical properties of single coconut filter (CF) and coconut husk (CH) fiber were compared under the same chemical treatment conditions. The fibers were subjected to various surface treatments as follow: CF and CH fibers were treated using 6%w/v NaOH solution at 95℃ for 3 hours, respectively, and then they were washed with water to remove NaOH solution sticking to the fiber surface and dried in oven for 24 hours at 70℃. After that they were soaked in 0.5%, 1%,3% acrylic acid for 0.5, 1 and 3 hours and then washed with distilled water and dried in oven at 70℃ for 72 hours. The tensile test is conducted according to ASTM standard (C1557-03). Tensile strength, Young's modulus (E) and strain at break (ε<SUB>b</SUB>) were evaluated. Mechanical properties of CF fiber are more than twice of those of CH fiber except the strain at break (ε<SUB>b</SUB>) is lower than that of CH. NaOH treated fibers (CF and CH) have higher tensile strength, E and ε<SUB>b</SUB> than those of untreated fibers. Based on the immersion time, the maximum tensile strength and E of CF occur at 0.5h immersion for all acrylic acid concentration. They show a decrease tendency when the immersion time increased. While the maximum tensile strength and E of CH occur at 3h immersion for all acrylic acid concentration and the lowest tensile strength and E at 1h acrylic acid immersion but higher than untreated. The maximum tensile strength and E of both CF and CH occur at 0.5% acrylic acid for all immersion time and show a decrease tendency when the acrylic acid concentration increased. Surface morphologies of the fiber were observed using SEM method and FTIR for characterizing chemically modified fiber.
Li, Wei,Zheng, Chang-Ji,Sun, Liang-Peng,Song, Ming-Xia,Wu, Yan,Li, Yin-Jing,Liu, Yi,Piao, Hu-Ri 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
A series of arylhydrazone derivatives bearing a rhodanine moiety have been synthesized, characterized, and evaluated as antibacterial agents. Some of these compounds showed potent antibacterial activities against several different strains of Gram-positive bacteria, including multidrug-resistant clinical isolates. Of the compounds tested, IIk and IIIk were identified as the most effective, with minimum inhibitory concentration values of $2-4{\mu}g/mL$ against multidrug-resistant Gram-positive organisms, including methicillin-resistant and quinolone-resistant Staphylococcus aureus. None of the compounds exhibited any activity against the Gram-negative bacteria Escherichia coli 1356 at $64{\mu}g/mL$.
Zhen-Hua Chen,Liang-Peng Sun,Wei Zhang,Qiang Shen,Li-Xin Gao,Jia Li,Hu-Ri Piao 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.5
Protein tyrosine phosphatase 1B (PTP1B) is a key factor in negative regulation of the insulin pathway, and is a promising target for the treatment of type-II diabetes, obesity and cancer. Herein, compound (4) was first observed to have moderate inhibitory activity against PTP1B with an IC50 value of 13.72 ± 1.53 μM. To obtain more potent PTP1B inhibitors, we synthesized a series of chalcone derivatives using compound (4) as the lead compound. Compound 4l (IC50 = 3.12 ± 0.18 μM) was 4.4-fold more potent than the lead compound 4 (IC50 = 13.72 ± 1.53 μM), and more potent than the positive control, ursolic acid (IC50 = 3.40 ± 0.21 μM). These results may help to provide suitable drug-like lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
Song, Ming-Xia,Deng, Xian-Qing,Wei, Zhi-Yu,Zheng, Chang-Ji,Wu, Yan,An, Chang-Shan,Piao, Hu-Ri Shaheed Beheshti University of Medical Sciences 2015 Iranian journal of pharmaceutical research Vol.14 No.1
<P>The microbial resistance has become a global hazard with the irrational use of antibiotics. Infection of drug-resistant bacteria seriously threatens human health. Currently, there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (<I>S</I><I>,Z</I>)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)pentanoic acids via a Knoevenagel condensation were synthesized and evaluated for their antibacterial activity <I>in</I><I>-</I><I>vitro</I>. The synthesized compounds were characterized by IR, <SUP>1</SUP>H NMR and MS. The antibacterial test<I> in</I><I>-</I><I>vitro</I> showed that all of the synthesized compounds had good antibacterial activity against several Gram-positive bacteria (including multidrug-resistant clinical isolates) with minimum inhibitory concentration (MIC) values in the range of 2–4 µg/mL. Especially compounds 4c, 4d, 4e and 4f were the most potent, with MIC values of 2 µg/mL against four multidrug-resistant Gram-positive bacterial strains.</P>
Chen, Zhen-Hua,Sun, Liang-Peng,Zhang, Wei,Shen, Qiang,Gao, Li-Xin,Li, Jia,Piao, Hu-Ri Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.5
Protein tyrosine phosphatase 1B (PTP1B) is a key factor in negative regulation of the insulin pathway, and is a promising target for the treatment of type-II diabetes, obesity and cancer. Herein, compound ($\mathbf{4}$) was first observed to have moderate inhibitory activity against PTP1B with an $IC_{50}$ value of $13.72{\pm}1.53{\mu}M$. To obtain more potent PTP1B inhibitors, we synthesized a series of chalcone derivatives using compound ($\mathbf{4}$) as the lead compound. Compound $\mathbf{4l}$ ($IC_{50}=3.12{\pm}0.18{\mu}M$) was 4.4-fold more potent than the lead compound $\mathbf{4}$ ($IC_{50}=13.72{\pm}1.53{\mu}M$), and more potent than the positive control, ursolic acid ($IC_{50}=3.40{\pm}0.21{\mu}M$). These results may help to provide suitable drug-like lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
Wei Li,Chang-Ji Zheng,Liang-Peng Sun,Ming-Xia Song,Yan Wu,Yin-Jing Li,Yi Liu,Hu-Ri Piao 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
A series of arylhydrazone derivatives bearing arhodanine moiety have been synthesized, characterized, andevaluated as antibacterial agents. Some of these compoundsshowed potent antibacterial activities against several differentstrains of Gram-positive bacteria, including multidrug-resistant clinical isolates. Of the compounds tested, IIkand IIIk were identified as the most effective, with minimuminhibitory concentration values of 2–4 lg/mL against multidrug-resistant Gram-positive organisms, including methicillin-resistant and quinolone-resistant Staphylococcusaureus. None of the compounds exhibited any activityagainst the Gram-negative bacteria Escherichia coli 1356 at64 lg/mL.