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Inhibition of KIF20A suppresses the replication of influenza A virus by inhibiting viral entry
Hoyeon Jeon,Younghyun Lim,In-Gu Lee,Dong-In Kim,Keun Pil Kim,So-Hee Hong,Jeongkyu Kim,Youn-Sang Jung,Young-Jin Seo 한국미생물학회 2022 The journal of microbiology Vol.60 No.11
The influenza A virus (IAV) has caused several pandemics, and therefore there are many ongoing efforts to identify novel antiviral therapeutic strategies including vaccines and antiviral drugs. However, influenza viruses continuously undergo antigenic drift and shift, resulting in the emergence of mutated viruses. In turn, this decreases the efficiency of existing vaccines and antiviral drugs to control IAV infection. Therefore, this study sought to identify alternative therapeutic strategies targeting host cell factors rather than viruses to avoid infection by mutated viruses. Particularly, we investigated the role of KIF20A that is one of kinesin superfamily proteins in the replication of IAV. The KIF20A increased viral protein levels in IAV-infected cells by regulating the initial entry stage during viral infection. Furthermore, the KIF20A inhibitor significantly suppressed viral replication, which protected mice from morbidity and mortality. Therefore, our findings demonstrated that KIF20A is highly involved in the viral replication process and viral propagation both in vitro and in vivo, and could thus be used as a target for the development of novel antiviral drugs.
황호연(Hoyeon Hwang),전정민(Jeongmin Jeon),정홍렬(Hong-ryul Jung),김수종(Sujoing Kim),문형필(Hyungpil Moon) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11
Task planning and motion planning are needed to handle the task the robot wants. The task planning is represented by a graph structure map of vertices and edges. At the vertex, the robot manipulator information, position, and object’s position were shown, and the edge represented the behavior of the robot, which was represented by a graph structure. With information about objects in the graph structure, geometric constraints can be considered in task planning. The heuristic can be used in the graph search algorithm to find the optimal path for task planning. Motion planning and v-rep simulator allow you to see the results of task planning.
Production of high-quality chemical materials through the catalytic pyrolysis of e-waste
( Hyunji Yim ),( Hoyeon Jang ),( Bo Sung Kang ),( Sugyeong Jeon ),( Haneul Shim ),( Youngeun Kang ),( Young-min Kim ),( Sumin Pyo ),( Young-kwon Park ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-
With the recent development of electronic device manufacturing technology, the demand of electrical and electronic equipment has increased rapidly, and the amount of electronic waste (e-waste) is also increasing accordingly. Although the recycling of e-waste has increased, it is still limited as metal recovery and most of organic parts, polymers and additives, were still treated simply via incineration or landfill. Pyrolysis can be considered as an eco-friendly process not only for the effective recovery of metal but also for the chemical recycling of organic parts of e-wastes. In this research, the thermal and catalytic pyrolysis of e-wastes have investigated focused on the production of high-quality oil and chemical feedstock. The non-catalytic pyrolysis of organic part in e-waste was prepared after the elimination of inorganic part and applied the pyrolysis under inert gas atmosphere using thermogravimetric (TG) analyzer and pyrolyzer-gas chromatography/mass spectrometry (Py-GC/MS). Kinetic analysis, analyzed by a model free kinetic analysis method to the TG analysis results of organic e-waste, indicated the change of thermal degradation pattern by applying the catalytic pyrolysis. Py-GC/MS result also indicated the quality of the pyrolysis oil can be upgraded efficiently with the decrease of undesirable product, such as halogen containing chemicals and oxygen containing pyrolyzates.
Selective resolution of phonon modes in STM-IETS on clean and oxygen-adsorbed Cu(100) surfaces
Lee, Minjun,Oh, Myungchul,Jeon, Hoyeon,Yi, Sunwouk,Zoh, Inhae,Zhang, Chao,Chae, Jungseok,Kuk, Young Elsevier 2019 Surface science Vol.689 No.-
<P><B>Abstract</B></P> <P>The observation of surface phonon using scanning probe microscopy can provide important information related to local structural and electrical properties. In this study, surface phonon modes on a Cu(100) surface were measured using inelastic tunneling spectroscopy of scanning tunneling microscopy. One phonon mode was measured at 3.6 meV on a clean Cu(100) surface. On an oxygen-adsorbed Cu(100) surface, another phonon mode was measured at 13.5 meV. This phonon mode was considered to be enhanced by the symmetry created by Cu-missing rows. The spatially varying <I>d<SUP>2</SUP>I/dV<SUP>2</SUP> </I> map showed the effect of surface stress relaxation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We measured the surface phonon modes on a bare Cu(100) surface and two reconstructed oxidized Cu(100) surfaces. </LI> <LI> These measurements were performed with different selection rules owing to the structures of the surfaces and the probing tips. </LI> <LI> A geometrically sharp STM tip was an important factor for resolving many phonon mode peaks on the surface. </LI> <LI> The symmetry of the phonon modes was directly related to the STM-IETS signal strength. </LI> <LI> Broken symmetry due to surface stress relaxation can be another factor determining the STM-IETS signal. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>