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Lee, Minjun,Lee, Seunghoon,Kim, Eunseok,Cho, Ye-Eun,Kang, Jung Won,Lee, Jae-Dong Elsevier 2018 COMPLEMENTARY THERAPIES IN MEDICINE Vol.41 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>To evaluate the risk of bleeding-related adverse events after acupuncture treatment in patients receiving anticoagulant or antiplatelet drugs.</P> <P><B>Design and setting</B></P> <P>: A total of 428 inpatients who received acupuncture treatment underwent two assessments for bleeding-related adverse events, such as micro-bleeding, hematoma, and ecchymosis: 1) immediately after acupuncture treatment on the first day and 2) before acupuncture treatment on the following day. Additional analyses were performed using the number of acupuncture needles as independent variables. Multivariable analysis using factors likely related to bleeding and subgroup analysis according to regions of needle insertion were also performed.</P> <P><B>Results</B></P> <P>A total of 169 patients receiving anticoagulant or antiplatelet drugs (exposure group) and 259 patients not receiving either drug (non-exposure group) were studied. Sixty-five (38.5%) patients in the exposure group and 115 (44.4%) patients in the non-exposure group had bleeding-related mild adverse events. There was no difference in the risk of bleeding-related adverse events between the two groups per sessions (relative risk (RR) 0.87, 95% confidence interval (CI), 0.69–1.10) and per needles (RR 0.89, 95% CI 0.70–1.13). In multivariable analysis, thickness of needle only increased risk of bleeding. Subgroup analysis showed that taking these drugs did not increase the risk of bleeding in any of the regions.</P> <P><B>Conclusion</B></P> <P>Our findings suggest that anticoagulant and antiplatelet drugs do not increase the incidence of bleeding-related adverse events after acupuncture treatment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The relative risk of exposure of the unexposed group was 0.87 (95% CI 0.69–1.10), indicating that exposure to anticoagulants or antiplatelet agents did not increase the incidence of bleeding-related adverse events. </LI> <LI> In the additional analysis using the number of acupuncture needles, the relative risk of exposure of the unexposed group was 0.89 (95% CI 0.70–1.13), with no statistically significant difference. </LI> <LI> In multivariable analysis, thickness of needle only increased risk of bleeding, and subgroup analysis showed that taking the drugs did not increase the risk of bleeding in any of the body regions. </LI> <LI> All bleeding-related adverse events were asymptomatic and insignificant. </LI> </UL> </P>
Real-time detection of chlorine gas using Ni/Si shell/core nanowires
Lee, Dong-Jin,Heo, Kwang,Lee, Hyungwoo,Jin, Joon-Hyung,Chang, Hochan,Park, Minjun,Lee, Han-Bo-Ram,Kim, Hyungjun,Lee, Byung Yang Springer US 2015 NANOSCALE RESEARCH LETTERS Vol.10 No.1
<P>We demonstrate the selective adsorption of Ni/Si shell/core nanowires (Ni-Si NWs) with a Ni outer shell and a Si inner core on molecularly patterned substrates and their application to sensors for the detection of chlorine gas, a toxic halogen gas. The molecularly patterned substrates consisted of polar SiO<SUB>2</SUB> regions and nonpolar regions of self-assembled monolayers of octadecyltrichlorosilane (OTS). The NWs showed selective adsorption on the polar SiO<SUB>2</SUB> regions, avoiding assembly on the nonpolar OTS regions. Utilizing these assembled Ni-Si NWs, we demonstrate a sensor for the detection of chlorine gas. The utilization of Ni-Si NWs resulted in a much larger sensor response of approximately 23% to 5 ppm of chlorine gas compared to bare Ni NWs, due to the increased surface-to-volume ratio of the Ni-Si shell/core structure. We expect that our sensor will be utilized in the future for the real-time detection of halogen gases including chlorine with high sensitivity and fast response.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s11671-015-0729-2) contains supplementary material, which is available to authorized users.</P>
Efficacy of Auditory Training Using Video Clips for Older Adults Who Wear Hearing Aids
Minjun Lee,Junghwa Bahng 한국청각언어재활학회 2020 Audiology and Speech Research Vol.16 No.3
Purpose: The purpose of this study was to evaluate the effectiveness of training using the developed videos in terms of speech perception in noise and cognitive ability. Methods: For the training materials, we had 16 video clips edited from new, TV shows, and movies. To evaluate the auditory training effect when using the video clips, a total of 17 subjects participated in this study; all of the subjects had worn hearing aids for 1 to 3 months. Among the 17 subjects, ten of them completed eight sessions, 40 minutes per session, of the auditory training, while the other seven subjects did not have any training chance. Sentence recognition in noise tests, cognition tests such as digit span (auditory-only and auditory-visual conditions) attention tests, and subjective satisfaction of hearing aids were evaluated at both pre- and post-auditory training. Results: There were significantly improved sentence recognition in noise, attention, and subjective hearing aid satisfaction in the auditory training group. However, there was no significant improvement in the digit span after the auditory training. In the non-training group, none of the tests’ scores were significantly changed, other than subjective hearing aid satisfaction. Conclusion: These results suggested that auditory training with video clip is an effective method to improve speech understanding in noise and subjective satisfaction as well as cognitive ability, attention. However, we did not observe working memory improvement after the training. For future study, we need to examine an effective method for improving cognitive ability, especially working memory.
Computational Study on Structure and Aggregation Pathway of Aβ<sub>42</sub> Amyloid Protofibril
Lee, MinJun,Yoon, Jeseong,Shin, Seokmin American Chemical Society 2019 The Journal of physical chemistry B Vol.123 No.37
<P>Amyloid deposits of Aβ protein in neuronal cells are known to be a major symptom of Alzheimer’s disease. In particular, Aβ<SUB>42</SUB> shows relatively high toxicity among the different Aβ isoforms, and its toxicity is thought to be because of its structural features. Recent ssNMR and cryo-EM experiments identified that Aβ<SUB>42</SUB> shows an S-shaped triple-β structure, in contrast to the previously suggested U-shaped β-arch structure. In order to associate the high toxicity of Aβ<SUB>42</SUB> with its structural features, it is essential to explain the conformational stability and aggregation mechanisms of this triple-β motif. We utilized several different simulation methods, including extensive straight molecular dynamics simulation, steered molecular dynamics simulation, and replica-exchange molecular dynamics simulation. The S-shaped triple-β motif showed remarkable structural stability because of its complex residual interactions that form stable hydrophobic cores. The triple-β structure of Aβ<SUB>42</SUB> is primarily made up of three β-sheet regions and two hydrophobic cores formed between β-sheet regions. Our analysis of β-sheet rupture patterns between adjacent chains showed that its two hydrophobic cores have different degrees of stability, indicating a lock phase mechanism. Our analysis of the docking pathway of monomeric Aβ<SUB>42</SUB> to the fibril motif using REMD simulations showed that each of the three β-sheet sequences plays a distinct role in the docking process by changing their conformational features. Our results provide an understanding for the stability and consequent high toxicity of the triple-β structure Aβ<SUB>42</SUB>.</P> [FIG OMISSION]</BR>
Selective resolution of phonon modes in STM-IETS on clean and oxygen-adsorbed Cu(100) surfaces
Lee, Minjun,Oh, Myungchul,Jeon, Hoyeon,Yi, Sunwouk,Zoh, Inhae,Zhang, Chao,Chae, Jungseok,Kuk, Young Elsevier 2019 Surface science Vol.689 No.-
<P><B>Abstract</B></P> <P>The observation of surface phonon using scanning probe microscopy can provide important information related to local structural and electrical properties. In this study, surface phonon modes on a Cu(100) surface were measured using inelastic tunneling spectroscopy of scanning tunneling microscopy. One phonon mode was measured at 3.6 meV on a clean Cu(100) surface. On an oxygen-adsorbed Cu(100) surface, another phonon mode was measured at 13.5 meV. This phonon mode was considered to be enhanced by the symmetry created by Cu-missing rows. The spatially varying <I>d<SUP>2</SUP>I/dV<SUP>2</SUP> </I> map showed the effect of surface stress relaxation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We measured the surface phonon modes on a bare Cu(100) surface and two reconstructed oxidized Cu(100) surfaces. </LI> <LI> These measurements were performed with different selection rules owing to the structures of the surfaces and the probing tips. </LI> <LI> A geometrically sharp STM tip was an important factor for resolving many phonon mode peaks on the surface. </LI> <LI> The symmetry of the phonon modes was directly related to the STM-IETS signal strength. </LI> <LI> Broken symmetry due to surface stress relaxation can be another factor determining the STM-IETS signal. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>