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Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents
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Waterborne outbreaks reported in the United States
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杜甫卷
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경계선 성격특성이 반응적 공격성에 미치는 영향: 거절민감성과 부적응적 정서대처전략의 매개효과 = The Effect of Borderline Personality Traits on Reactive Aggression: Mediating Effect of Rejection Sensitivity and Maladaptive Emotional Coping Strategies
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Monocyte Attachment and Migration through Collagen IV in Diabetes Mellitus
- 검색키워드
- 저자 : Horgan, G.W. (검색결과 5 건)
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Lally Richard D.,Murphy Richard,Horgan Karina 한국원예학회 2023 Horticulture, Environment, and Biotechnology Vol.64 No.4
To explore the possibility of reducing plant diseases with integrated pest management strategies, microbial fermentation products (MFPs) are being explored as elicitors of plant defence. This work examined the impact of MFP application on tomato plants ( Solanum lycopersicum) in a polytunnel environment. Two MFPs were assessed, at a concentration of 0.7% v/v, to determine their impact within 48-h of a foliar treatment application on the mRNA expression of common plant defence markers along with hydrogen peroxide and malondialdehyde levels, peroxidase and catalase activity, and leaf pigment concentrations. Treated plants were examined for indicators of diff erent defence responses. AOS , LOX2 and malondialdehyde were targeted as indicators of a jasmonic acid related response, while PAL and PR1 were examined as indicators of a salicylic acid related response. A yield study was also conducted over two harvest seasons to determine the impact of the MFP applications on fruit productivity. MFP 1 upregulated gene expression of AOS , CAT , LOX2 , PR2 and PA2 . It also resulted in greater malondialdehyde concentrations in leaf tissue and resulted in higher levels of catalase activity. At 24 h plant chlorophyll a, chlorophyll b, carotenoids and total pigment concentrations were higher with use of MFP 1. MFP 2 increased the expression of CAT , LOX2 , PAL , PR1 , PR2 , PR4 , PR5 and PA2 genes, hydrogen peroxide levels and peroxidase activity also increased. Yield analysis revealed that neither of the MFP applications had a negative impact on productivity, fruit numbers and average fruit weight were signifi cantly higher in year 1 with MFP1, while MFP 2 had greater fruit numbers in year 2. The data suggests, based on the behaviour of the plants in response to the MFP applications, that MFP 1 positively aff ected biomarkers associated with jasmonic acid defence responses ( AOS, LOX2 and malondialdehyde) and MFP 2 aff ected markers associated with salicylic acid responses ( PAL and PR1 ). The work indicates that MFPs could be used to elicit diff erent defence responses in tomato plants, which could play a role in helping improve crop productivity. Eliciting plant defence against biotic stress is crucial in integrated pest management strategies, this work provides evidence that MFPs may play a crucial role in eliciting defences in tomato plants and other crops against a range of agronomically challenging diseases.
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Matthewman, R.W.,Merrit, J.,Oldham, J.D.,Horgan, G.W. Asian Australasian Association of Animal Productio 1993 Animal Bioscience Vol.6 No.4
Three experiments were carried out in which lactating Hereford ${\times}$ Friesian cattle walked up to ten kilometers a day for three periods of five days with two non-walking days between each walking period and in which the animals were fed different diets. Measurements were made of milk yield, milk constituent yields and concentrations and blood metabolite concentrations. Exercise caused significant reductions in milk yield and in the yields of lactose and milk protein. Milk fat yield was not reduced when animals were exercised. During exercise the concentrations of ${\beta}-OH$ butyrate and free fatty acids increased, whereas the concentrations of glucose, magnesium and inorganic phosphorus decreased. Diet influenced the effect of exercise on some blood metabolite concentrations.
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Morphology of the Esophageal Hiatus: Is It Different in 3 Types of Hiatus Hernias?
( Dushyant Kumar ),( Ali Zifan ),( Gary Ghahremani ),( David C Kunkel ),( Santiago Horgan ),( Ravinder K Mittal ) 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1
Background/Aims The esophageal hiatus is formed by the right crus of the diaphragm in the majority of subjects. Contraction of the hiatus exerts a sphincter-like action on the lower esophageal sphincter (LES). The aim is to study the hiatal anatomy (using CT scan imaging) and function (using high-resolution manometry [HRM]), and esophageal motor function in patients with sliding and paraesophageal hiatal hernia. Methods We assessed normal subjects (n = 20), patients with sliding type 1 hernia (n = 18), paraesophageal type 2 hernia (n = 19), and mixed type 3 hernia (n = 19). Hernia diagnosis was confirmed on the upper gastrointestinal series. The hiatal morphology was constructed from the CT scan images. The LES pressure and relaxation, percent peristalsis, bolus pressure, and hiatal squeeze pressure were assessed by HRM. Results The CT images revealed that the esophageal hiatus is formed by the right crus of the diaphragm in all normal subjects and 86% of hernia patients. The hiatus is elliptical in shape with a surface area of 1037 mm<sup>2</sup> in normal subjects. The hiatal dimensions were larger in patients compared to normal subjects. The HRM revealed impaired LES relaxation and higher bolus pressure in patients with paraesophageal compared to the sliding hernia. The hiatal pinch on HRM was recognized in significantly higher number of patients with sliding as compared to paraesophageal hernia. Conclusions Using a novel approach, we provide details of the esophageal hiatus in patients with various kinds of hiatal hernia. Impaired LES relaxation in paraesophageal hernia may play a role in its pathophysiology and genesis of symptoms.
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Aorta protein networks in marginal and acute zinc deficiency
Beattie, John H.,Gordon, Margaret-Jane,Rucklidge, Garry J.,Reid, Martin D.,Duncan, Gary J.,Horgan, Graham W.,Cho, Young-Eun,Kwun, In-Sook WILEY-VCH Verlag 2008 Proteomics Vol.8 No.10
<P>Human zinc deficiency is a global problem and may influence the development of cardiovascular disease. Our objective was to determine Zn deficiency affected pathways and protein interactions in rat aorta and their likely influence on stress-induced atherogenesis. In two separate studies, rats were given diets acutely (<1 mg Zn/kg) or marginally (6 mg Zn/kg) deficient in Zn. Both studies included Zn adequate controls (35 mg Zn/kg) and the acute deficiency study included a pair-fed group. After 6 wk, proteins from thoracic aorta were separated by 2-DE. Proteins affected by zinc deficiency were identified by principal component analysis. Multiple correlations of identified proteins indicated protein networks of related function. Proteins clusters decreased in zinc deficiency were related to fatty acid and carbohydrate metabolism. Structurally related proteins, including zyxin and over nine transgelin 1 proteins, were either increased or decreased by acute and marginal deficiencies. PKCα was significantly decreased in Zn deficiency suggesting that Zn may regulate the phosphorylation of target proteins. Zn deficiency-related changes in structural, carbohydrate and fatty acid-related proteins may be disadvantageous for maintaining vascular health and are consistent with a protective role for zinc in the development of atherosclerosis.</P>
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