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Yuan-yuan Pei,Gao-chi Li,Jian Ran,Xin-hong Wan,Feng-xiang Wei,Lan Wang 한국유방암학회 2019 Journal of breast cancer Vol.22 No.4
Purpose: Our previous studies have shown that kinesin family member 11 (KIF11) is markedly overexpressed in human breast cancer cells or tissues and positively correlated with distant metastasis and prognosis in patients with breast cancer, suggesting an important role in the regulation of cancer stem cells. Herein, we examined the role of KIF11 in breast cancer stem cells. Methods: In the current study, we validated our previous findings through analysis of data collected in The Cancer Genome Atlas. Endogenous KIF11 was stably silenced in MCF-7 and SKBR-3 cells. Flow cytometry was used to measure the proportion of side-population (SP) cells. Mammosphere culture and tumor implantation experiments in immunodeficient mice were used to assess the self-renewal ability of breast cancer cells. Real-time polymerase chain reaction, western blot, immunofluorescence staining, luciferase reporter assays and Wnt agonist treatment were conducted to investigate the signaling pathways regulated by KIF11. Results: We found that the expression level of KIF11 was positively correlated with stem cell-enrichment genes. The proportion of SP cells was significantly reduced in KIF11-silenced cells. Silencing endogenous KIF11 not only reduced the size and number of mammospheres in vitro, but also reduced the ability of breast cancer cells to form tumors in mice. Simultaneously, we found that KIF11 was involved in regulating the activation of the Wnt/β-catenin signaling pathway. Conclusion: Endogenous KIF11 enhances the self-renewal of breast cancer cells by activating the Wnt/β-catenin signaling pathway, thereby enhancing the characteristics of breast cancer stem cells.
Thermo-optic Characteristics of Micro-structured Optical Fiber Infiltrated with Mixture Liquids
Ran Wang,Yuye Wang,Yinping Miao,Ying Lu,Nannan Luan,Congjing Hao,Liangcheng Duan,Cai Yuan,Jianquan Yao 한국광학회 2013 Current Optics and Photonics Vol.17 No.3
We present both theoretically and experimentally the thermo-optic characteristics of micro-structured optical fiber (MOF) filled with mixed liquid. The performance of MOF depends on the efficient interaction between the fundamental mode of the transmitted light wave and the tunable thermo-optic materials in the cladding. The numerical simulation indicates that the confinement loss of MOF presents higher temperature dependence with higher air-filling ratios d/Λ, longer incident wavelength and fewer air holes in the cladding. For the 4cm liquid-filled grapefruit MOF, we demonstrate from experiments that different proportions of solutions lead to tunable temperature sensitive ranges. The insertion loss and the extinction ratio are 3~4 dB and approximate 20 dB, respectively. The proposed liquid-filling MOF will be developed as thermo-optic sensor, attenuator or optical switch with the advantages of simple structure, compact configuration and easy fabrication.
CONDITIONAL CENTRAL LIMIT THEOREMS FOR A SEQUENCE OF CONDITIONAL INDEPENDENT RANDOM VARIABLES
Yuan, De-Mei,Wei, Li-Ran,Lei, Lan Korean Mathematical Society 2014 대한수학회지 Vol.51 No.1
A conditional version of the classical central limit theorem is derived rigorously by using conditional characteristic functions, and a more general version of conditional central limit theorem for the case of conditionally independent but not necessarily conditionally identically distributed random variables is established. These are done anticipating that the field of conditional limit theory will prove to be of significant applicability.
Identification of molecular markers for the oncogenicdifferentiation of hepatocellular carcinoma
Gyung-Ran Yu,Seong-Hun Kim,Seon-Hwa Park,Xiang-Dan Cui,Dong-Yuan Xu,Hee-Chul Yu,Baik-Hwan Cho,Young-Il Yeom,Sang-Soo Kim,Sang-Bae Kim,추인선,김대곤 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.5
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hep-atocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tu-tal 217 genes, 72 were expressed preferentialy in HCC tissues. Among 186 diferentialy regulated genes, there were molecular chaperone and tumor sup-pressor gene clusters in the Edmondson grades I and I (GI/I) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P = 0.0133) contained 122 diferentialy regulated genes with a cluster containing pared with the GI/II subclass. Imunohistochemical analysis revealed that ANXA2, one of the 72 genes pref-erentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses wil be useful molecular markers for the genesis and pro-gresion of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC.
Conditional central limit theorems for a sequence of conditional independent random variables
De-Mei Yuan,Li-Ran Wei,Lan Lei 대한수학회 2014 대한수학회지 Vol.51 No.1
A conditional version of the classical central limit theorem is derived rigorously by using conditional characteristic functions, and a more general version of conditional central limit theorem for the case of conditionally independent but not necessarily conditionally identically distributed random variables is established. These are done anticipating that the field of conditional limit theory will prove to be of significant applicability.