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- 저자 : Hongyi Wei (검색결과 5 건)
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Hongyi Wei,Ningning Pan,Wen Zhang,Guangwu Xiong,Wenping Guo,Zhe Dong,Caihong Ma 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.2
Objective: To conduct a systematic review and meta-analysis of studies evaluating the oncological and fertility outcomes of early-stage endometrial cancer (EC) treated with the levonorgestrel-releasing intrauterine system (LIUS)-based regimens. Methods: The Meta-analyses Of Observational Studies in Epidemiology statement for meta-analyses was followed. Searches were conducted on MEDLINE, Embase, PubMed, Preprints, and the Cochrane Central Register of Controlled Trials from January 1990 to August 4, 2022. The Joanna Briggs Institute Critical Appraisal Checklist was used for quality assessment. The primary endpoint was the complete response (CR) rate and the secondary endpoints were relapse, pregnancy, and live birth rate. Results: A total of 25 studies (821 women) were included. The CR rate of LIUS-based regimens was 63.4% (95% confidence interval [CI]=52.3%–73.2%), with 29.6% (95% CI=23.3%–36.8%) of cases experiencing recurrence during follow-up. In sensitivity analyses, patients younger than 45 years of age with a body mass index <30 kg/m2 who were treated with LIUS-based regimens achieved a high CR rate of 84.6% (95% CI=80.3%–88.1%) over a median follow-up of more than 24 months. Overall pregnancy and live birth rates were 37.9% (95% CI=24.1%–53.9%) and 39.3% (95% CI=24.0%–57.0%), respectively. No statistical differences were apparent in CR or relapse rates among the LIUS+GnRH agonist, LIUS+oral progesterone, or hysteroscopic resection followed by LIUS subgroups. Conclusion: LIUS-based therapies are viable for the conservative management of early-stage endometrioid EC on CR and fertility outcome.
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PCDH8 protects MPP+-induced neuronal injury in SH-SY5Y cells by inhibiting MAPK pathway
Wei Huaming,Wu Yuping,Zhuang Huanxia,Su Hongyi 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2
Background Parkinson's disease (PD) is a common degenerative disease of the nervous system in the elderly. Objectives To investigate the eff ect of protocadherin 8 (PCDH8) on PD and explore the underlying mechanism. Results PCDH8 was down-regulated in PD. Silencing PCDH8 inhibited cell viability, increased cell cytotoxicity and apoptosis, but overexpression of PCDH8 acted the opposed eff ects. Then, silencing PCDH8 increased the levels of IL-1β, IL-8, TNF-α and ROS production, but decreased SOD and CAT activity, while up-regulation of PCDH8 acted the opposed eff ects. In addition, down-regulation of PCDH8 activated MAPK pathway, but up-regulation of PCDH8 inhibited MAPK pathway. Furthermore, in SH-SY5Y cells treated by MPP + , SB203580 reversed cell injuries induced by silencing PCDH8. Conclusion PCDH8 was down-regulated in PD, and PCDH8 protected MPP + -induced neuronal injury in SH-SY5Y cells via inhibiting MAPK pathway.
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Xu Zhou,Hongyi Chen,Shu-Hong Gao,Songfang Han,Renjie Tu,Wei Wei,Chen Cai,Peng Liu,Wenbiao Jin,Qilin Wang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.10
The advanced oxidization process has proven to be an effective conditioning technique for the improvement of sludge dewaterability. Zero-valent iron (ZVI) is often used as the catalyst of the oxidization process. This study applied ZVI with different particle sizes to the ZVI- peroxydisulfate reactions, and investigated their effects on the improvement of sludge dewaterability. It was found that ZVI particles with smaller sizes (100 and 400 meshes) led to slightly higher enhancement of sludge dewaterability (69.1%-72%) than the larger size particles (20-40 meshes) with the reduction rate of CST by 64%. However, after the treatment, the recycle rate of larger size ZVI particles was obviously higher than the small sizes ZVI particles: 98.3% vs. 87.6-89.7%. Different surface areas of the ZVI particles with different sizes might contribute to the phenomenon. For the small ZVI particles with the sizes of 100 and 400 meshes, no obvious differences of oxidization effects and the improvements of sludge dewaterability were found between them, which might be because an oxide layer could have been formed on the surface of fine ZVI particles and led to agglomeration. According to the economical analysis, the small particles (100 and 400 meshes) of ZVI were more economically favorable for the oxidative conditioning process with ZVI-peroxydisulfate than large ZVI particles (20-40 meshes).
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Seismic Response Analysis of Self-anchored Suspension Bridge with Multi-tower
Zhiqiang Wang,Wei Xiao,Hongyi Wei 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4
Seismic performance of a self-anchored suspension bridge with three-tower were investigated. A three-dimensional nonlinear finite element model of the bridge was developed using Sap2000. Nonlinear time history analysis was conducted using Fast Nonlinear Analysis Method (FNA), while beam-column effect and nonlinear behavior of bearing and damper were taken into consideration. The analyze results showed that the middle tower was more vulnerable compared with the two side towers; there existed risk of buckling of composite beam, and the most vulnerable part lied near steel-concrete composite segment. Viscous dampers were effective to reduce seismic response of towers as well as girders.
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Zhang Jiali,Guo Xin,Xu Fanshu,Chen Lihui,Wei Hongyi 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.1
Metallothioneins are ubiquitously-expressed metal-binding proteins. Despite their potential ecological relevance, no prior reports have identified any metallothioneins in Ostrinia furnacalis or other Lepidoptera species. A better understanding of the molecular characteristics and regulatory dynamics of metallothionein genes in O. furnacalis under heavy metal stress conditions would enable future studies of the roles played by these proteins in the context of heavy metal detoxification. Herein, we identified and characterized two metallothionein (OfMT) genes in O. furnacalis, including the 147 bp OfMT1 gene encoding a 48 amino acid protein containing 10 cysteine residues, and the 141 bp OfMT2 gene encoding a 46 amino acid protein containing 12 cysteine residues. The expression of OfMT2 was found to be related to Cu and Cd concentrations in a dose-dependent manner but was unaffected by Zn exposure. Overall, these results indicate that OfMT genes likely encode metal-binding proteins consistent with their potential role in the maintenance of heavy metal homeostasis.
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