대장에 발생한 샘암종에서 MUC1과 MUC2 점소 발현의 의의

이윤경,이주호,이용,심재영,박정훈,오수섭,박진실,기근홍 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Background : Mucins possess the unique function of protecting and lubricating the epithelial surface and other important functions such as call growth, direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, immune regulation, cellular adhesion and metastasis. Purpose : This study was done to provide the significance of alteration of MUC1 and MUC2 expression in colorectal adenocarcinoma, A series of 131 colorectal adenocarcinomas including 11 mucinous carcinomas were screened immunohistochemically for their expression of MUCI and MUC2, Materials and mehtods : Of 131 carcinomas, 76 (58,5%) were MUCI positive and 91 (68, 9%) were MUC2 positive, In normal colonic goblet cells, MUCl was not expressed but MUC2 was expressed in cytoplasm, Conclusion There were up-regulation of MUCI and down-regulation of MUC2 in colorectal carcinomas, The frequency of MUC2 positivity according to differentiation was statistically reliable. (p=0.0001)

Experimental and numerical investigation of uplift behavior of umbrella-shaped ground anchor

Zhu, Hong-Hu,Mei, Guo-Xiong,Xu, Min,Liu, Yi,Yin, Jian-Hua Techno-Press 2014 Geomechanics & engineering Vol.7 No.2

In the past decade, different types of underreamed ground anchors have been developed for substructures requiring uplift resistance. This article introduces a new type of umbrella-shaped anchor. The uplift behavior of this ground anchor in clay is studied through a series of laboratory and field uplift tests. The test results show that the umbrella-shaped anchor has higher uplift capacity than conventional anchors. The failure mode of the umbrella-shaped anchor in a large embedment depth can be characterized by an arc failure surface and the dimension of the plastic zone depends on the anchor diameter. The anchor diameter and embedment depth have significant influence on the uplift behavior. A finite element model is established to simulate the pullout of the ground anchor. A parametric study using this model is conducted to study the effects of the elastic modulus, cohesion, and friction angle of soils on the load-displacement relationship of the ground anchor. It is found that the larger the elastic modulus and the shear strength parameters, the higher the uplift capacity of the ground anchor. It is suggested that in engineering design, the soil with stiffer modulus and higher shear strength should be selected as the bearing stratum of this type of anchor.

Physical modelling of sliding failure of concrete gravity dam under overloading condition

Zhu, Hong-Hu,Yin, Jian-Hua,Dong, Jian-Hua,Zhang, Lin Techno-Press 2010 Geomechanics & engineering Vol.2 No.2

Sliding within the dam foundation is one of the key failure modes of a gravity dam. A two-dimensional (2-D) physical model test has been conducted to study the sliding failure of a concrete gravity dam under overloading conditions. This model dam was instrumented with strain rosettes, linear variable displacement transformers (LVDTs), and embedded fiber Bragg grating (FBG) sensing bars. The surface and internal displacements of the dam structure and the strain distributions on the dam body were measured with high accuracy. The setup of the model with instrumentation is described and the monitoring data are presented and analyzed in this paper. The deformation process and failure mechanism of dam sliding within the rock foundation are investigated based on the test results. It is found that the horizontal displacements at the toe and heel indicate the dam stability condition. During overloading, the cracking zone in the foundation can be simplified as a triangle with gradually increased height and vertex angle.

An optical fibre monitoring system for evaluating the performance of a soil nailed slope

Hong-Hu Zhu,Albert N.L. Ho,Jian-Hua Yin,H.W. Sun,Hua-Fu Pei,Cheng-Yu Hong 국제구조공학회 2012 Smart Structures and Systems, An International Jou Vol.9 No.5

Conventional geotechnical instrumentation techniques available for monitoring of slopes, especially soil-nailed slopes have limitations such as electromagnetic interference, low accuracy, poor longterm reliability and difficulty in mounting a series of strain sensors on a soil nail bar with a small-diameter. This paper presents a slope monitoring system based on fibre Bragg grating (FBG) sensing technology. This monitoring system is designed to perform long-term monitoring of slope movements, strains along soil nails, and other slope reinforcement elements. All these FBG sensors are fabricated and calibrated in laboratory and a trial of this monitoring system has been successfully conducted on a roadside slope in Hong Kong. As part of the slope stability improvement works, soil nails and a toe support soldier-pile wall were constructed. During the slope works, more than 100 FBG sensors were installed on a soil nail, a soldier pile, and an in- place inclinometer. The paper presents the layout and arrangement of the instruments as well as the installation procedures adopted. Monitoring data have been collected since March 2008. This trial has demonstrated the great potential of the optical fibre monitoring system for long-term monitoring of slope performance. The advantages of the slope monitoring system and experience gained in the field implementation are also discussed in the paper.

Settlement analysis of viscoelastic foundation under vertical line load using a fractional Kelvin-Voigt model

Zhu, Hong-Hu,Liu, Lin-Chao,Pei, Hua-Fu,Shi, Bin Techno-Press 2012 Geomechanics & engineering Vol.4 No.1

Soil foundations exhibit significant creeping deformation, which may result in excessive settlement and failure of superstructures. Based on the theory of viscoelasticity and fractional calculus, a fractional Kelvin-Voigt model is proposed to account for the time-dependent behavior of soil foundation under vertical line load. Analytical solution of settlements in the foundation was derived using Laplace transforms. The influence of the model parameters on the time-dependent settlement is studied through a parametric study. Results indicate that the settlement-time relationship can be accurately captured by varying values of the fractional order of differential operator and the coefficient of viscosity. In comparison with the classical Kelvin-Voigt model, the fractional model can provide a more accurate prediction of long-term settlements of soil foundation. The determination of influential distance also affects the calculation of settlements.

A NOVEL FUNCTIONAL MATERIAL OF Ag-S$i_3N_4$ NANOSTRUCTURED COMPOSITE

Zhu, Zhu, Yi-Hun,Zhu, Zhu, Hong-Jie,Han, Han, Jin-Yi,Hu, Li-Ming 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.1

$Ag-Si_3N_4$ nanostrutured composite has been investigated. The results show that it exhibits some novel properties such as strong piezpelectricity and high dielectricity. It can be constituted a battery using graphite and aluminum as the positive and the negative electrodes, respectively. The origins of these properties have been discussed.

An optical fibre monitoring system for evaluating the performance of a soil nailed slope

Zhu, Hong-Hu,Ho, Albert N.L.,Yin, Jian-Hua,Sun, H.W.,Pei, Hua-Fu,Hong, Cheng-Yu Techno-Press 2012 Smart Structures and Systems, An International Jou Vol.9 No.5

Conventional geotechnical instrumentation techniques available for monitoring of slopes, especially soil-nailed slopes have limitations such as electromagnetic interference, low accuracy, poor longterm reliability and difficulty in mounting a series of strain sensors on a soil nail bar with a small-diameter. This paper presents a slope monitoring system based on fibre Bragg grating (FBG) sensing technology. This monitoring system is designed to perform long-term monitoring of slope movements, strains along soil nails, and other slope reinforcement elements. All these FBG sensors are fabricated and calibrated in laboratory and a trial of this monitoring system has been successfully conducted on a roadside slope in Hong Kong. As part of the slope stability improvement works, soil nails and a toe support soldier-pile wall were constructed. During the slope works, more than 100 FBG sensors were installed on a soil nail, a soldier pile, and an in- place inclinometer. The paper presents the layout and arrangement of the instruments as well as the installation procedures adopted. Monitoring data have been collected since March 2008. This trial has demonstrated the great potential of the optical fibre monitoring system for long-term monitoring of slope performance. The advantages of the slope monitoring system and experience gained in the field implementation are also discussed in the paper.

Comparison of the Adsorption Characteristics of Expanded Bed Adsorbent with Conventional Chromatographic Adsorbent

Hu, Hong Bo,Yao, Shan Jing,Zhu, Zi Qiang,Hur, Byung Ki 한국화학공학회 2001 Korean Journal of Chemical Engineering Vol.18 No.3

The static and kinetic adsorption characteristics of Streamline DEAF and DEAF-Sepharose FF were studied under various operating conditions. The adsorption isotherms for the two types of adsorbents were obtained and found to fit well to a Langmuir-type expression. The adsorption kinetics of Streamline DEAF at different concentrations, temperatures, and viscosities were studied and a mathematical model including particle size distribution was developed to describe the adsorption performance of Streamline DEAE. Comparing the uptake curves of Streamline DEAF with DEAF-Sepharose FF, it could be concluded that Streamline DEAF achieves equilibrium faster to get equilibrium than DEAE-Sepharose FF, indicating that Streamline DEAF could be used in higher flow rate systems.

Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies

Hu, Zheng-Hui,Lin, Yi-Wei,Xu, Xin,Chen, Hong,Mao, Ye-Qing,Wu, Jian,Zhu, Yi,Xu, Xiang-Lai,Xie, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: Many studies have investigated associations between the glutathione S-transferase M1 (GSTM1) null polymorphism and risk of prostate cancer, but the impact of GSTM1 in people who live in Asian countries is still unclear owing to inconsistencies across results. Methods: We searched the PubMed, Web of Science, Scopus, Ovid and CNKI databases for studies of associations between the GSTM1 null genotype and risk of prostate cancer in people who live in Asian countries, and estimated summary odds ratios (ORs) with 95% confidence intervals (95% CIs). Results: A total of 18 case-control studies with 2,172 cases and 3,258 controls were included in this meta-analysis, which showed the GSTM1 null genotype to be significantly associated with increased risk of prostate cancer in people who live in Asian countries (random-effects OR=1.74, 95% CI1.44-2.09, P<0.001). Similar results were found in East Asians (OR=1.41; 95% CI: 1.12-1.78; P=0.004) and Caucasians in Asia (OR=2.19; 95% CI: 1.85-2.60; P<0.001). No evidence of publication bias was observed. Conclusions: This meta-analysis of available data suggested that the GSTM1 null genotype does contribute to increased risk of prostate cancer in people who live in Asian countries.

Bayesian ballast damage detection utilizing a modified evolutionary algorithm

Hu, Qin,Lam, Heung Fai,Zhu, Hong Ping,Alabi, Stephen Adeyemi Techno-Press 2018 Smart Structures and Systems, An International Jou Vol.21 No.4

This paper reports the development of a theoretically rigorous method for permanent way engineers to assess the condition of railway ballast under a concrete sleeper with the potential to be extended to a smart system for long-term health monitoring of railway ballast. Owing to the uncertainties induced by the problems of modeling error and measurement noise, the Bayesian approach was followed in the development. After the selection of the most plausible model class for describing the damage status of the rail-sleeper-ballast system, Bayesian model updating is adopted to calculate the posterior PDF of the ballast stiffness at various regions under the sleeper. An obvious drop in ballast stiffness at a region under the sleeper is an evidence of ballast damage. In model updating, the model that can minimize the discrepancy between the measured and model-predicted modal parameters can be considered as the most probable model for calculating the posterior PDF under the Bayesian framework. To address the problems of non-uniqueness and local minima in the model updating process, a two-stage hybrid optimization method was developed. The modified evolutionary algorithm was developed in the first stage to identify the important regions in the parameter space and resulting in a set of initial trials for deterministic optimization to locate all most probable models in the second stage. The proposed methodology was numerically and experimentally verified. Using the identified model, a series of comprehensive numerical case studies was carried out to investigate the effects of data quantity and quality on the results of ballast damage detection. Difficulties to be overcome before the proposed method can be extended to a long-term ballast monitoring system are discussed in the conclusion.