근관세척액의 세포독성 효과

임미경,정희일,오세홍 원광대학교 생체재료·매식연구소 1995 원광생체재료·매식 Vol.4 No.1

Balance between antibacterial effectiveness and biocompatibility is important property of root canal irrigation solutions. The aim of this study was to evaluate the cytotoxic effect of irrigation solutions on cultured L929 cells. Seven irrigation solutions and thier serial dilution solution were applied to L929 cells. Radiochromium release of damaged L929 cells after five-minute, thirty-minute and four-hours exposure to each irrigation solutions were monitored using gamma particle counter. L929 cells which were exposed to 1:1 and 1:10 diluted solutions of sodium hypochlorite and cresol for five and thirty minutes showed cytotoxic change. Povidone had cytotoxic effect on L929 cells after five minutes, thirty minutes and four hours. Normal saline, alcohol, Wydex and hydrogen peroxide showed weak cytotoxic effect on L929 cells.

혈액투석환자의 우울에 관한 연구

소희영,김종임,김홍선 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1

This study was conducted to assess degree of depression of hemodialysis patients, and to determine the influence of self--concept and Locus of Control on depression. The subjects were 28 adult patients being treated for hemodialysis at the artificial kidney unit of three hospitals in Seoul and Taejeon. Data was collected from Aug. 1, 1984 to Feb. 28, 1985, referencing the Beck's Inventory for depression, Jacox and Stewart's Health self-concept scale, and Walston's Health Locus of Control Scale. The analysis of data was done by use of percentage, t-test, Analysis of Variance, Pearson Correlation Coefficient, and Multiple Stepwise Regression. The findings of this study are as follows; 1. There were no signicant differences between dermographic characteristics and variables except highly significant difference between depression and occupation (t=-2.38, p=0.025). 2. There was no signicant correlation with the depression and Locus of Control(r=0.3064, p=0.056), but highly significant negative correlation with the depression and self-concept(r=-0.6445, p=0.000). 3. 41.53% of depression can be explained by self concept and 1.1% by Locus of Control.

구강체온, 서혜부체온 및 액와체온에 관한 실험적 비교 연구

김종임,소희영,김홍선 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

The purposes of this study are to determine differences of body temperature between sublingual, groin and axilla areas and to determine the length of time necessary for temperature taking from 60 women who were student of nursing department, Chungnam National University School of Medicine. This experiment was conducted from May to July, 1983. The electric centigrade thermometer was utilized. Three electric centigrade thermometer probes were inserted in tern under groin, axilla and sublingual areas, and these areas were kept closed while probes were inserted. Temperature readings were taken and recorded at one minute intervals during 10-minute. The temperature was timed using a stopwatch. The data were statistically analyzed by means of the ANOVA, the 2-way ANOVA and cumulative percentage. The results obtained were as follows; 1. The average maximum body temperatures in the sublingual area, groin and axilla were 37.10℃, 36.53℃ and 36.74℃, respectively. The difference of three maximum temperatures was not significant (F=0.556, df=2.17, p=0.5745). 2. The time required for maximum body temperature of oral, groin and axillary temperature were 8.46 minutes, 9.81 minutes and 9.62 minutes. Out of these results, measuring groin temperature is a recommendable way of measuring body temperature, and the use of electric thermometer for body temperature measurement is not yet significant.

기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성

박태원,홍영준,박임순,김형섭,최인미,배수영,윤경식,강대희 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : Catechol-O-Methyltransferase(COMT)는 카테콜아민 신경전달물질의 불활성화를 담당하는 효소로서, 정신분열병과 관련된 후보 유전자로서 알려져 왔다. 최근, 기능성 COMT유전자 다형성과 정신분열병의 관련성이 제기되었는데, 한국인 정신분열병에서도 이러한 관련성이 있는지를 살피기 위해 본 연구를 시행하였다. 방 법 : 정신분열병으로 진단된 환자군 103명과 성별 및 연령별로 1:1 짝짓기 대조군 사이에 유전자형과 대립유전자의 분포를 비교하였다. 또한, 환자군은 공격적 행동, 가족력, 아동기 발병 여부에 따라 두 군으로 나누어 비교하였다. DNA의 다형성 부의를 중합효소연쇄반응에 의해 증폭한 후 ,NlaⅢ제한효소법과 전기영동을 실시하여 유전자형을 판별하였다. 결 과 : 환자군 전체와 대조군 사이에 유전자형과 대립유전자 빈도의 차이가 없었다. 가족력이 있는 환자군을 대조군과 비교하였을 때는, 대립유전자 L을 포함하는 유전자형과 그렇지 않은 유전자형의 분포에 있어 유의한 차이를 보였다(p=0.02, OR=3.9, 95% Cl=1.1∼14.3). 결 론 : 한국인 정신분열병과 기능성 COMT 유전자 다형성 사이에 유의한 관련성이 없었다. 따라서, 기능성 COMT 유전자 다형성이 한국인 정신분열병의 발병에 영향을 주지 못한다. 그러나, 정신분열병 가족력과 기능성 COMT유전자 다형성의 관련성이 시시돠어, 향후 본 연구에서 나타난 방법론적인 문제점을 보완하고 추가 대상자를 확보한 연구가 필요하다. Objectives : Catechol-O-methyltransferase(COMT) is involved in the degradation of catecholamine meurotransmitters and has been investigated as a candidate gene in schizophrenia. Recently, possible relationship between functional COMT gene polymorphism and schizophrenia has been suggested. To address the possible role of functional COMT gene polymorphism in the predisposition to schizophrenia, we carried out an association study in Korean schizophrenic patients and controls. Methods : One hundred and three Korean inpatients diagnosed as schizophrenia and 103 age and sex matched controls were selected as study subjects. Patients were subgrouped into two groups on the basis of history of aggressive behavior, family history of schizophrenia and related disorders, and age at onset. We determined COMT genotypes using PCR of the relevant region followed by digestion with NlaⅢ and electrophoresis. Results : No significant differences of allele and genotype frequencies were noted between patients and controls. However, when patients were categorized by the presence of family history of schizophrenia and related disorders, patients with family history showed almost 4 fold higher frequency of having COMT L allele containing genotype compared to controls(p=0.02, OR=3.9, 9.5% CI=1.10-14.33). Conclusion : Although our results do not support an association between functional polymorphism of COMT gene and schizophrenia overall, the findings suggest an association between functional COMT gene polymorphism and familial schizophrenia. Further studies with large samples are needed to confirm this association.

페트리 네트를 이용한 유연 로봇 조립셀의 시뮬레이션에 관한 연구

임용희(Yong-Hee Im),홍지민(Ji-Min Hong),이기동(Ki-Dong Lee),김대원(Dae-Won Kim),이범희(Bum-Hee Lee) 대한전자공학회 1992 대한전자공학회 학술대회 Vol.1992 No.10

A flexible robotic assembly cell is modeled using Petri net. A simulator is developed and used to predict the optimal status of the system. The assembly cell of flexible manufaturing system(FMS) pilot plant of Automation and Systems Research Institute(ASRI) in Seoul National University is modeled. The system consists of 3 robots, 4 conveyors, automatic guided vehicle(AGV) and auto-stacker. The simulator is programmed in Turbo C on IBM PC, supporting a simple graphic simulation with pull-down menu. The flexibility of the assembly cell in the FMS plant is guaranteed, since it is possible to predict the optimal status of the system using this simulator.

페트리 네트를 이용한 유연 로봇 조립셀의 시뮬레이션에 관한 연구

임용희(Yong-Hee Im),홍지민(Ji-Min Hong),이기동(Ki-Dong Lee),김대원(Dae-Won Kim),이범희(Bum-Hee Lee) 제어로봇시스템학회 1992 제어로봇시스템학회 국내학술대회 논문집 Vol.1 No.1

The outcome of hematopoietic stem cell transplantation in Korean children with hemophagocytic lymphohistiocytosis

Yoon, Hoi Soo,Im, Ho Joon,Moon, Hyung Nam,Lee, Jae Hee,Kim, Hee-Jin,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong Hoe,Kang, Hyung Jin,Shin, Hee Young,Ahn, Hyo Seop,Cho, Bin,Kim, Hack Ki,Lyu, Chuhl Joo,Lee, M Blackwell Publishing Ltd 2010 Pediatric transplantation Vol.14 No.6

<P>Yoon HS, Im HJ, Moon HN, Lee JH, Kim H-J, Yoo KH, Sung KW, Koo HH, Kang HJ, Shin HY, Ahn HS, Cho B, Kim HK, Lyu CJ, Lee MJ, Kook H, Hwang TJ, Seo JJ. The outcome of hematopoietic stem cell transplantation in Korean children with hemophagocytic lymphohistiocytosis.Pediatr Transplantation 2010: 14:735–740. © 2010 John Wiley & Sons A/S.</P><P>Abstract: </P><P>Chemoimmunotherapy-based treatments have improved the survival of patients with HLH, but outcomes of the patients are still unsatisfactory. We report here the outcome of Korean children with HLH who underwent HSCT, which was analyzed from the data of a nation-wide HLH registry. Retrospective nation-wide data recruitment for the pediatric HLH patients diagnosed between 1996 and 2008 was carried out by the Histiocytosis Working Party of the Korean Society of Hematology. Nineteen patients who received HSCT among the total of 148 enrolled children with HLH were analyzed for the transplant-related variables and events. The probability of five-yr survival after HSCT was 73.3% with a median follow-up of 57. Two months compared to 54.3% for the patients who were treated with chemoimmunotherapy only (p<I> </I>=<I> </I>0.05). The reasons for HSCT were active disease after eight wk of initial treatment (n = 9), relapsed disease (n = 5), and FHL (n = 5). Fourteen patients are currently alive without disease after HSCT, four patients died of treatment-related events (infection in two and graft failure in two) at early post-transplant period, and one patient died of relapse at one yr post transplantation. The survival of patients who were transplanted because of active disease after eight wk of initial treatment was worse compared to those patients who had inactive state at that time (60.6% vs. 100%, respectively, p<I> </I>=<I> </I>0.06). Of the four patients who received transplants using cord blood, three died of graft failure (n = 2) and relapse (n = 1). The five-yr probability of survival after HSCT according to the donor type was 85.7% for the MRDs (n = 6), 87.5% for the MUDs (n = 8), and 40% for the MMUDs (n = 5) (p<I> </I>=<I> </I>0.03). Other variables such as age, CNS involvement at the time of diagnosis, the etiology of HLH (familial or secondary), and the conditioning regimens had no influence on the five-yr OS of the HLH patients who underwent HSCT. HSCT improved the survival of the patients who had familial, relapsed, or severe and persistent SHLH in the Korean nation-wide HLH registry. Although numbers were small, these results are similar to other reports in the literature. The disease state after initial treatment, the stem cell source of the transplant, and the donor type were the important prognostic factors that affected the OS of the HLH patients who underwent HSCT.</P>

Functional SiO2–TiO2–PEG hybrid resin by direct chelation with catecholic compound

Hong, Lan-Young,Yoon, Tae-Ho,Ryoo, Hyang-Im,Jung, Sang-Hee,Kim, Dong-Pyo Springer-Verlag 2011 Journal of sol-gel science and technology Vol.57 No.3

Effect of water-droplet sizes and radiation-field exposure on the transfer of I2 and CH3I gases adsorbed in water

Im, Hee-Jung,Pham, Thang Tien,Kim, Hong-Hyun,Yeon, Jei-Won Springer-Verlag 2018 Journal of radioanalytical and nuclear chemistry Vol.317 No.2

환경특성과 환경경계연결활동에 관한 연구

임창희,이홍기 홍익대학교 경영연구소 1997 경영연구 Vol.22 No.-