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소아에서 편도절제술 시행시 진통효과 : Tramadol과 Meperidine의 비교
소금영,식홍림,임시경,안태훈,임태승 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.3
Background: Pain is major problem regarding quality of life in children undergoing tonsillectomy. Preemptive analgesia by medicine given before commencement of surgery is a new recommended for relief of pain during and after operation. We compared intra-and postoperative analgesic and recovery characteristics of tramadol, meperidine given at induction of anesthesia in 40 ASA I or II children undergoing tonsillectomy with or without adenoidectomy. Materias and Methods: Fourty children aged 4-7 years undergoing tonsillectomy with or without adenoidectomy were randomly assigned to receive either tramadol 2 mg/kg (group 1) or meperidine 1 mg/kg (group 2) at induction of anesthesia. Thiopental sodium (5 mg/kg) and rocuronium (0.6 mg/kg) were used for the induction of anesthesia, and it was maintained with sevoflurane in N₂O/O₂50/50 via an endotracheal tube. Pain assessment was done by facial pain scale. Agitation scores, time to recovery of spontaneous respiration and the incidence of postoperative nausea and vomiting. Heart rate and mean arterial pressure was recorded at regular intervals. Results: Facial pain scale scores were increased in group 1 at 10 and 20 min in recovery room. There was no difference for agitation scores in the two groups. Intraoperative mean arterial pressure (15th min) were found to be higher in group 1. The time to recovery of spontaneous respiration was delayed with group 2 compared with group 1. The incidence of nausea and vomiting was not statistically differed between groups. Conclusions: Meperidine was more effective for pain relief than tramadol after tonsillectomy in children.
강신몽,이원태,고영창,최상규,김윤희,이홍석,서재관,윤중진,이혜경,최득린,김종열,윤창육,변명식,이장홍 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2
Individual identification is an important part in medicolegal field especially in mass disaster. At July, 27, 1989, KAL KE-803 was crashed on landing at Tripoli International Airport, Liba. The plane was caught in fire and sixty eight Koreans were sacrified. The majority of victims were severely charred and injured. The authors examed all dead bodies and successfully identified all the cases through visual, anthropological, odontological, radiological and pathological methods including fingerprint and blood typing.
Hong-Lin Xu,Guang-Hong Chen,Yu-Ting Wu,Ling-Peng Xie,Zhang-Bin Tan,Bin Liu,Hui-Jie Fan,Hong-Mei Chen,Gui-Qiong Huang,Min Liu,Ying-Chun Zhou 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.1
Background: Panax ginseng Meyer (P. ginseng), a herb distributed in Korea, China and Japan, exerts benefits on diverse inflammatory conditions. However, the underlying mechanism and active ingredients remains largely unclear. Herein, we aimed to explore the active ingredients of P. ginseng against inflammation and elucidate underlying mechanisms. Methods: Inflammation model was constructed by lipopolysaccharide (LPS) in C57BL/6 mice and RAW264.7 macrophages. Molecular docking, molecular dynamics, surface plasmon resonance imaging (SPRi) and immunofluorescence were utilized to predict active component. Results: P. ginseng significantly inhibited LPS-induced lung injury and the expression of proinflammatory factors, including TNF-a, IL-6 and IL-1b. Additionally, P. ginseng blocked fluorescence-labeled LPS (LPS488) binding to the membranes of RAW264.7 macrophages, the phosphorylation of nuclear factor-kB (NF-kB) and mitogen-activated protein kinases (MAPKs). Furthermore, molecular docking demonstrated that ginsenoside Ro (GRo) docked into the LPS binding site of toll like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) complex. Molecular dynamic simulations showed that the MD2-GRo binding conformation was stable. SPRi demonstrated an excellent interaction between TLR4/MD2 complex and GRo (KD value of 1.16 × 10<SUP>-9</SUP> M). GRo significantly inhibited LPS488 binding to cell membranes. Further studies showed that GRo markedly suppressed LPS-triggered lung injury, the transcription and secretion levels of TNF-α, IL-6 and IL-1β. Moreover, the phosphorylation of NF-kB and MAPKs as well as the p65 subunit nuclear translocation were inhibited by GRo dose-dependently. Conclusion: Our results suggest that GRo exerts anti-inflammation actions by direct inhibition of TLR4 signaling pathway.
EFFECTIVE SYNTHESIS AND APPLICATION OF ZAO NANOPARTICLES WITH GOOD DISPERSION
LIN-LIN ZHANG,HONG-ZHEN XIE,MIN ZHANG,JIN-KU LIU,XIAO-HONG YANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.3
The well dispersed ZAO nanoparticle with 25?30 nm in diameter was prepared by an ultrasonictemplate method. The morphologies, structures, and photoelectricity of the ZAO nanoparticles were analyzed by TEM, XRD, UV-Vis, etc. The thermochemistry behaviors of the precursor were studied by TG-DSC. The composite ¯lm with semipermeable structure made from ZAO nanoparticles and collodion can be explored ¯rstly. The photocatalytic properties of the ZAO nanoparticles and composite ¯lm were investigated. The composite ¯lm can be applied in the sewage treatment ¯eld.
Chih-Hong Lin 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4
The Editor-in-Chief has retracted this article [1] because it contains significant overlap with a previous publication by the same author [2]. This article is therefore redundant. Author Chih-Hong Lin agrees to this retraction.
Improvement in the Image Quality and the Capacity of the Reversible Data Hiding
Hong Lin JIN,Masaaki FUJIYOSHI,Hitoshi KIYA 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
This paper proposes a reversible data hiding method in the spatial domain. A reversible data hiding method not only extracts hidden data from a stego image that conveys data but also restores the original image. The proposed method modulates pixel values adaptively and reversibly before an embedding process to improve the image quality of a stego image and simultaneously to increase the capacity. Simulation results show the effectiveness of the proposed method.
Hong-Lin Zhu,Hui Luo,Xiao-Xia Zuo 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.9
miRNAs are important post-transcriptional regulators. The aberrant expression of miRNAs is strongly associated with the initiation and progression of pathophysiologic processes in a wide range of human diseases. Scleroderma (systemic sclerosis;SSc) is a highly heterogeneous autoimmune disease that includes the progressive fibrotic replacement of normal tissue architecture in multiple organs. Our previous studies have suggested that SSc skin tissues display a different miRNA expression signature than that found in normal controls. miRNAs with pro- or antifibrotic properties are found to be dysregulated in SSc skin fibrosis. Serum miRNA levels are associated with SSc activity and severity. miRNAs have the potential to be therapeutic targets and serve as biomarkers for SSc diagnosis and assessment of disease state and severity. This review summarizes the SSc miRNA expression signature and the roles of dysregulation of miRNAs in SSc tissues and serum and examines the future therapeutic potential of targeting miRNAs in the management of SSc patients.
Lin, Chih-Hong The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.1
Because the wheel of V-belt continuously variable transmission (CVT) system driven by permanent magnet synchronous motor (PMSM) has much unknown nonlinear and time-varying characteristics, the better control performance design for the linear control design is a time consuming job. In order to overcome difficulties for design of the linear controllers, a hybrid recurrent Chebyshev neural network (NN) control system is proposed to control for a PMSM servo-driven V-belt CVT system under the occurrence of the lumped nonlinear load disturbances. The hybrid recurrent Chebyshev NN control system consists of an inspector control, a recurrent Chebyshev NN control with adaptive law and a recouped control. Moreover, the online parameters tuning methodology of adaptive law in the recurrent Chebyshev NN can be derived according to the Lyapunov stability theorem and the gradient descent method. Furthermore, the optimal learning rate of the parameters based on discrete-type Lyapunov function is derived to achieve fast convergence. The recurrent Chebyshev NN with fast convergence has the online learning ability to respond to the system's nonlinear and time-varying behaviors. Finally, to show the effectiveness of the proposed control scheme, comparative studies are demonstrated by experimental results.
중국 M&A의 실패사례에 관한 연구 -상하이자동차와 쌍용자동차의 M&A사례를 중심으로-
( Lin Hong ),정강원 ( Kang-one Jeong ) 공주대학교 KNU 기업경영연구소 2010 기업경영리뷰 Vol.1 No.1
본 논문은 중국 상하이 자동차와 쌍용 자동차의 합병사례를 통하여 중국기업들의 M&A과정에서 발생하는 문제점을 살펴보고 성공적인 M&A를 위한 방안을 모색하고자 하였으며, 중국기업의 성공적인 글로벌 M&A를 위해 고려하여야 할 요소로서 다음과 같은 결론을 도출하였다. 중국기업의 글로벌 M&A의 발전을 위해서는 국제시장의 통용되는 규칙을 준수해야 하는 것은 물론이고 다음과 같은 점들을 유념하여야 한다. 먼저, 인수합병 전 기업의 자기검진이 필요하다. 둘째, 확실한 인수합병 전략을 수립하라. 인수 시, 그 시장에서 획득할 수 있는 것이 무엇인가, 어떤 기업이 정말 필요한가를 명확히 알아야 한다. 인수합병 관련 법규를 확실히 알고 세밀히 연구해야 한다. 셋째, 인수합병의 방식을 결정해야 한다. 합병협상만으로 M&A가 종결되는 것이 아니라 인수합병은 M&A의 실질적인 시작이므로 장기적으로 이윤창출의 공동 목표를 실행하고, 안정적이고 현실적인 변혁의 방법을 통해 안정적인 관리 계획과 문제 해결체계를 구축해야 한다. This study is aimed to examine the concept of M&A and related theories and to analyze the case of SAIC's M&A of SSangyong Motor to look for the problems occurred in the process of M&A and the measures for a successful M&A. application of statistic data and existing literature was used as the research method. The construction of this study is as blow: In the introduction, the purpose and the method of this study were explained; in chapter 1 to chapter 2, the history and the trend of global M&A, the history and the trend of Chinese M&A, and M&A related theories (FDI theory, the basic theory of M&A, the strategic model of amalgamation, evaluation of target enterprise, analysis and selection of merger loan of multinational enterprise, integrated study of M&A) were described; in chapter 3, the M&A case of SAIC and Ssangyong Motor was analyzed. Regarding to the main cause of the failure of SAIC's M&A of Ssangyong, this study points that: (1)The analysis of Ssangyong which was SAIC's target enterprise was not thoroughgoing enough; (2)There was organizational mismanagement after the M&A; (3)The organizational and cultural integration between two companies has failed. It also suggested few measures for a successful M&A which are active government support, nurturing talent, and preparation of cultural integration of organization. However, this study has its limitation because: it only analyzed one case which made its problem related outcome restrictive; there was no analysis of successful case of M&A.