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막성 장염과 함께 발생한 반코마이신 내성 장구균 요로감염 예 1
김정관 ( Jeong Gwan Kim ),김기회 ( Ki Hoe Kim ),박성현 ( Sung Hyun Park ),송지은 ( Ji Eun Song ),오왕국 ( Wang Guk Oh ),김정화 ( Jeong Hwa Kim ),이광영 ( Kwang Yeong Lee ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.1
Infections are the second leading cause of mortality among patients with end-stage renal disease (ESRD). Recently, colonization or infection with vancomycin-resistant enterococci (VRE) is increasing in prevalence at many institutions and is often reported in dialysis patients. Enterococci are generally considered to be of low pathogenicity but may cause urinary tract infection, bacteremia, endocarditis or meningitis in debilitated patients. Three cases of VRE peritonitis in patients on CAPD were reported, but there was no report of VRE urinary tract infection (UTI) in hemodialysis patients in Korea. We present a case of VRE UTI with pseudomembranous colitis (PMC) in an ESRD patient with anal VRE colonization. The VRE UTI was treated successfully with linezolid.
Park, Soon-Young,Im, Jun-Sub,Park, Sung-Rye,Kim, Sang-Eun,Wang, Hoe-Jeong,Lee, Joon-Kyu Landes Bioscience 2012 Cell Cycle Vol.11 No.4
<P>Though the G(1) checkpoint in mammalian cells has been known for decades, the molecular targets that prevent S-phase entry remain unknown. Mimosine is a rare plant amino acid that arrests the cell cycle in the G(1) phase before entry into S phase. Here, we show that mimosine interrupts the binding of Ctf4 to chromatin, which is essential for the initiation of DNA replication in HeLa cells, and this effect is mediated by the Hif-1관-dependent increase in the level of p27. Depletion of Hif-1관 results in an increased binding of Ctf4 to chromatin and the entry of cells into S phase even in the presence of mimosine. These results suggest that the binding of Ctf4 to chromatin is the target of the Hif-1관-dependent checkpoint pathway for cell cycle arrest in G(1) phase. Although we observed Hif-1관-dependent arrest in mimosine-treated cells, it is possible that Ctf4 may act as a common target for G(1) arrest in various other checkpoint pathways.</P>