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Xuan Hung NGUYEN(Xuan Hung NGUYEN ),Thuy Dương TRAN(Thuy Dương TRAN ),Phan Hoai Diem VU(Phan Hoai Diem VU ),Yen Chi DINH(Yen Chi DINH ),Thi Mai Huong DUONG(Thi Mai Huong DUONG ),Thi Ngoc Hien THAN(Thi 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.9
The goal of the study is to examine and assess how the factors of logistics service quality provided by logistics service providers influence customer loyalty and satisfaction in Vietnam. This study employs samples of the Kansei technique. The article’s data was gathered through an online survey of 388 distinct Vietnamese customers who used logistics services before and during the Covid-19 outbreak. After the data was obtained, it was evaluated using SmartPLS 3.0’s Cronbach’s Alpha test and structural equation model (SEM). Staff service quality, operational service quality, and technical service quality are the three factors that determine the quality of logistics services in the study. Out of the 10 proposed hypotheses, research findings show that five are acceptable. The Covid-19 Pandemic in Vietnam had a significant impact on all dimensions, but it had no effect on how satisfied customers were with the logistics service providers. Nevertheless, loyalty is considerably influenced by only one factor, which is customer satisfaction, and customer trust moderates the relationship between these two factors. As a consequence of that, several managerial implications have been proposed to help logistics service providers improve their services to attract and keep Vietnamese customers using their service in the long term.
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Anti-inflammatory tirucallane saponins from Paramignya scandens.
Phan, Nguyen Huu Toan,Thuan, Nguyen Thi Dieu,Ngoc, Ninh Thi,Thao, Nguyen Phuong,Kim, Sohyun,Koh, Young Sang,Thanh, Nguyen Van,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Kiem, Phan Van,Kim, Young Ho,Minh, Cha Pharmaceutical Society of Japan 2015 Chemical & pharmaceutical bulletin Vol.63 No.7
<P>Five new tirucallane saponins, paramignyosides A-E (1-5), were isolated from the water fraction of the Paramignya scandens stem and leaves. Their structures were elucidated on the basis of spectroscopic evidence including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and one dimensional (1D)- and 2D-NMR. The effects of isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Paramignyoside C (3) exhibited selective and potent inhibitory effect (IC50=5.030.19??M) on the production of IL-12 p40 comparable to that of the positive control, SB203580 (IC50=5.000.16??M). Further studies are required to confirm efficacy in vivo and the mechanism of anti-inflammatory effects.</P>
Anti-inflammatory Asterosaponins from the Starfish <i>Astropecten monacanthus</i>
Thao, Nguyen Phuong,Cuong, Nguyen Xuan,Luyen, Bui Thi Thuy,Thanh, Nguyen Van,Nhiem, Nguyen Xuan,Koh, Young-Sang,Ly, Bui Minh,Nam, Nguyen Hoai,Kiem, Phan Van,Minh, Chau Van,Kim, Young Ho American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.9
<P>Four new asterosaponins, astrosteriosides A–D (<B>1</B>–<B>3</B> and <B>5</B>), and two known compounds, psilasteroside (<B>4</B>) and marthasteroside B (<B>6</B>), were isolated from the MeOH extract of the edible Vietnamese starfish <I>Astropecten monacanthus</I>. Their structures were elucidated by chemical and spectroscopic methods including FTICRMS and 1D and 2D NMR experiments. The effects of the extracts and isolated compounds on pro-inflammatory cytokines were evaluated by measuring the production of IL-12 p40, IL-6, and TNF-α in LPS-stimulated bone marrow-derived dendritic cells. Compounds <B>1</B>, <B>5</B>, and <B>6</B> exhibited potent anti-inflammatory activity comparable to that of the positive control. Further studies are required to confirm efficacy <I>in vivo</I> and the mechanism of effects. Such potent anti-inflammatory activities render compounds <B>1</B>, <B>5</B>, and <B>6</B> important materials for further applications including complementary inflammation remedies and/or functional foods and nutraceuticals.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-9/np400492a/production/images/medium/np-2013-00492a_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400492a'>ACS Electronic Supporting Info</A></P>
Two New C-Glucosyl Benzoic Acids and Flavonoids from Mallotus nanus and Their Antioxidant Activity
Phan Van Kiem,Nguyen Thi Mai,Chau Van Minh,Nguyen Huu Khoi,Nguyen Hai Dang,Nguyen Phuong Thao,Nguyen Xuan Cuong,Nguyen Hoai Nam,Nguyen Xuan Nhiem,Yvan Vander Heyden,Joëlle Quetin-Leclercq,김교남,장해동,김영호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.2
Two new 2-C-β-D-glucopyranosyl benzoic acid derivatives named mallonanosides A (1) and B (2) were isolated from the methanolic extract of the leaves of Mallotus nanus along with five known flavonoids, kaempferin (3), juglanin (4), quercitrin (5), myricitrin (6), and rhoifolin (7). Their structures were established on the basis of spectral and chemical evidence. Their antioxidant activities were shown to depend on the number of hydroxyl groups, and the location and species of sugar moiety.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Nguyen Thi Thanh Ngan,Le Duc Dat,Nguyen Xuan Cuong,Nguyen Hoai Nam,Phan Van Kiem,Seok Bean Song,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
Peroxisome proliferator-activated receptors(PPARs) are ligand-activated transcription factors thatregulate the expression of multiple genes involved inmetabolic, anti-inflammatory, and developmental processes. This study evaluated the PPARs transactivationaleffects of thirteen cembranoid diterpenoids 1–13 from thesoft coral Lobophytum crassum, using PPAR-responsiveelements–luciferase reporter and GAL4–PPAR chimeraassays. All isolated compounds activated the transcriptionof PPARs in a dose-dependent manner, with EC50 valuesranging from 2.07 ± 1.73 to 130.20 ± 1.85 lM. Moreover,compounds 6–9 affected the transactivation of allthree PPAR types, PPARa, c, b(d), in a dose-dependentmanner, with EC50 values in a ranging from 11.92 ± 1.23to 122.50 ± 2.12 lM. These results provide a scientificrationale for further studies on the soft coral L. crassum andits diterpenoid constituents to develop medicinal productsagainst inflammatory and metabolic diseases.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Chau Ngoc Diep,Bui Huu Tai,김은지,강희경,이상현,장해동,Nguyen The Cuong,Nguyen Van Thanh,Nguyen Xuan Cuong,Nguyen Hoai Nam,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
This study performed phytochemical and bioactiveassessments of the mangrove Lumnitzera racemosaWilld. leaves. Bioassay-guided fractionation of the methanolicextracts led to the identification of thirty-six compounds(1–36), their structures were elucidated using detailed NMRspectroscopic and MS analysis. The extracts, fractions, andthe isolated compounds were screened for potential antioxidantand cytotoxic activities. Antioxidant assays wereperformed using peroxyl radical-scavenging and reducingassays, whereas cytotoxicity was measured using MTTassays in HL-60 and Hel-299 cell lines. The methanolicextract, CH2Cl2 and n-BuOH fractions (10.0 lg/mL)exhibited potent antioxidant activity, with Trolox equivalent(TE) values of 24.94 ± 0.59, 28.34 ± 0.20, and27.09 ± 0.37 (lM), respectively. In addition, the isolatedcompounds exerted cytotoxic effects in a dose-dependentmanner; compounds 1 and 14 exhibited the most potentcytotoxicity in HL-60 cells, with IC50 values of 0.15 ± 0.29and 0.60 ± 0.16 lM, respectively. To clarify the mechanism(s) behind these cytotoxic effects, we measured thetime-dependent changes in apoptotic markers including thecondensation and fragmentation of nuclear chromatin, andthe downregulation of p-ERK1/2, p-AKT, and c-Myc levels.
Nguyen Phuong Thao,Nguyen Hoai Nam,Nguyen Xuan Cuong,Bui Thi Thuy Luyen,Bui Huu Tai,김지은,송석빈,Phan Van Kiem,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
Anti-inflammatory transcriptional effects ofnineteen compounds (1–19) from the soft coral Sinulariamaxima were evaluated using NF-jB luciferase and reversetranscriptase polymerase chain reaction. Compounds 1, 2,4, 8, 15, 17, and 18 significantly inhibited TNFa-inducedNF-jB transcriptional activity in HepG2 cells in a dosedependentmanner, with IC50 values ranging from15.81 ± 2.29 to 29.10 ± 1.54 lM. Furthermore, the transcriptionalinhibitory function of these compounds wasconfirmed by a decrease in intercellular adhesion molecule-1 and inducible nitric oxide synthase gene expressionlevels in HepG2 cells. These results provide a scientificrationale for the use of the soft coral S. maxima warrantfurther studies to develop new agents for the preventionand treatment of inflammatory.
Triterpenoid saponins from the roots of Rosa rugosa Thunb. as rat intestinal sucrase inhibitors
Nguyen Phuong Thao,Bui Thi Thuy Luyen,주성호,Tran Manh Hung,Nguyen Xuan Cuong,Nguyen Hoai Nam,권영인,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Medicinal plants constitute an important sourceof potential therapeutic agents for diabetes. The purpose ofpresent study is to investigate the effect of root extract ofRosa rugosa Thunb. on inhibition of sucrase related todiabetes mellitus (DM). Bioassay-guided fractionation ofthe methanol extract led to the identification of 13 triterpenoidsaponins (1–13). Their structures were elucidatedon the basis of extensive spectroscopic analysis, including1D, 2D NMR, and MS. The n-butanol fraction showedpotent rat intestinal sucrase inhibitory activity with value of87.62 ± 5.84 % inhibition compared to the positive controlacarbose (50.96 ± 2.97 % inhibition at 0.02 mM). Subsequently, compounds 11–13 (1.0 mM) exhibited significantsucrase inhibitory activity, with inhibition percentagevalues of 41.17 ± 3.52, 46.80 ± 4.00, and39.39 ± 4.19 %, respectively. Whereas, compounds 2–6,8, and 10 showed moderate sucrase inhibitory activity(ranging from 13.26 ± 7.00 to 32.08 ± 6.04 % inhibition)at a same concentration. The data provide a starting pointfor creating new sucrase inhibitors, which may be usefulfor the development of effective therapies for the treatmentof DM.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,김은지,강정일,강희경,Nguyen Xuan Cuong,Nguyen Hoai Nam,Phan Van Kiem,Chau Van Minh,김영호 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.1
Bioassay-directed fractionation and purification were used to isolate 12 steroids (1–12) from a CH2Cl2 extract of the edible Vietnamese sea urchin Diadema savignyi Michelin. The cytotoxic activity of the CH2Cl2 extract and 12 steroids was evaluated in three human cancer cell lines (HL-60, PC-3, and SNU-C5). Relative to the effects of the positive control, mitoxantrone, the CH2Cl2 extract (with an inhibitory concentration of 50% [IC50] values ranging from 1.37 ± 0.15 to 3.11 ± 0.15 μg/mL) and compounds 2 (with IC50 values ranging from 5.29 ± 0.11 to 6.80 ± 0.67 μM) and 11 (with IC50 values ranging from 4.95 ± 0.07 to 6.99 ± 0.28 μM) exhibited potent cytotoxic effects against all three tested human cancer cell lines. In addition, the CH2Cl2 extract and compounds 2 and 11 were found to induce apoptosis. The induction of apoptosis was accompanied by alterations of the apoptosis-related protein expression, inactivation of ERK1/2 mitogen-activated protein kinase signaling, and decreased c-Myc expression. These data suggest that compounds 2 and 11 from the edible sea urchin D. savignyi may have potential for the treatment of colon cancer, leukemia, and prostate cancer as complementary cancer remedies.