신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

전응집공정과 복합생물막 반응조를 이용한 하수고도처리

류완석,석진국,임경호 公州大學校 工學硏究院 生産技術硏究所 2003 論文集 Vol.11 No.-

This study was investigated the performance of hybrid denitrification systems using auto/hetero-trophic microorganisms to remove nitrogen from domestic wastewater. Results jof the research showed that the reactor could be operated efficiently at the hydraulic retention time from 24.4 to 7.0hr. During the HRT effect experiment, the effluent removal efficiencies of NO3--N ranged from 82.2%~88.4% without nitrite accumulation and the effluent sulfate concentration was lower than 46.81㎎/ℓ. The maximum volume-loading rate of the reactor was 55.87g NO3--N/m³?d. The maximum auto/ heterotrophic denitrification rate is about 41.39g NO3--N/m3?d during this experiment.

[논문]강성토조 및 연성전단상자 시스템의 진동특성에 대한 수치해석적 분석

김진만,류정호 釜山大學校生産技術硏究所 2007 生産技術硏究所論文集 Vol.66 No.-

지반의 정적 또는 동적거동을 살펴보기 위해 종종 토조를 사용하여 모형실험을 수행한다. 이때 사용되는 토조는 국내의 경우, 대부분 강성토조를 사용하고 있다. 강성토조는 정적인 모형실험 시 특별한 문제가 발생하지는 않지만, 동적인 거동을 살펴보기 위해 진동대 또는 지오센트리퓨지를 이용할 시에는 양쪽의 토조벽이 지반의 동적거동을 구속시킬 수 있다. 따라서 지반의 증폭현상이나 위상차를 반영하지 못하여 왜곡된 실험결과가 발생할 수 있다. 본 연구에서는 강성토조에서 발생할 수 있는 물리적 오류를 극복하기 위해 연성전단상자의 거동을 조사하였으며,수치해석을 이용하여 강성토조와 연성전단상자의 동적거동을 비교해보았다.

간경변증 환자의 정신과적 특성 및 아임상적 간성뇌병증 진단을 위한 연구 : 인지기능 및 유발전위를 중심으로 Cognitive Functions and Evoked Potentials

유승호,이소영,김진세,변관수,정인과 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 본 연구는 명백한 간성뇌병증이 없는 간경변증 환자에서 불안, 우울기분 및 삶의 질 등 정신과적 특징과 신경심리학적인 결손의 양상을 밝히기 위해서 고안되었다. 그리고 아임상적 간성뇌병증의 평가에서 체성감각 유발전위 검사의 역할을 연구하고자 하였다. 방 법 : 간경변증으로 진단된 41명의 환자군과 정상 대조군 31명을 대상으로 하였다. 이들에서 우울기분 및 불안을 평가하기 위해 Beck Depression Inventory와 State & Trait Anxiety Inventory를 시행하였고 삶의 질의 평가를 위해 Health-related Quality of Life Questionnaire를 시행하였다. 또한 어휘검사, 숫자외우기 검사, 토막짜기 검사, 숫자기호 바꿔쓰기 검사 및 선로잇기 검사 A와 B 등 간단하지만 포괄적인 인지기능검사를 시행하였다. 또한 41명의 환자군 중에서 인지기능검사 결과에 의거하여 분류된 13명의 아임상적 간성뇌병증군(SHE군)과 11명의 아임상적 간성뇌병증이 아닌 간경변증 환자군(non-SHE군) 그리고 8명의 정상 대조군에서 체성감각 유발전위를 측정하였다. 결 과 : 간경변증 환자는 정상인에 비해서 우울기분과 특성불안이 유의하게 증가하였다. 또한 건강과 관련된 일상생활의 삶의 질의 수준이 정상인보다 저하되었고, 특히 주의력과 각성이 요구되는 행동에서 수행이 저하되었다. 또한, 간경변증 환자는 숫자기호 바꿔쓰기 검사와 선로잇기 검사에서 정상 대조군보다 저하된 수행을 나타내었다. 또한 이러한 인지기능검사를 통해서 진단한 아임상적 간성뇌병증군에서 6개월 추적조사를 하였을 때, 명백한 간성뇌병증의 빈도가 아임상적 간성뇌병증이 아닌 군보다 유의하게 높았다. 체성감각 유발전위 소견은 N65 잠복기와 N20-N65 IPL의 경우 SHE군, non-SHE군 및 정상 대조군 사이의 유의한 차이가 있었다. 특히 N65는 SHE군만이 정상 대조군과 유의한 차이가 있었고 N95는 숫자기호 바꿔쓰기 검사 및 선로잇기 검사 A와 유의한 상관관계가 있었다. 결 론 : 간경변증 환자에게 우울 및 불안 등 정서적인 어려움에 대한 실제적인 관리 및 삶의 질을 높일 수 있는 치료적 접근이 고려되어야 하겠다. 또한 숫자기호 바꿔쓰기 검사와 선로잇기 검사가 아임상적 간성뇌병증의 조기 진단에 민감하고 유용한 도구로 생각되어 간경변증 환자에서 정례적으로 적용시키는 것이 간경변증 환자의 관리에 도움을 줄 수 있을 것으로 생각된다. 마지막으로, 본 연구에서의 체성감각 유발전위 소견은 간경변증 환자에서 아임상적 간성뇌병증 환자의 진단 및 연구에 중요한 의미를 지닌다고 생각된다. Objectives : This study was designed to elucidate the psychiatric characteristics and nature of the neuropsychological deficits associated with subclinical hepatic encephalopathy(SHE) in patients with non-alcoholic liver cirrhosis. And also the authors prospectively studied the role of somatosensory evoked potentials(SEP) in the assessment of SHE. Methods : Beck Depression Inventory(BDI) for measuring depression, State Trait Anxiety Inventory(STAI) for measuring anxiety, and Health-related Quality of Questionnaire(HQLQ) for measuring quality of life were administered the 41 non-encephalopathic liver cirrhosis patients(NELC) group and 31 carefully matched normal controls. And a prospective study to compare the performance of NELC group and normal controls on a short but comprehensive cognitive tests was conducted. After several cognitive, NELC group was divided into two groups, SHE group and non-SHE group by results of digit symbol substitution test(DSST) and/or trail making test(TMT) A and B. And then median nerve evoked cortical responses in 13 SHE patients group, 11 non-SHE patients group, and 8 normal controls were recorded for latencies of N13, P16, N20, P25, N30, P45, N65, and P95. And also responses for N13-N20 interpeak latency(IPL) and N20-N65 IPL were recorded. Results : There were significant differences between the NELC group and normal controls on BDI, trait anxiety scales in STAI, and almost all HQLQ except for the cognitive function, social interaction and life satisfaction(p<0.05). The NELC group exhibited poor performance in DSST, TMT A and TMT B compared with normal controls(p<0.05). As 17 NELC patients had abnormal cognitive test results, 41.5% of cirrhotic patients had SHE. In SEP assessment, NELC group with SHE and without SHE had higher N20-N65 IPL and only NELC group with SHE had higher N65 latency compared with normal controls(p<0.05). Conclusion : This study suggests that the patients with liver cirrhosis exhibit relatively selective deficits in complex attentional and fine motor skills, with preservation of general intellectual ability, memory, language and visuospatial perception. DSST, TMT A and TMT B seem to be useful screening tests for the detection of SHE. And also it is expected that late components and N20-N65 IPLs of SEP are helpful in the assessment of SHE.

참돌꽃 근경의 항산화작용

류광열,강원식,김영호,장해동,홍진태,유환수,윤여표 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

The purpose of this study was to determine the antioxidative effects of Rhodiola sachalinensis Rhodiola methanol extract was fractionated sequentially with dichloromethane and butanol. Each Rhodiola fraction (water, MeOH, BuOH and CH_2Cl_2 fractions) showed the potent superoxide dismutase (SOD) activity, and had inhibitory effets on peroxide value of linoleic acid (40~57%) and lipid peroxidation (47~70%) in FE^2+/ascorbate system-induced rat liver microsome. Rhodiola methanol extract also recovered carbon tetrachloride-induced decrease in SOD by 42% and catalase activities by 50%, and had inhibitory effects (54%) on carbon tetrachloride-induced lipid peroxidation in rat liver microsome. These results suggest that Rhodiola sachalinensis has the antioxidative effects.

매체순환식 가스연소기 적용을 위한 Ni계 및 NiO계 산소공여입자의 반응특성

류호정,배달희,조성호,진경태 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.1

매체순환식 가스연소기에 적용하기 위한 최적의 산소공여입자를 결정하기 위해 금속산화물(NiO)의 함량 변화에 따라 네 가지 (NiO 26, 44, 58, 78wt%)의 산소공여입자를 제조하여 열중량 분석기에서 환원반응특성을 측정 및 비교하였다. 제조된 입자들 중에서 NiO 약 60wt%인 입자가 산소전달능력 및 반응속도 면에서 다른 입자들에 비해 우수한 성능을 나타내었다. 산소공여입자의 제조과정에서 금속산화물 형태의 영향을 살펴보기 위해 금속산화물의 출발물질로 Ni과 NiO를 사용하여 NiO 함량이 동일한(약 60%) 두 종류의 입자를 제조하였으며 열중량 분석기와 고정층 반응기를 이용하여 반응속도, 재생성, 환원반응 유지시간 및 CO_(2) 선택도 등을 측정 및 고찰하였다. 금속산화물의 출발물질로 NiO를 사용한 입자가 Ni을 사용한 입자에 비해 반복 실험시에 정상반응조건에 빨리 도달하였고 반응속도와 CO_(2) 선택도가 높았으며 환원반응 유지시간인 길게 나타났다. 실험결과에 의해 본 연구에서 고려한 산소공여입자 중에서 금속산화물의 출발물질로 NiO를 사용한 NiO 함량이 60wt%인 입자를 최적의 산소공여입자로 선정하였다. To find a suitable oxygen carrier particle for chemical-looping combustor, four kinds of particles (NiO 26, 44, 58, 78wt%) were prepared and the reactivity of the reduction was measured and investigated by a thermo-gravimetrical analyzer. From the viewpoint of oxygen transfer capacity and reaction rate, the particle containing 60wt% of NiO showed better performance than the other particles. Also, we have prepared two kinds of oxygen carrier particles to investigate the effect of the starting material for a metal oxide component(i.e., Ni based and NiO based particles, where the weight percents of both samples were set at 60wt% as NiO). The reaction rate, regenerative ability, duration of the reduction, and CO₂ selectivity were easured and investigated by a thermo-gravimetrical analyzer and a fixed bed reactor. The results obtained here indicated that the NiO based oxygen carrier particle containing 60wt% of NiO showed better regenerative ability, reaction rate, CO₂ selectivity, and duration of the reduction, compared with the other particles, therefore we selected this particle as an optimum oxygen carrier particle.

卞季良 詩의 변모와 그 문학사적 의미

유호진 한국시가학회 2003 韓國 詩歌硏究 Vol.14 No.-

이 논문에서 春亭 卞季良의 漢詩에 주목하는 이유는 그것이 鮮初의 문학사적 전환을 예고하는 대표적인 사례이기 때문이다. 그의 시세계는 서로 이질적인 두 개의 작품군으로 형성되어 있다. 우선 조선 왕조에 출사하기 전에 창작된 前期 詩에서 춘정은 참신한 의경과 단련된 시어를 통해 비극적인 시대 인식을 전하는 한편 순결한 정신과 無慾의 삶에의 지향을 토로한다. 도학적 사유를 기반으로 한 이러한 정신적 지향은 不義한 외부세계와의 대결에서보다는 주로 세속적 욕망이 일어나는 자기 내면에 대한 성찰에서 파생한 것이었다. 결국 춘정의 전기 시는 道學을 수용하여 세계의 변혁과 인격적 정립을 기도했던 여말 지식인들의 문학과 그 氣息이 통한다고 할 수 있다. 그러나 춘정이 조선 왕조에 출사한 후에 창작된 후기 시들은 시적 긴장을 상실한 산문적인 진술과 진부하고 상투적인 수사가 빈번히 나타나며 내용에 있어서도 자신과 세계에 대한 깊은 성찰을 보여주지 못한다. 이는 당대의 시대적 분위기 속에서 춘정의 정치적 이상의 실현이 철저히 차단됨에 따라 도학적 사유에 의한 정신적 긴장이 차츰 이완되어 갔음을 시사한다. 여말 신흥사대부의 신선하고 열정적인 문학세계가 춘정 당대에 와서 퇴조하기 시작한 것이다. The poetry of Pyeon Kyeryang whose pseudonym is Chunjeong could be severed into two categories - the first and the second periods - marked by his taking up an official appointment in The Chosun dynasty at the age of 29. In his earlier poems written in days of youth, he produced different, creative images, through which he tried to speak of his own modest life of being aware of order of nature, and a pure conscience of intellectuals who didn't in the least compromise with those of injustice. What should be focused on is that the mental inclination lying in his works in days of youth derived from his internal conflict. Leaning toward pureness originated in internal conflict inside him rather than struggle with outside temptation or suppression. The thing he had to grapple with was chiefly his thirst for attaining fame, involved with self-realization. However, becaused by death of father and lost of friend his attitude to life as a poet changed. He intended to seclude himself from the world as he valued integrity. He decided to underline responsibility of intellectuals toward people of the nation and change aggressively the disorganized society. At this time, his poems of the second period began to be produced. As his political ambition was frustrated, the poems consisted of prosaic narrations with no poetic strain and conventional rhetoric. When it comes to the themes, they lacked sharp insight into the world drastic introspection of his life. Mental strain caused by moral philosophy gradually faded away from his recognition. Finally, established on the combination of moral philosophy and letters, the novel, enthusiastic literature of intellectuals at the end of the Koryo dynasty began to be on the ebb in the Chosun dynasty.

鄭道傳 詩에 투영된 삶에 대한 熱愛에 관하여

柳浩珍 韓國古典文學會 2002 古典文學硏究 Vol.21 No.-

The poetry of Jeong Dojeon, which was highly appraised by many ancestors, is rather not rhetorically sumptuous because it mainly uses unsophisticated words, plane poetic dictions, and indicative or direct metaphors. The reason that Jeong Dojeon's poetry profoundly inspires readers is, however, due to his enthusiasm for life buried deep in every line Of Verse. His will to realize his ideal, Which is Caused from his passion for life, attains the poetic truthfulness. Through his poetry, Jeong Dojeon, who was innate with a passionate disposition, appears to be more inspired for his enthusiasm of life, after experiencing the chaos of society and vanity in life. The understanding, especially, of the nothingness of life, was continued to the longing for eternal being, and it led him to establish the moral goals called "the spirit of solemnity(凜烈)", and "the personality of gentleness(和順)". Among them, "the spitit of solemnity" is the connection between his passion and the Confucianist's "principles of righteousness(義理精神)" and shows the most peculiar aspect of him. It is natural that his poetry that contains this kind of his spiritual property is the most vivid phase in Jeong Dojeon's work. Jeong Dojeon tried to became prominent in history by achieving his great work Standing on the basis of this kind of ideal personality. He established the ideal paragon called the "True Confucianist(眞儒)". Ultimately, this suggestion of the "True Confucianist(眞儒)" is his reply to the needs of the Goryeo Dynasty period which highly demands the advent of the new a model of what a man ought to be.

Gemfibrozil이 정상 성인의 기분 및 신경인지기능에 미치는 영향

유승호,장순주,김진세,정인과 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.2

Objectives : Many studies have reported that the mood and cognitive functions are related to serum lipid concentration. The current study sought to determine whether gemfibrozil, lipid-lowering agent, affects mood and neurocognitive functions in normal adults. Methods : Subjects were 15 healthy medical students and gemfibrozil of 600mg administered to them daily for 4 weeks. The levels of serum total cholesterol, high lipoprotein(HDL), low-density lipoprotein(LDL), and triglyceride were measured before the treatment and after 4weeks of the treatment. The depressive mood and anxiety were estimated from Beck Depression Inventory and Spielberger State and Trait Anxiety Inventory at the baseline and the 4th week. Neurocognitive functions were estimated from digit span test, digit symbol substitution test, finger tapping test, visual continuous performance test and cued test at the baseline and the 4th week. Results : After four weeks, the subjects administered gemfibozil showed significant reductions in serum triglyceride levels(p=0.033), but other lipid levels did not show significant changes during the treatment. During gemfibrozil administration, no statistically significant changes were found in Beck Depression Inventory scales, Spielberger State and Trait Anxiety Inventory and other neurocognitive scales except for the digit symbol substitution test(p=0.000) between the baseline and following the 4th week. Conclusions : Even though we need more well-controlled and long-term follow-up study in various and a large number of groups, these findings suggest that the gemfibrozil administration do not affect the mood and the neurocognitive functions comprehensively.

매체순환식 가스연소기 산소공여입자의 최소유동화속도 및 고속유동층으로의 전이유속

류호정,임남윤,배달희,진경태 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.5

기포유동층과 고속유동층의 2탑 연결 가압순환유동층으로 조업되는 매체순환식 가스연소기의 설계와 조업조건 선정을 위해 산소공여입자의 최소유동화속도와 고속유동층으로의 전이유속을 측정 및 고찰하였다. 층물질로 매체순환식 가스연소기의 산소공여입자인 NiO/bentonite (평균입경 : 0.181 mm, 입자밀도 : 4,080 kg/㎥)를 사용하여 가압 기포유동층(내경 0.052 m, 높이 1.66 m)에서 층압력강하를 측정하여 온도(25-1,000℃)와 압력(1-6 atm)의 변화에 따른 최소유동화속도의 변화를 측정 및 고찰하였고 고온순환유동층(내경 0.02 m, 높이 2.0 m)에서 emptying time method에 의해 고속유동층으로의 전이유속(U_(tr))에 대한 온도(25-600℃)의 영향을 측정 및 고찰하였다. 측정된 최소유동화속도는 온도와 압력이 증가함에 따라 감소하였으며, 고속유동층으로의 전이유속은 온도가 증가함에 따라 증가하였다. 최소유동화속도와 고속유동층으로의 전이유속에 대한 본 실험의 측정값을 기존의 상관식과 비교하였으며 기존 상관식을 바탕으로 수정된 상관식을 제시하였다. In order 10 design and select appropriate operating conditions for the practical operation of chemical-loaping combustor, which consists of two interconnected fluidized beds (bubbling fluidized bed and fast fluidized bed), minimum fluidization velocity and transition velocity to fast fluidization were measured and investigated. Oxygen carrier particle of NiO bentonite particle (specific surface mean diameter: 0.181 mm, particle density: 4,080 ㎏/㎥) was used as a bed material. The minimum fluidization velocity was determined by measuring the bed pressure drop in the pressurized fluidized bed (0.052 m i.d. and 1.66 m high) with variations of temperature (25-1,000℃) and pressure (1-6 atm). The transition velocity from bubbling to fast fluidization was determined by means of emptying tim method in the high temperature circulating fluidized bed (0.02 m i.d. and 2.0 m high) with variation of temperature (25-600℃). The measured minimum fluidization velocity was increased with increasing temperature and pressure. The measured transition velocity to fast fluidization was increased with increasing temperature. The previous correlations on the minimum fluidization velocity and transition velocity to fast fluidization were compared with the present measured values to develop new correlation.