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Li, Bin,Lee, Dong-Sung,Choi, Hyun-Gyu,Kim, Kyoung-Su,Kang, Dae-Gil,Lee, Ho-Sub,Jeong, Gil-Saeng,Kim, Youn-Chul Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.10
<P>Sauchinone, a biologically active lignan isolated from the roots of <I>Saururus chinensis</I> (L<SMALL>OUR</SMALL>.) B<SMALL>AILL</SMALL>. (Saururaceae), is reported to exert a variety of biological activities, such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated the effect of sauchinone in suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to a reduction in COX-2-derived prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. Present study also demonstrates the effects of sauchinone in inducing heme oxygenase-1 (HO-1) expression and an increase in heme oxygenase (HO) activity in RAW264.7 macrophages. The effects of sauchinone on LPS-induced PGE<SUB>2</SUB>, NO, tumor necrosis factor-α (TNF-α) and interlukine-1β (IL-1β) production were partially reversed by the HO-1 inhibitor Tin protoporphyrin was also seen in this study. In addition, we found that treatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) reduced sauchinone-induced HO-1 expression. Sauchinone also increased ERK phosphorylation. These results suggest that sauchinone inhibits pro-inflammatory mediators through expression of anti-inflammatory HO-1 <I>via</I> ERK pathway.</P>
BCR-ABL 융합유전자를 동반한 급성 골수구성 백혈병 1예
최정민,송성은,이규진,이규원,이호섭 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1
BCR-ABL 융합 유전자를 동반한 급성골수구성백혈병은 그 빈도가 매우 낮고, 만성골수구성백혈병의 급성악화기와 임상적으로 유사한 특징을 가진다. 항암화학요법으로 관해유도가 되기 어렵거나, 관해유도 후 재발의 빈도가 높은 특징을 가지고 있어 예후가 나쁘다고 알려져있다. 저자들은 BCR-ABL 융합 유전자를 동반한 급성골 수구성백혈병1례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. BCR-ABL fusion gene is the hallmark of chronic myelogenous leukemia (CML), but it has been rarely reported in acute myeloid leukemia (AML). AML with BCR-ABL fusion gene has different features from blast crisis of CML. We experienced a rare case of AML with BCR-ABL fusion gene. Here we report this case with a brief review of literatures.
Omeprazole 투여시 위산분비 억제능에 대한 CYP2C19 의 영향
박수헌(Soo Heon Park),김종원(Jong Won Kim),이수연(Soo Youn Lee),최명규(Myung Gyu Choi),김재광(Jae Kwang Kim),정인식(In Sik Chung),정규원(Gyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: CYP2C19 has an important role in the catabolism of several proton pump inhibitors. However, the relative contribution of CYP2C19-mediated metabolism varies among the different proton pump inhibitors. We investigate to determine the effect of CYP2C19 genotype status on intragastric pH during dosing with omeprazole. Methods: The subjects were 16 healthy volunteers. Their CYP2C19 genotype status was determined by a polymerase chain reaction-restriction fragment length polymorphism method. Twenty-four-hour monitoring of intragastric acidity were performed on the day without medication and day 4 after omeprazole administration. Results: A single dose of omeprazole significantly decreased 24 hour intragastric acidity (1.7±0.3 vs. 5.1±0.4). Subjects were divided into three groups on the basis of their CYP2C19 genotype status: homozygous extensive metabolizers (Ho-EMs, n=5), heterozygous extensive metabolizers (Ht-EMs, n=6), and poor metabolizers (PMs, n=5). Median 24 hour intragastric pH in the Ho-EM group was 3.1 compared with 5.5 in Ht-EM group and 5.9 in PM group(P<0.05). The median pH during omeprazole administration was influenced by CYP2C19 genotype. On the other hand, the Helicobacter pylori infection did not influence the median intragastric pH during omeprazole administration (p= NS). Conclusions: The effects of omeprazole on intragastric acidity is influenced by the CYP2C19 polymorphism. (Korean J Gastroenterol 2001;38:399-404)
Diethyl 3,4,5, - Trimethoxybenzylmalonate의 새로운 합성법
李茶浩,李英行,李晩求,蔡奎允 圓光大學校 1984 論文集 Vol.18 No.2
3,4,5 - Trimethoxybenjoyl chloride 와 diethyl malonate를 축합시키고 이어서 염소화반응 및 수소화반응에 의하여 70%의 수득률로서 diethyl 3,4,5 - trimethoxybenzylmalonate를 얻었다. direct condensation of 3,4,5 - trimethoxybenzoyl chloried with diethyl malonate followed by chlorination and hydrogenation afforded diethyl 3,4,5 - trimethoxybenzylmalonate in 70% overall yield.
이규진,이송주,옥철호,장태원,정만홍,김영옥,박성달 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4
저자들은 객혈을 주소로 내원한 75세 남자 환자에서 기관지내시경 육안 소견상 양성 종양이 의심 되었으나 조직 검사상 지방종을 확진하지 못하였고 악성종양을 배제할 수 없는 상황에서 종괴에 의한 왼쪽 폐의 허탈과 농흉 때문에 수술적 치료를 시행 하였으며, 수술 결과 기관지 지방종에 의한 폐허탈, 농흉 및 기관지 확장증, 이로 인한 객혈이 발생한 예가 있어 보고하는 바이다. Lipoma is a common neoplasm on soft tissues. However, bronchial lipoma is rare benign tumor. Patients with bronchial lipoma might have a malignant potential, and there were case reports of lung cancer accompanied with lipoma. Therefore, it should initially be treated by fibrotic bronchoscopy or surgery. We encountered a 75 year-old male patients with bronchial lipoma, causing hemoptysis.
강의 수소취화에 대한 국부영역에서의 수소의 거동(Ⅰ) : 지연파괴의 수소집적에 미치는 응력 및 소성변형의 영향
이영호,이진우,배명일,고준빈,이규천 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1
Hydrogen embrittlement cause decrease of it's mechanical properties during hydrogen dissolved in steels. Many mechanisms of hydrogen concentration researches have done, but it is not clearly known yet. In this study the effect of plastic deformation and external stress on mechanism of hydrogen concentration by high temperature hydro-genation treatment were investigated. The main results are as follow : 1)For short time fracture process, a defect rate of chemical potential energy is an important factor on hydrogen concentration for delayed fracture of steel processed with high temperature hydrogen. 2)For long time fracture process, the important element is long range diffusion of hydrogen due to the rate of effective hydrogen density and plastic deformation. 3)hydrogen concentration as plastic deformation vary in proportion to slope of plastic deformation. 4)Hydrogen concentration due to the effect of external stress, but this effect is limited in short range. 5)External stress is an acceleration element for delayed fracture of steel.
GC/MS-SIM과 ³²P-postlabeling방법에 의한 염료와안료를 제조하는 사업장 근로자들의 방광암 조기발견을 위한 Biomarker개발에 관한 연구
이진선,신호상,김양호,노재훈,이범규 공주대학교 자원재활용신소재지역협력센터 2000 2차년도 센터 사업 성과집 Vol.2000 No.1
To develop the biomarker of non-invasive biomonitoring among workers who exposed benzidine-based dyes in its manufacturing and treating industries, we examined and evaluated the specific carciaogen-DNA adducts in exfoliated urothelial cells of 33 exposed workers. Samples were collected from urine of workers, and then isolated DNA from them. DNA adducts were analyzed using 32P-postlabeling, along with Nuclease P1. One adducts was predominated in those samples with 6 adducts present. It was formed in all exposed workers, but the others not. Its relative adducts level(RAL) was 73.2×107, which was statistically significantly higher than any other adducts' level(p<0.05). Analyzing regression between its RAL and employment period of workers, simple linear regression was positively increased with slop of 6.922(p<0.05, r2=0.548). And also, DNA adducts were analyzed using GC/MS-SIM, along with n-butanol extraction and trifluoroacetyl auhydride(TFA) derivatization. Standard material was synthetic N-(deoxyguanosin-8-yl)-N'-acetylbenzidine. The characteristics of sample and standard were observed on the same sites, such as M+(m/z 376) and M+(m/z 279) for benzidine-di-TFA and mono-TFA. And then, they were confirmed by analyzing with secondary ion mass(SIM). This study showed that benzidine-based dyes was formed one DNA adduct into significantly high levels in bladder of all exposed workers, its chemical formula was N-(deoxyguanosin-8-yl)-N'-acetylbenzidine. So we can do monitoring the workers with exfoliated urothelial cells of them by analyzing above DNA adduct as biomarker for preventing bladder cancer causing the exposure of the benzidine-based dyes.
이은영,장태원,정만홍,옥철호,이규원,손창배,이지숙,신은경,서정아,백종현,김영옥 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
Actinomycosis is a chronic suppurative infection, whitch infiltrates mucosa-associated tissues. Thoracic, pelvic and cervicofacial infections of actinomyces are not uncommon, but endobronchial actinomycosis is rarely reported. We report a case of a 29 year old man who presented with a recurrent pneumonia and chronic cough. Fiberoptic bronchoscopy revealed occlusion of the right. lower medio-basal segment bronchus with exophytic endobronchial mass. The diagnosis was confirmed histologically by demonstration of sulfur granules in the bronchoscopic biopsy of the mass. Intravenous administration of amoxacillin and clindamycin followed by oral amoxacillin and clindamycin therapy resulted in complete recovery.
기관지 탄분 섬유화증 환자의 임상 경과와 고감도 C-반응 단백(high sensitivity C-reactive protein, hsCRP)과의 상관 관계 비교
이규원,옥철호,장태원,정만홍 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4
Background: To investigate the association between bronchial anthracofibrosis(AF) and tuberculosis(TB). and the clinical utility of high sensitivity C-reactive protein(hsCRP) for diagnosis of active pulmonary TB in patients with bronchial AF. Method: Eighty three patients(62 women and 21 men ranging in age from 55 to 87), who were diagnosed with bronchial AF by a bronchoscopy, were enrolled in this study. The hsCRP was measured in patient's blood. The hsCRP results were compared with the bacteriological, and clinical finding. Results: The common respiratory symptoms were cough(70%), sputum(35%), dyspnea(20%), and hemoptysis(10%). The sputum AFB smear, culture were positive in 20(22.8%) and 37(44.5%) patients, respectively. The level of hsCRP in patients with postive culture was significantly higher than that of patients with negative culture.(4.67±7.5, 0.90±1.59, p=0.005). Of 63 patients with negative smear, the level of hsCRP in patients(n=18) with positive culture was higher than that of patients(n=45) with negative culture.(3.39±5.78, 0.92±1.50, p=0.013). Of 20 patients with negative smear and positive culture who were empirically treated with anti-TB medication, 11 patients showed radiologic response. and their level of hsCRP was higher than that of 9 patients who showed no radiologic response.(1.56±1.89, 0.81±0.10,p=0.03) Conclusion: hsCRP appears to be useful diagnostic tool for predicting active pulmonary tuberculosis. in patients with bronchial AF.