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Toshihiko Tomita,Hirokazu Fukui,Daisuke Morishita,Ayako Maeda,Yutaka Makizaki,Yoshiki Tanaka,Hiroshi Ohno,Tadayuki Oshima,Hiroto Miwa 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.1
Background/AimsDiarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms frequently occur in patients with quiescent Crohn’s disease (CD). To investigate the factors underlying IBS-D-like symptoms in patients with quiescent CD, we performed a comprehensive analysis of the clinical features and intestinal environment in those patients. MethodsWe performed a prospective observational study of 27 patients with quiescent CD (CD activity index [CDAI] ≤ 150; C-reactive protein ≤ 0.3 mg/dL). The presence and severity of IBS-D-like symptoms, health-related quality of life, disease-specific quality of life, and status of depression and anxiety were evaluated. The level of intestinal permeability, fecal calprotectin and organic acids and the profiles of gut microbiome were analyzed. ResultsTwelve of the 27 patients with quiescent CD (44.4%) had IBS-like symptoms, and these patients showed a significantly higher CDAI, IBS severity index and anxiety score than those without. The inflammatory bowel disease questionnaire score was significantly lower in the patients with IBS-D-like symptoms. There were no significant differences in small intestinal/colonic permeability or the levels of organic acids between the patients with and without IBS-D-like symptoms. Fusicatenibacter was significantly less abundant in the patients with IBS-D-like symptoms whereas their fecal calprotectin level was significantly higher (384.8 ± 310.6 mg/kg) than in patients without (161.0 ± 251.0 mg/kg). The receiver operating characteristic curve constructed to predict IBS-D-like symptoms in patients with quiescent CD using the fecal calprotectin level (cutoff, 125 mg/kg) showed a sensitivity and specificity of 73.3% and 91.7%, respectively. ConclusionMinimal inflammation is closely associated with the development of IBS-D-like symptoms in patients with quiescent CD.
Measuring Multipath Error of a Pseudo Quasi-Zenith Satellite
Toshiaki Tsujii,Hiroshi Tomita,Yoshinori Okuno,Ivan Petrovski,Masahiro Asako,Kazuki Okano 한국항해항만학회 2006 한국항해항만학회 학술대회논문집 Vol.2 No.-
Japan has been investigating a new satellite based positioning system called Quasi-Zenith Satellite System (QZSS). Since the improvement of positioning availability in urban area is one of the most important advantages of the QZSS, multipath mitigation is a key factor for the QZSS positioning system. Therefore, Japan Aerospace Exploration Agency (JAXA) and GNSS Inc. have commenced the R&D of a pseudolite, which transmits the next-generation signal such as BOC(1,1), in order to evaluate the effect of multipath on the new signal. A prototype BOC pseudolite was developed in 2005, and ground tests showed a capability of generating proper pseudorange. Also, preliminary flight experiments using a pseudo quasi-zenith satellite, a helicopter on which the pseudolite is installed, were conducted in early 2006, and the BOC-type correlation function was monitored in real time.
( Toshihiko Hata ),( Ken Ueda ),( Hiroshi Maruyama ),( Toshiki Takaya ),( Hiroshi Kuraishi ),( Kenji Maeda ),( Hiroki Tomita ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In super acute phase after the Great East Japan Earthquake (11 March 2011), Disaster medical association team (DMAT) consisted of emergency physicians acted in disaster areas in the East Coast of Japan. On the other hand, these areas needed chronic care support by general physicians because of the enormous destructions of the medical facilities by the tsunami. So then, the Japanese Red Cross Society had sent disaster emergency outpatient assistance doctors to Isinomaki Red Cross Hospital, was intact because it was moved away from the Pacifi c Ocean three years ago. Methods: Determination of specialism by direct hearing and information from home page of each Red Cross Hospitals. Results: Cumulative 81 medical doctors were 38 internal medicine physicians, trainees 15, emergency physicians 12, surgeon 6, pediatrician 3, orthopedic surgeon 3, anesthesiologist 2, obstetrician 2, from April to August 2011. At fi rst 6 dispatched doctors were resident and did emergency outpatient work in Ishinomaki Red Cross Hospital for 6 days and dipatched. A lot of Cases of pneumonia and bronchial asthma due to debris and rubble by Tsunami were seen. All dispatch doctors corresponded to primary surgery including fractures and trauma, pediatric diseases, and posttraumatic stress disorder due to earthquake itself, tsunami damage, and radiation problem of Fukushima. Conclusions: The role of general physicians is very important in chronic phase of disaster medical assistance. Medical facilities in the area with many earthquakes should be moved apart from the sea in order to avoid the damage of tsunami.
Improvement of a Low Cost MEMS-based GPS/INS, Micro-GAIA
Takeshi Fujiwara,Toshiaki Tsujii,Hiroshi Tomita,Masatoshi Harigae 한국항해항만학회 2006 한국항해항만학회 학술대회논문집 Vol.1 No.-
Recently, inertial sensors like gyros and accelerometers have been quite miniaturized by Micro Electro-Mechanical Systems (MEMS) technology. JAXA is developing a MEMS-based GPS/INS hybrid navigation system named Micro-GAIA. The navigation performance of Micro-GAIA was evaluated through off-line analysis by using flight test data. The estimation errors of the roll, pitch, and azimuth were 0.03°, 0.05°, and 0.33° (1ο), respectively. The horizontal position errors after 60-second GPS outages were reduced to 25m CEP. The attitude errors and position errors are nearly half of ones reported previously[2]. Furthermore, using the adaptive Kalman filters, the robustness against the uncertainty of the measurement noise was improved. Comparing the innovation-based and residual-based adaptive Kalman filters, it was confirmed that the latter is robuster than the former.
Ji Hyun Kim,Koichiro Sakanaka,Naomitsu Tomita,Gen Murakami,Hiroshi Abe,Shinichi Abe 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.1
Pacinian corpuscle-like structures were identified in the digital tendon sheaths and nail beds of hands obtained from eight of 12 human fetuses of gestational age 20–34 weeks (crown-rump length, 150–290 mm). The aberrant corpuscles were present in tight fibrous tissue connecting the flexor tendon sheath to the dorsal aponeurosis (138 corpuscles in the thumbs and all fingers of eight fetuses); loose fibrous tissue inside the sheath on the dorsal side of the tendon (37 corpuscles in the thumbs and all fingers of four fetuses); and the nail bed (10 clusters in the thumbs and second fingers of four smaller fetuses). The aberrant corpuscles in the tendon sheath were classified into two types: thin and short, with tightly packed lamellae, of diameter 20–40 μm and length 20–200 μm; and thick and long, with loosely packed lamellae, of diameter 70–150 μm and length 0.5–1.5 mm. The small corpuscles tended to form clusters, each containing 5–10 structures. Their similarity indicated that the tight and loose lamellae in these two types of corpuscles corresponded to typical immature and mature corpuscles, respectively, usually distributed along the palmar digital nerve. However, mature, large corpuscles were absent from the nail bed, and most aberrant corpuscles were smaller than typical corpuscles along the nerve. The aberrant corpuscles were apparently incorporated into the tendon sheath or nail bed during fetal vascular development, but they appeared to degenerate after birth due to mechanical stress from the tendon or nail.