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DESIGN OF POTENT K+ CHANNEL OPENERS BY PHARMACOPHORE MODEL
Koga, Hiroshi,Ohta, Masateru,Sato, Haruhiko,Ishizawa, Takenori,Nabata, Hiroyuki 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1
A pharmacophore model which explains rationally structure-activity relationships of chemically diverse potent K+ channel openers, has been constructed. Potent benzopyran derivatives with thioamide, amide, and (N-cyano)amidine groups at the 4-position have been designed using the model.
Kazunori Toyoda,Hiroshi Yamagami,Masatoshi Koga 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.3
Development of direct oral anticoagulants and their antidotes has led to the need to reconsider the eligibility of acute stroke patients who have been taking oral anticoagulants for intravenous thrombolysis. Officially authorized Japanese guidelines on this issue were revised twice at the time of approval for clinical use of direct oral anticoagulants and idarucizumab, a specific reversal agent for dabigatran. A unique recommendation in the latest Japanese clinical guides was that thrombolysis can be recommended if the time of the last dose of direct oral anticoagulants exceeds 4 hours and if commonly available anticoagulation markers are normal or subnormal, i.e., international normalized ratio of prothrombin time <1.7 and activated partial thromboplastin time <1.5 times the baseline value (≤40 seconds only as a guide). These criteria are partly supported by the findings of domestic multicenter and single-center surveys that symptomatic or asymptomatic intracranial hemorrhage following thrombolysis was rare under the conditions of the criteria. Even for dabigatran users, stroke thrombolysis can be considered without pretreatment by idarucizumab if patients meet the above criteria. If not, direct mechanical thrombectomy can be considered without pretreatment by idarucizumab or thrombolysis, and use of idarucizumab, followed immediately by thrombolysis, can be considered only when thrombectomy cannot be quickly performed. These clinical guides are practical and to some extent economical, but they have some limitations, including lack of corroborating information from sufficient numbers of relevant cases. The guides will be further modified based on the results of future research.
Matsuo, Kiyomi,Murata, Tomoyuki,Koga, Takanori,Kubo, Atsuko,Yoshida, Yuichi,Karakawa, Yosuke,Kawaguchi, Hiroshi,Tanaka, Toru,Masaki, Jun,Taketomi, Toshikatsu,Kitajima, Takeo Rehabilitation Engineering And Assistive Technolog 2008 재활복지공학회논문지 Vol.2 No.1
In this paper, I will report the cases of children who are able to study at kindergarten or elementary school because they learned how to move by themselves using a moving aid before school age, and I will also discuss the development of a mobility device which allows severely disabled preschoolers to practice moving around by themselves safely and easily at home and institutions.
Kiyomi Matsuo,Tomoyuki Murata,Takanori Koga,Atsuko Kubo,Yuichi Yoshida,Yosuke Karakawa,Hiroshi Kawaguchi,Tom Tanaka,Jun Masaki,Toshikatsu Taketorni,Takeo Kitajima 한국재활복지공학회 2008 한국재활복지공학회 학술대회논문집 Vol.2008 No.11
In this paper, I will report the cases of children who are able to study at kindergarten or elementary school because they learned how to move by themselves using a moving aid before school age, and I will also discuss the development of a mobility device which allows severely disabled preschoolers to practice moving around by themselves safely and easily at home and institutions.