H∞ Switching Filter Design for LPV Systems in Finite Frequency Domain

Heng Wang,He-Hua Ju,Yu-Long Wang 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.3

This article studies the problem of finite frequency H∞ filter design for switching linear parameter varying (LPV) systems with disturbance frequency affected by system parameters. A set of switching filters are designed, each suitable for a specific parameter subregion and a specific finite frequency performance index. A hysteresis switching logic is adopted, and the design problem is finally formulated into linear matrix inequality (LMI) which can be solved efficiently with LMI Control Tool-box. A numerical example is given to illustrate the effectiveness of the proposed method.

Erythropoietin-Modified Mesenchymal Stem Cells Enhance Anti-fibrosis Efficacy in Mouse Liver Fibrosis Model

Wang Xianyao,Wang Huizhen,Lu Junhou,Feng Zhanhui,Liu Zhongshan,Song Hailiang,Wang Heng,Zhou Yanhua,Xu Jianwei 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5

BACKGROUND: Mesenchymal stem cell (MSC)-based cell transplantation is an effective means of treating chronic liver injury, fibrosis and end-stage liver disease. However, extensive studies have found that only a small number of transplanted cells migrate to the site of injury or lesion, and repair efficacy is very limited. METHODS: Bone marrow-derived MSCs (BM-MSCs) were generated that overexpressed the erythropoietin (EPO) gene using a lentivirus. Cell Counting Kit-8 was used to detect the viability of BM-MSCs after overexpressing EPO. Cell migration and apoptosis were verified using Boyden chamber and flow cytometry, respectively. Finally, the anti-fibrosis efficacy of EPO-MSCs was evaluated in vivo using immunohistochemical analysis. RESULTS: EPO overexpression promoted cell viability and migration of BM-MSCs without inducing apoptosis, and EPO-MSC treatment significantly alleviated liver fibrosis in a carbon tetrachloride (CCl4) induced mouse liver fibrosis model. CONCLUSION: EPO-MSCs enhance anti-fibrotic efficacy, with higher cell viability and stronger migration ability compared with treatment with BM-MSCs only. These findings support improving the efficiency of MSCs transplantation as a potential therapeutic strategy for liver fibrosis.

Trophic Effect of Bee Pollen on Small Intestine in Broiler Chickens

Heng Wang,Jue Wang,Shenghe Li,Qifa Wang,Baozhong Xin 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2

In this study, the effects of bee pollen on the development of digestive organs were evaluated in broiler chick-ens. A total of 144 1-day-old AA broiler chickens were randomly and equally divided into two groups, assigned as the con-trol group and the pollen group, respectively. The control group was fed with a basic diet, while the pollen group was fedwith a basic diet supplemented with 1.5% bee pollen over a period of 6 weeks. At the end of each week, the digestive organswere obtained for comparison from 12 broilers randomly selected from each group. The results demonstrated that comparedto the control group, the small intestine villi from the duodenum, jejunum, and ileum were longer and thicker in the pollengroup. This difference was more significant during early development, especially through the first 2 weeks. Bee pollen in-creased the length of the villi by 37.1% and 29.4% in the duodenum, 28.1% and 33.7% in the jejunum, and 18.6% and 16.2%in the ileum in week 1 and 2, respectively. Furthermore, the small intestinal glands were developed at a higher density in thepollen group, and the depth of the glands was significantly increased by bee pollen in the first 2 weeks. These findings sug-gest that bee pollen could promote the early development of the digestive system and therefore is a potentially beneficial foodsupplement for certain conditions, such as short bowel syndrome.

Prognostic Value of Serum AFP, AFP-L3, and GP73 in Monitoring Short-term Treatment Response and Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation

Wang, Nan-Ya,Wang, Cong,Li, Wei,Wang, Guan-Jun,Cui, Guo-Zhen,He, Hua,Zhao, Heng-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Purpose: Alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and Golgi protein 73 (GP73) levels have been widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to investigate whether these tumor markers could be used to monitor short-term treatment response and recurrence of HCC in patients undergoing radiofrequency ablation (RFA). Methods: Between July 2012 and July 2013, 53 consecutive patients with newly diagnosed HCC were prospectively enrolled in this study. Among these, 32 patients underwent RFA, after which they were followed up prospectively at the First Hospital of Jilin University in China. Results: AFP, AFP-L3, and GP-73 values pre-RFA were not associated with tumor size, whereas AFP and GP-73 levels tended to be associated with tumor number, the presence of vascular invasion, deterioration of liver function, advanced-stage disease, and a poor performance status. GP-73 levels were dramatically elevated in the patients with hepatitis C-associated HCC. Neither pre-RFA nor 1-month post-RFA tumor marker values were associated with short-term outcome. The short-term recurrence rate of AFP-positive patients measured 1 month post-RFA was obviously higher than that of AFP-negative patients. Conclusions: AFP and GP-73 values were associated with clinical variables representing tumor growth and invasiveness, and the AFP value measured 1 month post-RFA was a strong predictor of short-term recurrence in patients with HCC.

Output common mode voltage of a newly combined three‑phase full‑bridge duplex inverter

Hengli Wang,Lei Yuan,Qiang Ren 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.9

Multilevel inverters, owing to their high equivalent switching frequency, high quality of output waveforms, fast dynamic response, and high redundancy, contribute significantly to high-efficiency and high-power inverter applications. However, in practical scenarios, multilevel inverters also have negative impacts. The output common mode voltage is one of the typical problems, which may harm the reliability of systems. In this study, a combined three-phase full-bridge duplex inverter is proposed. Then, the general expression of the proposed inverter’s output common mode voltage is derived based on the numerical double Fourier series. The generation mechanism of the output common mode voltage is subsequently revealed. A common mode voltage suppression strategy, which is universal and applicable to other multiple inverter topologies, is also proposed. The effectiveness of the proposed theory and control strategy is validated through the simulation and the experiment.

Application of Hilbert-Huang transformation in fluidized bed with two-component (biomass particles and quartz sands) mixing flow

Xiaoyi Wang,Zhaoping Zhong,Heng Wang,Zeyu Wang 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.1

Hilbert-Huang transformation was used to investigate the nonlinear characteristics of two-component (bio-mass particles and quartz sand) mixing flow by analyzing the pressure fluctuation signals in fluidized bed. Based onempirical mode decomposition (EMD), the Hilbert-Huang spectra in bubbling and slugging flow patterns were ob-tained and analyzed. In bubbling flow pattern, compared with one-component (quartz sand) flow, the energy of two-component mixing flow is lower in 0-5 Hz and higher in 40-50 Hz. In slugging flow pattern, the energy in pressurefluctuation mainly lies in 0-5 Hz. and the effect of biomass particles on the Hilbert-Huang spectrum is not very obvi-ous. Compared with traditional power spectral density (PSD), HHT is much more suitable for investigating pressurefluctuation signals in fluidized beds.

Contact characteristics and interfacial motion states during sphere oblique impact with initial spin

Qingpeng Wang,Kai Zhang,Zhenfeng Wang,Heng Wang,Yufeng Sun,Xiankun Gao,Guangyin Xu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.5

The impact between a sphere and flat surface plays a significant role in the granular handling process. A method is proposed to investigate the evolution of interfacial states for the sphere oblique impact with initial spin. Firstly, the sphere with irregular surface structures is applied, and the imprinted surfaces are recorded with a thin carbon paper. Then the interfacial characteristics are analyzed in cases of impact angle, contact material and drop height, etc. The geometrical parameters decrease exponentially with impact angle and include three main stages: plateau, slow decrease and sharp decrease. The motional ratio corresponds to slow increase, steady state and sharp increase. For the no pre-spin, it goes through five interfacial states with impact angle. Comparatively, the forward spin decreases the critical angle, and the backward spin decreases the number of states. Furthermore, the parameters increase linearly with drop height, while the effect on interfacial states is very little.

Wide-Tunable Mid Infrared Intra-cavity Optical Parametric Oscillator Based on Multi-period MgO:PPLN

Xiao-Chan Wang,Yu-Heng Wang,Hao Zheng,Hong-Zhi Liu,Yong-Ji Yu,Zi-Jian Wang 한국광학회 2021 Current Optics and Photonics Vol.5 No.1

This paper reports a tunable diode-pumped folded intracavity Q-switched singly resonant optical parametric oscillator based on multi-period MgO:PPLN. A wide tuning mid-infrared parametric lightfrom 2.78 μm to 4.17 μm was obtained in real time by changing the poled periods and temperatures. The maximum output power of 1.89 W at 3.2 μm, 1.53 W at 3.5 μm, 0.87 W at 3.8 μm and 0.486 W at 4.1 μm were achieved. The highest optical-optical conversion efficiency was 7.89%. During experiments, a range tunable output of 2.78–4.17 μm in the mid-infrared range was achieved.

Antiproliferative and Antitumorigenic Activity of Toona sinensis Leaf Extracts in Lung Adenocarcinoma

Chih-Jen Yang,Yu-Jung Huang,Cheng-Yuan Wang,Chuan-Sheng Wang,Pei-Hui Wang,Jen-Yu Hung,Tung-Heng Wang,Hseng-Kuang Hsu,Hurng-Wern Huang,S.P. Anand Kumar,Ming-Shyan Huang,Ching-Feng Weng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1

Toona sinensis is a traditional Chinese herb, and the extracts of T. sinensis leaf possess a variety of biological functions. This study attempted to test the antiproliferative effect of TSL-1 (a bioactive fraction of T. sinensis) in H441 cells (lung adenocarcinoma). The data showed that the antiproliferative effect of TSL-1 on H441 cells is prominent using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. TSL-1-induced apoptosis was confirmed by cell morphology, sub-G1 peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining. Furthermore, decreased Bcl-2 accompanied by increased Bax (in western blotting) was found with TSL-1 treatment of H441 cells. TSL-1 treatment-induced G1 arrest was concurrent with the down-regulation of protein levels of cyclin D1 and cyclin-dependent kinase 4 in H441 cells. Peroral and intraperitoneal administrations of TSL-1 were performed to evaluate the therapeutic efficacy, and peroral administration of TSL-1 was also used to elucidate the therapeutic efficacy in the H441 cell xenograft model in vivo. The data revealed that TSL-1 treatment inhibited H441 tumor growth in both therapeutic and preventive experiments. Taken together, these results demonstrate that TSL-1 possesses the capability of preventing and alleviating lung cancer proliferation in vitro and in vivo with proven nephrological and hepatic safety and has the potential to be developed as an anti–lung cancer drug.

Preliminary Study of Protective Effects of Flavonoids against Radiation-induced Lung Injury in Mice

Wang, Juan,Xu, Heng-Wei,Li, Bao-Sheng,Zhang, Jian,Cheng, Jian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: Radiation therapy plays an important role in lung carcinoma treatment. However, the incidence of symptomatic radiation-induced lung injury is high. This study aimed to evaluate radioprotective effects of flavonoids extracted from Astragalus complanatus and mechanisms of action against radiation damage. Methods: Alteration in antioxidant status and levles of several cytokines were investigated in BABL/C mice treated with 4 mg/kg b.wt. flavonoids after exposure to 10Gy thoracic radiation. Results: Serum levels of SOD in the flavonoids+radiation group were significantly higher compared to the radiation control group, while TGF-${\beta}1$ and IL-6 were lower. Mice in the radiation control group displayed more severe lung damage compared with the flavonoids+radiation group. The expression of TGF-${\beta}1$ and TNF-${\alpha}$ in the radiation control group was markedly increased in alveolar epithelial cells and macrophages of the alveolar septum. Conclusions: From the results of the present study, flavonoids could be excellent candidates as protective agents against radiation-induced lung injury.