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RISS 인기검색어
- 검색키워드
- 저자 : Hejun Liu (검색결과 5 건)
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Li, Hejun,Li, Yuhua,Qiu, Xiaotian,Niu, Xiaoyan,Liu, Yang,Zhang, Qin Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.4
In 2004, Jorgensen and coworkers proposed the MUC4 gene as a candidate gene of enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor in piglets and a mutation of $G{\rightarrow}C$ in intron 7 of MUC4 was identified to be associated with the ETEC F4ab/ac adhesion phenotypes. In this study, we used 310 piglets of three breeds (Landrace, Large White and Chinese Songliao Black) to analyze the relationship between this mutation and the F4ab/ac adhesion phenotype. The results show that the genotypes at this site and the ETEC F4ab/ac adhesion phenotypes were not completely consistent, although they are very strongly associated. Among the individuals with genotype CC, which was identified as a resistant genotype to F4ab/ac adhesion, only 72.1% (124/172) were non-adhesive to ETEC F4ab and 77.9% (134/172) were non-adhesive to ETEC F4ac infections. This suggests that this mutation may not be the causative mutation for ETEC F4ab/ac adhesion, rather, the actual causative mutation may be in another gene closely linked to MUC4, or at aother site within the MUC4 gene. Our results also suggest that the receptors of F4ab and F4ac may be determined by two different but closely linked loci. In order to screen other genes related to F4ab/ac adhesion in piglets, the mRNA profiles from six full sib piglets, of which three were adhesive to ETEC F4ab/ac and three non-adhesive, were analyzed by suppression subtractive hybridization (SSH). One up-regulated gene, Ep-CAM, was selected for further analysis based on its role in the intestinal epithelial cells adhesion. Using real-time RT-PCR, we found that the Ep-CAM gene was significantly up-regulated in the piglets adhesive to F4ab/ac. It was mapped to SSC3q11-q14 by radiation hybrid mapping.
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Kong, Xiangfeng,Yin, Yulong,Wu, Guoyao,Liu, Hejun,Yin, Fugui,Li, Tiejun,Huang, Ruilin,Ruan, Zheng,Xiong, Hua,Deng, Zeyuan,Xie, Mingyong,Liao, Yiping,Kim, Sungwoo Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.9
This study was conducted to test the hypothesis that dietary supplementation with an herbal extract of Acanthopanax senticosus (AS) enhances the immune response in weaned piglets. Sixty piglets weaned at 21 days of age were randomly assigned to 3 treatment groups representing the addition of 0 or 1 g/kg of the AS extract or 0.2 g/kg of colistin (an antibiotic) to maize- and soybean meal-based diets (n = 20 per group). On days 7, 14 and 28 after initiation of the addition, total and differential counts of leucocytes, proliferating activity of peripheral lymphocytes, serum levels of immunoglobulins (Ig) and cytokines and the spleen index were determined. The AS extract decreased (p<0.05) the number of neutrophils on days 7 and 28 in comparison with the control group and reduced (p<0.05) serum interleukin-$1{\beta}$ level on day 28 compared with the other 2 groups. Dietary supplementation with the AS extract increased (p<0.05) the lymphocyte/leukocyte ratio on day 28 compared with the control group and increased the proliferating activity of lymphocytes on days 14 and 28 compared with the other 2 groups. The AS extract increased (p<0.05) the serum content of IgG on day 7 and of IgG and IgM on day 28 compared with the other 2 groups, as well as increasing the serum content of tumor necrosis factor on day 7 and spleen index on days 7 and 28 compared with the control group. Collectively, these findings suggest that the AS extract as a dietary additive enhances the cellular and humoral immune responses of weaned piglets by modulating the production of immunocytes, cytokines and antibodies.
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Study on the interventional path planning method of bronchoscope catheter
Yudong Bao,Xu LI,Wen Wei,Hejun Liu,Shengqian Qu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.5
This paper presents a scientific approach to catheter intervention path planning. Firstly, it gives a three-dimensional reconstruction of bronchi using Mimics software based on CT image data. It also measures and analyzes geometric morphological data of the 3D model, which includes diameter, cross-sectional area, node spacing, and curvature at different locations. Secondly, starting from the bending structure of the catheter, Adams simulation experiments and with and without constraints of the serpentine bending structure were conducted. Comparison and analysis of the experimental results of the above three experiments to obtain the quantitative relationship of the bending angle. This study established a simple control device for interventional examination, verified the effect of the method on linear motion of the device, and provided some theoretical basis for future research to realize an automatic machine for human tracheal intervention.
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Analysis of mechanical contact behavior between the catheter and trachea tissue during bronchoscopy
Yudong Bao,Shengqian Qu,Dongbo Qi,Wen Wei,Yang Zhan,Hejun Liu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.3
As for the contact mechanics between the catheter and trachea tissue during bronchoscopy, the anterior and curved part of the catheter were selected for analysis. The material parameters of each sample were obtained by uniaxial tensile experiments. And this paper verified the stress changes during the contact process using ABAQUS software from three aspects: different material property parameters, contact angle, and catheter bending angle. The results show that: when the characteristic parameter is 90°, the force on the trachea is minimal. And the force changes in a small range when the contact angle is kept at 45°-75°. When the catheter enters the next level of the trachea, the bending part is in contact with the trachea wall. At this time, keeping the bending angle at 15°-30° helps to reduce the contact force. This study could provide a theoretical basis for surgical instruments' interventional therapy.
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Loading capacity evaluation of composite box girder with corrugated webs and steel tube slab
He, Jun,Liu, Yuqing,Xu, Xiaoqing,Li, Laibin Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.50 No.4
This paper presents a type of composite box girder with corrugated webs and concrete filled steel tube slab to overcome cracking on the web and reduce self-weight. Utilizing corrugated steel web improves the efficiency of prestressing introduced into the top and bottom slabs due to the accordion effect. In order to understand the loading capacity of such new composite structure, experimental and numerical analyses were conducted. A full-scale model was loaded monotonically to investigate the deflection, strain distribution, loading capacity and stiffness during the whole process. The experimental results show that test specimen has enough loading capacity and ductility. Based on experimental works, a finite element (FE) model was established. The load-displacement curves and stress distribution predicted by FE model agree well with that obtained from experiments, which demonstrates the accuracy of proposed FE model. Moreover, simplified theoretical analysis was conducted depending on the assumptions which were confirmed by the experimental and numerical results. The simplified analysis results are identical with the tested and numerical results, which indicate that simplified analytical model can be used to predict the loading capacity of such composite girder accurately. All the findings of present study may provide reference for the application of such structure in bridge construction.
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