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안삼근,강형철,안상열,이균필,변희섭 경상대학교 농업생명과학연구원 2002 농업생명과학연구 Vol.36 No.4
본 연구는 집성 염색 무니목 개발을 위하여 사용 가능한 수종과 3종류의 염료를 사용하여 염색시간, 염색온도, 함수율 및 Flitch 제작에 대하여 연구한 결과는 다음과 같다. 실험에 사용한 4수종 중에서 선삭성이 불량한 은수원 사시나무를 제외한 3수종인 소나무와 이태리 포플러, 마티카가 사용 가능한 수종으로 밝혀졌다. Stain은 번지거나 얼룩이 지는 현상, Dylon은 침투 불균일로 부적당하였으나 Fine은 염색상태가 양호하였다. 염색시간은 5시간 이상 되어야 염색정도가 양호하였고, 염색온도는 90℃에서 가장 적당하였으며 생재와 기건재 및 포수재에 대한 영향은 큰 차이가 없었다. Flitch제작에 적당한 함수율은 9%이었다. This study was carried out to develop laminated dyeing wood, for which usable three sixties of trees and 3 kinds of dye stuffs were used to investigate dyeing time, dyeing temperature, moisture content and manufacture of flitch, the results were as follows: Out of four species of trees used in the experiment, it was found that three species, Pinus densiflora, Populus euramercana and Dyrea costulata were usable excluding Populus tomentiglandulosa whose cutting ability was bad. As to influence according to the kind of dye stuff, the Stain of low price could be used as a coloring agent but it was not proper as a dyeing agent due to spreading or staining phenomenon. As Dylon which was generally used to dye textile penetrated them uneven, dyeing only their surface, it was also found improper to be used. On the other hand, the dyed condition was good with Fine. The dyed condition was good when dyeing time was more than 5 hours and it was the most adequate when the temperature was at 90℃. There was no significant difference between their influence on green, dried and saturated wood.-In the manufacture of Flitch, the most appropriate moisture content was 9%.
열수 및 마이크로웨이브처리 맹종죽재의 물리적·기계적 특성
신훈재,안상열,변희섭,박상범,공영토 한국목재공학회 2004 목재공학 Vol.32 No.2
열수 및 마이크로웨이브조사 처리가 별채시기 및 부위별에 따른 맹종죽재의 물리적 기계적 특성을 평가하고, 효율적인 연화조건을 탐색하기 위하여 경남 진주시 가좌동에 위치한 남부임업시험장내에서 생육이 양호한 1, 2, 3년생의 죽재를 8월과 1월에 벌채하여 실험한 결과는 다음과 같았다. 1. 윗부위, 중간부위, 아랫부위의 부위별에 따른 휨탄성계수의 차이는 윗부위가 가장 높은 값을 나타내었고 중간부위, 아랫부위 순으로 낮은 값을 나타내었으며 대부분이 70,000~110,000 kgf/㎠의 범위에 있었다. 2. 동적 탄성계수의 범위는 80,000~130,000 kgf/㎠의 범위로 정적 탄성계수보다 10~25% 정도 높게 나타났으며, 8월과 1월의 상관관계 R값이 각각 0.87과 0.68로 나타나 일반적인 목재와 같이 맹종죽재의 탄성계수 측정에도 비파괴 방법인 양단자유진동에 의해서도 예측 가능하였다. 3. 95℃의 열수로 처리했을 때 연화율은 10~30%를 나타내었다. 4. 생재 및 포수 두 조건 모두 마이크로웨이브조사 처리 시간이 길어질수록 탄성계수가 낮아졌으며, 20초 및 30초간 처리했을 때 생재 휨탄성계수의 약 50% 이하로 떨어져 생재를 20초간 마이크로웨이브조사 처리했을 때가 본 연구에서 죽재를 연화시키는데 가장 효과적인 방법이었다.
Adverse fetal outcomes in pregnant rabbits experimentally infected with rabbit hepatitis E virus
Ahn, Hee-Seop,Han, Sang-Hoon,Kim, Yong-Hyun,Park, Byung-Joo,Kim, Dong-Hwi,Lee, Joong-Bok,Park, Seung-Yong,Song, Chang-Seon,Lee, Sang-Won,Choi, Changsun,Myoung, Jinjong,Choi, In-Soo 3M Company 2017 Virology Vol.512 No.-
<P>Hepatitis E virus (HEV) causes severe hepatitis in pregnant women, with associated poor fetal outcomes. To study HEV viral pathogenesis, pregnant rabbits were infected with low-and high-dose rabbit HEV at 2 weeks gestation. HEV was identified in the serum, feces, and liver tissue of infected rabbits, and dose-dependent fetal mortality rates ranging from 67% to 80% were observed. The aspartate transaminase (AST)/alanine transaminase ratio was significantly higher (P < 0.01) in high-dose infected rabbits than low-dose infected and negative control rabbits 14 days post infection (dpi). Tumor necrosis factor-alpha (TNF-alpha) was significantly higher in low dose (P < 0.01) and high-dose infected rabbits (P < 0.001) than in negative controls 7 dpi. High-dose HEV-infected rabbits produced significantly more interferon-gamma (IFN-gamma; P < 0.05) than negative control rabbits at 7 and 14 dpi. High levels of AST, TNF-alpha, and IFN-gamma may substantially influence adverse fetal outcomes in pregnant rabbits infected with high-dose HEV.</P>
Hemophagocytic lymphohistiocytosis diagnosed by brain biopsy
Ju, Hee Young,Hong, Che Ry,Kim, Sung Jin,Lee, Ji Won,Kim, Hyery,Kang, Hyoung Jin,Park, Kyung Duk,Shin, Hee Young,Chae, Jong-Hee,Phi, Ji Hoon,Cheon, Jung-Eun,Park, Sung-Hye,Ahn, Hyo Seop The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.9
Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, jaundice, and pathologic findings of hemophagocytosis in bone marrow or other tissues such as the lymph nodes and liver. Pleocytosis, or the presence of elevated protein levels in cerebrospinal fluid, could be helpful in diagnosing HLH. However, the pathologic diagnosis of the brain is not included in the diagnostic criteria for this condition. In the present report, we describe the case of a patient diagnosed with HLH, in whom the brain pathology, but not the bone marrow pathology, showed hemophagocytosis. As the diagnosis of HLH is difficult in many cases, a high level of suspicion is required. Moreover, the pathologic diagnosis of organs other than the bone marrow, liver, and lymph nodes may be a useful alternative.
( Ji Hee Yu ),( Jae Hee Ahn ),( Hye Jin Yoo ),( Ji A Seo ),( Sin Gon Kim ),( Kyung Mook Choi ),( Sei Hyun Baik ),( Dong Seop Choi ),( Chol Shin ),( Nan Hee Kim ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6
Background/Aims: Obstructive sleep apnea (OSA) is associated with an increased risk of obesity and non-alcoholic fatty liver disease (NAFLD), but it remains unclear whether the risk of NAFLD is independently related to OSA regardless of visceral obesity. Thus, the aim of the present study was to examine whether OSA alone or in combination with excessive daytime sleepiness (EDS) or short sleep duration was associated with NAFLD independent of visceral fat in Korean adults. Methods: A total of 621 participants were selected from the Korean Genome and Epidemiology Study (KoGES). The abdominal visceral fat area (VFA) and hepatic fat components of the participants were assessed using computed tomography scans and they were then categorized into four groups depending on the presence of OSA and EDS. Results: The proportions of NAFLD were 21.1%, 18.5%, 32.4%, and 46.7% in participants without OSA/EDS, with only EDS, with only OSA, and with both OSA and EDS, respectively. A combination of OSA and EDS increased the odds ratio (OR) for developing NAFLD (OR, 2.75; 95% confidence interval [CI], 1.21 to 6.28) compared to those without OSA/EDS, and this association remained significant (OR, 2.38; 95% CI, 1.01 to 5.59) even after adjusting for VFA. In short sleepers (< 5 hours) with OSA, the adjusted OR for NAFLD was 2.50 (95% CI, 1.08 to 5.75) compared to those sleeping longer than 5 hours without OSA. Conclusions: In the present study, OSA was closely associated with NAFLD in Korean adults. This association was particularly strong in those with EDS or short sleep duration regardless of VFA.
Evening Chronotype Is Associated With Metabolic Disorders and Body Composition in Middle-Aged Adults
Yu, Ji Hee,Yun, Chang-Ho,Ahn, Jae Hee,Suh, Sooyeon,Cho, Hyun Joo,Lee, Seung Ku,Yoo, Hye Jin,Seo, Ji A,Kim, Sin Gon,Choi, Kyung Mook,Baik, Sei Hyun,Choi, Dong Seop,Shin, Chol,Kim, Nan Hee Issued for the Endocrine Society by the Williams & 2015 The Journal of clinical endocrinology & metabolism Vol.100 No.4
Yoo, Keon Hee,Lee, Soo Hyun,Sung, Ki Woong,Koo, Hong Hoe,Chung, Nak Gyun,Cho, Bin,Kim, Hack Ki,Kang, Hyoung Jin,Shin, Hee Young,Ahn, Hyo Seop,Baek, Hee Jo,Han, Dong Kyun,Kook, Hoon,Hwang, Tai Ju,Kim, Wiley Subscription Services, Inc., A Wiley Company 2011 American journal of hematology Vol.86 No.1
<P><B>Abstract</B></P><P>We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that the sources of the grafts were mostly unrelated donors (<I>n</I> = 226; 95.8%), only the results of unrelated UCBT were included for all statistics. The most frequent primary disease was acute leukemia (<I>n</I> = 167). In total, 91.7% of recipients were seropositive for cytomegalovirus (CMV). The median doses of nucleated cells and CD34+ cells were 4.84 × 10<SUP>7</SUP>/kg and 2.00 × 10<SUP>5</SUP>/kg, respectively. The median times to neutrophil (>0.5 × 10<SUP>9</SUP>/L) and platelet recovery (>20 × 10<SUP>9</SUP>/L) were 18 and 45 days, respectively. Grade 2–4 acute graft‐versus‐host‐disease (GVHD) and chronic GVHD developed in 41.1 and 36.1% of cases, respectively. Forty‐five patients developed CMV disease. The 5‐year overall and event‐free survival were 47.5 and 36.9%, respectively. Multivariate analysis revealed that adverse factors for survival of the whole cohort were total body irradiation‐based conditioning (<I>P</I> = 0.007), salvage transplant (<I>P</I> = 0.001), failure to achieve early complete chimerism (<I>P</I> < 0.0005), and CMV disease (<I>P</I> = 0.001). The outcomes of the single‐ and double‐unit UCBT (<I>n</I> = 64) were similar, while double‐unit recipients were heavier (<I>P</I> < 0.0005) and older (<I>P</I> < 0.0005). We conclude that double‐unit UCBT is a reasonable option for older or heavier children and that the thorough surveillance of CMV infection and the development of an effective CMV therapeutic strategy may be especially important for Korean children, whose CMV seroprevalence exceeds 90%. Am. J. Hematol., 2011. © 2010 Wiley‐Liss, Inc.</P>
Genetic Variants in Interleukin-2 and Risk of Lymphoma among Children in Korea
Song, Nan,Han, So-Hee,Lee, Kyoung-Mu,Choi, Ji-Yeob,Park, Sue-K,Jeon, Su-Jee,Lee, Yun-Hee,Ahn, Hyo-Seop,Shin, Hee-Young,Kang, Hyoung-Jin,Koo, Hong-Hoe,Seo, Jong-Jin,Choi, Ji-Eun,Kang, Dae-Hee Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma ($P_{trend}$ <0.05) in six genes ($IL1RN$, $IL2$, $IL12RB1$, $JAK3$, $TNFRSF13B$, and $XRCC3$). The most significant association was seen for $IL2$ variant rs2069762 ($OR_{TG+GG}$ vs. TT=3.43 (1.29-9.11), $P_{trend}$=0.002, min$P$=0.005). These findings suggest that common genetic variants in $IL2$ might play a role in the pathogenesis of childhood lymphoma.
Yoon, Hoi Soo,Im, Ho Joon,Moon, Hyung Nam,Lee, Jae Hee,Kim, Hee-Jin,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong Hoe,Kang, Hyung Jin,Shin, Hee Young,Ahn, Hyo Seop,Cho, Bin,Kim, Hack Ki,Lyu, Chuhl Joo,Lee, M Blackwell Publishing Ltd 2010 Pediatric transplantation Vol.14 No.6
<P>Yoon HS, Im HJ, Moon HN, Lee JH, Kim H-J, Yoo KH, Sung KW, Koo HH, Kang HJ, Shin HY, Ahn HS, Cho B, Kim HK, Lyu CJ, Lee MJ, Kook H, Hwang TJ, Seo JJ. The outcome of hematopoietic stem cell transplantation in Korean children with hemophagocytic lymphohistiocytosis.Pediatr Transplantation 2010: 14:735–740. © 2010 John Wiley & Sons A/S.</P><P>Abstract: </P><P>Chemoimmunotherapy-based treatments have improved the survival of patients with HLH, but outcomes of the patients are still unsatisfactory. We report here the outcome of Korean children with HLH who underwent HSCT, which was analyzed from the data of a nation-wide HLH registry. Retrospective nation-wide data recruitment for the pediatric HLH patients diagnosed between 1996 and 2008 was carried out by the Histiocytosis Working Party of the Korean Society of Hematology. Nineteen patients who received HSCT among the total of 148 enrolled children with HLH were analyzed for the transplant-related variables and events. The probability of five-yr survival after HSCT was 73.3% with a median follow-up of 57. Two months compared to 54.3% for the patients who were treated with chemoimmunotherapy only (p<I> </I>=<I> </I>0.05). The reasons for HSCT were active disease after eight wk of initial treatment (n = 9), relapsed disease (n = 5), and FHL (n = 5). Fourteen patients are currently alive without disease after HSCT, four patients died of treatment-related events (infection in two and graft failure in two) at early post-transplant period, and one patient died of relapse at one yr post transplantation. The survival of patients who were transplanted because of active disease after eight wk of initial treatment was worse compared to those patients who had inactive state at that time (60.6% vs. 100%, respectively, p<I> </I>=<I> </I>0.06). Of the four patients who received transplants using cord blood, three died of graft failure (n = 2) and relapse (n = 1). The five-yr probability of survival after HSCT according to the donor type was 85.7% for the MRDs (n = 6), 87.5% for the MUDs (n = 8), and 40% for the MMUDs (n = 5) (p<I> </I>=<I> </I>0.03). Other variables such as age, CNS involvement at the time of diagnosis, the etiology of HLH (familial or secondary), and the conditioning regimens had no influence on the five-yr OS of the HLH patients who underwent HSCT. HSCT improved the survival of the patients who had familial, relapsed, or severe and persistent SHLH in the Korean nation-wide HLH registry. Although numbers were small, these results are similar to other reports in the literature. The disease state after initial treatment, the stem cell source of the transplant, and the donor type were the important prognostic factors that affected the OS of the HLH patients who underwent HSCT.</P>