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RISS 인기검색어
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- 저자 : Hee Jeung Lim (검색결과 64 건)
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이명희,박선희,임선영,정은경,서정근 한국식물인간환경학회 2000 인간식물환경학회지 Vol.3 No.4
This study was performed on 10 older adult at Cheonan City Day care facility for once a week for 15weeks. And then preference was examined through investigation of interesting, work-attitude, feeling reaction. The results were as follows ; 1.Preference of activities which used various plants such as 'Dish garden', which satisfied needs for health of older adult such as 'Aromatherapy' was high on Interesting. 2.Preference of skilled activities by repetition such as 'Making flower basket' was high on Work-Attitude. 3.Preference of activities which they can express their own idea such as 'Making flower basket', which feel accomplishment through products was high on Feeling Reaction.
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황해익,임재택,김정신,송연숙,이경화,김남희 부산대학교 영유아보육연구소 1998 영유아보육연구 Vol.4 No.-
This study aimed to develop Materials for (The Infant Educare Program) (Dept. of Health & Welfare, 1996). Infant educare Materials were developed through following procedures: 1) analysis of reference and other educare materials 2) content analysis of (The Infant Educare Program) 3) developing materials and 4)testing and revising materials by professionals. Infant educare Materials that developed in this study were constituted of 12 kinds in 5 areas - Materials for management of daycare center, the nursery stories for infants, musical materials for infants, play things for infants, and educational materials for parents. First, materials for management of daycare center were considered various conditions whithin daycare centers and were compased of 2 kinds - diary for educare plan and diskettes for documents. Second, the nursery stories for infants were compased of materials for 3 stages-the weaning stage, the toddling stage, and the independent stage. Similarly, musical materials for infants were composed of 3 stages. And play things for infants were composed of 2 kinds - play things to be easily founded and easily making play things. Finally, educational materials for parents were composed of 2 kinds - guide book for parents education and diskettes for communication with parents. It is needed that persistent attention from professionals in developing and testing materials for infant educare. Also, further educational implications were discussed
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Poly(ADP-ribose)Polymerase 억제제가 신생백서의 저산소성 허혈성 뇌손상에 미치는 영향/1H 자기공명분광법을 이용한 연구
황현숙,이정희,박평환,석은하,임근호,곽미정 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.42 No.2
Background : Poly (ADP-ribose) polymerase (PARP) has been described as an important candidate for mediation of neurotoxicity after brain ischemia. This study was purposed to evaluate the effects of a PARP inhibitor on hypoxic-ischemic injury in the neonatal rat brain. In this study, a highly potent inhibitor of PARP, 3, 4-Dihydro-5-[4-(1-piperidinyl) butoxy]-1 (2H)-isoquinolinone (DPQ) was investigated. Methods : Seven-day old Sprague-Dawley rat pups were used. The right common carotid artery was ligated under halothane anesthesia. After a recovery period of 3 hours, they were exposed to 8% oxygen at 37℃ for about 120 minutes. The animals were divided into four groups: the pre-treatment group (n = 13) and post-treatment group (n = 21) were given DPQ 10 ㎎/㎏ and the pre-control group (n = 7) and post-control group (n = 14) were given a vehicle for controls. Pre-treatment and pre-control groups were injected 30 minutes prior to the hypoxic injury while post-treatment and post-control groups were injected 30 minutes after the hypoxic period intraperitoneally. The right cerebral hemisphere of the rats were examined with localized ^1H magnetic resonance spectroscopy on day 1 and 7 after the hypoxic insult. Lipid/N-acetyl aspartate (Lip/NAA) and lipid/creatine (Lip/Cr) ratios were used as apoptotic markers. On day 14, the degree of brain injury was scored by morphological changes. Results : In the DPQ treated groups, the Lip/NAA and Lip/Cr ratios were lower than those of the control groups on day 1 after the hypoxic-ischemic injury (P < 0.05). However on day 7, only the ratios of the pre-treatment group were lower than those of the control group (P < 0.05). The degree of morphological changes of the brain injury on day 14 were lower in the DPQ treated groups (P < 0.05). Conclusions : These results suggest that DPQ exerts a neuroprotective effect in cerebral hypoxicischemic injury probably by inhibiting apoptosis especially in the early stage after an insult. Acute inhibiton of PARP can have a therapeutic value in preventing ischemic brain injury. (Korean J Anesthesiol 2002; 42: 228~240)
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Lim, Mi-Hee,Jeung, In Cheul,Jeong, Jinyoung,Yoon, Sung-Jin,Lee, Sang-Hyun,Park, Jongjin,Kang, Yu-Seon,Lee, Hansu,Park, Young-Jun,Lee, Hee Gu,Lee, Seon-Jin,Han, Baek Soo,Song, Nam Woong,Lee, Sang Chul Elsevier 2016 Acta Biomaterialia: structure-property-function re Vol.46 No.-
<P><B>Abstract</B></P> <P>Despite the rapid expansion of the biomedical applications of graphene oxide (GO), safety issues related to GO, particularly with regard to its effects on vascular endothelial cells (ECs), have been poorly evaluated. To explore possible GO-mediated vasculature cytotoxicity and determine lateral GO size relevance, we constructed four types of GO: micrometer-sized GO (MGO; 1089.9±135.3nm), submicrometer-sized GO (SGO; 390.2±51.4nm), nanometer-sized GO (NGO; 65.5±16.3nm), and graphene quantum dots (GQDs). All types but GQD showed a significant decrease in cellular viability in a dose-dependent manner. Notably, SGO or NGO, but not MGO, potently induced apoptosis while causing no detectable necrosis. Subsequently, SGO or NGO markedly induced autophagy through a process dependent on the c-Jun N-terminal kinase (JNK)-mediated phosphorylation of B-cell lymphoma 2 (Bcl-2), leading to the dissociation of Beclin-1 from the Beclin-1–Bcl-2 complex. Autophagy suppression attenuated the SGO- or NGO-induced apoptotic cell death of ECs, suggesting that SGO- or NGO-induced cytotoxicity is associated with autophagy. Moreover, SGO or NGO significantly induced increased intracellular calcium ion (Ca<SUP>2+</SUP>) levels. Intracellular Ca<SUP>2+</SUP> chelation with BAPTA-AM significantly attenuated microtubule-associated protein 1A/1B-light chain 3-II accumulation and JNK phosphorylation, resulting in reduced autophagy. Furthermore, we found that SGO or NGO induced Ca<SUP>2+</SUP> release from the endoplasmic reticulum through the PLC β3/IP<SUB>3</SUB>/IP<SUB>3</SUB>R signaling axis. These results elucidate the mechanism underlying the size-dependent cytotoxicity of GOs in the vasculature and may facilitate the development of a safer biomedical application of GOs.</P> <P><B>Statement of Significance</B></P> <P>Graphene oxide (GO) have received considerable attention with respect to their utilization in biomedical applications. However, GO-related safety issues concerning human vasculature are very limited. In this manuscript, we report for the first time the differential size-related biological effects of GOs on endothelial cells (ECs). Notably, Subnanometer- and nanometersized GOs induce apoptotic death in ECs via autophagy activation. We propose a molecular mechanism for the GO-induced autophagic cell death through the PLCβ3/IP3/Ca<SUP>2+</SUP>/JNK signaling axis. Our findings could be provide a better understanding of the GO sizedependent cytotoxicity in vasculature and facilitate the future development of safer biomedical applications of GOs.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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( Jeung-min Lee ),( Young Hee Kim ),( Jin Young Hong ),( Boa Lim ),( Ji Hee Park ) 한국목재공학회 2020 목재공학 Vol.48 No.3
우리나라는 울릉도 및 제주도를 포함한 전국에서 흰개미에 의한 목조 문화재의 피해가 보고되어 있다. 흰개미에 의한 피해를 감소시키고자 훈증처리나 토양에 약물을 처리하여 살충 및 방충을 하는 것이 대부분이며 비용과 안전성의 문제로 인해 점점 처리하는 횟수가 감소하는 추세이다. 이런 상황을 대처하기 위해 새로운 방법이 필요한 실정이므로 전남 신안에서 채집한 흰개미에서 일개미만 선별하여 효소를 추출한 후 목재 구성성분인 cellulose와 hemicellulose의 xylan을 기질로 하여 효소 활성을 측정한 결과, 분자량이 큰 cellulose 보다 xylan에서 흰개미 장내 효소의 활성이 크게 나타났다. 그러므로 본 연구에서는 xylan을 기질로 하여 흰개미 장내 효소의 활성을 억제하는 약용식물 추출물 600여 종을 탐색한 결과, 용뇌, 마황, 박하뇌에서 억제효과가 크게 나타났다. 선별된 용뇌(Borneolum Syntheticum), 마황(Ephedra sinica), 박하뇌(Menthol) 추출물은 흰개미 장내 효소의 활성을 억제할 뿐만 아니라 직접 처리한 결과에서도 살충활성 및 섭식 저해 효과가 있음을 확인하였다. In Korea, damages to wooden cultural properties by termites have been reported all over the country, including Ulleungdo Island and Jeju Island. In order to reduce the damage caused by termites, most cultural properties damaged by them are treated with fumigation or drug treatment on the soil to kill or repel them. The number of treatments is decreasing due to cost and safety problems, and new methods needed to cope with this situation. After extracting an enzyme by selecting only worker termites from the termites collected in Shinan, Jeonnam, as a result of measuring the enzyme activity using xylan of cellulose and hemicellulose that are the components of wood, the activity of termite intestinal enzymes in xylan was higher than that of cellulose having a high molecular weight. Therefore, in this study, as a result of exploring over 600 species of medicinal plant extracts that inhibit the activity of termite intestinal enzymes using xylan as a substrate, the inhibitory effect was significant in Borneolum Syntheticum, Ephedra sinica, and Menthol. Selected Borneolum Syntheticum, Ephedra sinica, and Menthol's extracts not only inhibited the activity of termite intestinal enzymes, but also confirmed that they have insecticidal activation and inhibitory effects on feeding in the result of the direct treatment.
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Jeung, Hee-Do,Keshavmurthy, Shashank,Lim, Hyun-Jeong,Kim, Su-Kyoung,Choi, Kwang-Sik Elsevier 2016 Aquaculture Vol.464 No.-
<P><B>Abstract</B></P> <P>Oyster culture forms one of the major produce of aquaculture industry in Korea. Due to the demand for production, it is necessary to maintain a steady culture process. However, as a result of oil spill accident and other environmental problems in the west coast, there is a need to find a quick recovery in the production of oysters. While oyster culture in Korea is dominated by use of diploid oysters, an alternative to fast recovery for oyster industry is to introduce the use of triploid oysters. Triploid oysters have advantage in terms of faster growth and negligible quantity of reproductive effort during spawning, resulting in shorter grow-out period and improved meat quality compared to diploid oysters. In this study, we determined the reproductive effort in triploid females of Pacific oyster, <I>Crassostrea gigas</I> using an indirect enzyme-linked immunosorbent assay (ELISA). Two years old triploid and diploid female oysters raised in rack and bag oyster culture system on the west coast of Korea were collected during spawning and post-spawning season in 2013. Histology revealed that the diploid females spawned from June to September, with a peak in June. Unlike diploids, the triploid females exhibited no sign of spawning as the diploids were actively engaged in spawning. During post-spawning season, the triploid oysters reabsorbed the mature remnant eggs in their follicles. Gonad somatic index (GSI), determined using ELISA, of the diploid females reached its peak in June as 22.2%. In contrast, GSI of the triploids recorded during spawning peak was only 3.4%. Carbohydrate and glycogen contents in the triploid oyster tissues during spawning season were much higher than in diploids, suggesting that the triploids used minimum energy for reproduction in summer season, containing very small amount of gonad and high level of glycogen.</P> <P><B>Statement of relevance</B></P> <P>Reproductive efforts (amount and number of eggs) of the diploid and triploid Pacific oysters measured in this study clearly demonstrated sterility of the triploid oysters during spawning season in summer. The present study also report gametogenic pattern of the triploid, crucial in the management of oyster aquaculture.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Precise quantification of the reproductive effort in a triploid oyster by indirect ELISA </LI> <LI> Diploid oysters grown in natural environment </LI> <LI> Faster growth and negligible reproductive effort during spawning </LI> <LI> Economical and profitable due to faster production and increased quality </LI> </UL> </P>
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Lee, Jeung-Eun,Kim, Jung-Min,Jang, Hyun-Jun,Lim, Se-Young,Choi, Seon-Jeong,Lee, Nan-Hee,Suh, Pann-Ghill,Choi, Ung-Kyu Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.4
Propyl gallate (PG) used as an additive in various foods has antioxidant and anti-inflammatory effects. Although the functional roles of PG in various cell types are well characterized, it is unknown whether PG has effect on stem cell differentiation. In this study, we demonstrated that PG could inhibit adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells (hAMSCs) by decreasing the accumulation of intracellular lipid droplets. In addition, PG significantly reduced the expression of adipocyte-specific markers including peroxisome proliferator-activated receptor-${\gamma}$ (PPAR-${\gamma}$), CCAAT enhancer binding protein-${\alpha}$ (C/EBP-${\alpha}$), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein 2 (aP2). PG inhibited adipogenesis in hAMSCs through extracellular regulated kinase (ERK) pathway. Decreased adipogenesis following PG treatment was recovered in response to ERK blocking. Taken together, these results suggest a novel effect of PG on adipocyte differentiation in hAMSCs, supporting a negative role of ERK1/2 pathway in adipogenic differentiation.
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