Minoxidil에 의한 모발절대휴지기 탈출 유도 효과

이은정,조영롱,조경혜 서울여자대학교 자연과학연구소 2011 자연과학연구논문집 Vol.23 No.-

Hair follicle (HF), a small physiological organ in the human body which produces hair, repeats a four-phased hair cycle consisting of anagen, catagen, telogen, and exogen phases and affects the growth, maintenance, and loss of hair. Recent studies revealed that the hair growth and loss are controlled by the balance between bmp and nog expressed from dermal papilla cells (DP cells) which control the physiological characteristics of the hair growth cycle and that a phase transition from refractory telogen phase to competent telogen phase, caused from the reduction in expression of bmp gene in the telogen phase, is indispensible for the regeneration of hair cycle. This study is conducted to verify the effect of minoxidil, a depilatory lotion widely used around the globe on the molecular mechanism in the hair cycle process occurring in the DP cells, especially in the expression of bmp and nog genes. DP-enriched cells were separated and cultured from the back skin of 1 day-old new born rats and observed the effects after processing minoxidil on the cells. Minoxidil reduced the expression of bmp4 and bmp6 genes, which stimulate differentiation but inhibit multiplication of DP cells in the hair cycle control process, and reduced the expression of bmprla gene, as its receptor. Minoxidil also reduced the expression of nog genes known as an antagonist of bmp produced from DP cells and an essential element in the telogen-anagen phase transition. From this results, minoxidil induced the DP cells to stay at the competent telogen phase, a prior phase of the initiation of the anagen phase, and to escape from refractory telogen phase of the hair cycle. Also, minoxidil induced DP cells to an ‘undifferentiated state of hair cell' of competent telogen phase, a prior phase of early anagen phase, rather than that inducing the cell to an initiation phase of hair cycle, the anagen phase. Minoxidil reduced the expression of nog gene which is an essential element in the regeneration of hair cycle, but increased the expression of bfgf gene, a upstream growth factor which stimulates the expression of nog and vegf genes which foster the growth of DP cell. Thus, it can be suggested that there is possibility that minoxidil indirectly affects telogen-anagen phase transition and the initiation of anagen phase. In conclusion, this study verified that minoxidil leads escape from refractory telogen phase of a hair growth cycle and thereby reduces the period of the telogen phase. Key words:dermal papilla cells, minoxidil, bmp, noggin, hair cycle.

창원대학교 재학생들의 식생활 태도와 영양섭취상태에 관한 연구(II) : On Nutrient intakes 영양섭취상태를 중심으로

허은실,이경혜 창원대학교 생활과학연구소 1997 생활과학연구 Vol.- No.1

The purpose of this survey was to assess nutrient intakes of 648 college students in Changwon National University by anthropometric measurements and estimating dietary intakes. The results obtained were as follows. 1. The averages of height and weight of the students were slightly lower those of Korean standard. 2. Daily energy and protein intake of students were lower than those of Korean RDA. The average energy intake of freshmen was significantly higher than other grades. Students in the boarding home with self cooking among residences and students in college of fine arts among colleges showed the lowest energy intake. 3. Intake of calcium of all students was lower than that of Korean RDA. Intake of iron in male students was higher than that of RDA, however, iron intake of female students was 61.7% of RDA. The lowest intake of calcium and iron showed the boarding home with self cooking. 4. Vitamine C and A intake in vitamins were only enough. Students in boarding home with self cooking also showed the lowest intake of vitamins in residences. Proportion of energy intake from alcohol were 15% in male and 8% in female students. From the above results, it is suggested that nutrition education for college students is needed, and menus of campus cafeterias showed be developed to meet the various needs of students.

경남과 전북지역 초등학교 영양사의 인터넷 및 식생활정보 이용실태

허은실,이경혜 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

This study was carried out to investigate the status of the utilization of internet and dietary information by elementary school dietitians (total = 201). The results were summarized as follows: All subjects used the internet regularly and the major purpose they mentioned for using it was "data search" (72.3%). Those having a frequency of using the internet 6 to 7 times per week were 46.7% of the subjects and the majority indicated the duration of their use of the internet was " , 2 hours" (68.5%). They mainly used the internet at "school" (81.8%), and their favorite search engines were "Daum" (41.1%) and "Yahoo" (34.7%). They stated that the organization that offered reliable internet information were those "related to society and organizations" (36.9%) and "educational institutions" (33.8%). Ninety-five percent of the subjects searched for dietary information mainly "for public affairs" (80.0%). Their degree of satisfaction when searching for information was high (78.7%). Those dissatisfied with internet sites when searching for dietary information gave the following reasons: "poor information" (39.1%) and "slow updates" (25.4%). They acquired information on nutrition and health management mainly through "the internet" (63.6%). The most frequently requested information about public affairs was on "Materials for nutritional education" (38.6%) and "up-to-date nutritional information" (36.0%). The desirable update periods for websites was "1 - 3 months" (51.8%) and "< 1 month" (30.6%), and the favorite site colors were "blue" (37.8%) and "green" (37.8%). The results of this study showed that, although the internet usage was high, the dietitians were dissatisfied with the information obtained. Therefore, the information donors should find out what kind of dietary information is needed by elementary school dietitians.

마임 건강식품 홍삼진을 이용한 전통과 모던의 융합적 브랜드 이벤트 프로모션 산업체 연계를 통한 아트, 디자인, 공학, 마케팅 융합 디자인을 중심으로-

길혜경,박민지,이하은,조예린,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 융합 연출 디자인 이라는 목적에서 출발하여 마임 브랜드 홍삼진 제품을 다각적 측면에서 기획 및 분석하는데 목적이 있다. 이에 본 연구는 2017년 3월~ 6월 15주 동안 숙명여대 환경디자인학과<융합 캡스톤 디자인>수업을 통해 이루어졌다. 또한 본 연구는 마임브랜드 중, 건강식품을 브랜딩하고 있는 <홍삼 진>을 선택하였다. 그 결과 본 연구는 기존 이벤트 프로모션과 전시의 사회적 문제를 도출하였고, 이를 해결하기 위한 방안으로서 전통과 현대의 융합의 오감적 체험 프로모션을 주제로 선정하였다. 아울러 본 연구는 SWOT/STP 마케 팅 분석 방법과 브레인스토밍을 사용하여 아트, 디자인, ICT, Marketing의 융합 브랜드를 구축하였다.끝으로 본 연구는 향후 마케팅을 기반한 융합 브랜드 개발에 있어 기초 자료로 활용될 수 있을 것이라 기대된다.

리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.

스프렌딜 지속정(펠로디핀 5㎎)에 대한 스타핀 지속정의 생물학적동등성

조혜영,강현아,이석,백승희,박은자,최후균,문재동,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by means of a direct, selective action on smooth muscle in arterial resistance vessels. Furthermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). THe felodipine release from the two felodipine formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method at pH 6.5 buffer solution. Twenty six healthy male subjects, 22.73±1.78 years in age and 66.66±7.28 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 5 ㎎ as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as AUG_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for AUC_(t), C_(max) and T_(mzx), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.86)∼log(1.20) and long(0.89)∼long(1.23) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.

성인 암환자의 질병 특성에 따른 증상발생 정도

허혜경,이은현,이원희,소향숙,정복례,강은실 성인간호학회 2002 성인간호학회지 Vol.14 No.3

Purpose: This study was to investigate symptom occurrence related to the disease characteristics of patients with cancer. Method: A total of 301 patients with cancer participated in this study. The participants were recruited from University Hospitals located in Seoul, Wonju, Kwangju, Daegu, and Pusan. Data collection was performed by using a questionnaire on symptom occurrence. The obtained data was analyzed using SPSS computer program that included descriptive statistics, Pearson correlation, one-way ANOVA, and t-test. Result: The mean score of fatigue was the highest (3.24), followed by loss of appetite, lack of concentration, change in appearance, pain, insomnia, change in bowel pattern, nausea/vomiting, coughing, and dyspnea. Most symptoms were significantly correlated with each other. The level of symptom occurrence in patients with lung cancer or cervix cancer was significantly higher than the level in patients with stomach cancer. Patients receiving radiation therapy or a combined therapy of radiation therapy and chemotherapy experienced significantly higher level of symptom occurrence significantly higher level of symptom occurrence than those receiving chemotherapy only. Also, female patients experienced higher level of symptom occurrence than male patients did. Conclusion: The sites of cancer, types of treatment, and gender influence the level of symptom occurrence of patients with cancer. Thus, these variables should be considered when assessing and planing for symptom occurrence of patients with cancer.

아마릴 정(글리메피리드 2㎎)에 대한 글리메드 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,김세미,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tables, Amaryl^(?)(Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn Ⅱ Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, 22.65±2.19 years in age and 66.55±8.85 kg in body weight, were divided into two groups and randomized 2×2 cross-over study was employed. After one tablet containing 2 ㎎ as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detctor. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.84)∼log(1.04) and log(0.82)∼log(1.03) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

창원대학교 신입생의 체중조절에 대한 태도와 식습관 및 영양지식에 관한 연구

허은실,이경혜 창원대학교 생활과학연구소 1998 생활과학연구 Vol.- No.2

The purpose of this survey was to assess attitude toward weight control, food habits and nutrition knowlege by self questionnaire of 1650 freshmans in Changwon National University. The results obtained were summarized as follows: Self-evaluation for weight was found the underestimation in normal weighted male students and the overestimation in underweighted female students. The main reason for meal was to satisfy hungry and to nutrient intake. But the objectives of meal were significantly difference between male and female. compared to male. In sack time, male had more snack after dinner and before sleeping. It showed women had more nutrition knowledge.

비유피-4 정(염산프로피베린 20㎎)에 대한 건일염산프로피베린 정의 생물학적동등성

조혜영,박은자,강현아,백승희,김세미,박찬호,오인준,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The purpose of the present study was to evaluate the bioequivalence of two propiverine hydrochloride tablets. BUP-4 (Jeil Pharm. Co., Ltd.) and Kuhnil Propiverine Hydrochloride (Kuhnil Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The propiverine release from the two propiverine hydrochloride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solutions, water and blend of polysorbate 80 into pH 6.8). Twenty six healthy male subjects, 23.73 ± 2.79 years in age and 67.04 ± 7.93 kg in body weight, were divided into two groups and a randomized 2 x 2 cross-over study was employed. After one tablet containing 20 mg as propiverine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of propiverine in serum were determined using HPLC method with UV detector. The dis-solution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC" C _(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, C_(max), and untransformed T_(max). The results showed that the differences between two formulations based on the BUP-4 were 0.17%, 7.98% and 4.55% for AUC,, C_(max), and respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically trans-formed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.88)-log(l .12) and log(0.90)-log(l.15) for AUC, and _(max), respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kuhnil Propiverine Hydrochloride tablet was bioequivalent to BUP-4 tablet.