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채완순(Chae, Wan Soon),Hardiman, Eric R. 한국정신건강사회복지학회 2016 정신보건과 사회사업 Vol.44 No.2
이 연구는 정신장애인들의 회복을 위한 목표설정 과정을 탐색하였다. 이를 위해 근거이론 방법을 활용하여 사회복귀시설을 이용하고 있는 정신장애인 15명을 대상으로 심층 인터뷰하였다. 연구결과 97개의 개념, 21개의 하위범주, 그리고 13개의 상위범주로 유목화할 수 있었다. 정신장애인의 회복을 위한 목표설정 과정의 개념적 틀에서 중심 현상은 ‘나에게 적합한 목표를 갖고 싶음’으로 나타났다. 이러한 중심 현상은 ‘이루고 싶은 것들을 갈망함’이라는 인과적 조건과 ‘몸이 안 따라 줌’과 ‘교육이 부족함’이라는 맥락적 조건의 영향을 받는 것으로 나타났다. 작용/상호작용 전략은 ‘하나씩 도전하기’, ‘작은 것 실천하기’, ‘우선순위 정하기’로 나타났고, 이에 영향을 미치는 중재적 조건은 ‘한을 풀고 싶음’, ‘가족이 힘이 됨’과 ‘프로그램에 참여함’으로 나타났다. 이러한 작용/상호작용 전략으로 인해 ‘자신감이 생김’, ‘행복감을 느낌’, ‘건강이 나아짐’의 3가지 결과가 나타났다. 정신장애인들은 나에게 적합한 목표를 찾아가는 과정에서 회복을 경험하고 있었다. 본 연구는 국내에서 처음으로 정신장애인의 목표설정 과정을 연구함으로써 정책적ㆍ임상적 개입에 그 함의가 클 것으로 기대한다. In this research, we explored the goal-setting process of people with schizophrenia for recovery. To do so, we conducted in-depth interviews with 15 schizophrenics using social rehabilitation centers based on the grounded theory method. As a result, we were able to identify 13 categories, 21 sub-categories and 97 concepts. In the conceptual framework of the goal-setting process for the recovery of schizophrenics, the central phenomenon turned out to be ‘I want to have a goal that suits me.’ The central phenomenon was influenced by the causal condition of ‘I desire to pursue what I want to realize’ and the contextual conditions of ‘I am not physically strong enough’ and ‘I do not have sufficient education.’ The action-interaction strategies are ‘try to achieve one by one’, ‘start trying a small task first’, and ‘prioritize tasks’, which is affected by the intervening conditions of ‘I want to vent my spite’, ‘I feel secure because my family give me their support’ and ‘I participate in programs’. The action-interaction strategies led to three results: ‘I became more confident’, ‘I feel happy’ and ‘My health is improving’. People with schizophrenia felt recovered in the process of finding their goal. Since this is the very first research on the goal-setting process of schizophrenics in Korea, we expect this research to have significant implications for policy and clinical interventions in the country.
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채완순(Chae, Wan-Soon),Hardiman, Eric R. 한국정신건강사회복지학회 2015 정신보건과 사회사업 Vol.43 No.4
본 연구의 목적은 결혼이민여성의 조현병을 가진 배우자와의 결혼생활과정을 밝히는 것이다. 연구방법은 질적 연구의 한 방법인 근거이론을 사용하였다. 연구대상은 전국의 132개의 정신보건센터와 208개의 정신장애인 사회복귀시설의 도움을 받아 12명의 대상자를 선정하였다. 연구참여자는 조현병이 있는 남성과 결혼하였고, 아이가 있는 결혼이민여성이었다. 심도 깊은 인터뷰를 통해 자료를 수집하였다. 본 연구의 결과로 190개의 개념과 25개의 하위범주와 15개의 상위범주를 발견하였다. 그리고 조현병을 가진 배우자와 결혼한 결혼이민여성의 결혼생활과정 4단계를 밝혔다. 그 과정의 첫 번째 단계는 ‘절망하기’이고 마지막 단계는 ‘지탱하기’이다. 핵심범주는 ‘참고 견디며 척박한 땅에 뿌리내리기’이다. 그리고 결혼생활을 유지해 가는 유형 3가지를 밝혔는데, 가장 많은 유형은 ‘탈출갈망형’이다. 마지막으로 조현병을 가진 배우자와 결혼한 결혼이민여성의 친구, 가족, 지역사회, 국가와 관련한 상황 모형을 밝혔다. 본 연구는 조현병을 가진 배우자와 결혼한 결혼이민여성의 결혼생활에 대한 연구가 거의 전무한 상태에서 이들의 결혼생활과정을 밝힘으로써 지역사회와 국가가 어떻게 서비스를 지원해야 할 것인가에 대한 구체적인 방안을 제공할 수 있는 틀을 마련하였다. Immigrant women married to men with schizophrenia in Korea are experiencing difficulties in adjusting to the unexpected marital life. This paper aims to analyze the process and patterns of these women’s marital life and provide implications for interventions to help them. This paper is based on the grounded theory methodology. Twelve women, all mothers, were selected as research participants by aid of mental health centers, halfway houses, and multicultural family centers nationwide. The personal stories were collected by in-depth interviews. The data analysis resulted in 190 concepts, 25 subcategories, and 15 superordinate categories. These women’s adjustment process to marital life showed 4 stages from “Disappointment” to “Survival.” The core category was “Enduring and Taking Root in the Infertile Soil.” Their marital life had 3 patterns, and the most common pattern was “Reality-escaping.” This paper initially reveals what the immigrant women married to men with schizophrenia in Korea suffer, and how they handle the unexpected marital life. To help these women to establish sound relationships with their families and to sustainably take root in Korean society, the local communities and the government should provide them with customized services to fit each stage and pattern.
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The HadGEM2-ES implementation of CMIP5 centennial simulations
Jones, C. D.,Hughes, J. K.,Bellouin, N.,Hardiman, S. C.,Jones, G. S.,Knight, J.,Liddicoat, S.,O&,apos,Connor, F. M.,Andres, R. J.,Bell, C.,Boo, K.-O.,Bozzo, A.,Butchart, N.,Cadule, P.,Corbin, K. D. Copernicus GmbH 2011 Geoscientific model development Vol.4 No.3
<P><p><strong>Abstract.</strong> The scientific understanding of the Earth's climate system, including the central question of how the climate system is likely to respond to human-induced perturbations, is comprehensively captured in GCMs and Earth System Models (ESM). Diagnosing the simulated climate response, and comparing responses across different models, is crucially dependent on transparent assumptions of how the GCM/ESM has been driven - especially because the implementation can involve subjective decisions and may differ between modelling groups performing the same experiment. This paper outlines the climate forcings and setup of the Met Office Hadley Centre ESM, HadGEM2-ES for the CMIP5 set of centennial experiments. We document the prescribed greenhouse gas concentrations, aerosol precursors, stratospheric and tropospheric ozone assumptions, as well as implementation of land-use change and natural forcings for the HadGEM2-ES historical and future experiments following the Representative Concentration Pathways. In addition, we provide details of how HadGEM2-ES ensemble members were initialised from the control run and how the palaeoclimate and AMIP experiments, as well as the 'emission-driven' RCP experiments were performed.</p> </P>
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Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
Kwon, H.,Bajaj, J.,Ito, T.,Blevins, A.,Konuma, T.,Weeks, J.,Lytle, Nikki K.,Koechlein, Claire S.,Rizzieri, D.,Chuah, C.,Oehler, Vivian G.,Sasik, R.,Hardiman, G.,Reya, T. Cell Press 2015 Cell stem cell Vol.17 No.2
Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML. We generated Tspan3 knockout mice that were born without overt defects. However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML. Additionally, Tspan3 inhibition blocked growth of AML patient samples, suggesting that Tspan3 is also important in human disease. As part of the mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in AML localization within the niche. These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.
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